{"id":"https://openalex.org/W2016132086","doi":"https://doi.org/10.1002/bit.10007","title":"Towards the development of a minimal cell model by generalization of a model of Escherichia coli: Use of dimensionless rate parameters","display_name":"Towards the development of a minimal cell model by generalization of a model of Escherichia coli: Use of dimensionless rate parameters","publication_year":2001,"publication_date":"2001-10-01","ids":{"openalex":"https://openalex.org/W2016132086","doi":"https://doi.org/10.1002/bit.10007","mag":"2016132086","pmid":"https://pubmed.ncbi.nlm.nih.gov/11668452"},"language":"en","primary_location":{"id":"doi:10.1002/bit.10007","doi":"https://doi.org/10.1002/bit.10007","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bit.10007","pdf_url":null,"source":{"id":"https://openalex.org/S151564723","display_name":"Biotechnology and Bioengineering","issn_l":"0006-3592","issn":["0006-3592","1097-0290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Bioengineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084069179","display_name":"Samuel T. Browning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel T. Browning","raw_affiliation_strings":["School of Chemical Engineering, 120 Olin Hall, Cornell University, Ithaca, NY 14853-5201, USA","120 Olin Hall, School of Chemical Engineering, Cornell University, Ithaca, New York 14853-5201","fax: 607-255-1136","telephone: 607-255-7577"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Engineering, 120 Olin Hall, Cornell University, Ithaca, NY 14853-5201, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"120 Olin Hall, School of Chemical Engineering, Cornell University, Ithaca, New York 14853-5201","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"fax: 607-255-1136","institution_ids":[]},{"raw_affiliation_string":"telephone: 607-255-7577","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008392252","display_name":"Michael Louis Shuler","orcid":"https://orcid.org/0000-0002-4662-317X","observed_orcids":["https://orcid.org/0000-0002-4662-317X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael L. Shuler","raw_affiliation_strings":["120 Olin Hall, School of Chemical Engineering, Cornell University, Ithaca, New York 14853-5201; telephone: 607-255-7577; fax: 607-255-1136","120 Olin Hall, School of Chemical Engineering, Cornell University, Ithaca, New York 14853-5201","fax: 607-255-1136","telephone: 607-255-7577"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"120 Olin Hall, School of Chemical Engineering, Cornell University, Ithaca, New York 14853-5201; telephone: 607-255-7577; fax: 607-255-1136","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"120 Olin Hall, School of Chemical Engineering, Cornell University, Ithaca, New York 14853-5201","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"fax: 607-255-1136","institution_ids":[]},{"raw_affiliation_string":"telephone: 607-255-7577","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008392252"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":5060,"currency":"USD","value_usd":5060},"apc_paid":null,"fwci":0.3491,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.55152154,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"76","issue":"3","first_page":"187","last_page":"192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.7235999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.7235999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.2709999978542328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/minimal-cell-model","display_name":"minimal cell model","score":0.9959999918937683},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9430000185966492},{"id":"https://openalex.org/keywords/enzymatic-reactions","display_name":"enzymatic reactions","score":0.8600000143051147},{"id":"https://openalex.org/keywords/metabolic-network-model","display_name":"metabolic network model","score":0.4779999852180481},{"id":"https://openalex.org/keywords/genome-function","display_name":"genome function","score":0.3330000042915344},{"id":"https://openalex.org/keywords/reaction-rate-ratios","display_name":"reaction rate ratios","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C177148314","wikidata":"https://www.wikidata.org/wiki/Q170084","display_name":"Generalization","level":2,"score":0.750773549079895},{"id":"https://openalex.org/C24872484","wikidata":"https://www.wikidata.org/wiki/Q126818","display_name":"Dimensionless quantity","level":2,"score":0.7342419624328613},{"id":"https://openalex.org/C99844830","wikidata":"https://www.wikidata.org/wiki/Q102441924","display_name":"Scaling","level":2,"score":0.6402673721313477},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6020531058311462},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5467596650123596},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.5398516058921814},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.49803686141967773},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3607847988605499},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.32370591163635254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27884671092033386},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22091886401176453},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.19812238216400146},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1786191463470459},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16444477438926697},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.12361645698547363},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0978834331035614},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/bit.10007","doi":"https://doi.org/10.1002/bit.10007","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bit.10007","pdf_url":null,"source":{"id":"https://openalex.org/S151564723","display_name":"Biotechnology and Bioengineering","issn_l":"0006-3592","issn":["0006-3592","1097-0290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Bioengineering","raw_type":"journal-article"},{"id":"pmid:11668452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11668452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and bioengineering","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.505.7557","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.505.7557","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://complex.upf.es/~andreea/2006/Bib/Browning.DevelopmentMinimalCell.p.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life on land","score":0.699999988079071}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W208046272","https://openalex.org/W1512810258","https://openalex.org/W1558456135","https://openalex.org/W1577806554","https://openalex.org/W1763240259","https://openalex.org/W1988691705","https://openalex.org/W1989104313","https://openalex.org/W2011743601","https://openalex.org/W2015823673","https://openalex.org/W2022573834","https://openalex.org/W2040280990","https://openalex.org/W2041652393","https://openalex.org/W2053096433","https://openalex.org/W2075828988","https://openalex.org/W2082578449","https://openalex.org/W2090232842","https://openalex.org/W2090622331","https://openalex.org/W2096718691","https://openalex.org/W2153373497","https://openalex.org/W2164698321","https://openalex.org/W2332754257","https://openalex.org/W4239578492","https://openalex.org/W4245943235","https://openalex.org/W4249226311"],"related_works":["https://openalex.org/W2413214195","https://openalex.org/W2120080235","https://openalex.org/W2462439856","https://openalex.org/W2921247036","https://openalex.org/W10914140","https://openalex.org/W2104765182","https://openalex.org/W4247190712","https://openalex.org/W2101719057","https://openalex.org/W4391641402","https://openalex.org/W2003643556"],"abstract_inverted_index":{"A":[0],"model":[1,40,47,65,71,92,138],"of":[2,22,29,48,60,89,97,119,131],"a":[3,8,37,58,67,90,116,136],"minimal":[4,38,69],"cell":[5,39,70],"would":[6],"be":[7,74],"valuable":[9],"tool":[10],"in":[11,102,135,142],"identifying":[12],"the":[13,18,23,26,30,87,95,103,123,129,143],"organizing":[14],"principles":[15],"that":[16,72],"relate":[17],"static":[19],"sequence":[20],"information":[21],"genome":[24],"to":[25,42,57,79,140],"dynamic":[27],"functioning":[28],"living":[31],"cell.":[32],"Our":[33],"approach":[34],"for":[35,115],"developing":[36],"is":[41,66,126],"first":[43],"generalize":[44],"an":[45],"existing":[46],"Escherichia":[49],"coli":[50,105,145],"by":[51,76,93],"expressing":[52],"reaction":[53],"rates":[54],"as":[55,128],"ratios":[56],"set":[59],"reference":[61],"parameters.":[62],"This":[63],"generalized":[64,91],"prototype":[68],"will":[73],"developed":[75],"adding":[77],"detail":[78],"explicitly":[80],"include":[81],"each":[82],"chemical":[83],"species.":[84],"We":[85],"tested":[86],"concept":[88],"testing":[94],"effect":[96,111],"scaling":[98,108],"all":[99,132],"enzyme-catalyzed":[100,133],"reactions":[101,134],"E.":[104,144],"model.":[106,146],"The":[107],"has":[109],"little":[110],"on":[112],"cellular":[113],"function":[114],"wide":[117],"range":[118],"kinetic":[120,124],"ratios,":[121],"where":[122],"ratio":[125],"defined":[127],"rate":[130],"given":[137],"relative":[139],"those":[141]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}