{"id":"https://openalex.org/W2016153631","doi":"https://doi.org/10.1182/blood-2004-06-2242","title":"A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress","display_name":"A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress","publication_year":2005,"publication_date":"2005-02-03","ids":{"openalex":"https://openalex.org/W2016153631","doi":"https://doi.org/10.1182/blood-2004-06-2242","mag":"2016153631","pmid":"https://pubmed.ncbi.nlm.nih.gov/15692066","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1895157"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2004-06-2242","doi":"https://doi.org/10.1182/blood-2004-06-2242","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2004-06-2242","pdf_url":"https://ashpublications.org/blood/article-pdf/106/3/827/1711473/zh801505000827.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/106/3/827/1711473/zh801505000827.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109422422","display_name":"Lilia Stepanova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lilia Stepanova","raw_affiliation_strings":["From the Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, TN; and Division of Experimental Hematology, Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, TN","From the Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, TN; and Division of Experimental Hematology, Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"From the Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110023421","display_name":"Brian P. Sorrentino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian P. Sorrentino","raw_affiliation_strings":["From the Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, TN; and Division of Experimental Hematology, Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, TN","From the Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, TN; and Division of Experimental Hematology, Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"From the Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":5.1739,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.95777057,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"106","issue":"3","first_page":"827","last_page":"832"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":0.9869999885559082},{"id":"https://openalex.org/keywords/p19arf","display_name":"p19ARF","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ink4a-arf-locus","display_name":"INK4a/ARF locus","score":0.8820000290870667},{"id":"https://openalex.org/keywords/serial-transplantation","display_name":"serial transplantation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/competitive-repopulation","display_name":"competitive repopulation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.5099999904632568},{"id":"https://openalex.org/keywords/hematopoietic-failure","display_name":"hematopoietic failure","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7491909861564636},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6815417408943176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6304323077201843},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6094664931297302},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5662766695022583},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43539106845855713},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4206516742706299},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34195366501808167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17840278148651123},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14282011985778809}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D025803","descriptor_name":"Tumor Suppressor Protein p14ARF","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2004-06-2242","doi":"https://doi.org/10.1182/blood-2004-06-2242","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2004-06-2242","pdf_url":"https://ashpublications.org/blood/article-pdf/106/3/827/1711473/zh801505000827.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1895157","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1895157","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},{"id":"pmid:15692066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15692066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood-2004-06-2242","doi":"https://doi.org/10.1182/blood-2004-06-2242","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2004-06-2242","pdf_url":"https://ashpublications.org/blood/article-pdf/106/3/827/1711473/zh801505000827.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1133392925","display_name":"Lentiviral Gene Therapy for Sickle Cell Disease And Immunodeficiency Disorders","funder_award_id":"P01HL053749","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G865138149","display_name":null,"funder_award_id":"CA 21765","funder_id":"https://openalex.org/F4320313598","funder_display_name":"American Lebanese Syrian Associated Charities"},{"id":"https://openalex.org/G9000904664","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA021765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306242","display_name":"Assisi Foundation of Memphis","ror":"https://ror.org/03b8ttp75"},{"id":"https://openalex.org/F4320313598","display_name":"American Lebanese Syrian Associated Charities","ror":"https://ror.org/03rx10x31"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016153631.pdf","grobid_xml":"https://content.openalex.org/works/W2016153631.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W134011100","https://openalex.org/W1481473039","https://openalex.org/W1492396077","https://openalex.org/W1569324890","https://openalex.org/W1973886069","https://openalex.org/W1975268103","https://openalex.org/W1977970490","https://openalex.org/W1980835609","https://openalex.org/W1992996777","https://openalex.org/W2003223749","https://openalex.org/W2011221227","https://openalex.org/W2017235640","https://openalex.org/W2021050536","https://openalex.org/W2021550815","https://openalex.org/W2029073164","https://openalex.org/W2046958356","https://openalex.org/W2049085719","https://openalex.org/W2071110704","https://openalex.org/W2092015913","https://openalex.org/W2093958228","https://openalex.org/W2134893659","https://openalex.org/W2167732166","https://openalex.org/W2324248025"],"related_works":["https://openalex.org/W1587259088","https://openalex.org/W2116043907","https://openalex.org/W2146707026","https://openalex.org/W3031480177","https://openalex.org/W2001407037","https://openalex.org/W131312159","https://openalex.org/W2080364970","https://openalex.org/W2571601099","https://openalex.org/W2550345424","https://openalex.org/W2562374344"],"abstract_inverted_index":{"It":[0],"has":[1],"long":[2],"been":[3],"known":[4],"that":[5,32,178],"prolonged":[6],"culture":[7],"or":[8,36,38,57,93],"serial":[9,129],"transplantation":[10],"leads":[11],"to":[12,80,98,156],"the":[13,21,45,117,124,171,182],"loss":[14,25,46,125,192],"of":[15,34,47,51,119,126,151,162,167,174,181,195],"hematopoietic":[16,168],"stem":[17],"cells":[18,77,89,100,133],"(HSCs);":[19],"however,":[20],"mechanisms":[22,179],"for":[23],"this":[24],"are":[26],"not":[27,62,137],"well":[28],"understood.":[29],"We":[30,114,176],"hypothesized":[31],"expression":[33],"p16Ink4a":[35,122],"p19Arf":[37,120],"both":[39],"may":[40],"play":[41,186],"a":[42,102,141,187],"role":[43,118,189],"in":[44,55,58,64,74,83,101,109,123,170,190],"HSCs":[48,67,127],"during":[49,128,193],"conditions":[50,194],"enhanced":[52],"proliferation,":[53],"either":[54,91],"vitro":[56],"vivo.":[59],"Arf":[60],"was":[61,72],"expressed":[63],"freshly":[65],"isolated":[66],"from":[68,90,134],"adult":[69],"mice":[70,95,139],"but":[71,136],"induced":[73],"phenotypically":[75],"primitive":[76],"after":[78],"10":[79],"12":[81],"days":[82],"culture.":[84],"When":[85],"cultured":[86],"bone":[87],"marrow":[88,132],"Arf-/-":[92],"Ink4a-Arf-/-":[94],"were":[96,112],"compared":[97,155],"wild-type":[99,157],"competitive":[103],"repopulation":[104],"assay,":[105],"no":[106],"significant":[107],"differences":[108],"HSC":[110,191],"activity":[111],"seen.":[113],"then":[115],"evaluated":[116],"and":[121],"transplantation.":[130,175],"Bone":[131],"Ink4a-Arf-/-,":[135],"Arf-/-,":[138],"had":[140],"modestly":[142],"extended":[143],"life":[144],"span":[145],"and,":[146],"on":[147],"average,":[148],"supported":[149],"reconstitution":[150],"one":[152],"additional":[153],"recipient":[154],"cells.":[158],"Mice":[159],"given":[160],"transplants":[161],"Ink4a-Arf-/-cells":[163],"eventually":[164],"did":[165],"die":[166],"failure":[169],"next":[172],"round":[173],"conclude":[177],"independent":[180],"Ink4a-Arf":[183],"gene":[184],"locus":[185],"dominant":[188],"proliferative":[196],"stress.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
