{"id":"https://openalex.org/W2016092001","doi":"https://doi.org/10.1097/00005792-197705000-00004","title":"SYSTEMIC CAPILLARY LEAK SYNDROME AND MONOCLONAL IgG GAMMOPATHY","display_name":"SYSTEMIC CAPILLARY LEAK SYNDROME AND MONOCLONAL IgG GAMMOPATHY","publication_year":1977,"publication_date":"1977-05-01","ids":{"openalex":"https://openalex.org/W2016092001","doi":"https://doi.org/10.1097/00005792-197705000-00004","mag":"2016092001","pmid":"https://pubmed.ncbi.nlm.nih.gov/870792"},"language":"en","primary_location":{"id":"doi:10.1097/00005792-197705000-00004","doi":"https://doi.org/10.1097/00005792-197705000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005792-197705000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008114290","display_name":"John P. Atkinson","orcid":"https://orcid.org/0000-0002-2514-3441","observed_orcids":["https://orcid.org/0000-0002-2514-3441","https://orcid.org/0000-0003-2809-9308"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"JOHN P. ATKINSON","raw_affiliation_strings":["From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","Center","Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210123359","https://openalex.org/I4210134534","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Center","institution_ids":[]},{"raw_affiliation_string":"Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035996420","display_name":"Thomas A. Waldmann","orcid":"https://orcid.org/0000-0003-4500-6660","observed_orcids":["https://orcid.org/0000-0003-4500-6660"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"THOMAS A. WALDMANN","raw_affiliation_strings":["From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","Center","Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210123359","https://openalex.org/I4210134534","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Center","institution_ids":[]},{"raw_affiliation_string":"Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109850136","display_name":"Sidney F. Stein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"SIDNEY F. STEIN","raw_affiliation_strings":["From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","Center","Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210123359","https://openalex.org/I4210134534","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Center","institution_ids":[]},{"raw_affiliation_string":"Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064487873","display_name":"Jeffrey A. Gelfand","orcid":"https://orcid.org/0000-0002-4118-5676","observed_orcids":["https://orcid.org/0000-0002-4118-5676"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"JEFFREY A. GELFAND","raw_affiliation_strings":["From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","Center","Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210123359","https://openalex.org/I4210134534","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Center","institution_ids":[]},{"raw_affiliation_string":"Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022222522","display_name":"Walter J. MacDonald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"WALTER J. MacDONALD","raw_affiliation_strings":["From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","Center","Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210123359","https://openalex.org/I4210134534","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Center","institution_ids":[]},{"raw_affiliation_string":"Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109196249","display_name":"Louis W. Heck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"LOUIS W. HECK","raw_affiliation_strings":["From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","Center","Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210123359","https://openalex.org/I4210134534","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Center","institution_ids":[]},{"raw_affiliation_string":"Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010648096","display_name":"Edwin L. Cohen","orcid":"https://orcid.org/0000-0002-9782-0720","observed_orcids":["https://orcid.org/0000-0002-9782-0720"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"EDWIN L. COHEN","raw_affiliation_strings":["From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","Center","Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210123359","https://openalex.org/I4210134534","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Center","institution_ids":[]},{"raw_affiliation_string":"Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053946031","display_name":"Allen P. Kaplan","orcid":"https://orcid.org/0000-0002-6566-4743","observed_orcids":["https://orcid.org/0000-0002-6566-4743"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"ALLEN P. KAPLAN","raw_affiliation_strings":["From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","Center","Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210123359","https://openalex.org/I4210134534","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Center","institution_ids":[]},{"raw_affiliation_string":"Health","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104101411","display_name":"Michael M. Frank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"MICHAEL M. FRANK","raw_affiliation_strings":["From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","Center","Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases and the Metabolism and Immunology Branches, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210123359","https://openalex.org/I4210134534","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"and the Division of Endocrinology and Metabolism and the Clinical Research Unit, University of Michigan Medical Center","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Center","institution_ids":[]},{"raw_affiliation_string":"Health","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1950,"currency":"USD","value_usd":1950},"apc_paid":null,"fwci":1.2873,"has_fulltext":false,"cited_by_count":150,"citation_normalized_percentile":{"value":0.78834524,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"56","issue":"3","first_page":"225","last_page":"240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.4584999978542328,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.4584999978542328,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.09210000187158585,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.08219999819993973,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoclonal-gammopathy","display_name":"monoclonal gammopathy","score":0.6980000138282776},{"id":"https://openalex.org/keywords/capillary-permeability","display_name":"capillary permeability","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hemoconcentration","display_name":"hemoconcentration","score":0.8299999833106995},{"id":"https://openalex.org/keywords/fluid-overload","display_name":"fluid overload","score":0.3580000102519989},{"id":"https://openalex.org/keywords/pressor-agents","display_name":"pressor agents","score":0.6800000071525574},{"id":"https://openalex.org/keywords/etiology","display_name":"etiology","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9539340734481812},{"id":"https://openalex.org/C2778112473","wikidata":"https://www.wikidata.org/wiki/Q4301818","display_name":"Monoclonal gammopathy","level":5,"score":0.8704034686088562},{"id":"https://openalex.org/C2909682104","wikidata":"https://www.wikidata.org/wiki/Q4301818","display_name":"Paraproteinemias","level":5,"score":0.544424831867218},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.45190563797950745},{"id":"https://openalex.org/C2777250017","wikidata":"https://www.wikidata.org/wiki/Q458138","display_name":"Monoclonal gammopathy of undetermined significance","level":5,"score":0.4139930009841919},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.37799641489982605},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3544444143772125},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.28038734197616577},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27601978182792664},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2058873474597931}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001810","descriptor_name":"Blood Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006942","descriptor_name":"Hypergammaglobulinemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006942","descriptor_name":"Hypergammaglobulinemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006942","descriptor_name":"Hypergammaglobulinemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007263","descriptor_name":"Infusions, Parenteral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013610","descriptor_name":"Tachycardia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D013894","descriptor_name":"Thirst","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005792-197705000-00004","doi":"https://doi.org/10.1097/00005792-197705000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005792-197705000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},{"id":"pmid:870792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/870792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W101317317","https://openalex.org/W1888125523","https://openalex.org/W2102764443","https://openalex.org/W2901139342","https://openalex.org/W2044652056","https://openalex.org/W2604955853","https://openalex.org/W7223088344","https://openalex.org/W2058758644","https://openalex.org/W4386278243","https://openalex.org/W1579675324"],"abstract_inverted_index":{"The":[0,65,85,108,118],"clincical":[1],"and":[2,59,68,76,94,141,154,201,220,230],"laboratory":[3],"features":[4,229],"of":[5,26,43,48,55,88,114,131,157,166,180,185,191,209,216,232],"a":[6,23,53,124,137,177],"sixth":[7],"patient":[8,109],"with":[9,176,189],"periodic":[10],"systemic":[11],"capillary":[12,106,144,211,234],"leak":[13,235],"syndrome":[14,236],"are":[15,149],"reported.":[16],"During":[17],"an":[18,162,197],"attack":[19,50],"metabolic":[20],"studies":[21,130],"demonstrated":[22,81],"marked":[24],"shift":[25],"plasma":[27],"(10":[28],"to":[29,34,61,73,100,172,204],"70%)":[30],"from":[31],"the":[32,35,46,49,56,62,104,142,174,186,227,233,240],"intravascular":[33,63,199],"extravascular":[36],"space":[37],"resulting":[38],"in":[39,82],"hemoconcentration":[40],"(highest":[41],"hematocrit":[42],"82).":[44],"At":[45],"termination":[47],"there":[51],"was":[52,71,110,123,169],"return":[54,208],"electrolytes,":[57],"water":[58],"proteins":[60],"compartment.":[64],"cardiovascular,":[66],"renal":[67],"endocrine":[69],"compensation":[70],"appropriate":[72],"this":[74,132],"insult":[75],"no":[77,217],"underlying":[78],"abnormalities":[79],"were":[80,215],"these":[83,115,158,167],"systems.":[84],"effector":[86],"pathways":[87],"coagulation,":[89],"complement,":[90],"bradykinin":[91],"generation,":[92],"prostaglandins":[93],"histamine":[95],"metabolism":[96],"did":[97,134,194],"not":[98,111,135,195],"appear":[99],"be":[101],"responsible":[102],"for":[103],"altered":[105],"permeability.":[107,145],"missing":[112],"inhibitors":[113],"same":[116],"pathways.":[117],"only":[119],"persistently":[120],"abnormal":[121,143],"finding":[122],"monoclonal":[125],"IgG":[126,163],"gammopathy.":[127],"However,":[128],"further":[129],"paraprotein":[133],"uncover":[136],"link":[138],"between":[139],"it":[140],"Five":[146],"similar":[147],"cases":[148],"reviewed;":[150],"at":[151],"least":[152],"four":[153],"possibly":[155],"all":[156],"patients":[159],"also":[160],"had":[161],"paraprotein.":[164],"Treatment":[165,184],"attacks":[168,188],"unsuccessful.":[170],"Attemps":[171],"prevent":[173],"episodes":[175],"wide":[178],"variety":[179],"therapeutic":[181],"agents":[182,214],"failed.":[183],"acute":[187],"administration":[190],"intravenous":[192],"fluids,":[193],"maintain":[196],"adequate":[198],"volume":[200],"may":[202,221],"lead":[203],"fluid":[205],"overload":[206],"upon":[207],"normal":[210],"integrity.":[212],"Pressor":[213],"apparent":[218],"value":[219],"cause":[222],"increased":[223],"cardiac":[224],"irritability.":[225],"Although":[226],"clinical":[228],"pathophysiology":[231],"have":[237],"been":[238],"defined,":[239],"etiology":[241],"remains":[242],"unknown.":[243]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}