{"id":"https://openalex.org/W2016116775","doi":"https://doi.org/10.1038/sj.onc.1203483","title":"STAT signaling in head and neck cancer","display_name":"STAT signaling in head and neck cancer","publication_year":2000,"publication_date":"2000-05-25","ids":{"openalex":"https://openalex.org/W2016116775","doi":"https://doi.org/10.1038/sj.onc.1203483","mag":"2016116775","pmid":"https://pubmed.ncbi.nlm.nih.gov/10851047"},"language":"en","primary_location":{"id":"doi:10.1038/sj.onc.1203483","doi":"https://doi.org/10.1038/sj.onc.1203483","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1203483","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065943671","display_name":"John I. Song","orcid":"https://orcid.org/0009-0004-8210-3173","observed_orcids":["https://orcid.org/0009-0004-8210-3173"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John I Song","raw_affiliation_strings":["Department of Otolaryngology, University of Pittsburgh School of Medicine and The University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, PA 15213, USA","Department of Otolaryngology, University of Pittsburgh School of Medicine and The University of Pittsburgh Cancer Institute, Pittsburgh, 15213, Pennsylvania, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University of Pittsburgh School of Medicine and The University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, PA 15213, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"raw_affiliation_string":"Department of Otolaryngology, University of Pittsburgh School of Medicine and The University of Pittsburgh Cancer Institute, Pittsburgh, 15213, Pennsylvania, PA, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088286120","display_name":"Jennifer Rubin Grandis","orcid":"https://orcid.org/0000-0002-1013-8965","observed_orcids":["https://orcid.org/0000-0002-1013-8965"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Rubin Grandis","raw_affiliation_strings":["Department of Otolaryngology, University of Pittsburgh School of Medicine and The University of Pittsburgh Cancer Institute, Pittsburgh, 15213, Pennsylvania, PA, USA","Department of Pharmacology, University of Pittsburgh School of Medicine and The University of Pittsburgh Cancer Institute, Pittsburgh, 15213, Pennsylvania, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University of Pittsburgh School of Medicine and The University of Pittsburgh Cancer Institute, Pittsburgh, 15213, Pennsylvania, PA, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"raw_affiliation_string":"Department of Pharmacology, University of Pittsburgh School of Medicine and The University of Pittsburgh Cancer Institute, Pittsburgh, 15213, Pennsylvania, PA, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5990,"currency":"USD","value_usd":5990},"apc_paid":null,"fwci":1.6282,"has_fulltext":false,"cited_by_count":372,"citation_normalized_percentile":{"value":0.83585565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"19","issue":"21","first_page":"2489","last_page":"2495"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.05689999833703041,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.6919999718666077},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.7039999961853027},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.9539999961853027},{"id":"https://openalex.org/keywords/field-cancerization","display_name":"field cancerization","score":0.9110000133514404},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/autocrine-signaling","display_name":"autocrine signaling","score":0.75},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.8790000081062317},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/growth-inhibition","display_name":"growth inhibition","score":0.5099999904632568},{"id":"https://openalex.org/keywords/upper-aerodigestive-tract","display_name":"upper aerodigestive tract","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.7698836326599121},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.725167453289032},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7144896984100342},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.680966854095459},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.643151581287384},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.6090805530548096},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5042270421981812},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.49951672554016113},{"id":"https://openalex.org/C60120401","wikidata":"https://www.wikidata.org/wiki/Q17119253","display_name":"Field cancerization","level":3,"score":0.4963412880897522},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49496811628341675},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.49184560775756836},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4618235230445862},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4379432201385498},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.42904385924339294},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.41346442699432373},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.37933146953582764},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.13013634085655212},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09838747978210449},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05643162131309509},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016372","descriptor_name":"RNA, Antisense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.onc.1203483","doi":"https://doi.org/10.1038/sj.onc.1203483","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1203483","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},{"id":"pmid:10851047","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10851047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W588859157","https://openalex.org/W1245819034","https://openalex.org/W1496109170","https://openalex.org/W1537076792","https://openalex.org/W1553277501","https://openalex.org/W1553385403","https://openalex.org/W1581824974","https://openalex.org/W1686153396","https://openalex.org/W1792964657","https://openalex.org/W1970901225","https://openalex.org/W1975225141","https://openalex.org/W1979320081","https://openalex.org/W1981799488","https://openalex.org/W1994603111","https://openalex.org/W1997408529","https://openalex.org/W1998947396","https://openalex.org/W2005204942","https://openalex.org/W2006412180","https://openalex.org/W2012558233","https://openalex.org/W2017788990","https://openalex.org/W2018142850","https://openalex.org/W2021401778","https://openalex.org/W2024282024","https://openalex.org/W2024728491","https://openalex.org/W2029275361","https://openalex.org/W2031368014","https://openalex.org/W2032359283","https://openalex.org/W2032674547","https://openalex.org/W2034974668","https://openalex.org/W2036223010","https://openalex.org/W2038249986","https://openalex.org/W2038443998","https://openalex.org/W2039441335","https://openalex.org/W2040712355","https://openalex.org/W2044991100","https://openalex.org/W2047670432","https://openalex.org/W2049948758","https://openalex.org/W2051316659","https://openalex.org/W2062468721","https://openalex.org/W2066703183","https://openalex.org/W2066952573","https://openalex.org/W2069637592","https://openalex.org/W2074356752","https://openalex.org/W2081987610","https://openalex.org/W2083802827","https://openalex.org/W2086715846","https://openalex.org/W2094128049","https://openalex.org/W2103824972","https://openalex.org/W2114375471","https://openalex.org/W2115798976","https://openalex.org/W2116401711","https://openalex.org/W2118310862","https://openalex.org/W2124720318","https://openalex.org/W2132633540","https://openalex.org/W2136015499","https://openalex.org/W2138899227","https://openalex.org/W2138988606","https://openalex.org/W2140252749","https://openalex.org/W2154578438","https://openalex.org/W2156875255","https://openalex.org/W2312336311","https://openalex.org/W2323084066","https://openalex.org/W2799941631","https://openalex.org/W4255169631","https://openalex.org/W4256558619"],"related_works":["https://openalex.org/W2103141427","https://openalex.org/W2100429833","https://openalex.org/W7098105296","https://openalex.org/W2012558233","https://openalex.org/W2071900493","https://openalex.org/W2116401711","https://openalex.org/W2099792017","https://openalex.org/W1982852897","https://openalex.org/W2207542692","https://openalex.org/W2101494546"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}