{"id":"https://openalex.org/W2016026936","doi":"https://doi.org/10.3109/10717549609029458","title":"Dendrimer Delivery of Oligonucleotides","display_name":"Dendrimer Delivery of Oligonucleotides","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2016026936","doi":"https://doi.org/10.3109/10717549609029458","mag":"2016026936"},"language":"en","primary_location":{"id":"doi:10.3109/10717549609029458","doi":"https://doi.org/10.3109/10717549609029458","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10717549609029458","pdf_url":null,"source":{"id":"https://openalex.org/S70174254","display_name":"Drug Delivery","issn_l":"1071-7544","issn":["1071-7544","1521-0464"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Delivery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000447132","display_name":"Scott W. Poxon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. W. Poxon","raw_affiliation_strings":["Department of Pharmaceutics, University of Florida, Gainesville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027724169","display_name":"Peggy Mitchell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. M. Mitchell","raw_affiliation_strings":["Department of Pharmaceutics, University of Florida, Gainesville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E. Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Liang","raw_affiliation_strings":["Department of Pharmaceutics, University of Florida, Gainesville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103689052","display_name":"Jeffrey A. Hughes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. A. Hughes","raw_affiliation_strings":["Department of Pharmaceutics, University of Florida, Gainesville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103689052"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":2335,"currency":"GBP","value_usd":2864},"apc_paid":null,"fwci":3.0885,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.90243595,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"3","issue":"4","first_page":"255","last_page":"261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pamam-dendrimers","display_name":"PAMAM dendrimers","score":0.921999990940094},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.9599999785423279},{"id":"https://openalex.org/keywords/oligonucleotide-delivery","display_name":"oligonucleotide delivery","score":0.8389999866485596},{"id":"https://openalex.org/keywords/electrostatic-complexation","display_name":"electrostatic complexation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/serum-stability","display_name":"serum stability","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.7409999966621399},{"id":"https://openalex.org/keywords/ph-sensitivity","display_name":"pH sensitivity","score":0.4830000102519989},{"id":"https://openalex.org/keywords/ionic-strength","display_name":"ionic strength","score":0.9670000076293945},{"id":"https://openalex.org/keywords/dendrimer-generation","display_name":"dendrimer generation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.675000011920929},{"id":"https://openalex.org/keywords/phosphodiester-oligonucleotides","display_name":"phosphodiester oligonucleotides","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C55637122","wikidata":"https://www.wikidata.org/wiki/Q903923","display_name":"Dendrimer","level":2,"score":0.9371881484985352},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.8987537622451782},{"id":"https://openalex.org/C38441620","wikidata":"https://www.wikidata.org/wiki/Q863983","display_name":"Phosphodiester bond","level":4,"score":0.8211908340454102},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6138656139373779},{"id":"https://openalex.org/C187428577","wikidata":"https://www.wikidata.org/wiki/Q898396","display_name":"Ionic strength","level":3,"score":0.6064980030059814},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.4217478632926941},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4209991693496704},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.35376957058906555},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.328870952129364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22535482048988342},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.17091774940490723},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.11508870124816895},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10713157057762146},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3109/10717549609029458","doi":"https://doi.org/10.3109/10717549609029458","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10717549609029458","pdf_url":null,"source":{"id":"https://openalex.org/S70174254","display_name":"Drug Delivery","issn_l":"1071-7544","issn":["1071-7544","1521-0464"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Delivery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W113281638","https://openalex.org/W1234513633","https://openalex.org/W1573240065","https://openalex.org/W1774527113","https://openalex.org/W1849697331","https://openalex.org/W1963931542","https://openalex.org/W1971804040","https://openalex.org/W1975654586","https://openalex.org/W1976451048","https://openalex.org/W1979687564","https://openalex.org/W1982849453","https://openalex.org/W1983902665","https://openalex.org/W1997585381","https://openalex.org/W2003794641","https://openalex.org/W2005478644","https://openalex.org/W2013745321","https://openalex.org/W2023104469","https://openalex.org/W2050487488","https://openalex.org/W2055876104","https://openalex.org/W2064023432","https://openalex.org/W2064491818","https://openalex.org/W2067193940","https://openalex.org/W2087549781","https://openalex.org/W2088971854","https://openalex.org/W2093124501","https://openalex.org/W2107859047","https://openalex.org/W2167149351","https://openalex.org/W2168206768","https://openalex.org/W2170813995","https://openalex.org/W2314418458"],"related_works":["https://openalex.org/W2060725321","https://openalex.org/W2260676403","https://openalex.org/W108016466","https://openalex.org/W2029349973","https://openalex.org/W2586616170","https://openalex.org/W2064184973","https://openalex.org/W1986699255","https://openalex.org/W2950034526","https://openalex.org/W2142177142","https://openalex.org/W2019838927"],"abstract_inverted_index":{"Factors":[0],"limiting":[1],"the":[2,12,26,61,65,70,108,185,201,216,220,244],"pharmacological":[3,80],"effectiveness":[4,221],"of":[5,23,39,57,163,222],"antisense":[6],"oligonucleotides":[7,48,59,145,164,223],"include":[8],"serum":[9,62],"stability":[10,135,235],"and":[11,28,63,87,98,165,180,192,236,249,257],"fact":[13],"that":[14,43,200,229],"these":[15,118],"agents":[16],"are":[17,33,44],"inefficiently":[18],"transported":[19],"to":[20,46,72,90,116,127,131,147,159,175,178,181,205,218,232,253],"their":[21,79,88,105,152,254,258],"sites":[22],"action":[24],"in":[25,60,64,96,99],"cytoplasm":[27],"nucleus.":[29],"Polyamidoamine":[30],"(PAMAM)":[31],"dendrimers":[32,128,148,214,250],"nonlinear":[34],"polycationic":[35],"cascade":[36],"polymers":[37],"composed":[38],"interconnected":[40],"ethylenediamine":[41],"molecules":[42],"able":[45],"bind":[47],"electrostatically.":[49],"This":[50],"new":[51],"complex":[52,203,228],"potentially":[53],"reduces":[54],"metabolic":[55,134,234],"degradation":[56],"phosphodiester":[58,93,247],"lysosome.":[66],"Dendrimers":[67],"also":[68],"have":[69,132,215],"potential":[71,217],"increase":[73,219],"oligonucleotide":[74,113],"cellular":[75,237,259],"uptake,":[76],"thus":[77],"augmenting":[78],"effectiveness.":[81],"We":[82],"studied":[83,103,150],"various":[84],"dendrimer":[85,166],"generations":[86],"ability":[89],"interact":[91],"with":[92,137,184,251],"oligonucleotides.":[94,139,211],"Alterations":[95],"pH":[97,179,191],"ionic":[100,182,193],"strength":[101],"were":[102,129,149],"for":[104,151],"effects":[106],"on":[107],"dendrimer\u2013oligonucleotide":[109],"complex.":[110],"A":[111],"fluorescent-labeled":[112,144,196],"was":[114,157,173],"utilized":[115],"study":[117],"interactions":[119,245,256],"through":[120],"a":[121,206],"fluorescence":[122,162],"anisotropy":[123],"method.":[124],"Oligonucleotides":[125],"complexed":[126,146],"shown":[130],"increased":[133],"compared":[136],"free":[138,210],"Using":[140,195],"tissue":[141],"culture":[142],"models,":[143],"transport":[153],"properties.":[154],"Flow":[155],"cytometry":[156],"used":[158],"monitor":[160],"cell-associated":[161],"systems.":[167],"The":[168],"electrostatic":[169,227,255],"oligodeoxynucleotide":[170],"(ODN)\u2013dendrimer":[171],"interaction":[172,187],"found":[174],"be":[176],"sensitive":[177],"strength,":[183],"maximal":[186],"occurring":[188],"at":[189],"low":[190],"strength.":[194],"ODN,":[197],"we":[198,242],"demonstrated":[199],"ODN\u2013DEN":[202],"accumulated":[204],"greater":[207],"extent":[208],"than":[209],"In":[212,239],"summary,":[213],"by":[224],"forming":[225],"an":[226],"is":[230],"conducive":[231],"increasing":[233],"accumulation.":[238],"this":[240],"report":[241],"describe":[243],"between":[246],"ODNs":[248],"regard":[252],"uptake.":[260]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
