{"id":"https://openalex.org/W2015995999","doi":"https://doi.org/10.1007/bf03033883","title":"Increased extracellular glutamate evoked by 1-Methyl-4-phenylpyridinium (MPP+) in the rat striatum is not essential for dopaminergic neurotoxicity and is not derived from released glutathione","display_name":"Increased extracellular glutamate evoked by 1-Methyl-4-phenylpyridinium (MPP+) in the rat striatum is not essential for dopaminergic neurotoxicity and is not derived from released glutathione","publication_year":2005,"publication_date":"2005-12-01","ids":{"openalex":"https://openalex.org/W2015995999","doi":"https://doi.org/10.1007/bf03033883","mag":"2015995999","pmid":"https://pubmed.ncbi.nlm.nih.gov/16179262"},"language":"en","primary_location":{"id":"doi:10.1007/bf03033883","doi":"https://doi.org/10.1007/bf03033883","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf03033883","pdf_url":null,"source":{"id":"https://openalex.org/S95346388","display_name":"Neurotoxicity Research","issn_l":"1029-8428","issn":["1029-8428","1476-3524"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotoxicity Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091094466","display_name":"Steven B. Foster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven B. Foster","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA","Department of Chemistry and Biochemistry, University of Oklahoma, Norman,,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA","institution_ids":["https://openalex.org/I8692664"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Oklahoma, Norman,,USA","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010645186","display_name":"Haiwang Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haiwang Tang","raw_affiliation_strings":["Oklahoma Medical Research Foundation, 73104, Oklahoma City, OK, USA","Oklahoma Medical Research Foundation, Oklahoma City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Medical Research Foundation, 73104, Oklahoma City, OK, USA","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"Oklahoma Medical Research Foundation, Oklahoma City, USA","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018997536","display_name":"Kenneth E. Miller","orcid":"https://orcid.org/0000-0002-1162-8624","observed_orcids":["https://orcid.org/0000-0002-1162-8624"]},"institutions":[{"id":"https://openalex.org/I74022624","display_name":"Oklahoma State University Center for Health Sciences","ror":"https://ror.org/02mfxdp77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I74022624"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth E. Miller","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Oklahoma State University Center for Health Sciences, 74107, Tulsa, OK, USA","Department of Anatomy and Cell Biology, Oklahoma State University Center for Health Sciences, Tulsa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Oklahoma State University Center for Health Sciences, 74107, Tulsa, OK, USA","institution_ids":["https://openalex.org/I74022624"]},{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Oklahoma State University Center for Health Sciences, Tulsa, USA","institution_ids":["https://openalex.org/I74022624"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044762308","display_name":"Glenn Dryhurst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Glenn Dryhurst","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Oklahoma, 73019, Norman, OK, USA","Department of Chemistry and Biochemistry, University of Oklahoma, Norman,,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Oklahoma, 73019, Norman, OK, USA","institution_ids":["https://openalex.org/I8692664"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Oklahoma, Norman,,USA","institution_ids":["https://openalex.org/I8692664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5044762308","https://openalex.org/A5091094466"],"corresponding_institution_ids":["https://openalex.org/I8692664"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.4279,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.65026042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"7","issue":"4","first_page":"251","last_page":"263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mpp","display_name":"MPP+","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dopaminergic-neurotoxicity","display_name":"dopaminergic neurotoxicity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/extracellular-glutamate","display_name":"extracellular glutamate","score":0.8769999742507935},{"id":"https://openalex.org/keywords/glutathione-release","display_name":"glutathione release","score":0.746999979019165},{"id":"https://openalex.org/keywords/gamma-glutamyl-transferase","display_name":"gamma-glutamyl transferase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/acivicin","display_name":"acivicin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.9620000123977661},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.8399999737739563},{"id":"https://openalex.org/keywords/excitatory-amino-acids","display_name":"excitatory amino acids","score":0.7950000166893005},{"id":"https://openalex.org/keywords/parkinson-s-disease-model","display_name":"Parkinson's disease model","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.8298566937446594},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.7618840932846069},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.6582660675048828},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6450340747833252},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6226083636283875},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.577877402305603},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.5739335417747498},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5145939588546753},{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.5041066408157349},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4921928942203522},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4551749527454376},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.41985979676246643},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.273526668548584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24499133229255676},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.1524049937725067},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.142791748046875},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08827301859855652},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004563","descriptor_name":"Electrochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005723","descriptor_name":"gamma-Glutamyltransferase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D005723","descriptor_name":"gamma-Glutamyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015259","descriptor_name":"Dopamine Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D015655","descriptor_name":"1-Methyl-4-phenylpyridinium","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017551","descriptor_name":"Microdialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf03033883","doi":"https://doi.org/10.1007/bf03033883","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf03033883","pdf_url":null,"source":{"id":"https://openalex.org/S95346388","display_name":"Neurotoxicity Research","issn_l":"1029-8428","issn":["1029-8428","1476-3524"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotoxicity Research","raw_type":"journal-article"},{"id":"pmid:16179262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16179262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotoxicity research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5636023133","display_name":"OXIDATION CHEMISTRY OF INDOLES","funder_award_id":"R01GM032367","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W54933682","https://openalex.org/W969775097","https://openalex.org/W1486607502","https://openalex.org/W1530199299","https://openalex.org/W1581416262","https://openalex.org/W1594226632","https://openalex.org/W1900227502","https://openalex.org/W1936912164","https://openalex.org/W1940052720","https://openalex.org/W1947093063","https://openalex.org/W1963636976","https://openalex.org/W1964671322","https://openalex.org/W1965477067","https://openalex.org/W1977642609","https://openalex.org/W1977817124","https://openalex.org/W1984274895","https://openalex.org/W1986716278","https://openalex.org/W1989645955","https://openalex.org/W1990056937","https://openalex.org/W1994343367","https://openalex.org/W1995762813","https://openalex.org/W1997071370","https://openalex.org/W1997243628","https://openalex.org/W2004698905","https://openalex.org/W2007071029","https://openalex.org/W2008631075","https://openalex.org/W2010024285","https://openalex.org/W2010094123","https://openalex.org/W2012561969","https://openalex.org/W2017862027","https://openalex.org/W2018260404","https://openalex.org/W2021380809","https://openalex.org/W2026840058","https://openalex.org/W2029704951","https://openalex.org/W2034128042","https://openalex.org/W2035044775","https://openalex.org/W2035395665","https://openalex.org/W2041293207","https://openalex.org/W2042853579","https://openalex.org/W2048367257","https://openalex.org/W2050903686","https://openalex.org/W2052262213","https://openalex.org/W2056189825","https://openalex.org/W2058441068","https://openalex.org/W2062833196","https://openalex.org/W2063877848","https://openalex.org/W2064127705","https://openalex.org/W2066949311","https://openalex.org/W2067481580","https://openalex.org/W2068521882","https://openalex.org/W2080267632","https://openalex.org/W2089071582","https://openalex.org/W2092305488","https://openalex.org/W2093202434","https://openalex.org/W2101962512","https://openalex.org/W2113809202","https://openalex.org/W2117573289","https://openalex.org/W2117909173","https://openalex.org/W2122373956","https://openalex.org/W2150648464","https://openalex.org/W2158439853","https://openalex.org/W2158500293","https://openalex.org/W2168117073","https://openalex.org/W2197521137","https://openalex.org/W2304435879","https://openalex.org/W2495882796","https://openalex.org/W2990007984"],"related_works":["https://openalex.org/W1594226632","https://openalex.org/W2027288915","https://openalex.org/W2035044775","https://openalex.org/W2010861165","https://openalex.org/W2071347351","https://openalex.org/W2026840058","https://openalex.org/W2076362974","https://openalex.org/W2062530699","https://openalex.org/W2093028833","https://openalex.org/W4414321441"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}