{"id":"https://openalex.org/W2016124159","doi":"https://doi.org/10.1038/nm1369","title":"Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates","display_name":"Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates","publication_year":2006,"publication_date":"2006-02-19","ids":{"openalex":"https://openalex.org/W2016124159","doi":"https://doi.org/10.1038/nm1369","mag":"2016124159","pmid":"https://pubmed.ncbi.nlm.nih.gov/16491083"},"language":"en","primary_location":{"id":"doi:10.1038/nm1369","doi":"https://doi.org/10.1038/nm1369","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nm1369","pdf_url":null,"source":{"id":"https://openalex.org/S203256638","display_name":"Nature Medicine","issn_l":"1078-8956","issn":["1078-8956","1546-170X","1744-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039801066","display_name":"Bernhard J. Hering","orcid":"https://orcid.org/0000-0002-5962-7284","observed_orcids":["https://orcid.org/0000-0002-5962-7284"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bernhard J Hering","raw_affiliation_strings":["Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, 424 Harvard Street SE, Minneapolis, Minnesota 55455, USA. bhering@umn.edu","Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, 424 Harvard Street SE, Minneapolis, Minnesota 55455, USA. bhering@umn.edu","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081922442","display_name":"Martin N. Wijkstrom","orcid":"https://orcid.org/0000-0001-6848-1478","observed_orcids":["https://orcid.org/0000-0001-6848-1478"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Wijkstrom","raw_affiliation_strings":["Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Melanie L Graham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie L Graham","raw_affiliation_strings":["Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063875996","display_name":"Maria H\u00e5rdstedt","orcid":"https://orcid.org/0000-0002-3671-5046","observed_orcids":["https://orcid.org/0000-0002-3671-5046"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria H\u00e5rdstedt","raw_affiliation_strings":["Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061649431","display_name":"Tor C. Aasheim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tor C Aasheim","raw_affiliation_strings":["Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111660723","display_name":"Tun Jie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tun Jie","raw_affiliation_strings":["Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072810449","display_name":"Jeffrey D. Ansite","orcid":"https://orcid.org/0000-0001-6241-0468","observed_orcids":["https://orcid.org/0000-0001-6241-0468"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey D Ansite","raw_affiliation_strings":["Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003809550","display_name":"Masahiko Nakano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masahiko Nakano","raw_affiliation_strings":["Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108384805","display_name":"Jane J. Cheng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jane Cheng","raw_affiliation_strings":["Immerge BioTherapeutics, Inc., Building 75, Third Avenue, Charlestown, 02129, Massachusetts, USA","#N##TAB##TAB##TAB##TAB# Novartis#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immerge BioTherapeutics, Inc., Building 75, Third Avenue, Charlestown, 02129, Massachusetts, USA","institution_ids":[]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Novartis#N##TAB##TAB##TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318008","display_name":"Wei Shan Li","orcid":"https://orcid.org/0000-0001-7458-2590","observed_orcids":["https://orcid.org/0000-0001-7458-2590"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Immerge BioTherapeutics, Inc., Building 75, Third Avenue, Charlestown, 02129, Massachusetts, USA","#N##TAB##TAB##TAB##TAB# Novartis#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immerge BioTherapeutics, Inc., Building 75, Third Avenue, Charlestown, 02129, Massachusetts, USA","institution_ids":[]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Novartis#N##TAB##TAB##TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082293155","display_name":"Kathleen Moran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathleen Moran","raw_affiliation_strings":["Immerge BioTherapeutics, Inc., Building 75, Third Avenue, Charlestown, 02129, Massachusetts, USA","#N##TAB##TAB##TAB##TAB# Novartis#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immerge BioTherapeutics, Inc., Building 75, Third Avenue, Charlestown, 02129, Massachusetts, USA","institution_ids":[]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Novartis#N##TAB##TAB##TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044011869","display_name":"Uwe Christians","orcid":"https://orcid.org/0000-0001-7297-147X","observed_orcids":["https://orcid.org/0000-0001-7297-147X"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uwe Christians","raw_affiliation_strings":["Department of Anesthesia, University of Colorado Health Sciences Center, 4200 East 9th Avenue B113, Denver, 80262, Colorado, USA","University of Colorado, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, University of Colorado Health Sciences Center, 4200 East 9th Avenue B113, Denver, 80262, Colorado, USA","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]},{"raw_affiliation_string":"University of Colorado, Denver","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090588141","display_name":"Colleen P. Finnegan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen Finnegan","raw_affiliation_strings":["Department of Veterinary and Biomedical Sciences, University of Minnesota, 205 Veterinary Science Building, 1971 Commonwealth Avenue, St. Paul, 55108, Minnesota, USA","Department of Veterinary and Biomedical Sciences, University of Minnesota, 205 Veterinary Science Building, St. Paul, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, University of Minnesota, 205 Veterinary Science Building, 1971 Commonwealth Avenue, St. Paul, 55108, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, University of Minnesota, 205 Veterinary Science Building, St. Paul, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104669634","display_name":"Charles Dudley Mills","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles D Mills","raw_affiliation_strings":["Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030109410","display_name":"David E.R. Sutherland","orcid":"https://orcid.org/0000-0003-0728-0386","observed_orcids":["https://orcid.org/0000-0003-0728-0386"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E Sutherland","raw_affiliation_strings":["Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031251681","display_name":"Pratima Bansal\u2010Pakala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratima Bansal-Pakala","raw_affiliation_strings":["Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, 424 Harvard Street SE, Minneapolis, 55455, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023910062","display_name":"Michael P. Murtaugh","orcid":"https://orcid.org/0000-0002-1538-7151","observed_orcids":["https://orcid.org/0000-0002-1538-7151"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P Murtaugh","raw_affiliation_strings":["Department of Veterinary and Biomedical Sciences, University of Minnesota, 205 Veterinary Science Building, 1971 Commonwealth Avenue, St. Paul, 55108, Minnesota, USA","Department of Veterinary and Biomedical Sciences, University of Minnesota, 205 Veterinary Science Building, St. Paul, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, University of Minnesota, 205 Veterinary Science Building, 1971 Commonwealth Avenue, St. Paul, 55108, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, University of Minnesota, 205 Veterinary Science Building, St. Paul, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065804047","display_name":"Nicole Kirchhof","orcid":"https://orcid.org/0000-0002-5748-0813","observed_orcids":["https://orcid.org/0000-0002-5748-0813"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Kirchhof","raw_affiliation_strings":["Department of Veterinary Population Medicine, 225 Veterinary Medical Center, 1365 Gortner Avenue, University of Minnesota, St. Paul, 55108, Minnesota, USA","Department of Veterinary Population Medicine, 225 Veterinary Medical Center, St. Paul, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Population Medicine, 225 Veterinary Medical Center, 1365 Gortner Avenue, University of Minnesota, St. Paul, 55108, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Veterinary Population Medicine, 225 Veterinary Medical Center, St. Paul, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028525879","display_name":"Henk\u2010Jan Schuurman","orcid":"https://orcid.org/0000-0002-3277-7741","observed_orcids":["https://orcid.org/0000-0002-3277-7741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henk-Jan Schuurman","raw_affiliation_strings":["Immerge BioTherapeutics, Inc., Building 75, Third Avenue, Charlestown, 02129, Massachusetts, USA","#N##TAB##TAB##TAB##TAB# Novartis#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immerge BioTherapeutics, Inc., Building 75, Third Avenue, Charlestown, 02129, Massachusetts, USA","institution_ids":[]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Novartis#N##TAB##TAB##TAB#","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039801066"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":49.515,"has_fulltext":false,"cited_by_count":548,"citation_normalized_percentile":{"value":0.9993647,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"12","issue":"3","first_page":"301","last_page":"303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.04439999908208847,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xenotransplantation","display_name":"xenotransplantation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/porcine-islets","display_name":"porcine islets","score":0.9259999990463257},{"id":"https://openalex.org/keywords/intraportal-islet-transplantation","display_name":"intraportal islet transplantation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/diabetes-reversal","display_name":"diabetes reversal","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cynomolgus-macaques","display_name":"cynomolgus macaques","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nonhuman-primates","display_name":"non-human primates","score":0.7289999723434448},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6779999732971191},{"id":"https://openalex.org/keywords/fingolimod","display_name":"fingolimod","score":0.875},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.9049999713897705},{"id":"https://openalex.org/keywords/everolimus","display_name":"everolimus","score":0.996999979019165},{"id":"https://openalex.org/keywords/leflunomide","display_name":"leflunomide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/indirect-allorecognition","display_name":"indirect allorecognition","score":0.7020000219345093},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mononuclear-cell-infiltration","display_name":"mononuclear cell infiltration","score":0.7979999780654907},{"id":"https://openalex.org/keywords/islet-graft-survival","display_name":"islet graft survival","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C2778442404","wikidata":"https://www.wikidata.org/wiki/Q55505","display_name":"Xenotransplantation","level":3,"score":0.9328186511993408},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6612259149551392},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6124701499938965},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.5712014436721802},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5678659081459045},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5323401093482971},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.5255119800567627},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5004684925079346},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.46357327699661255},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.46179911494255066},{"id":"https://openalex.org/C2779234475","wikidata":"https://www.wikidata.org/wiki/Q14897851","display_name":"CD154","level":5,"score":0.45956212282180786},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.45340341329574585},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.4165623188018799},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3522670567035675},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.35090693831443787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3315611481666565},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22392350435256958},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18774083256721497},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.14509937167167664},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.13429531455039978},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.0837583839893341},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D011168","descriptor_name":"Portal System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011168","descriptor_name":"Portal System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011168","descriptor_name":"Portal System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016381","descriptor_name":"Islets of Langerhans Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016381","descriptor_name":"Islets of Langerhans Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016381","descriptor_name":"Islets of Langerhans Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nm1369","doi":"https://doi.org/10.1038/nm1369","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nm1369","pdf_url":null,"source":{"id":"https://openalex.org/S203256638","display_name":"Nature Medicine","issn_l":"1078-8956","issn":["1078-8956","1546-170X","1744-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Medicine","raw_type":"journal-article"},{"id":"pmid:16491083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16491083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","score":0.7200000286102295,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307778","display_name":"Novartis","ror":"https://ror.org/02f9zrr09"},{"id":"https://openalex.org/F4320332736","display_name":"Novartis Pharma","ror":"https://ror.org/0013shd50"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1556819412","https://openalex.org/W1842917036","https://openalex.org/W1994186764","https://openalex.org/W2008367578","https://openalex.org/W2024711583","https://openalex.org/W2029300568","https://openalex.org/W2057607651","https://openalex.org/W2086786165","https://openalex.org/W2099001943","https://openalex.org/W2115802380","https://openalex.org/W2119253720","https://openalex.org/W2131937708","https://openalex.org/W2166069068","https://openalex.org/W2169901386"],"related_works":["https://openalex.org/W1489857015","https://openalex.org/W2001833660","https://openalex.org/W873940110","https://openalex.org/W4386761976","https://openalex.org/W2531402314","https://openalex.org/W1829956524","https://openalex.org/W2034418400","https://openalex.org/W2048789895","https://openalex.org/W2170386768","https://openalex.org/W3174685478"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":26},{"year":2016,"cited_by_count":39},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":36},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":46}],"updated_date":"2026-10-22T09:42:04.148104","created_date":"2025-10-10T00:00:00"}
