{"id":"https://openalex.org/W2016133306","doi":"https://doi.org/10.1158/0008-5472.can-14-2643-t","title":"Serine Deprivation Enhances Antineoplastic Activity of Biguanides","display_name":"Serine Deprivation Enhances Antineoplastic Activity of Biguanides","publication_year":2014,"publication_date":"2014-11-07","ids":{"openalex":"https://openalex.org/W2016133306","doi":"https://doi.org/10.1158/0008-5472.can-14-2643-t","mag":"2016133306","pmid":"https://pubmed.ncbi.nlm.nih.gov/25377470"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-14-2643-t","doi":"https://doi.org/10.1158/0008-5472.can-14-2643-t","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-14-2643-t","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079752291","display_name":"Simon\u2010Pierre Gravel","orcid":"https://orcid.org/0000-0001-8411-8054","observed_orcids":["https://orcid.org/0000-0001-8411-8054"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Simon-Pierre Gravel","raw_affiliation_strings":["1Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada","2Department of Biochemistry, McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"2Department of Biochemistry, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083273593","display_name":"Laura Hulea","orcid":"https://orcid.org/0000-0001-7585-7760","observed_orcids":["https://orcid.org/0000-0001-7585-7760"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Laura Hulea","raw_affiliation_strings":["3Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada","4Department of Oncology, McGill University, Montreal, Quebec, Canada","5Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"4Department of Oncology, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"5Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035883116","display_name":"Nader Toban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nader Toban","raw_affiliation_strings":["3Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada","5Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"5Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067887370","display_name":"Elena Birman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Elena Birman","raw_affiliation_strings":["5Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111903079","display_name":"Marie\u2010Jos\u00e9 Blouin","orcid":"https://orcid.org/0009-0003-8032-2789","observed_orcids":["https://orcid.org/0009-0003-8032-2789"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marie-Jos\u00e9 Blouin","raw_affiliation_strings":["5Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068822443","display_name":"Mahvash Zakikhani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mahvash Zakikhani","raw_affiliation_strings":["5Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101112097","display_name":"Yunhua Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yunhua Zhao","raw_affiliation_strings":["5Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011530890","display_name":"Ivan Topisirovi\u0107","orcid":"https://orcid.org/0000-0002-5510-9762","observed_orcids":["https://orcid.org/0000-0002-5510-9762"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Ivan Topisirovic","raw_affiliation_strings":["2Department of Biochemistry, McGill University, Montreal, Quebec, Canada","3Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada","4Department of Oncology, McGill University, Montreal, Quebec, Canada","5Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Biochemistry, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"3Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"4Department of Oncology, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"5Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048843465","display_name":"Julie St\u2010Pierre","orcid":"https://orcid.org/0000-0002-2815-7099","observed_orcids":["https://orcid.org/0000-0002-2815-7099"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Julie St-Pierre","raw_affiliation_strings":["1Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada","2Department of Biochemistry, McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"2Department of Biochemistry, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005616347","display_name":"Micha\u00ebl Pollak","orcid":"https://orcid.org/0000-0003-3047-0604","observed_orcids":["https://orcid.org/0000-0003-3047-0604"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Michael Pollak","raw_affiliation_strings":["3Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada","4Department of Oncology, McGill University, Montreal, Quebec, Canada","5Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada","6Division of Cancer Prevention, McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"4Department of Oncology, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"5Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]},{"raw_affiliation_string":"6Division of Cancer Prevention, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005616347","https://openalex.org/A5011530890","https://openalex.org/A5048843465"],"corresponding_institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356","https://openalex.org/I5023651"],"apc_list":null,"apc_paid":null,"fwci":2.799,"has_fulltext":false,"cited_by_count":138,"citation_normalized_percentile":{"value":0.9126706,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"74","issue":"24","first_page":"7521","last_page":"7533"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biguanides","display_name":"biguanides","score":0.8510000109672546},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/phenformin","display_name":"phenformin","score":1.0},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9509999752044678},{"id":"https://openalex.org/keywords/oxidative-phosphorylation-inhibition","display_name":"oxidative phosphorylation inhibition","score":0.8880000114440918},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cancer-cell-energy-metabolism","display_name":"cancer cell energy metabolism","score":0.8560000061988831},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.8220000267028809},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C2777688063","wikidata":"https://www.wikidata.org/wiki/Q142880","display_name":"Biguanide","level":4,"score":0.9634734392166138},{"id":"https://openalex.org/C2778877718","wikidata":"https://www.wikidata.org/wiki/Q753100","display_name":"Phenformin","level":4,"score":0.905290961265564},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.7783370018005371},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.7300326228141785},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6263561248779297},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.615113377571106},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47063538432121277},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45702263712882996},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3755485713481903},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.34764158725738525},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.331536203622818},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.28021979331970215},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2746683955192566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26655691862106323}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001645","descriptor_name":"Biguanides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001645","descriptor_name":"Biguanides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001645","descriptor_name":"Biguanides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010629","descriptor_name":"Phenformin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010629","descriptor_name":"Phenformin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010629","descriptor_name":"Phenformin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.can-14-2643-t","doi":"https://doi.org/10.1158/0008-5472.can-14-2643-t","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-14-2643-t","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:25377470","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25377470","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7900000214576721}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1460986868","display_name":null,"funder_award_id":"MOP115-195","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G5421241657","display_name":null,"funder_award_id":"FRN53888","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G7228652678","display_name":"The role of the PGC-1 transcriptional coactivators in the regulation of breast cancer metabolism","funder_award_id":"106603_1","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W238923612","https://openalex.org/W1586805947","https://openalex.org/W1980181091","https://openalex.org/W1982324715","https://openalex.org/W1985079385","https://openalex.org/W1991473393","https://openalex.org/W1995069275","https://openalex.org/W1998771362","https://openalex.org/W2002583208","https://openalex.org/W2006978335","https://openalex.org/W2010238890","https://openalex.org/W2012442095","https://openalex.org/W2013047715","https://openalex.org/W2014460958","https://openalex.org/W2019683289","https://openalex.org/W2022899908","https://openalex.org/W2026413615","https://openalex.org/W2028743750","https://openalex.org/W2039558597","https://openalex.org/W2043585619","https://openalex.org/W2043614750","https://openalex.org/W2047516613","https://openalex.org/W2051522090","https://openalex.org/W2064656431","https://openalex.org/W2078190084","https://openalex.org/W2080971278","https://openalex.org/W2082564115","https://openalex.org/W2092152920","https://openalex.org/W2092340120","https://openalex.org/W2097259163","https://openalex.org/W2104696999","https://openalex.org/W2108281860","https://openalex.org/W2116516144","https://openalex.org/W2119437574","https://openalex.org/W2123014930","https://openalex.org/W2126464915","https://openalex.org/W2126524529","https://openalex.org/W2135617839","https://openalex.org/W2143681046","https://openalex.org/W2145640842","https://openalex.org/W2146654374","https://openalex.org/W2146780639","https://openalex.org/W2149343603","https://openalex.org/W2152647938","https://openalex.org/W2160615487","https://openalex.org/W2192730946","https://openalex.org/W2988150099"],"related_works":["https://openalex.org/W2256742939","https://openalex.org/W2035556663","https://openalex.org/W3094613791","https://openalex.org/W2003064295","https://openalex.org/W201275986","https://openalex.org/W2001497361","https://openalex.org/W2123409499","https://openalex.org/W3000483898","https://openalex.org/W1965699597","https://openalex.org/W2412099407"],"abstract_inverted_index":{"Metformin,":[0],"a":[1,82,121,142],"biguanide":[2,66,137],"widely":[3],"used":[4],"in":[5,16,27,94,127],"the":[6,59,104,109,115,132,148],"treatment":[7],"of":[8,49,62,106,112,136,150],"type":[9],"II":[10],"diabetes,":[11],"clearly":[12],"exhibits":[13],"antineoplastic":[14,60,153],"activity":[15,45],"experimental":[17],"models":[18],"and":[19,129],"has":[20],"been":[21],"reported":[22],"to":[23,34,42,69,86,89],"reduce":[24],"cancer":[25,157],"incidence":[26],"diabetics.":[28],"There":[29],"are":[30],"ongoing":[31],"clinical":[32],"trials":[33],"evaluate":[35],"its":[36,43],"antitumor":[37],"properties,":[38],"which":[39],"may":[40],"relate":[41],"fundamental":[44],"as":[46,152],"an":[47],"inhibitor":[48],"oxidative":[50,95],"phosphorylation.":[51],"Here,":[52],"we":[53],"show":[54],"that":[55,145,155],"serine":[56,85,101,125],"withdrawal":[57],"increases":[58],"effects":[61],"phenformin":[63],"(a":[64],"potent":[65],"structurally":[67],"related":[68],"metformin).":[70],"Serine":[71],"synthesis":[72],"was":[73],"not":[74],"inhibited":[75],"by":[76,97],"biguanides.":[77],"Instead,":[78],"metabolic":[79],"studies":[80],"indicated":[81],"requirement":[83],"for":[84,91],"allow":[87],"cells":[88],"compensate":[90],"biguanide-induced":[92],"decrease":[93],"phosphorylation":[96],"upregulating":[98],"glycolysis.":[99],"Furthermore,":[100],"deprivation":[102],"modified":[103],"impact":[105],"metformin":[107],"on":[108],"relative":[110],"abundance":[111],"metabolites":[113],"within":[114],"citric":[116],"acid":[117],"cycle.":[118],"In":[119],"mice,":[120],"serine-deficient":[122],"diet":[123],"reduced":[124],"levels":[126],"tumors":[128],"significantly":[130],"enhanced":[131],"tumor":[133],"growth-inhibitory":[134],"actions":[135],"treatment.":[138],"Our":[139],"results":[140],"define":[141],"dietary":[143],"manipulation":[144],"can":[146],"enhance":[147],"efficacy":[149],"biguanides":[151],"agents":[154],"target":[156],"cell":[158],"energy":[159],"metabolism.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":5}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
