{"id":"https://openalex.org/W2016120804","doi":"https://doi.org/10.1097/00006454-199307000-00006","title":"Cimetidine as an immunomodulator in subacute sclerosing panencephalitis","display_name":"Cimetidine as an immunomodulator in subacute sclerosing panencephalitis","publication_year":1993,"publication_date":"1993-07-01","ids":{"openalex":"https://openalex.org/W2016120804","doi":"https://doi.org/10.1097/00006454-199307000-00006","mag":"2016120804","pmid":"https://pubmed.ncbi.nlm.nih.gov/8346000"},"language":"en","primary_location":{"id":"doi:10.1097/00006454-199307000-00006","doi":"https://doi.org/10.1097/00006454-199307000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006454-199307000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S109369870","display_name":"The Pediatric Infectious Disease Journal","issn_l":"0891-3668","issn":["0891-3668","1532-0987"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Pediatric Infectious Disease Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079021764","display_name":"Banu Anlar","orcid":"https://orcid.org/0000-0001-6727-6229","observed_orcids":["https://orcid.org/0000-0001-6727-6229"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]},{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"BANU ANLAR","raw_affiliation_strings":["Department of Pediatric Neurology, Hacettepe University, Ankara, Turkey","Department of Pediatric Neurology, Hacettepe University, (BA,KG, KY, YR), and Department of Microbiology-Immunology, Gazi University, (TI) Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Neurology, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Department of Pediatric Neurology, Hacettepe University, (BA,KG, KY, YR), and Department of Microbiology-Immunology, Gazi University, (TI) Ankara, Turkey","institution_ids":["https://openalex.org/I66514158","https://openalex.org/I95634034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069668267","display_name":"K\u0131v\u0131lc\u0131m G\u00fcc\u00fcyener","orcid":"https://orcid.org/0000-0002-3390-2794","observed_orcids":["https://orcid.org/0000-0002-3390-2794"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]},{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"KIVILCIM G\u00dcC\u00dcYENER","raw_affiliation_strings":["Department of Pediatric Neurology, Hacettepe University, (BA,KG, KY, YR), and Department of Microbiology-Immunology, Gazi University, (TI) Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Neurology, Hacettepe University, (BA,KG, KY, YR), and Department of Microbiology-Immunology, Gazi University, (TI) Ankara, Turkey","institution_ids":["https://openalex.org/I66514158","https://openalex.org/I95634034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110025934","display_name":"Turgut \u0130mir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]},{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"TURGUT IMIR","raw_affiliation_strings":["Department of Pediatric Neurology, Hacettepe University, (BA,KG, KY, YR), and Department of Microbiology-Immunology, Gazi University, (TI) Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Neurology, Hacettepe University, (BA,KG, KY, YR), and Department of Microbiology-Immunology, Gazi University, (TI) Ankara, Turkey","institution_ids":["https://openalex.org/I66514158","https://openalex.org/I95634034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043489841","display_name":"Kalbiye Yalaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]},{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"KALBIYE YALAZ","raw_affiliation_strings":["Department of Pediatric Neurology, Hacettepe University, (BA,KG, KY, YR), and Department of Microbiology-Immunology, Gazi University, (TI) Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Neurology, Hacettepe University, (BA,KG, KY, YR), and Department of Microbiology-Immunology, Gazi University, (TI) Ankara, Turkey","institution_ids":["https://openalex.org/I66514158","https://openalex.org/I95634034"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033593526","display_name":"Yavuz Renda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]},{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"YAVUZ RENDA","raw_affiliation_strings":["Department of Pediatric Neurology, Hacettepe University, (BA,KG, KY, YR), and Department of Microbiology-Immunology, Gazi University, (TI) Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Neurology, Hacettepe University, (BA,KG, KY, YR), and Department of Microbiology-Immunology, Gazi University, (TI) Ankara, Turkey","institution_ids":["https://openalex.org/I66514158","https://openalex.org/I95634034"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1395,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.86290738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"12","issue":"7","first_page":"578","last_page":"581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cimetidine","display_name":"cimetidine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/subacute-sclerosing-panencephalitis","display_name":"subacute sclerosing panencephalitis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/h2-receptor-antagonists","display_name":"H2 receptor antagonists","score":0.9020000100135803},{"id":"https://openalex.org/keywords/measles","display_name":"measles","score":0.5059999823570251},{"id":"https://openalex.org/keywords/neurodisability","display_name":"neurodisability","score":0.8899999856948853},{"id":"https://openalex.org/keywords/lymphocyte-function","display_name":"lymphocyte function","score":0.8859999775886536},{"id":"https://openalex.org/keywords/igg-index","display_name":"IgG index","score":0.8539999723434448},{"id":"https://openalex.org/keywords/clinical-progression","display_name":"clinical progression","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C2780719153","wikidata":"https://www.wikidata.org/wiki/Q409492","display_name":"Cimetidine","level":2,"score":0.9087423086166382},{"id":"https://openalex.org/C2776264772","wikidata":"https://www.wikidata.org/wiki/Q2475919","display_name":"Subacute sclerosing panencephalitis","level":5,"score":0.893059253692627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7435429692268372},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.6027340292930603},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5186775922775269},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47838345170021057},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.4763786494731903},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4739760756492615},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4419060945510864},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43670955300331116},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.41763097047805786},{"id":"https://openalex.org/C2778199166","wikidata":"https://www.wikidata.org/wiki/Q573943","display_name":"Measles virus","level":4,"score":0.4083253741264343},{"id":"https://openalex.org/C2776438120","wikidata":"https://www.wikidata.org/wiki/Q79793","display_name":"Measles","level":3,"score":0.3971100151538849},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17451506853103638},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.172509104013443},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.0679067075252533},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002927","descriptor_name":"Cimetidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002927","descriptor_name":"Cimetidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013344","descriptor_name":"Subacute Sclerosing Panencephalitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013344","descriptor_name":"Subacute Sclerosing Panencephalitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00006454-199307000-00006","doi":"https://doi.org/10.1097/00006454-199307000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006454-199307000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S109369870","display_name":"The Pediatric Infectious Disease Journal","issn_l":"0891-3668","issn":["0891-3668","1532-0987"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Pediatric Infectious Disease Journal","raw_type":"journal-article"},{"id":"pmid:8346000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8346000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Pediatric infectious disease journal","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2413952214","https://openalex.org/W2412981328","https://openalex.org/W2430659319","https://openalex.org/W2025059532","https://openalex.org/W2396598360","https://openalex.org/W2169621493","https://openalex.org/W1480055847","https://openalex.org/W2418730690","https://openalex.org/W3217688045","https://openalex.org/W2081178781"],"abstract_inverted_index":{"Cimetidine,":[0],"an":[1],"H2":[2],"histamine":[3],"receptor":[4],"antagonist,":[5],"was":[6],"used":[7],"in":[8,76,125],"subacute":[9,108],"sclerosing":[10,109],"panencephalitis":[11],"patients":[12],"for":[13],"its":[14,117],"immunomodulatory":[15],"effect.":[16],"Patients":[17],"were":[18,44,73],"randomly":[19],"assigned":[20],"to":[21,115],"cimetidine":[22,59,97],"(n":[23,28],"=":[24,29],"7)":[25,30],"and":[26,41,47,86,121],"placebo":[27,69],"groups.":[31,92],"Neurologic":[32],"disability":[33,55],"index,":[34],"lymphocyte":[35],"functions,":[36],"cerebrospinal":[37,81],"fluid":[38,82],"measles":[39,83],"antibodies":[40],"IgG":[42,87],"index":[43,56,88],"evaluated":[45],"before":[46],"after":[48],"2":[49],"months":[50],"of":[51,57,89,107,119],"treatment.":[52],"The":[53],"neurologic":[54],"the":[58,64,68,77,90,104,122],"group":[60,70],"remained":[61],"stable":[62],"during":[63],"study":[65,94],"period":[66],"whereas":[67],"worsened.":[71],"There":[72],"no":[74],"differences":[75],"immunologic":[78],"test":[79],"results,":[80],"antibody":[84],"titers":[85],"two":[91],"This":[93],"suggests":[95],"that":[96],"may":[98],"have":[99],"a":[100],"favorable":[101],"effect":[102],"on":[103],"clinical":[105],"progression":[106],"panencephalitis.":[110],"Further":[111],"studies":[112],"are":[113],"required":[114],"investigate":[116],"mechanism":[118],"action":[120],"associated":[123],"changes":[124],"immune":[126],"status.":[127]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}