{"id":"https://openalex.org/W2016116174","doi":"https://doi.org/10.1213/00000539-199802000-00020","title":"The Effect of Hemodilution on Cerebral Blood Flow Velocity in Anesthetized Patients","display_name":"The Effect of Hemodilution on Cerebral Blood Flow Velocity in Anesthetized Patients","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W2016116174","doi":"https://doi.org/10.1213/00000539-199802000-00020","mag":"2016116174","pmid":"https://pubmed.ncbi.nlm.nih.gov/9459242"},"language":"en","primary_location":{"id":"doi:10.1213/00000539-199802000-00020","doi":"https://doi.org/10.1213/00000539-199802000-00020","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-199802000-00020","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007346051","display_name":"Nicolas\u00a0J. Bruder","orcid":"https://orcid.org/0000-0003-1958-6876","observed_orcids":["https://orcid.org/0000-0003-1958-6876"]},"institutions":[{"id":"https://openalex.org/I4210162909","display_name":"H\u00f4pital de la Timone","ror":"https://ror.org/05jrr4320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210162909"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Nicolas Bruder","raw_affiliation_strings":["D\u00e9partement d'Anesth\u00e9sie-R\u00e9animation, H\u00f4pital Timone, Marseille, France","Accepted for publication October 10, 1997","Departement d'Anesthesie-Reanimation, Hopital Timone, Marseille, France","Section Editor: David S. Warner"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement d'Anesth\u00e9sie-R\u00e9animation, H\u00f4pital Timone, Marseille, France","institution_ids":["https://openalex.org/I4210162909"]},{"raw_affiliation_string":"Accepted for publication October 10, 1997","institution_ids":[]},{"raw_affiliation_string":"Departement d'Anesthesie-Reanimation, Hopital Timone, Marseille, France","institution_ids":["https://openalex.org/I4210162909"]},{"raw_affiliation_string":"Section Editor: David S. Warner","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070118749","display_name":"Bruno Cohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162909","display_name":"H\u00f4pital de la Timone","ror":"https://ror.org/05jrr4320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210162909"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Cohen","raw_affiliation_strings":["Departement d'Anesthesie-Reanimation, Hopital Timone, Marseille, France","Section Editor: David S. Warner","Accepted for publication October 10, 1997"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departement d'Anesthesie-Reanimation, Hopital Timone, Marseille, France","institution_ids":["https://openalex.org/I4210162909"]},{"raw_affiliation_string":"Section Editor: David S. Warner","institution_ids":[]},{"raw_affiliation_string":"Accepted for publication October 10, 1997","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020851451","display_name":"Daniel Pellissier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162909","display_name":"H\u00f4pital de la Timone","ror":"https://ror.org/05jrr4320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210162909"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Pellissier","raw_affiliation_strings":["Departement d'Anesthesie-Reanimation, Hopital Timone, Marseille, France","Section Editor: David S. Warner","Accepted for publication October 10, 1997"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departement d'Anesthesie-Reanimation, Hopital Timone, Marseille, France","institution_ids":["https://openalex.org/I4210162909"]},{"raw_affiliation_string":"Section Editor: David S. Warner","institution_ids":[]},{"raw_affiliation_string":"Accepted for publication October 10, 1997","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111542223","display_name":"Georges Fran\u00e7ois","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162909","display_name":"H\u00f4pital de la Timone","ror":"https://ror.org/05jrr4320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210162909"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Georges Francois","raw_affiliation_strings":["Departement d'Anesthesie-Reanimation, Hopital Timone, Marseille, France","Section Editor: David S. Warner","Accepted for publication October 10, 1997"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departement d'Anesthesie-Reanimation, Hopital Timone, Marseille, France","institution_ids":["https://openalex.org/I4210162909"]},{"raw_affiliation_string":"Section Editor: David S. Warner","institution_ids":[]},{"raw_affiliation_string":"Accepted for publication October 10, 1997","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007346051"],"corresponding_institution_ids":["https://openalex.org/I4210162909"],"apc_list":null,"apc_paid":null,"fwci":1.0626,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.75492535,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"86","issue":"2","first_page":"320","last_page":"324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.4528999924659729,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.4528999924659729,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.2685999870300293,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.17990000545978546,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemodilution","display_name":"hemodilution","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cerebral-blood-flow-velocity","display_name":"cerebral blood flow velocity","score":0.9660000205039978},{"id":"https://openalex.org/keywords/isovolemic-hemodilution","display_name":"isovolemic hemodilution","score":0.8539999723434448},{"id":"https://openalex.org/keywords/transcranial-doppler","display_name":"transcranial Doppler","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-pressure","display_name":"cerebrospinal fluid pressure","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.75},{"id":"https://openalex.org/keywords/arterial-oxygen-content","display_name":"arterial oxygen content","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cerebral-oxygen-delivery","display_name":"cerebral oxygen delivery","score":0.8790000081062317},{"id":"https://openalex.org/keywords/anesthetized-patients","display_name":"anesthetized patients","score":0.9440000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8797169923782349},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.7672441005706787},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.7567634582519531},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7197917699813843},{"id":"https://openalex.org/C191616109","wikidata":"https://www.wikidata.org/wiki/Q3512319","display_name":"Transcranial Doppler","level":2,"score":0.6506252884864807},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4666239023208618},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4368181824684143},{"id":"https://openalex.org/C119671327","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral circulation","level":2,"score":0.43586140871047974},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.4272816777229309},{"id":"https://openalex.org/C84359808","wikidata":"https://www.wikidata.org/wiki/Q13365173","display_name":"Cerebral autoregulation","level":4,"score":0.4228881597518921},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.30466681718826294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24288737773895264},{"id":"https://openalex.org/C111774379","wikidata":"https://www.wikidata.org/wiki/Q1364253","display_name":"Autoregulation","level":3,"score":0.18407639861106873}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000758","descriptor_name":"Anesthesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006438","descriptor_name":"Hemodilution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017585","descriptor_name":"Ultrasonography, Doppler, Transcranial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1213/00000539-199802000-00020","doi":"https://doi.org/10.1213/00000539-199802000-00020","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-199802000-00020","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},{"id":"doi:10.1097/00000539-199802000-00020","doi":"https://doi.org/10.1097/00000539-199802000-00020","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000539-199802000-00020","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},{"id":"pmid:9459242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9459242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W175064070","https://openalex.org/W198113816","https://openalex.org/W1580316167","https://openalex.org/W1755237470","https://openalex.org/W1818939941","https://openalex.org/W1997331757","https://openalex.org/W2027918441","https://openalex.org/W2036023034","https://openalex.org/W2042078816","https://openalex.org/W2042479445","https://openalex.org/W2053023325","https://openalex.org/W2056904598","https://openalex.org/W2057542901","https://openalex.org/W2060600075","https://openalex.org/W2066002230","https://openalex.org/W2066084293","https://openalex.org/W2084786512","https://openalex.org/W2095494448","https://openalex.org/W2103474422","https://openalex.org/W2103496702","https://openalex.org/W2103928627","https://openalex.org/W2120910018","https://openalex.org/W2291585982","https://openalex.org/W6638606382"],"related_works":["https://openalex.org/W2054138655","https://openalex.org/W2414972826","https://openalex.org/W2097020576","https://openalex.org/W16955062","https://openalex.org/W2042471800","https://openalex.org/W160367041","https://openalex.org/W2181854863","https://openalex.org/W2099751397","https://openalex.org/W2087926337","https://openalex.org/W1996667313"],"abstract_inverted_index":{"UNLABELLED:":[0],"Transcranial":[1],"Doppler":[2,202],"is":[3],"used":[4],"to":[5,36,84,97,109,204,223],"estimate":[6],"changes":[7,138,172],"in":[8,23,51,56,139,149,161],"cerebral":[9,18,117,169,178,185,194,213,227],"blood":[10,19,154,170,179,195,228],"flow,":[11],"but":[12,181,215],"the":[13,38,131,140,184,207,212,216],"effect":[14,39],"of":[15,32,40,116,193,209],"hemodilution":[16,42,66,210],"on":[17,43,211],"flow":[20,171,180,196,229],"velocity":[21,230],"(CBFV)":[22],"anesthetized":[24,52],"patients":[25,53],"has":[26],"not":[27,127],"been":[28],"evaluated.":[29],"The":[30],"aim":[31],"this":[33],"study":[34,199],"was":[35,144],"measure":[37],"isovolemic":[41],"CBFV":[44,103,125,167],"and":[45,102],"lumbar":[46],"cerebrospinal":[47],"fluid":[48],"pressure":[49],"(P(CSF))":[50],"without":[54],"change":[55,148,183],"other":[57],"physiological":[58],"variables":[59],"that":[60,166],"may":[61,182],"affect":[62],"CBFV.":[63],"Patients":[64],"undergoing":[65,73],"were":[67,136],"compared":[68],"with":[69],"a":[70],"control":[71,141],"group":[72],"no":[74,137,145],"hemodilution.":[75,174],"With":[76],"hemodilution,":[77],"hematocrit":[78,217],"decreased":[79,92],"from":[80,93,105],"38%":[81],"+/-":[82,86,95,99,107,111],"3%":[83],"30%":[85],"2%,":[87],"arterial":[88,118],"oxygen":[89],"content":[90],"(Cao2)":[91],"17.5":[94],"1.3":[96],"13.9":[98],"0.9":[100],"mL/dL,":[101],"increased":[104],"50":[106],"10":[108,112],"58":[110],"cm/s.":[113],"An":[114],"equivalent":[115],"O2":[119],"transport":[120],"calculated":[121],"as":[122],"Cao2":[123],"x":[124],"did":[126],"significantly":[128],"change.":[129],"Over":[130],"same":[132],"time":[133],"interval,":[134],"there":[135],"group.":[142,163],"There":[143],"statistically":[146],"significant":[147],"P(CSF),":[150],"pulsatility":[151],"index,":[152],"Paco2,":[153],"pressure,":[155],"heart":[156],"rate,":[157],"or":[158],"body":[159],"temperature":[160],"either":[162],"We":[164],"conclude":[165],"reflects":[168],"after":[173],"IMPLICATIONS:":[175],"Hemodilution":[176],"increases":[177],"artery":[186],"diameter,":[187],"which":[188],"could":[189],"confound":[190],"perioperative":[191,226],"measurement":[192],"velocity.":[197],"This":[198],"found":[200],"transcranial":[201],"ultrasonography":[203],"accurately":[205],"assess":[206],"effects":[208],"circulation,":[214],"should":[218],"be":[219],"taken":[220],"into":[221],"account":[222],"fully":[224],"understand":[225],"changes.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}