{"id":"https://openalex.org/W2016012006","doi":"https://doi.org/10.1016/s0168-6445(01)00056-0","title":"The virulence factors of Bordetella pertussis: a matter of control","display_name":"The virulence factors of Bordetella pertussis: a matter of control","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W2016012006","doi":"https://doi.org/10.1016/s0168-6445(01)00056-0","mag":"2016012006","pmid":"https://pubmed.ncbi.nlm.nih.gov/11348687"},"language":"en","primary_location":{"id":"doi:10.1016/s0168-6445(01)00056-0","doi":"https://doi.org/10.1016/s0168-6445(01)00056-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-6445(01)00056-0","pdf_url":null,"source":{"id":"https://openalex.org/S7317325","display_name":"FEMS Microbiology Reviews","issn_l":"0168-6445","issn":["0168-6445","1574-6976"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/femsre/article-pdf/25/3/309/18125063/25-3-309.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067915984","display_name":"Adam M. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Adam M. Smith","raw_affiliation_strings":["Department of Biological Sciences, University of Wollongong, Wollongong. N.S.W. 2522, Australia","Department of Biological Sciences, University of Wollongong, Wollongong, N.S.W. 2522, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Wollongong, Wollongong. N.S.W. 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Wollongong, Wollongong, N.S.W. 2522, Australia","institution_ids":["https://openalex.org/I204824540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044311719","display_name":"Carlos A. Guzm\u00e1n","orcid":"https://orcid.org/0000-0002-2913-5254","observed_orcids":["https://orcid.org/0000-0002-2913-5254"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carlos A. Guzm\u00e1n","raw_affiliation_strings":["Department of Microbial Pathogenicity and Vaccine Research, Division of Microbiology, GBF-National Research Centre for Biotechnology, Braunschweig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenicity and Vaccine Research, Division of Microbiology, GBF-National Research Centre for Biotechnology, Braunschweig, Germany","institution_ids":["https://openalex.org/I4210124929"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013266227","display_name":"Mark J. Walker","orcid":"https://orcid.org/0000-0001-7423-2769","observed_orcids":["https://orcid.org/0000-0001-7423-2769","https://orcid.org/0000-0002-0507-1954"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark J. Walker","raw_affiliation_strings":["Department of Biological Sciences , University of Wollongong , Wollongong , N.S.W. 2522 , Australia","Department of Biological Sciences, University of Wollongong, Wollongong, N.S.W. 2522, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences , University of Wollongong , Wollongong , N.S.W. 2522 , Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Wollongong, Wollongong, N.S.W. 2522, Australia","institution_ids":["https://openalex.org/I204824540"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"GBP","value_usd":3297},"apc_paid":null,"fwci":3.0202,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.90192606,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"3","first_page":"309","last_page":"333"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12499","display_name":"Diphtheria, Corynebacterium, and Tetanus","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bordetella-pertussis","display_name":"Bordetella pertussis","score":1.0},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.8130000233650208},{"id":"https://openalex.org/keywords/pertussis","display_name":"pertussis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/pertussis-vaccine","display_name":"pertussis vaccine","score":0.6380000114440918},{"id":"https://openalex.org/keywords/adhesins","display_name":"adhesins","score":0.8109999895095825},{"id":"https://openalex.org/keywords/filamentous-hemagglutinin","display_name":"filamentous hemagglutinin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/fimbriae","display_name":"fimbriae","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pertactin","display_name":"pertactin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bacterial-toxins","display_name":"bacterial toxins","score":0.722000002861023},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6690000295639038},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.5400000214576721},{"id":"https://openalex.org/keywords/respiratory-tract-colonization","display_name":"respiratory tract colonization","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C2777582894","wikidata":"https://www.wikidata.org/wiki/Q137103","display_name":"Bordetella pertussis","level":3,"score":0.9425463676452637},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.8823239803314209},{"id":"https://openalex.org/C39103817","wikidata":"https://www.wikidata.org/wiki/Q1810775","display_name":"Fimbria","level":4,"score":0.8258460760116577},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7906297445297241},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7428817749023438},{"id":"https://openalex.org/C179470777","wikidata":"https://www.wikidata.org/wiki/Q356661","display_name":"Bacterial adhesin","level":4,"score":0.7003387212753296},{"id":"https://openalex.org/C196419574","wikidata":"https://www.wikidata.org/wiki/Q24723791","display_name":"Pertactin","level":5,"score":0.697506308555603},{"id":"https://openalex.org/C2779214499","wikidata":"https://www.wikidata.org/wiki/Q134859","display_name":"Whooping cough","level":3,"score":0.6678529381752014},{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.6626598238945007},{"id":"https://openalex.org/C2781090273","wikidata":"https://www.wikidata.org/wiki/Q1623405","display_name":"Virulence factor","level":4,"score":0.5713093280792236},{"id":"https://openalex.org/C2777824465","wikidata":"https://www.wikidata.org/wiki/Q893440","display_name":"Bordetella","level":4,"score":0.44551941752433777},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4064463973045349},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32682618498802185},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.3186296820640564},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2999267578125},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17306563258171082},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.10091215372085571},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.07253396511077881}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001886","descriptor_name":"Bordetella pertussis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001886","descriptor_name":"Bordetella pertussis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001886","descriptor_name":"Bordetella pertussis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001886","descriptor_name":"Bordetella pertussis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001886","descriptor_name":"Bordetella pertussis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001886","descriptor_name":"Bordetella pertussis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001886","descriptor_name":"Bordetella pertussis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D001886","descriptor_name":"Bordetella pertussis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D001886","descriptor_name":"Bordetella pertussis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010567","descriptor_name":"Pertussis Vaccine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010567","descriptor_name":"Pertussis Vaccine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010567","descriptor_name":"Pertussis Vaccine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010567","descriptor_name":"Pertussis Vaccine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010567","descriptor_name":"Pertussis Vaccine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010567","descriptor_name":"Pertussis Vaccine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014917","descriptor_name":"Whooping Cough","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014917","descriptor_name":"Whooping Cough","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014917","descriptor_name":"Whooping Cough","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0168-6445(01)00056-0","doi":"https://doi.org/10.1016/s0168-6445(01)00056-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-6445(01)00056-0","pdf_url":null,"source":{"id":"https://openalex.org/S7317325","display_name":"FEMS Microbiology Reviews","issn_l":"0168-6445","issn":["0168-6445","1574-6976"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Reviews","raw_type":"journal-article"},{"id":"doi:10.1111/j.1574-6976.2001.tb00580.x","doi":"https://doi.org/10.1111/j.1574-6976.2001.tb00580.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1574-6976.2001.tb00580.x","pdf_url":"https://academic.oup.com/femsre/article-pdf/25/3/309/18125063/25-3-309.pdf","source":{"id":"https://openalex.org/S7317325","display_name":"FEMS Microbiology Reviews","issn_l":"0168-6445","issn":["0168-6445","1574-6976"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Reviews","raw_type":"journal-article"},{"id":"pmid:11348687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11348687","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS microbiology reviews","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1574-6976.2001.tb00580.x","doi":"https://doi.org/10.1111/j.1574-6976.2001.tb00580.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1574-6976.2001.tb00580.x","pdf_url":"https://academic.oup.com/femsre/article-pdf/25/3/309/18125063/25-3-309.pdf","source":{"id":"https://openalex.org/S7317325","display_name":"FEMS Microbiology Reviews","issn_l":"0168-6445","issn":["0168-6445","1574-6976"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016012006.pdf","grobid_xml":"https://content.openalex.org/works/W2016012006.grobid-xml"},"referenced_works_count":266,"referenced_works":["https://openalex.org/W59375687","https://openalex.org/W179059320","https://openalex.org/W186907087","https://openalex.org/W1218937928","https://openalex.org/W1484283460","https://openalex.org/W1492445430","https://openalex.org/W1501994989","https://openalex.org/W1517204647","https://openalex.org/W1517788279","https://openalex.org/W1519081123","https://openalex.org/W1525578450","https://openalex.org/W1526838717","https://openalex.org/W1528306047","https://openalex.org/W1550190036","https://openalex.org/W1551413691","https://openalex.org/W1560783131","https://openalex.org/W1562632975","https://openalex.org/W1562814705","https://openalex.org/W1566044277","https://openalex.org/W1566975483","https://openalex.org/W1567895313","https://openalex.org/W1569826234","https://openalex.org/W1572028032","https://openalex.org/W1573969935","https://openalex.org/W1578008908","https://openalex.org/W1591663501","https://openalex.org/W1597468158","https://openalex.org/W1602739040","https://openalex.org/W1605587783","https://openalex.org/W1622600192","https://openalex.org/W1633836763","https://openalex.org/W1659172260","https://openalex.org/W1736256052","https://openalex.org/W1745436806","https://openalex.org/W1756785067","https://openalex.org/W1775809907","https://openalex.org/W1782935928","https://openalex.org/W1795852098","https://openalex.org/W1806758340","https://openalex.org/W1826648618","https://openalex.org/W1837682829","https://openalex.org/W1838165025","https://openalex.org/W1838940282","https://openalex.org/W1841294727","https://openalex.org/W1842286347","https://openalex.org/W1843274727","https://openalex.org/W1843873636","https://openalex.org/W1866752002","https://openalex.org/W1885498252","https://openalex.org/W1892341493","https://openalex.org/W1893030966","https://openalex.org/W1901472609","https://openalex.org/W1901642177","https://openalex.org/W1903871422","https://openalex.org/W1905644921","https://openalex.org/W1908076291","https://openalex.org/W1908268229","https://openalex.org/W1911671962","https://openalex.org/W1912492511","https://openalex.org/W1919759039","https://openalex.org/W1922548901","https://openalex.org/W1927634469","https://openalex.org/W1929171476","https://openalex.org/W1929961174","https://openalex.org/W1932302518","https://openalex.org/W1939181112","https://openalex.org/W1939644720","https://openalex.org/W1944496202","https://openalex.org/W1950690572","https://openalex.org/W1956975404","https://openalex.org/W1958296930","https://openalex.org/W1963184160","https://openalex.org/W1963722963","https://openalex.org/W1965432401","https://openalex.org/W1965875952","https://openalex.org/W1966000425","https://openalex.org/W1967470321","https://openalex.org/W1971623716","https://openalex.org/W1972673475","https://openalex.org/W1973454831","https://openalex.org/W1974956807","https://openalex.org/W1975085668","https://openalex.org/W1978175755","https://openalex.org/W1980025514","https://openalex.org/W1980108836","https://openalex.org/W1981104297","https://openalex.org/W1982051667","https://openalex.org/W1982141108","https://openalex.org/W1982795035","https://openalex.org/W1983337679","https://openalex.org/W1986962387","https://openalex.org/W1989725152","https://openalex.org/W1989770414","https://openalex.org/W1990669291","https://openalex.org/W1991489939","https://openalex.org/W1993292439","https://openalex.org/W1994774830","https://openalex.org/W1995923973","https://openalex.org/W1997645846","https://openalex.org/W1998296446","https://openalex.org/W1999188933","https://openalex.org/W2000136358","https://openalex.org/W2000378006","https://openalex.org/W2001249476","https://openalex.org/W2001600700","https://openalex.org/W2003132014","https://openalex.org/W2004169639","https://openalex.org/W2004669026","https://openalex.org/W2008103563","https://openalex.org/W2010320204","https://openalex.org/W2011521909","https://openalex.org/W2012319023","https://openalex.org/W2012411223","https://openalex.org/W2013381560","https://openalex.org/W2013537559","https://openalex.org/W2014417618","https://openalex.org/W2018684976","https://openalex.org/W2019207089","https://openalex.org/W2019358271","https://openalex.org/W2019785296","https://openalex.org/W2020251095","https://openalex.org/W2026166402","https://openalex.org/W2027983416","https://openalex.org/W2029011180","https://openalex.org/W2029231027","https://openalex.org/W2029971483","https://openalex.org/W2030939015","https://openalex.org/W2031168593","https://openalex.org/W2032494769","https://openalex.org/W2033801961","https://openalex.org/W2036846779","https://openalex.org/W2038509945","https://openalex.org/W2039141958","https://openalex.org/W2040200245","https://openalex.org/W2040442184","https://openalex.org/W2042696120","https://openalex.org/W2043178667","https://openalex.org/W2044605314","https://openalex.org/W2047034219","https://openalex.org/W2048895914","https://openalex.org/W2051743070","https://openalex.org/W2052545305","https://openalex.org/W2056239892","https://openalex.org/W2063507120","https://openalex.org/W2069732580","https://openalex.org/W2070110792","https://openalex.org/W2071056443","https://openalex.org/W2074880414","https://openalex.org/W2075034167","https://openalex.org/W2075909846","https://openalex.org/W2076477984","https://openalex.org/W2076520489","https://openalex.org/W2080702148","https://openalex.org/W2081976308","https://openalex.org/W2083275231","https://openalex.org/W2086774202","https://openalex.org/W2088591108","https://openalex.org/W2089481955","https://openalex.org/W2089677120","https://openalex.org/W2091065579","https://openalex.org/W2091675850","https://openalex.org/W2091963591","https://openalex.org/W2093398954","https://openalex.org/W2093445223","https://openalex.org/W2096280089","https://openalex.org/W2097405030","https://openalex.org/W2101762132","https://openalex.org/W2102016372","https://openalex.org/W2104084818","https://openalex.org/W2105021885","https://openalex.org/W2105160424","https://openalex.org/W2105618179","https://openalex.org/W2105697827","https://openalex.org/W2106220886","https://openalex.org/W2106560192","https://openalex.org/W2107415611","https://openalex.org/W2108141139","https://openalex.org/W2108331903","https://openalex.org/W2108555285","https://openalex.org/W2109351754","https://openalex.org/W2109498842","https://openalex.org/W2110607221","https://openalex.org/W2111738712","https://openalex.org/W2112268998","https://openalex.org/W2113827457","https://openalex.org/W2114262690","https://openalex.org/W2114426018","https://openalex.org/W2115024759","https://openalex.org/W2115390463","https://openalex.org/W2115582669","https://openalex.org/W2116023534","https://openalex.org/W2119383231","https://openalex.org/W2121552216","https://openalex.org/W2122962962","https://openalex.org/W2123179119","https://openalex.org/W2123449947","https://openalex.org/W2124446488","https://openalex.org/W2124734134","https://openalex.org/W2125542634","https://openalex.org/W2126308454","https://openalex.org/W2126336794","https://openalex.org/W2126897976","https://openalex.org/W2127632644","https://openalex.org/W2127896956","https://openalex.org/W2128690685","https://openalex.org/W2132617216","https://openalex.org/W2132871066","https://openalex.org/W2133107465","https://openalex.org/W2135085772","https://openalex.org/W2136571158","https://openalex.org/W2138560347","https://openalex.org/W2139180895","https://openalex.org/W2139744992","https://openalex.org/W2141702540","https://openalex.org/W2142419935","https://openalex.org/W2143863574","https://openalex.org/W2144178165","https://openalex.org/W2147390576","https://openalex.org/W2148585338","https://openalex.org/W2149482954","https://openalex.org/W2149492066","https://openalex.org/W2149638691","https://openalex.org/W2150777899","https://openalex.org/W2151339836","https://openalex.org/W2152385842","https://openalex.org/W2153707947","https://openalex.org/W2153771329","https://openalex.org/W2154039603","https://openalex.org/W2154238237","https://openalex.org/W2154354487","https://openalex.org/W2154378875","https://openalex.org/W2154787471","https://openalex.org/W2156980724","https://openalex.org/W2159256209","https://openalex.org/W2160520475","https://openalex.org/W2160961975","https://openalex.org/W2161281144","https://openalex.org/W2161283918","https://openalex.org/W2161432462","https://openalex.org/W2162217398","https://openalex.org/W2162450454","https://openalex.org/W2163854906","https://openalex.org/W2164533597","https://openalex.org/W2167312910","https://openalex.org/W2169636497","https://openalex.org/W2169994060","https://openalex.org/W2171011222","https://openalex.org/W2172212210","https://openalex.org/W2172260392","https://openalex.org/W2233242637","https://openalex.org/W2288371903","https://openalex.org/W2313950713","https://openalex.org/W2320619603","https://openalex.org/W2321584961","https://openalex.org/W2328100509","https://openalex.org/W2398280244","https://openalex.org/W2400255823","https://openalex.org/W2401697718","https://openalex.org/W2403367930","https://openalex.org/W2413216124","https://openalex.org/W2415185913","https://openalex.org/W2980489063","https://openalex.org/W2981210860","https://openalex.org/W4245650492","https://openalex.org/W4253914308","https://openalex.org/W4317527852"],"related_works":["https://openalex.org/W2137127559","https://openalex.org/W1659172260","https://openalex.org/W2014087452","https://openalex.org/W2132201861","https://openalex.org/W2338719560","https://openalex.org/W2098080999","https://openalex.org/W2137423654","https://openalex.org/W4230278641","https://openalex.org/W1977912042","https://openalex.org/W2075909846"],"abstract_inverted_index":{"Bordetella":[0,120],"pertussis":[1,60,78,110],"is":[2,92],"the":[3,18,33,36,40,53,86,97,113,119,141,153,157],"causative":[4],"agent":[5],"of":[6,20,35,42,57,115,159],"whooping":[7],"cough,":[8],"a":[9,29,127],"contagious":[10],"childhood":[11],"respiratory":[12,88],"disease.":[13,37],"Increasing":[14],"public":[15],"concern":[16],"over":[17],"safety":[19],"whole-cell":[21],"vaccines":[22],"led":[23],"to":[24,79,81,101,143,156],"decreased":[25],"immunisation":[26],"rates":[27],"and":[28,55,73,134],"subsequent":[30],"increase":[31],"in":[32,85,148],"incidence":[34],"Research":[38],"into":[39],"development":[41],"safer,":[43],"more":[44],"efficacious,":[45],"less":[46],"reactogenic":[47],"vaccine":[48],"preparations":[49],"was":[50],"concentrated":[51],"on":[52],"production":[54],"purification":[56],"detoxified":[58],"B.":[59,77,109],"virulence":[61,64,116,121],"factors.":[62],"These":[63],"factors":[65,117],"include":[66],"adhesins":[67],"such":[68],"as":[69],"filamentous":[70],"haemagglutinin,":[71],"fimbriae":[72],"pertactin,":[74],"which":[75,125],"allow":[76],"bind":[80],"ciliated":[82],"epithelial":[83],"cells":[84],"upper":[87],"tract.":[89],"Once":[90],"attachment":[91],"initiated,":[93],"toxins":[94],"produced":[95],"by":[96,103],"bacterium":[98,142],"enable":[99],"colonisation":[100],"proceed":[102],"interfering":[104],"with":[105],"host":[106],"clearance":[107],"mechanisms.":[108],"co-ordinately":[111],"regulates":[112],"expression":[114],"via":[118],"gene":[122,146],"(bvg)":[123],"locus,":[124],"encodes":[126],"response":[128],"regulator":[129],"responsible":[130],"for":[131],"signal-mediated":[132],"activation":[133],"repression.":[135],"This":[136],"strict":[137],"regulation":[138],"mechanism":[139],"allows":[140],"express":[144],"different":[145,149],"subsets":[147],"environmental":[150],"niches":[151],"within":[152],"host,":[154],"according":[155],"stage":[158],"disease":[160],"progression.":[161]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}