{"id":"https://openalex.org/W2016133156","doi":"https://doi.org/10.1159/000082764","title":"Effects of Cataractogenesis on the CDP-Choline Pathway: Increased Phospholipid Synthesis in Lenses from Galactosemic Rats and 13/N Guinea Pigs","display_name":"Effects of Cataractogenesis on the CDP-Choline Pathway: Increased Phospholipid Synthesis in Lenses from Galactosemic Rats and 13/N Guinea Pigs","publication_year":2004,"publication_date":"2004-12-30","ids":{"openalex":"https://openalex.org/W2016133156","doi":"https://doi.org/10.1159/000082764","mag":"2016133156","pmid":"https://pubmed.ncbi.nlm.nih.gov/15604593"},"language":"en","primary_location":{"id":"doi:10.1159/000082764","doi":"https://doi.org/10.1159/000082764","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000082764","pdf_url":null,"source":{"id":"https://openalex.org/S177566603","display_name":"Ophthalmic Research","issn_l":"0030-3747","issn":["0030-3747","1423-0259"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmic Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089720392","display_name":"Howard M. Jernigan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799495847","display_name":"University of Tennessee System","ror":"https://ror.org/00xzqjh13","country_code":"US","type":"education","lineage":["https://openalex.org/I2799495847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard M. Jernigan Jr.","raw_affiliation_strings":["Department of Molecular Sciences, University of Tennessee, Memphis, TN 38163, USA. hjernigan@utmem.edu","Molecular Sciences and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sciences, University of Tennessee, Memphis, TN 38163, USA. hjernigan@utmem.edu","institution_ids":["https://openalex.org/I2799495847"]},{"raw_affiliation_string":"Molecular Sciences and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113638343","display_name":"Penny S. Blum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Penny S. Blum","raw_affiliation_strings":["Molecular Sciences and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Sciences and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072042618","display_name":"Ipsit Chakrabarti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ipsit Chakrabarti","raw_affiliation_strings":["Molecular Sciences and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Sciences and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058410302","display_name":"Yin Su","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yin Su","raw_affiliation_strings":["Molecular Sciences and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Sciences and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075071635","display_name":"J. Samuel Zigler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Samuel Zigler Jr.","raw_affiliation_strings":["Lens and Cataract Biology Section, National Eye Institute, Bethesda, Md., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lens and Cataract Biology Section, National Eye Institute, Bethesda, Md., USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.10679708,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"37","issue":"1","first_page":"7","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.5737000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.5737000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.266400009393692,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cataract-formation","display_name":"cataract formation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cdp-choline-pathway","display_name":"CDP-choline pathway","score":0.8360000252723694},{"id":"https://openalex.org/keywords/phospholipid-synthesis","display_name":"phospholipid synthesis","score":0.949999988079071},{"id":"https://openalex.org/keywords/lens","display_name":"lens","score":0.6990000009536743},{"id":"https://openalex.org/keywords/hereditary-cataract","display_name":"hereditary cataract","score":0.9309999942779541},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":0.9200000166893005},{"id":"https://openalex.org/keywords/phosphatidylethanolamine","display_name":"phosphatidylethanolamine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/choline","display_name":"choline","score":0.7450000047683716},{"id":"https://openalex.org/keywords/monoethanolamine","display_name":"monoethanolamine","score":0.9779999852180481},{"id":"https://openalex.org/keywords/membrane-repair","display_name":"membrane repair","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C2780225610","wikidata":"https://www.wikidata.org/wiki/Q127724","display_name":"Cataracts","level":2,"score":0.807007908821106},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.7540448904037476},{"id":"https://openalex.org/C2781170229","wikidata":"https://www.wikidata.org/wiki/Q426095","display_name":"Phosphatidylethanolamine","level":5,"score":0.7332623600959778},{"id":"https://openalex.org/C2779274956","wikidata":"https://www.wikidata.org/wiki/Q774483","display_name":"Galactosemia","level":3,"score":0.6718606948852539},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.6671648025512695},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.6529773473739624},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6055095195770264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5613732933998108},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.5080142021179199},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43573832511901855},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4242449700832367},{"id":"https://openalex.org/C2779564620","wikidata":"https://www.wikidata.org/wiki/Q241595","display_name":"Lecithin","level":2,"score":0.4230755567550659},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41191089153289795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28030943870544434},{"id":"https://openalex.org/C2778173381","wikidata":"https://www.wikidata.org/wiki/Q66589593","display_name":"Galactose","level":2,"score":0.2652766704559326},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.18129873275756836},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001834","descriptor_name":"Body Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003566","descriptor_name":"Cytidine Diphosphate Choline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004983","descriptor_name":"Ethanolamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005693","descriptor_name":"Galactosemias","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010714","descriptor_name":"Phosphatidylethanolamines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010767","descriptor_name":"Phosphorylcholine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000082764","doi":"https://doi.org/10.1159/000082764","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000082764","pdf_url":null,"source":{"id":"https://openalex.org/S177566603","display_name":"Ophthalmic Research","issn_l":"0030-3747","issn":["0030-3747","1423-0259"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmic Research","raw_type":"journal-article"},{"id":"pmid:15604593","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15604593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmic research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3948592803","display_name":"ORGANIC PHOSPHATE METABOLISM IN LENS STRESS &CATARACT","funder_award_id":"R01EY007938","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G6207562927","display_name":null,"funder_award_id":"EY07938","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W4562572","https://openalex.org/W35202202","https://openalex.org/W125205471","https://openalex.org/W131291697","https://openalex.org/W1498327239","https://openalex.org/W1575864823","https://openalex.org/W1577248693","https://openalex.org/W1581680249","https://openalex.org/W1587662096","https://openalex.org/W1593691922","https://openalex.org/W1601868493","https://openalex.org/W1970536605","https://openalex.org/W1971532939","https://openalex.org/W1999726562","https://openalex.org/W2004880253","https://openalex.org/W2010242622","https://openalex.org/W2022239421","https://openalex.org/W2025488960","https://openalex.org/W2027927438","https://openalex.org/W2035232616","https://openalex.org/W2036300942","https://openalex.org/W2041425482","https://openalex.org/W2042362891","https://openalex.org/W2045176963","https://openalex.org/W2045492272","https://openalex.org/W2047769313","https://openalex.org/W2051054352","https://openalex.org/W2059116369","https://openalex.org/W2059598932","https://openalex.org/W2059629421","https://openalex.org/W2061619178","https://openalex.org/W2073957082","https://openalex.org/W2074610409","https://openalex.org/W2087878738","https://openalex.org/W2088607825","https://openalex.org/W2088757547","https://openalex.org/W2089496150","https://openalex.org/W2091536560","https://openalex.org/W2091975377","https://openalex.org/W2102065346","https://openalex.org/W2141810718","https://openalex.org/W2165646315","https://openalex.org/W2168952933","https://openalex.org/W4300545919"],"related_works":["https://openalex.org/W2059629421","https://openalex.org/W2000895386","https://openalex.org/W2050736703","https://openalex.org/W1977919154","https://openalex.org/W1444012309","https://openalex.org/W2088607825","https://openalex.org/W1530588973","https://openalex.org/W4210983978","https://openalex.org/W148856772","https://openalex.org/W154494144"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,46,93],"effects":[3],"of":[4,71],"cataractogenesis":[5],"on":[6],"phospholipid":[7],"(P-lipid)":[8],"synthesis":[9,65,85,108],"in":[10,17,83,99,102,109],"sugar":[11],"cataracts":[12,19,52,100,111],"from":[13,20,26,74],"galactosemic":[14,51],"rats":[15,27],"and":[16,45,63],"hereditary":[18],"13/N":[21,76],"guinea":[22,77],"pigs.":[23],"Cataractous":[24],"lenses":[25,73],"fed":[28],"a":[29,80,114],"50%":[30],"galactose":[31],"diet":[32],"for":[33],"7":[34],"days":[35],"were":[36,48],"incubated":[37],"24":[38],"h":[39],"with":[40,87],"radiolabeled":[41],"choline":[42],"or":[43],"ethanolamine":[44],"P-lipids":[47],"extracted.":[49],"The":[50,105],"synthesized":[53],"twice":[54],"as":[55,59],"much":[56],"phosphatidylcholine":[57],"(PtdCho)":[58],"control":[60,88,103],"rat":[61],"lenses,":[62],"phosphatidylethanolamine":[64],"also":[66],"was":[67,97],"increased.":[68],"Similar":[69],"analysis":[70],"cataractous":[72],"3-week-old":[75],"pigs":[78],"showed":[79],"3-fold":[81],"increase":[82],"PtdCho":[84],"compared":[86],"lenses.":[89,104],"In":[90],"all":[91],"cases,":[92],"P-lipid":[94,107],"precursor":[95],"pool":[96],"lower":[98],"than":[101],"increased":[106],"these":[110],"may":[112],"represent":[113],"membrane":[115],"repair":[116],"response":[117],"to":[118],"cataractogenic":[119],"stress.":[120]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
