{"id":"https://openalex.org/W2016144997","doi":"https://doi.org/10.1159/000018600","title":"Cytokines in Surgical Trauma: Cholecystectomy as an Example","display_name":"Cytokines in Surgical Trauma: Cholecystectomy as an Example","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2016144997","doi":"https://doi.org/10.1159/000018600","mag":"2016144997","pmid":"https://pubmed.ncbi.nlm.nih.gov/9845569"},"language":"en","primary_location":{"id":"doi:10.1159/000018600","doi":"https://doi.org/10.1159/000018600","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000018600","pdf_url":null,"source":{"id":"https://openalex.org/S178239422","display_name":"Digestive Surgery","issn_l":"0253-4886","issn":["0253-4886","1421-9883","1421-9983"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109282452","display_name":"P.U. Reber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"P.U. Reber","raw_affiliation_strings":["Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105737697","display_name":"\u00c5. Andr\u00e9n-Sandberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"\u00c5. Andr\u00e9n-Sandberg","raw_affiliation_strings":["Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068464373","display_name":"BM Schmied","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"B. Schmied","raw_affiliation_strings":["Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113513730","display_name":"M.W. B\u00fcchler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M.W. B\u00fcchler","raw_affiliation_strings":["Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9379,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.73926584,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"15","issue":"2","first_page":"92","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.3359000086784363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.3359000086784363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.28929999470710754,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.10279999673366547,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9300000071525574},{"id":"https://openalex.org/keywords/surgical-trauma","display_name":"surgical trauma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cholecystectomy","display_name":"cholecystectomy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/acute-phase-response","display_name":"acute phase response","score":0.9879999756813049},{"id":"https://openalex.org/keywords/anti-inflammatory-cytokines","display_name":"anti-inflammatory cytokines","score":0.7509999871253967},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9139999747276306},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9620000123977661},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.9919999837875366},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8679999709129333},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.843999981880188},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.9290000200271606},{"id":"https://openalex.org/keywords/minimally-invasive-surgery","display_name":"minimally invasive surgery","score":0.9409999847412109},{"id":"https://openalex.org/keywords/systemic-cytokine-response","display_name":"systemic cytokine response","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9372962117195129},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.7068471312522888},{"id":"https://openalex.org/C2776641081","wikidata":"https://www.wikidata.org/wiki/Q638774","display_name":"Cholecystectomy","level":2,"score":0.6132369637489319},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5805317759513855},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5308390855789185},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.4959011971950531},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.46416619420051575},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.44687962532043457},{"id":"https://openalex.org/C2781090800","wikidata":"https://www.wikidata.org/wiki/Q776030","display_name":"Systemic inflammatory response syndrome","level":3,"score":0.4344962239265442},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4319838285446167},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3490513563156128},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3479885458946228},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26337361335754395},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.13800999522209167}],"mesh":[{"descriptor_ui":"D002763","descriptor_name":"Cholecystectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013514","descriptor_name":"Surgical Procedures, Operative","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019060","descriptor_name":"Minimally Invasive Surgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000018600","doi":"https://doi.org/10.1159/000018600","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000018600","pdf_url":null,"source":{"id":"https://openalex.org/S178239422","display_name":"Digestive Surgery","issn_l":"0253-4886","issn":["0253-4886","1421-9883","1421-9983"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Surgery","raw_type":"journal-article"},{"id":"pmid:9845569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9845569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W1494177","https://openalex.org/W50057296","https://openalex.org/W101003761","https://openalex.org/W145721345","https://openalex.org/W156288104","https://openalex.org/W1510730676","https://openalex.org/W1527087951","https://openalex.org/W1527174508","https://openalex.org/W1657108383","https://openalex.org/W1678649710","https://openalex.org/W1832527043","https://openalex.org/W1845196765","https://openalex.org/W1855316965","https://openalex.org/W1910433138","https://openalex.org/W1963957687","https://openalex.org/W1966752509","https://openalex.org/W1966980702","https://openalex.org/W1971226765","https://openalex.org/W1972229497","https://openalex.org/W1973190276","https://openalex.org/W1973478081","https://openalex.org/W1974100071","https://openalex.org/W1974159935","https://openalex.org/W1975773833","https://openalex.org/W1977404595","https://openalex.org/W1982746360","https://openalex.org/W1983239749","https://openalex.org/W1984204145","https://openalex.org/W1985109870","https://openalex.org/W1988181809","https://openalex.org/W1996025216","https://openalex.org/W1996865385","https://openalex.org/W1997739078","https://openalex.org/W2001594081","https://openalex.org/W2002230234","https://openalex.org/W2002296857","https://openalex.org/W2003830776","https://openalex.org/W2005211946","https://openalex.org/W2005362266","https://openalex.org/W2010385299","https://openalex.org/W2012909860","https://openalex.org/W2013790920","https://openalex.org/W2018666008","https://openalex.org/W2019723733","https://openalex.org/W2026073203","https://openalex.org/W2029545109","https://openalex.org/W2031801800","https://openalex.org/W2032944586","https://openalex.org/W2033064780","https://openalex.org/W2034170689","https://openalex.org/W2048325240","https://openalex.org/W2048540725","https://openalex.org/W2051808553","https://openalex.org/W2053397495","https://openalex.org/W2056225363","https://openalex.org/W2061050790","https://openalex.org/W2066597122","https://openalex.org/W2070659456","https://openalex.org/W2072486140","https://openalex.org/W2082616460","https://openalex.org/W2085911628","https://openalex.org/W2086858064","https://openalex.org/W2089593001","https://openalex.org/W2089822346","https://openalex.org/W2092202350","https://openalex.org/W2104062445","https://openalex.org/W2109769967","https://openalex.org/W2123884323","https://openalex.org/W2126726439","https://openalex.org/W2150674484","https://openalex.org/W2163518925","https://openalex.org/W2172413152","https://openalex.org/W2301774737","https://openalex.org/W2304531976","https://openalex.org/W2332739634","https://openalex.org/W2387025069","https://openalex.org/W2401380572","https://openalex.org/W2408552104","https://openalex.org/W2409056966","https://openalex.org/W2410330794","https://openalex.org/W2418004245","https://openalex.org/W2463468187","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2092202350","https://openalex.org/W1974100071","https://openalex.org/W1982746360","https://openalex.org/W2416296058","https://openalex.org/W2005362266","https://openalex.org/W2110906891","https://openalex.org/W2092177387","https://openalex.org/W2081582624","https://openalex.org/W1979327126","https://openalex.org/W2410828592"],"abstract_inverted_index":{"Interleukin-1":[0],"(IL-1),":[1],"tumor":[2],"necrosis":[3],"factor":[4,73],"and":[5,14,21,35,42,98],"particularly":[6],"IL-6":[7],"are":[8,91,105],"potent":[9],"mediators":[10],"of":[11,45,48,65,102],"the":[12,46,99,103],"immune":[13],"acute":[15],"phase":[16],"response":[17,90],"caused":[18],"by":[19,28],"surgery":[20,51,104],"trauma.":[22],"Their":[23],"production":[24],"can":[25],"be":[26,53,76,93],"reduced":[27],"steroids,":[29],"nonsteroidal":[30],"anti-inflammatory":[31,36],"agents,":[32],"nitric":[33],"oxide":[34],"cytokines":[37],"such":[38],"as":[39],"IL-4,":[40],"IL-10":[41],"IL-13.":[43],"Some":[44],"benefits":[47],"minimal":[49],"invasive":[50],"may":[52],"due":[54],"to":[55,63,92],"lower":[56,87],"cytokine":[57,89],"levels":[58],"in":[59],"these":[60],"procedures":[61,83],"compared":[62],"those":[64],"conventional":[66],"surgery,":[67],"although":[68],"this":[69],"is":[70],"but":[71],"one":[72],"that":[74,84],"should":[75],"taken":[77],"into":[78],"account.":[79],"Therefore,":[80],"all":[81],"surgical":[82],"cause":[85],"a":[86],"systemic":[88],"favored":[94],"if":[95],"other":[96],"effects":[97,101],"side":[100],"equal.":[106]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}