{"id":"https://openalex.org/W2016106739","doi":"https://doi.org/10.1021/jf0716937","title":"Enzymatic Modification of Saponins from Platycodon grandiflorum with Aspergillus niger","display_name":"Enzymatic Modification of Saponins from Platycodon grandiflorum with Aspergillus niger","publication_year":2007,"publication_date":"2007-10-01","ids":{"openalex":"https://openalex.org/W2016106739","doi":"https://doi.org/10.1021/jf0716937","mag":"2016106739","pmid":"https://pubmed.ncbi.nlm.nih.gov/17927135"},"language":"en","primary_location":{"id":"doi:10.1021/jf0716937","doi":"https://doi.org/10.1021/jf0716937","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jf0716937","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032136422","display_name":"Hye Jeong Wie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Jeong Wie","raw_affiliation_strings":["Department of Food and Nutrition, Graduate school, and Natural Product Research Institute, Seoul National University, Shillim-dong, Kwanak-ku, Seoul 151, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Nutrition, Graduate school, and Natural Product Research Institute, Seoul National University, Shillim-dong, Kwanak-ku, Seoul 151, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112769366","display_name":"Hai Lin Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hai Lin Zhao","raw_affiliation_strings":["Department of Food and Nutrition, Graduate school, and Natural Product Research Institute, Seoul National University, Shillim-dong, Kwanak-ku, Seoul 151, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Nutrition, Graduate school, and Natural Product Research Institute, Seoul National University, Shillim-dong, Kwanak-ku, Seoul 151, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011405525","display_name":"Jeong Hwa Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeong Hwa Chang","raw_affiliation_strings":["Department of Food and Nutrition, Graduate school, and Natural Product Research Institute, Seoul National University, Shillim-dong, Kwanak-ku, Seoul 151, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Nutrition, Graduate school, and Natural Product Research Institute, Seoul National University, Shillim-dong, Kwanak-ku, Seoul 151, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005358084","display_name":"Yeong Shik Kim","orcid":"https://orcid.org/0000-0003-1353-3925","observed_orcids":["https://orcid.org/0000-0003-1353-3925"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeong Shik Kim","raw_affiliation_strings":["Department of Food and Nutrition, Graduate school, and Natural Product Research Institute, Seoul National University, Shillim-dong, Kwanak-ku, Seoul 151, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Nutrition, Graduate school, and Natural Product Research Institute, Seoul National University, Shillim-dong, Kwanak-ku, Seoul 151, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002067880","display_name":"In Koo Hwang","orcid":"https://orcid.org/0000-0002-0533-4638","observed_orcids":["https://orcid.org/0000-0002-0533-4638"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"In Kyeong Hwang","raw_affiliation_strings":["Department of Food and Nutrition, Graduate school, and Natural Product Research Institute, Seoul National University, Shillim-dong, Kwanak-ku, Seoul 151, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Nutrition, Graduate school, and Natural Product Research Institute, Seoul National University, Shillim-dong, Kwanak-ku, Seoul 151, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036601136","display_name":"Geun Eog Ji","orcid":"https://orcid.org/0000-0002-6436-6824","observed_orcids":["https://orcid.org/0000-0002-6436-6824"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Geun Eog Ji","raw_affiliation_strings":["Department of Food and Nutrition, Graduate school, and Natural Product Research Institute, Seoul National University, Shillim-dong, Kwanak-ku, Seoul 151, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Nutrition, Graduate school, and Natural Product Research Institute, Seoul National University, Shillim-dong, Kwanak-ku, Seoul 151, Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036601136"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6817,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.63823116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"55","issue":"22","first_page":"8908","last_page":"8913"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.7856000065803528,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.7856000065803528,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.04190000146627426,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platycodin-d","display_name":"platycodin D","score":0.8740000128746033},{"id":"https://openalex.org/keywords/platycodon-grandiflorum","display_name":"Platycodon grandiflorum","score":0.9200000166893005},{"id":"https://openalex.org/keywords/aspergillus-niger","display_name":"Aspergillus niger","score":0.9729999899864197},{"id":"https://openalex.org/keywords/enzymatic-modification","display_name":"enzyme modification","score":0.7369999885559082},{"id":"https://openalex.org/keywords/microbial-degradation","display_name":"microbial degradation","score":0.3709999918937683},{"id":"https://openalex.org/keywords/saponins","display_name":"saponins","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hemolytic-toxicity","display_name":"hemolytic toxicity","score":0.871999979019165},{"id":"https://openalex.org/keywords/nitrite-scavenging","display_name":"nitrite scavenging","score":0.9100000262260437},{"id":"https://openalex.org/keywords/sensory-evaluation","display_name":"sensory evaluation","score":0.6159999966621399},{"id":"https://openalex.org/keywords/platycodi-radix","display_name":"Platycodi Radix","score":0.8119999766349792},{"id":"https://openalex.org/keywords/traditional-medicinal-plants","display_name":"traditional medicinal plants","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C2775960407","wikidata":"https://www.wikidata.org/wiki/Q132014","display_name":"Aspergillus niger","level":2,"score":0.8444726467132568},{"id":"https://openalex.org/C2778564307","wikidata":"https://www.wikidata.org/wiki/Q207653","display_name":"Saponin","level":3,"score":0.7704688310623169},{"id":"https://openalex.org/C194671627","wikidata":"https://www.wikidata.org/wiki/Q192639","display_name":"Glycoside","level":2,"score":0.7361292839050293},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6654141545295715},{"id":"https://openalex.org/C2780527577","wikidata":"https://www.wikidata.org/wiki/Q2915788","display_name":"Triterpene","level":3,"score":0.5380020141601562},{"id":"https://openalex.org/C2775876792","wikidata":"https://www.wikidata.org/wiki/Q155802","display_name":"Campanulaceae","level":2,"score":0.4792592525482178},{"id":"https://openalex.org/C2779232237","wikidata":"https://www.wikidata.org/wiki/Q20817212","display_name":"Ginseng","level":3,"score":0.44003826379776},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.40375465154647827},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3567173480987549},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2693363130092621},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22556647658348083},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.19416239857673645},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001234","descriptor_name":"Aspergillus niger","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012503","descriptor_name":"Saponins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012503","descriptor_name":"Saponins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031238","descriptor_name":"Platycodon","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jf0716937","doi":"https://doi.org/10.1021/jf0716937","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jf0716937","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},{"id":"pmid:17927135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17927135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of agricultural and food chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1857015957","https://openalex.org/W1893304510","https://openalex.org/W1962610370","https://openalex.org/W1981086510","https://openalex.org/W1987107938","https://openalex.org/W2015006948","https://openalex.org/W2019928112","https://openalex.org/W2034982232","https://openalex.org/W2036837512","https://openalex.org/W2038874051","https://openalex.org/W2132110052","https://openalex.org/W2157412052","https://openalex.org/W2328352651","https://openalex.org/W2430447859","https://openalex.org/W4233941484"],"related_works":["https://openalex.org/W753040483","https://openalex.org/W3176177972","https://openalex.org/W4414171019","https://openalex.org/W1903903605","https://openalex.org/W7214500701","https://openalex.org/W4220931915","https://openalex.org/W2063128372","https://openalex.org/W2910875416","https://openalex.org/W3203511453","https://openalex.org/W1983741514"],"abstract_inverted_index":{"Platycodon":[0],"grandiflorum":[1],"A.":[2,137],"DC":[3],"(Campanulaceae)":[4],"is":[5,26],"a":[6,47,73,87,93,142],"traditional":[7],"medicinal":[8],"plant.":[9],"Its":[10],"root,":[11],"Platycodi":[12],"Radix,":[13],"contains":[14],"an":[15],"abundant":[16],"amount":[17],"of":[18,22,28,35,43],"saponin":[19],"glycosides,":[20],"platycodins,":[21],"which":[23,148],"platycodin":[24,60,68,84,116,132,146],"D":[25,61,85],"one":[27],"the":[29,108,114,130],"major":[30],"components.":[31],"The":[32,82],"chemical":[33,44],"structures":[34],"platycodins":[36],"can":[37],"be":[38],"modified":[39,63,83,115,131],"by":[40],"various":[41],"types":[42],"processing,":[45],"but":[46],"modification":[48,140],"mediated":[49,139],"with":[50,72,157],"microorganisms":[51],"has":[52],"been":[53],"not":[54],"reported":[55],"yet.":[56],"In":[57],"this":[58],"study,":[59],"was":[62,111],"to":[64],"several":[65],"partially":[66,144],"degraded":[67,145],"glycosides":[69],"after":[70],"treatment":[71],"crude":[74],"enzyme":[75],"extract":[76],"from":[77],"Aspergillus":[78],"niger":[79,138],"(A.":[80],"niger).":[81],"possessed":[86],"shorter":[88],"sugar":[89],"side-chain,":[90],"and":[91,103,123,152],"presented":[92],"remarkably":[94],"reduced":[95,158],"V79-4":[96],"cell":[97],"(Chinese":[98],"hamster":[99],"lung":[100],"fibroblasts)":[101],"cytotoxicity":[102],"erythrocyte":[104],"hemolytic":[105],"toxicity,":[106],"whereas":[107],"nitrite-scavenging":[109],"activity":[110],"increased":[112,150],"in":[113,129],"D.":[117,133],"Sensory":[118],"scores":[119],"for":[120],"pungency,":[121],"bitterness":[122],"after-taste":[124],"were":[125],"improved":[126,153],"as":[127],"well":[128],"Results":[134],"suggest":[135],"that":[136],"yielded":[141],"novel":[143],"glycoside":[147],"possesses":[149],"bioactivities":[151],"sensory":[154],"values,":[155],"yet":[156],"toxic":[159],"profiles.":[160]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}