{"id":"https://openalex.org/W2016129444","doi":"https://doi.org/10.1172/jci119314","title":"Hemorrhage increases cytokine expression in lung mononuclear cells in mice: involvement of catecholamines in nuclear factor-kappaB regulation and cytokine expression.","display_name":"Hemorrhage increases cytokine expression in lung mononuclear cells in mice: involvement of catecholamines in nuclear factor-kappaB regulation and cytokine expression.","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W2016129444","doi":"https://doi.org/10.1172/jci119314","mag":"2016129444","pmid":"https://pubmed.ncbi.nlm.nih.gov/9119995","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/507971"},"language":"en","primary_location":{"id":"doi:10.1172/jci119314","doi":"https://doi.org/10.1172/jci119314","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci119314","pdf_url":"http://www.jci.org/articles/view/119314/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/119314/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110049975","display_name":"Yves Le Tulzo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Le Tulzo","raw_affiliation_strings":["Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050082012","display_name":"Robert Shenkar","orcid":"https://orcid.org/0000-0002-1300-6845","observed_orcids":["https://orcid.org/0000-0002-1300-6845"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Shenkar","raw_affiliation_strings":["Division of Pulmonary Sciences and Critical Care Medicine , University of Colorado Health Sciences Center , Denver , Colorado 80262","University of Colorado, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Sciences and Critical Care Medicine , University of Colorado Health Sciences Center , Denver , Colorado 80262","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]},{"raw_affiliation_string":"University of Colorado, Denver","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053356227","display_name":"Debra Kaneko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Kaneko","raw_affiliation_strings":["Division of Pulmonary Sciences and Critical Care Medicine , University of Colorado Health Sciences Center , Denver , Colorado 80262","University of Colorado, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Sciences and Critical Care Medicine , University of Colorado Health Sciences Center , Denver , Colorado 80262","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]},{"raw_affiliation_string":"University of Colorado, Denver","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042321820","display_name":"Pierre Moine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Moine","raw_affiliation_strings":["Division of Pulmonary Sciences and Critical Care Medicine , University of Colorado Health Sciences Center , Denver , Colorado 80262","University of Colorado, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Sciences and Critical Care Medicine , University of Colorado Health Sciences Center , Denver , Colorado 80262","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]},{"raw_affiliation_string":"University of Colorado, Denver","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088316508","display_name":"Giamila Fantuzzi","orcid":"https://orcid.org/0000-0001-5334-0082","observed_orcids":["https://orcid.org/0000-0001-5334-0082"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Fantuzzi","raw_affiliation_strings":["Division of Pulmonary Sciences and Critical Care Medicine , University of Colorado Health Sciences Center , Denver , Colorado 80262","Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Sciences and Critical Care Medicine , University of Colorado Health Sciences Center , Denver , Colorado 80262","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Cancer Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028234430","display_name":"Charles Anthony Dinarello","orcid":"https://orcid.org/0000-0002-5073-8316","observed_orcids":["https://orcid.org/0000-0002-5073-8316"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C A Dinarello","raw_affiliation_strings":["Division of Pulmonary Sciences and Critical Care Medicine , University of Colorado Health Sciences Center , Denver , Colorado 80262","University of Colorado, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Sciences and Critical Care Medicine , University of Colorado Health Sciences Center , Denver , Colorado 80262","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]},{"raw_affiliation_string":"University of Colorado, Denver","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102795262","display_name":"Edward H Abraham","orcid":"https://orcid.org/0000-0002-4429-2389","observed_orcids":["https://orcid.org/0000-0002-4429-2389"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Abraham","raw_affiliation_strings":["Division of Pulmo- nary Sciences and Critical Care Medicine , University of Colorado Health Sciences Center , Box C272 , 4200 East Ninth Avenue , Denver , CO 80262 ","Division of Pulmonary Sciences and Critical Care Medicine , University of Colorado Health Sciences Center , Denver , Colorado 80262","University of Colorado, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmo- nary Sciences and Critical Care Medicine , University of Colorado Health Sciences Center , Box C272 , 4200 East Ninth Avenue , Denver , CO 80262 ","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Division of Pulmonary Sciences and Critical Care Medicine , University of Colorado Health Sciences Center , Denver , Colorado 80262","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]},{"raw_affiliation_string":"University of Colorado, Denver","institution_ids":["https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":5.5071,"has_fulltext":true,"cited_by_count":187,"citation_normalized_percentile":{"value":0.96669918,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"99","issue":"7","first_page":"1516","last_page":"1524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.40549999475479126,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.40549999475479126,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.20200000703334808,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.19089999794960022,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cytokine-expression","display_name":"cytokine expression","score":0.796999990940094},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.984000027179718},{"id":"https://openalex.org/keywords/alpha-adrenergic-receptors","display_name":"alpha-adrenergic receptors","score":0.972000002861023},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/phentolamine","display_name":"phentolamine","score":0.890999972820282},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":1.0},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.890999972820282},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.7360000014305115},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":1.0},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.7170000076293945},{"id":"https://openalex.org/keywords/inflammatory-lung-injury","display_name":"inflammatory lung injury","score":0.5080000162124634},{"id":"https://openalex.org/keywords/blood-loss","display_name":"blood loss","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.6871981620788574},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6847676038742065},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6335878372192383},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6105163097381592},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6041783690452576},{"id":"https://openalex.org/C40465926","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Adrenergic receptor","level":3,"score":0.49206918478012085},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.47209805250167847},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.44930651783943176},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4457361698150635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39898261427879333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.336387038230896},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.2664557099342346},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.23626402020454407}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010646","descriptor_name":"Phentolamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010646","descriptor_name":"Phentolamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010646","descriptor_name":"Phentolamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci119314","doi":"https://doi.org/10.1172/jci119314","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci119314","pdf_url":"http://www.jci.org/articles/view/119314/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:507971","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/507971","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:9119995","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9119995","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci119314","doi":"https://doi.org/10.1172/jci119314","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci119314","pdf_url":"http://www.jci.org/articles/view/119314/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"study_designs":[],"awards":[{"id":"https://openalex.org/G78422977","display_name":"CYTOKINES AND POSTHEMORRHAGE PULMONARY IMMUNODEPRESSION","funder_award_id":"5r01hl050284-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G827048359","display_name":null,"funder_award_id":"HL 50284","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320325386","display_name":"Soci\u00e9t\u00e9 de R\u00e9animation de Langue Fran\u00e7aise","ror":"https://ror.org/005tvz367"},{"id":"https://openalex.org/F4320327892","display_name":"European Society of Intensive Care Medicine","ror":"https://ror.org/0222qrf24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016129444.pdf","grobid_xml":"https://content.openalex.org/works/W2016129444.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W12952247","https://openalex.org/W21746843","https://openalex.org/W67995918","https://openalex.org/W98862664","https://openalex.org/W119797726","https://openalex.org/W128911665","https://openalex.org/W1480581382","https://openalex.org/W1485104973","https://openalex.org/W1486943611","https://openalex.org/W1549562401","https://openalex.org/W1556805910","https://openalex.org/W1564556915","https://openalex.org/W1568529372","https://openalex.org/W1598422803","https://openalex.org/W1602117004","https://openalex.org/W1607956110","https://openalex.org/W1672814326","https://openalex.org/W1823504924","https://openalex.org/W1868478050","https://openalex.org/W1904705252","https://openalex.org/W1914411412","https://openalex.org/W1920787626","https://openalex.org/W1931331902","https://openalex.org/W1964974445","https://openalex.org/W1965391727","https://openalex.org/W1975345113","https://openalex.org/W1981406037","https://openalex.org/W1984613280","https://openalex.org/W1991121223","https://openalex.org/W1991771163","https://openalex.org/W1993736002","https://openalex.org/W1998579754","https://openalex.org/W2013293102","https://openalex.org/W2018384981","https://openalex.org/W2024209406","https://openalex.org/W2024981885","https://openalex.org/W2026190778","https://openalex.org/W2027967898","https://openalex.org/W2031433004","https://openalex.org/W2034099880","https://openalex.org/W2036702266","https://openalex.org/W2048519644","https://openalex.org/W2051371077","https://openalex.org/W2054169253","https://openalex.org/W2054658792","https://openalex.org/W2055231692","https://openalex.org/W2059954873","https://openalex.org/W2061607472","https://openalex.org/W2065714116","https://openalex.org/W2066012308","https://openalex.org/W2068596614","https://openalex.org/W2074728285","https://openalex.org/W2076772936","https://openalex.org/W2082869216","https://openalex.org/W2083304301","https://openalex.org/W2085976990","https://openalex.org/W2095860222","https://openalex.org/W2097713392","https://openalex.org/W2098451760","https://openalex.org/W2099332798","https://openalex.org/W2116064835","https://openalex.org/W2118477707","https://openalex.org/W2134812217","https://openalex.org/W2151892297","https://openalex.org/W2167800649","https://openalex.org/W2168889062","https://openalex.org/W2236227678","https://openalex.org/W2314282423","https://openalex.org/W2403329072","https://openalex.org/W2405980989","https://openalex.org/W2421037982","https://openalex.org/W2489523323","https://openalex.org/W2584373698","https://openalex.org/W4237042838","https://openalex.org/W4239066152","https://openalex.org/W4254075371","https://openalex.org/W4290359384"],"related_works":["https://openalex.org/W2049243219","https://openalex.org/W1964974445","https://openalex.org/W2236227678","https://openalex.org/W1855398794","https://openalex.org/W1947823487","https://openalex.org/W2085976990","https://openalex.org/W2411315629","https://openalex.org/W7097168350","https://openalex.org/W2132910712","https://openalex.org/W2414015381"],"abstract_inverted_index":{"The":[0],"expression":[1,195],"of":[2,22,69,85,99,115,173,184,211],"proinflammatory":[3],"and":[4,14,41,51,64,88,103,145,157,202],"immunoregulatory":[5],"cytokines":[6],"rapidly":[7],"increases":[8,138,162,192],"in":[9,27,35,38,57,82,92,112,139,153,163],"the":[10,19,39,45,72,80,90,97,119,130,212],"lungs":[11],"after":[12,122],"hemorrhage,":[13],"such":[15,205],"alterations":[16],"contribute":[17],"to":[18,55],"frequent":[20],"development":[21],"acute":[23],"inflammatory":[24],"lung":[25,113,164],"injury":[26],"this":[28],"setting.":[29],"Blood":[30],"loss":[31],"also":[32,96],"produces":[33],"elevations":[34],"catecholamine":[36],"concentrations":[37],"pulmonary":[40,65,193],"systemic":[42],"circulation.":[43],"In":[44,124],"present":[46,152],"experiments,":[47],"we":[48],"used":[49],"alpha-":[50,197],"beta-adrenergic":[52,131,200],"receptor":[53,74,132],"blockade":[54],"examine":[56],"vivo":[58],"interactions":[59],"between":[60],"hemorrhage-induced":[61,171],"adrenergic":[62],"stimulation":[63],"cytokine":[66,194],"expression.":[67],"Treatment":[68,167],"mice":[70],"with":[71,129,137,168],"alpha-adrenergic":[73],"antagonist":[75,133],"phentolamine":[76],"prevented":[77,170],"not":[78,159,199],"only":[79],"elevation":[81],"mRNA":[83,140],"levels":[84,141],"IL-1beta,":[86,143],"TNF-alpha,":[87,144],"TGF-beta1,":[89,146],"increase":[91],"IL-1beta":[93,165],"protein,":[94,109,179],"but":[95,180,198],"activation":[98,183,210],"nuclear":[100],"factor":[101,215],"(NF)-KB":[102],"cyclic":[104,174],"AMP":[105,175],"response":[106,176],"element":[107,177],"binding":[108,178],"which":[110,147],"occurred":[111],"cells":[114],"untreated":[116,154],"animals":[117],"during":[118],"first":[120],"hour":[121],"hemorrhage.":[123],"contrast,":[125],"treatment":[126],"before":[127],"hemorrhage":[128,190],"propranolol":[134,169],"was":[135],"associated":[136],"for":[142],"were":[148],"greater":[149],"than":[150],"those":[151],"hemorrhaged":[155],"mice,":[156],"did":[158],"prevent":[160],"hemorrhage-associated":[161,182],"protein.":[166],"phosphorylation":[172],"increased":[181],"NF-KB.":[185],"These":[186],"results":[187],"demonstrate":[188],"that":[189,204],"initially":[191],"through":[196,209],"stimulation,":[201],"suggest":[203],"alpha-adrenergic-mediated":[206],"effects":[207],"occur":[208],"transcriptional":[213],"regulatory":[214],"NF-kappaB.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}