{"id":"https://openalex.org/W2016105046","doi":"https://doi.org/10.3109/03639045.2011.639076","title":"Development of chitosan-based ondansetron buccal delivery system for the treatment of emesis","display_name":"Development of chitosan-based ondansetron buccal delivery system for the treatment of emesis","publication_year":2011,"publication_date":"2011-12-19","ids":{"openalex":"https://openalex.org/W2016105046","doi":"https://doi.org/10.3109/03639045.2011.639076","mag":"2016105046","pmid":"https://pubmed.ncbi.nlm.nih.gov/22182584"},"language":"en","primary_location":{"id":"doi:10.3109/03639045.2011.639076","doi":"https://doi.org/10.3109/03639045.2011.639076","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03639045.2011.639076","pdf_url":null,"source":{"id":"https://openalex.org/S162444473","display_name":"Drug Development and Industrial Pharmacy","issn_l":"0363-9045","issn":["0363-9045","1520-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Development and Industrial Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071321560","display_name":"Dong-Min Park","orcid":"https://orcid.org/0000-0002-9074-2299","observed_orcids":["https://orcid.org/0000-0002-9074-2299","https://orcid.org/0009-0006-3794-0567"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Min Park","raw_affiliation_strings":["College of Pharmacy, Seoul National University, Seoul, Republic of Korea","College of Pharmacy, Seoul National Univ, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"College of Pharmacy, Seoul National Univ, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066853982","display_name":"Yun\u2010Kyoung Song","orcid":"https://orcid.org/0000-0003-3687-4052","observed_orcids":["https://orcid.org/0000-0003-3687-4052"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yun-Kyoung Song","raw_affiliation_strings":["College of Pharmacy, Seoul National University, Seoul, Republic of Korea","College of Pharmacy, Seoul National Univ, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"College of Pharmacy, Seoul National Univ, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007220606","display_name":"Jun\u2010Pil Jee","orcid":"https://orcid.org/0000-0002-8497-2231","observed_orcids":["https://orcid.org/0000-0002-8497-2231"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jun-Pil Jee","raw_affiliation_strings":["College of Pharmacy, Seoul National University, Seoul, Republic of Korea","College of Pharmacy, Seoul National Univ, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"College of Pharmacy, Seoul National Univ, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110665640","display_name":"Hyung Tae Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142845","display_name":"Hanyang University Seoul Hospital","ror":"https://ror.org/04n76mm80","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210142845","https://openalex.org/I4210152466","https://openalex.org/I4575257"]},{"id":"https://openalex.org/I4210152466","display_name":"Hanyang University Medical Center","ror":"https://ror.org/05tn05n57","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210152466","https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyung Tae Kim","raw_affiliation_strings":["Division of Internal Medicine, Hanyang University Medical Center, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine, Hanyang University Medical Center, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210142845","https://openalex.org/I4210152466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110577979","display_name":"Chong\u2010Kook Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Chong-Kook Kim","raw_affiliation_strings":["College of Pharmacy, Inje University, Gyungnam, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Inje University, Gyungnam, Republic of Korea","institution_ids":["https://openalex.org/I104338594"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5110577979"],"corresponding_institution_ids":["https://openalex.org/I104338594"],"apc_list":null,"apc_paid":null,"fwci":2.1228,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.84556213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"38","issue":"9","first_page":"1077","last_page":"1083"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ondansetron","display_name":"ondansetron","score":0.953000009059906},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.9089999794960022},{"id":"https://openalex.org/keywords/buccal-drug-delivery","display_name":"buccal drug delivery","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mucoadhesive-films","display_name":"mucoadhesive films","score":0.921999990940094},{"id":"https://openalex.org/keywords/vomiting","display_name":"vomiting","score":0.8209999799728394},{"id":"https://openalex.org/keywords/antiemetics","display_name":"antiemetics","score":0.5960000157356262},{"id":"https://openalex.org/keywords/mucoadhesion","display_name":"mucoadhesion","score":0.7879999876022339},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.6980000138282776},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9819999933242798},{"id":"https://openalex.org/keywords/swelling-ratio","display_name":"swelling ratio","score":0.6150000095367432},{"id":"https://openalex.org/keywords/in-vitro-drug-release","display_name":"in vitro drug release","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C195735259","wikidata":"https://www.wikidata.org/wiki/Q16963239","display_name":"Buccal administration","level":2,"score":0.7817087173461914},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7553606033325195},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.6542583703994751},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.5684705376625061},{"id":"https://openalex.org/C2777170512","wikidata":"https://www.wikidata.org/wiki/Q410011","display_name":"Ondansetron","level":3,"score":0.5432901978492737},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5317042469978333},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5221895575523376},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.47392281889915466},{"id":"https://openalex.org/C2776634624","wikidata":"https://www.wikidata.org/wiki/Q4914690","display_name":"Bioadhesive","level":3,"score":0.4644726514816284},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.458124041557312},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.44060489535331726},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4341731071472168},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.4284449815750122},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40925514698028564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.269445538520813},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.11937963962554932},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.11086654663085938},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.09800314903259277},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.09529641270637512},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07007086277008057}],"mesh":[{"descriptor_ui":"D000042","descriptor_name":"Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000268","descriptor_name":"Adhesiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000278","descriptor_name":"Administration, Buccal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000932","descriptor_name":"Antiemetics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000932","descriptor_name":"Antiemetics","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000932","descriptor_name":"Antiemetics","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000932","descriptor_name":"Antiemetics","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005079","descriptor_name":"Excipients","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014677","descriptor_name":"Pharmaceutical Vehicles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017294","descriptor_name":"Ondansetron","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017294","descriptor_name":"Ondansetron","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017294","descriptor_name":"Ondansetron","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D017294","descriptor_name":"Ondansetron","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D058831","descriptor_name":"Serotonin 5-HT3 Receptor Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D058831","descriptor_name":"Serotonin 5-HT3 Receptor Antagonists","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D058831","descriptor_name":"Serotonin 5-HT3 Receptor Antagonists","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D058831","descriptor_name":"Serotonin 5-HT3 Receptor Antagonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/03639045.2011.639076","doi":"https://doi.org/10.3109/03639045.2011.639076","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03639045.2011.639076","pdf_url":null,"source":{"id":"https://openalex.org/S162444473","display_name":"Drug Development and Industrial Pharmacy","issn_l":"0363-9045","issn":["0363-9045","1520-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Development and Industrial Pharmacy","raw_type":"journal-article"},{"id":"pmid:22182584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22182584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug development and industrial pharmacy","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W60759778","https://openalex.org/W581765212","https://openalex.org/W1527507383","https://openalex.org/W1554181190","https://openalex.org/W1682768769","https://openalex.org/W1975887141","https://openalex.org/W1976218475","https://openalex.org/W1984335257","https://openalex.org/W1984666108","https://openalex.org/W1986774418","https://openalex.org/W1993345718","https://openalex.org/W2000251811","https://openalex.org/W2002811693","https://openalex.org/W2006458202","https://openalex.org/W2008151430","https://openalex.org/W2020406291","https://openalex.org/W2022359259","https://openalex.org/W2026237079","https://openalex.org/W2028311524","https://openalex.org/W2042927990","https://openalex.org/W2050283599","https://openalex.org/W2050394939","https://openalex.org/W2056997504","https://openalex.org/W2064708481","https://openalex.org/W2066312718","https://openalex.org/W2067758452","https://openalex.org/W2071504541","https://openalex.org/W2123764876","https://openalex.org/W2962791630","https://openalex.org/W4206686865"],"related_works":["https://openalex.org/W2132345616","https://openalex.org/W7220611105","https://openalex.org/W7213751894","https://openalex.org/W4415765375","https://openalex.org/W2049985892","https://openalex.org/W7217070603","https://openalex.org/W7212217785","https://openalex.org/W2414792251","https://openalex.org/W2050283599","https://openalex.org/W3012489120"],"abstract_inverted_index":{"BACKGROUND:":[0],"For":[1],"the":[2,37,77,82,102,108,124,131,149,163,171,180,192,206,221,237],"buccal":[3,34,213],"drug":[4,13,20,86],"delivery,":[5],"chitosan":[6],"(CS)":[7],"can":[8],"be":[9,216],"used":[10,129],"to":[11,28,106,205,220],"improve":[12],"absorption":[14],"and":[15,19,30,70,92,95,127,143,160,165,176,186,201,226,233],"reduce":[16],"application":[17],"frequency":[18],"amount.":[21],"The":[22,48,110,155,196,210],"aim":[23],"of":[24,39,57,76,81,138,158,162,179,191,239],"this":[25,141],"study":[26],"is":[27],"develop":[29],"evaluate":[31,107],"mucoadhesive":[32,45,62,93,211],"ondansetron":[33,58,98,139,212],"films":[35,83,103,111],"for":[36,130,236],"treatment":[38,238],"emesis":[40],"using":[41],"CS":[42,69,114],"as":[43,123],"a":[44,217],"polymer.":[46],"METHODS:":[47],"film":[49,142,164,181,197,214],"prepared":[50],"by":[51],"solvent":[52],"casting":[53],"method":[54],"was":[55,121],"comprised":[56],"(approximately":[59],"65":[60],"\u03bcg)-loaded":[61],"gels":[63],"containing":[64,112],"1,":[65],"2":[66],"or":[67],"3%":[68,113],"impermeable":[71],"backing":[72],"layer.":[73],"Rheological":[74],"property":[75],"gels,":[78],"physiochemical":[79],"properties":[80],"(weight,":[84],"thickness,":[85],"content,":[87],"swelling":[88],"ratio,":[89],"adhesion":[90],"time":[91,175],"force)":[94],"in":[96,132,152],"vitro":[97],"release":[99],"profile":[100],"from":[101],"were":[104,128,146,168,182],"determined":[105],"formulation.":[109],"(diameter:":[115],"0.5":[116],"cm;":[117],"thickness:":[118],"170":[119],"\u03bcm)":[120],"selected":[122],"novel":[125],"formulation,":[126,224],"vivo":[133],"study.":[134],"Comparative":[135],"pharmacokinetic":[136],"studies":[137],"with":[140,229],"oral":[144,166,193,207,223],"solution":[145,167],"performed":[147],"at":[148],"same":[150],"dose":[151],"hamsters.":[153],"RESULTS:":[154],"mean":[156,173],"values":[157],"T(max)":[159],"C(max)":[161],"similar.":[169],"However,":[170],"half-life,":[172],"residence":[174],"AUC(0-24":[177],"h)":[178],"about":[183],"1.7,":[184],"1.4":[185],"2.0-fold":[187],"higher":[188,234],"than":[189],"those":[190],"solution,":[194],"respectively.":[195],"showed":[198],"enhanced":[199],"bioavailability":[200,235],"prolonged":[202],"efficacy":[203],"compared":[204],"solution.":[208],"CONCLUSIONS:":[209],"may":[215],"potential":[218],"alternative":[219],"marketed":[222],"parenterals":[225],"solid":[227],"suppositories":[228],"better":[230],"patient":[231],"compliance":[232],"emesis.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}