{"id":"https://openalex.org/W2016016013","doi":"https://doi.org/10.1530/rep.1.00644","title":"Caffeine promotes premature chromosome condensation formation and in vitro development in porcine reconstructed embryos via a high level of maturation promoting factor activity during nuclear transfer","display_name":"Caffeine promotes premature chromosome condensation formation and in vitro development in porcine reconstructed embryos via a high level of maturation promoting factor activity during nuclear transfer","publication_year":2005,"publication_date":"2005-08-25","ids":{"openalex":"https://openalex.org/W2016016013","doi":"https://doi.org/10.1530/rep.1.00644","mag":"2016016013","pmid":"https://pubmed.ncbi.nlm.nih.gov/16123242"},"language":"en","primary_location":{"id":"doi:10.1530/rep.1.00644","doi":"https://doi.org/10.1530/rep.1.00644","is_oa":true,"landing_page_url":"https://doi.org/10.1530/rep.1.00644","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/130/3/1300351.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/130/3/1300351.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035764701","display_name":"Manabu Kawahara","orcid":"https://orcid.org/0000-0002-7172-6082","observed_orcids":["https://orcid.org/0000-0002-7172-6082"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Manabu Kawahara","raw_affiliation_strings":["Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101645738","display_name":"Takuya Wakai","orcid":"https://orcid.org/0000-0003-4705-8974","observed_orcids":["https://orcid.org/0000-0003-4705-8974"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Wakai","raw_affiliation_strings":["Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan","Tohoku Univ.#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Tohoku Univ.#TAB#","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ken-Ichi Yamanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken-Ichi Yamanaka","raw_affiliation_strings":["Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan","Tohoku Univ.#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Tohoku Univ.#TAB#","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055953942","display_name":"Jin Kobayashi","orcid":"https://orcid.org/0000-0001-8267-1315","observed_orcids":["https://orcid.org/0000-0001-8267-1315"]},"institutions":[{"id":"https://openalex.org/I25892078","display_name":"Miyagi University","ror":"https://ror.org/05nsdjj25","country_code":"JP","type":"education","lineage":["https://openalex.org/I25892078"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jin Kobayashi","raw_affiliation_strings":["Research Farm, Miyagi Agricultural College, Sendai, Japan","Miyagi university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Farm, Miyagi Agricultural College, Sendai, Japan","institution_ids":[]},{"raw_affiliation_string":"Miyagi university","institution_ids":["https://openalex.org/I25892078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035470160","display_name":"Satoshi Sugimura","orcid":"https://orcid.org/0000-0002-6473-5941","observed_orcids":["https://orcid.org/0000-0002-6473-5941"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Sugimura","raw_affiliation_strings":["Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan","Tohoku Univ.#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Tohoku Univ.#TAB#","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103514462","display_name":"Takashi Shimizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Shimizu","raw_affiliation_strings":["Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan","Tohoku Univ.#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Tohoku Univ.#TAB#","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029878803","display_name":"Hiromichi Matsumoto","orcid":"https://orcid.org/0000-0002-0104-6866","observed_orcids":["https://orcid.org/0000-0002-0104-6866"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromichi Matsumoto","raw_affiliation_strings":["Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan","Tohoku Univ.#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Tohoku Univ.#TAB#","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001188270","display_name":"Jin\u2010Hoi Kim","orcid":"https://orcid.org/0000-0003-1232-5307","observed_orcids":["https://orcid.org/0000-0003-1232-5307"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin-Hoi Kim","raw_affiliation_strings":["Division of Applied Life Science, GyeongSang National University, Chinju, GyeongNam, Korea","Gyeongsang National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Life Science, GyeongSang National University, Chinju, GyeongNam, Korea","institution_ids":["https://openalex.org/I189442560"]},{"raw_affiliation_string":"Gyeongsang National University","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042185616","display_name":"Hiroshi Sasada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Sasada","raw_affiliation_strings":["Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan","Tohoku Univ.#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Tohoku Univ.#TAB#","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053482370","display_name":"Eimei Sato","orcid":"https://orcid.org/0009-0006-6269-5049","observed_orcids":["https://orcid.org/0009-0006-6269-5049"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eimei Sato","raw_affiliation_strings":["Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan","Tohoku Univ.#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Tohoku Univ.#TAB#","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5591,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.81007543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"130","issue":"3","first_page":"351","last_page":"357"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.05480000004172325,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/maturation-promoting-factor","display_name":"maturation-promoting factor","score":0.8539999723434448},{"id":"https://openalex.org/keywords/nuclear-transfer","display_name":"nuclear transfer","score":0.7149999737739563},{"id":"https://openalex.org/keywords/chromosome-condensation","display_name":"chromosome condensation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/p34cdc2-kinase","display_name":"p34cdc2 kinase","score":0.9440000057220459},{"id":"https://openalex.org/keywords/blastocyst-development","display_name":"blastocyst development","score":0.8339999914169312},{"id":"https://openalex.org/keywords/oocyte-activation","display_name":"oocyte activation","score":0.6430000066757202},{"id":"https://openalex.org/keywords/somatic-cell-nuclear-transfer","display_name":"somatic cell nuclear transfer","score":0.6850000023841858},{"id":"https://openalex.org/keywords/nuclear-envelope-remodeling","display_name":"nuclear envelope remodeling","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C6902291","wikidata":"https://www.wikidata.org/wiki/Q417889","display_name":"Maturation promoting factor","level":5,"score":0.8332439064979553},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.7186495065689087},{"id":"https://openalex.org/C178108356","wikidata":"https://www.wikidata.org/wiki/Q7240230","display_name":"Premature chromosome condensation","level":4,"score":0.6975706815719604},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.6848309636116028},{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.6744207739830017},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.574527382850647},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5697520971298218},{"id":"https://openalex.org/C160099875","wikidata":"https://www.wikidata.org/wiki/Q237118","display_name":"Embryo transfer","level":3,"score":0.4738248586654663},{"id":"https://openalex.org/C29452124","wikidata":"https://www.wikidata.org/wiki/Q835950","display_name":"Interphase","level":2,"score":0.47288909554481506},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.351237416267395},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34357184171676636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3217138350009918},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28449389338493347},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.2680419683456421},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2274949848651886},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.1451786756515503},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.12759217619895935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10171124339103699}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016200","descriptor_name":"Maturation-Promoting Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019976","descriptor_name":"Cloning, Organism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046149","descriptor_name":"Embryo Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D053652","descriptor_name":"Nuclear Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1530/rep.1.00644","doi":"https://doi.org/10.1530/rep.1.00644","is_oa":true,"landing_page_url":"https://doi.org/10.1530/rep.1.00644","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/130/3/1300351.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},{"id":"pmid:16123242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16123242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1530/rep.1.00644","doi":"https://doi.org/10.1530/rep.1.00644","is_oa":true,"landing_page_url":"https://doi.org/10.1530/rep.1.00644","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/130/3/1300351.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016016013.pdf","grobid_xml":"https://content.openalex.org/works/W2016016013.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1487014009","https://openalex.org/W1974095094","https://openalex.org/W1974302507","https://openalex.org/W1978687637","https://openalex.org/W1981358712","https://openalex.org/W1983234868","https://openalex.org/W1996882938","https://openalex.org/W1998965637","https://openalex.org/W2002340799","https://openalex.org/W2018442011","https://openalex.org/W2018615497","https://openalex.org/W2027287513","https://openalex.org/W2034873828","https://openalex.org/W2037525608","https://openalex.org/W2038632075","https://openalex.org/W2082215944","https://openalex.org/W2083665321","https://openalex.org/W2087711917","https://openalex.org/W2094000612","https://openalex.org/W2100170064","https://openalex.org/W2113894208","https://openalex.org/W2128449641","https://openalex.org/W2129594505","https://openalex.org/W2131372407","https://openalex.org/W2133378445","https://openalex.org/W2146114919","https://openalex.org/W2149224534","https://openalex.org/W2149346011","https://openalex.org/W2155323291","https://openalex.org/W2180680955"],"related_works":["https://openalex.org/W2087188288","https://openalex.org/W2227859276","https://openalex.org/W1524499781","https://openalex.org/W2025655844","https://openalex.org/W2317143278","https://openalex.org/W7098998390","https://openalex.org/W2164167860","https://openalex.org/W2946666075","https://openalex.org/W2027393723","https://openalex.org/W2766168353"],"abstract_inverted_index":{"When":[0,76],"the":[1,36,83,86,105,127,132,159,166,170,184,190],"nucleus":[2,39],"in":[3,117,143],"G0/G1":[4],"phase":[5],"is":[6,19,179],"transferred":[7,37],"to":[8,41,64,68,82,131,169,183],"an":[9],"enucleated":[10],"oocyte":[11],"by":[12,22,27],"nuclear":[13,17],"transfer":[14],"(NT),":[15],"its":[16],"envelope":[18],"broken,":[20],"followed":[21],"condensation":[23,163],"of":[24,35,47,88,107,129,161,173,186,192],"chromosome":[25,93,162],"structure":[26],"maturation":[28],"promoting":[29],"factor":[30],"(MPF).":[31],"This":[32,177],"morphological":[33],"remodeling":[34],"interphase":[38],"seems":[40],"be":[42],"essential":[43],"for":[44],"subsequent":[45],"development":[46,130],"NT":[48,56,89,100,144,175],"embryos.":[49,176],"In":[50,99,125],"this":[51],"study,":[52],"we":[53],"treated":[54,102,146],"porcine":[55,174],"embryos":[57,90,101,145],"with":[58,103,147],"caffeine,":[59,104],"which":[60],"has":[61],"been":[62],"reported":[63],"increase":[65,156],"MPF":[66,71,187],"activity,":[67],"keep":[69],"their":[70],"level":[72],"high":[73],"during":[74],"NT.":[75,193],"2.5":[77],"mM":[78],"caffeine":[79,120,153],"was":[80,110,137],"added":[81],"handling":[84],"medium,":[85],"proportion":[87],"showing":[91],"condensed":[92],"increased":[94],"significantly":[95,111,138],"(P":[96,112,139],"<":[97,113,140],"0.05).":[98],"activity":[106,188],"p34(cdc2)":[108],"kinase":[109],"0.05)":[114,141],"higher":[115,142],"than":[116],"those":[118],"without":[119],"at":[121],"3":[122],"h":[123],"post-injection.":[124],"addition,":[126],"rate":[128,160,168],"blastocyst":[133,171],"stage":[134,172],"after":[135],"activation":[136],"caffeine.":[148],"These":[149],"results":[150],"indicate":[151],"that":[152],"treatment":[154],"can":[155],"not":[157],"only":[158],"but":[164],"also":[165],"developmental":[167],"action":[178],"most":[180],"likely":[181],"due":[182],"support/increase":[185],"throughout":[189],"process":[191]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}