{"id":"https://openalex.org/W2016104324","doi":"https://doi.org/10.1159/000339065","title":"Downregulation of Fetuin-B and Zinc-a2-glycoprotein is Linked to Impaired Fatty Acid Metabolism in Liver Cells","display_name":"Downregulation of Fetuin-B and Zinc-a2-glycoprotein is Linked to Impaired Fatty Acid Metabolism in Liver Cells","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2016104324","doi":"https://doi.org/10.1159/000339065","mag":"2016104324","pmid":"https://pubmed.ncbi.nlm.nih.gov/22739111"},"language":"en","primary_location":{"id":"doi:10.1159/000339065","doi":"https://doi.org/10.1159/000339065","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000339065","pdf_url":null,"source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1159/000339065","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101947963","display_name":"Jungwon Choi","orcid":"https://orcid.org/0000-0003-0027-2068","observed_orcids":["https://orcid.org/0000-0003-0027-2068"]},"institutions":[{"id":"https://openalex.org/I9323808","display_name":"Daegu University","ror":"https://ror.org/01zqccq48","country_code":"KR","type":"education","lineage":["https://openalex.org/I9323808"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung-Won Choi","raw_affiliation_strings":["Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk, Republic of Korea","Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk, Republic of Korea","institution_ids":["https://openalex.org/I9323808"]},{"raw_affiliation_string":"Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk","institution_ids":["https://openalex.org/I9323808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100458816","display_name":"Hao Liu","orcid":"https://orcid.org/0000-0002-5181-7024","observed_orcids":["https://orcid.org/0000-0002-5181-7024","https://orcid.org/0000-0002-3477-8174"]},"institutions":[{"id":"https://openalex.org/I9323808","display_name":"Daegu University","ror":"https://ror.org/01zqccq48","country_code":"KR","type":"education","lineage":["https://openalex.org/I9323808"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hao Liu","raw_affiliation_strings":["Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk","institution_ids":["https://openalex.org/I9323808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080359466","display_name":"Rajib Mukherjee","orcid":"https://orcid.org/0000-0002-3509-4997","observed_orcids":["https://orcid.org/0000-0002-3509-4997"]},"institutions":[{"id":"https://openalex.org/I9323808","display_name":"Daegu University","ror":"https://ror.org/01zqccq48","country_code":"KR","type":"education","lineage":["https://openalex.org/I9323808"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Rajib Mukherjee","raw_affiliation_strings":["Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk","institution_ids":["https://openalex.org/I9323808"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079655788","display_name":"Jong Won Yun","orcid":"https://orcid.org/0000-0003-2453-2282","observed_orcids":["https://orcid.org/0000-0003-2453-2282","https://orcid.org/0009-0002-1857-7070"]},"institutions":[{"id":"https://openalex.org/I9323808","display_name":"Daegu University","ror":"https://ror.org/01zqccq48","country_code":"KR","type":"education","lineage":["https://openalex.org/I9323808"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Won Yun","raw_affiliation_strings":["Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk","institution_ids":["https://openalex.org/I9323808"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I9323808"],"apc_list":{"value":1785,"currency":"EUR","value_usd":1925},"apc_paid":{"value":1785,"currency":"EUR","value_usd":1925},"fwci":1.6476,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.8315944,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"30","issue":"2","first_page":"295","last_page":"306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.19900000095367432,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.10610000044107437,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fetuin-b","display_name":"fetuin-B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/zinc-alpha-2-glycoprotein","display_name":"zinc-alpha2-glycoprotein","score":0.9169999957084656},{"id":"https://openalex.org/keywords/azgp1","display_name":"AZGP1","score":0.8709999918937683},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":0.7179999947547913},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.8029999732971191},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.8790000081062317},{"id":"https://openalex.org/keywords/obesity-resistant-rats","display_name":"obesity-resistant rats","score":0.7720000147819519},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8669999837875366},{"id":"https://openalex.org/keywords/plasma-protein-levels","display_name":"plasma protein levels","score":0.7289999723434448},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.8130000233650208},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.6019999980926514},{"id":"https://openalex.org/keywords/lipogenic-gene-expression","display_name":"lipogenic gene expression","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.7654000520706177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7085003852844238},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6900970935821533},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6887937784194946},{"id":"https://openalex.org/C2778541144","wikidata":"https://www.wikidata.org/wiki/Q908191","display_name":"Fetuin","level":3,"score":0.6108058094978333},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.6033321619033813},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.524655818939209},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5200309753417969},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.5121381282806396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4796867072582245},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.4258766174316406},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39561957120895386},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.384673535823822},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2731423079967499},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16716954112052917}],"mesh":[{"descriptor_ui":"D000090203","descriptor_name":"Zn-Alpha-2-Glycoprotein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029589","descriptor_name":"Seminal Plasma Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D029589","descriptor_name":"Seminal Plasma Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029589","descriptor_name":"Seminal Plasma Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050155","descriptor_name":"Lipogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060752","descriptor_name":"Fetuin-B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D060752","descriptor_name":"Fetuin-B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060752","descriptor_name":"Fetuin-B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000339065","doi":"https://doi.org/10.1159/000339065","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000339065","pdf_url":null,"source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},{"id":"pmid:22739111","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22739111","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1159/000339065","doi":"https://doi.org/10.1159/000339065","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000339065","pdf_url":null,"source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2757211655","https://openalex.org/W1981827427","https://openalex.org/W2167541966","https://openalex.org/W2419289283","https://openalex.org/W7160914692","https://openalex.org/W3029168473","https://openalex.org/W1969259827","https://openalex.org/W2883230127","https://openalex.org/W2975143733","https://openalex.org/W2152727172"],"abstract_inverted_index":{"BACKGROUND:":[0],"Our":[1,144],"recent":[2],"proteomic":[3],"study":[4],"has":[5,43],"shown":[6,44],"that":[7,123,131],"plasma":[8,34,133,152],"protein":[9,134,153],"levels":[10,111,135,154],"of":[11,32,36,47,54,91,103,155,162],"fetuin-B":[12],"(Ft-B)":[13],"and":[14,38,75,79,93,157,159],"zinc-\u03b12-glycoprotein":[15],"(ZAG)":[16],"are":[17],"significantly":[18],"elevated":[19],"in":[20,40,65,84,100,108,112,130,139,170],"obesity-resistant":[21],"(OR)":[22],"rats":[23,42],"exposed":[24],"to":[25,96],"a":[26,97,147],"high":[27],"fat":[28],"diet.":[29],"Time":[30],"profiling":[31],"the":[33,51,72,101],"concentrations":[35],"Ft-B":[37,78,124,156],"ZAG":[39,158],"OR":[41],"stable":[45],"regulation":[46],"these":[48,63],"proteins":[49,64],"throughout":[50],"entire":[52],"period":[53],"rat":[55],"breeding.":[56],"METHODS:":[57],"To":[58],"firmly":[59],"establish":[60],"roles":[61],"for":[62],"lipogenesis,":[66],"we":[67,121],"efficiently":[68],"knocked":[69],"down":[70],"(KD)":[71],"genes":[73],"FETUB":[74,92],"AZGP1":[76,94],"encoding":[77],"ZAG,":[80],"respectively,":[81],"using":[82],"siRNA":[83],"Chang":[85],"liver":[86],"cells.":[87,115],"RESULTS:":[88],"Reduced":[89],"expression":[90,102],"led":[95],"significant":[98],"increase":[99],"lipogenic":[104],"genes,":[105],"thereby":[106],"resulting":[107],"higher":[109,160],"lipid":[110],"both":[113],"KD":[114],"Collectively":[116],"with":[117,128],"our":[118],"previous":[119],"findings,":[120],"confirmed":[122],"was":[125],"similarly":[126],"regulated":[127],"Ft-A,":[129],"their":[132],"were":[136],"commonly":[137],"reduced":[138,151],"diet-induced":[140,163],"obese":[141],"rats.":[142],"CONCLUSION:":[143],"results":[145],"provide":[146],"possible":[148],"relationship":[149],"between":[150],"risk":[161],"obesity":[164],"through":[165],"impaired":[166],"fatty":[167],"acid":[168],"metabolism":[169],"hepatocytes.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}