{"id":"https://openalex.org/W2015995038","doi":"https://doi.org/10.1371/journal.pone.0032571","title":"M3 Subtype of Muscarinic Acetylcholine Receptor Promotes Cardioprotection via the Suppression of miR-376b-5p","display_name":"M3 Subtype of Muscarinic Acetylcholine Receptor Promotes Cardioprotection via the Suppression of miR-376b-5p","publication_year":2012,"publication_date":"2012-03-02","ids":{"openalex":"https://openalex.org/W2015995038","doi":"https://doi.org/10.1371/journal.pone.0032571","mag":"2015995038","pmid":"https://pubmed.ncbi.nlm.nih.gov/22396777","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3292572"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0032571","doi":"https://doi.org/10.1371/journal.pone.0032571","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0032571","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032571&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032571&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhenyu Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyu Pan","raw_affiliation_strings":["Department of Pharmacology, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People's Republic of China","Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People's Republic of China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027513507","display_name":"Yueping Guo","orcid":"https://orcid.org/0000-0002-7252-5055","observed_orcids":["https://orcid.org/0000-0002-7252-5055"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210132813","display_name":"Second Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/03s8txj32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yueping Guo","raw_affiliation_strings":["Department of Anesthesiology of the Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology of the Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210132813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071253666","display_name":"Hanping Qi","orcid":"https://orcid.org/0000-0002-3802-4409","observed_orcids":["https://orcid.org/0000-0002-3802-4409"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanping Qi","raw_affiliation_strings":["Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030403431","display_name":"Kai Fan","orcid":"https://orcid.org/0000-0001-5217-5935","observed_orcids":["https://orcid.org/0000-0001-5217-5935"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Fan","raw_affiliation_strings":["Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100335448","display_name":"Shu Fen Wang","orcid":"https://orcid.org/0000-0001-8078-9942","observed_orcids":["https://orcid.org/0000-0001-8078-9942"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu Wang","raw_affiliation_strings":["Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005955092","display_name":"Hua Zhao","orcid":"https://orcid.org/0000-0001-7139-1844","observed_orcids":["https://orcid.org/0000-0001-7139-1844"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Zhao","raw_affiliation_strings":["Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075558036","display_name":"Yuhua Fan","orcid":"https://orcid.org/0000-0002-1172-1490","observed_orcids":["https://orcid.org/0000-0002-1172-1490"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210132813","display_name":"Second Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/03s8txj32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhua Fan","raw_affiliation_strings":["Institute of Clinical Pharmacology of the Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Pharmacology of the Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210132813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052051242","display_name":"Jing Xie","orcid":"https://orcid.org/0000-0002-9317-6907","observed_orcids":["https://orcid.org/0000-0002-9317-6907"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Xie","raw_affiliation_strings":["Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102223319","display_name":"Feng Guo","orcid":"https://orcid.org/0000-0001-9627-7722","observed_orcids":["https://orcid.org/0000-0001-9627-7722"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Guo","raw_affiliation_strings":["Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040834612","display_name":"Yunlong Hou","orcid":"https://orcid.org/0000-0002-6989-8221","observed_orcids":["https://orcid.org/0000-0002-6989-8221"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunlong Hou","raw_affiliation_strings":["Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387207","display_name":"Ning Wang","orcid":"https://orcid.org/0000-0003-1410-329X","observed_orcids":["https://orcid.org/0000-0003-1410-329X"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Wang","raw_affiliation_strings":["Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101359402","display_name":"Rong Huo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Huo","raw_affiliation_strings":["Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100607116","display_name":"Yong Zhang","orcid":"https://orcid.org/0000-0002-5831-637X","observed_orcids":["https://orcid.org/0000-0002-5831-637X","https://orcid.org/0000-0003-0635-331X"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Zhang","raw_affiliation_strings":["Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351076","display_name":"Yan Liu","orcid":"https://orcid.org/0000-0002-3961-9172","observed_orcids":["https://orcid.org/0000-0002-3961-9172","https://orcid.org/0000-0002-3518-1505","https://orcid.org/0009-0008-7722-6389"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Liu","raw_affiliation_strings":["Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101871323","display_name":"Zhimin Du","orcid":"https://orcid.org/0000-0002-0346-2863","observed_orcids":["https://orcid.org/0000-0002-0346-2863"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210132813","display_name":"Second Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/03s8txj32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132813"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhimin Du","raw_affiliation_strings":["Institute of Clinical Pharmacology of the Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Pharmacology of the Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, People\u2032s Republic of China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210132813"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100351076","https://openalex.org/A5101871323"],"corresponding_institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210132813"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.0956,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.92352586,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"3","first_page":"e32571","last_page":"e32571"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscarinic-m3-receptor","display_name":"M3 muscarinic receptor","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9269999861717224},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7730000019073486},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9739999771118164},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8009999990463257},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.9829999804496765},{"id":"https://openalex.org/keywords/h9c2-cells","display_name":"H9c2 cells","score":0.8299999833106995},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6269999742507935},{"id":"https://openalex.org/keywords/myocardial-ischemic-injury","display_name":"myocardial ischemic injury","score":0.5550000071525574},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.9201900362968445},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.7580589056015015},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5586731433868408},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5399854183197021},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48517948389053345},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.43455618619918823},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.41827917098999023},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.41537654399871826},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.41465187072753906},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.412385493516922},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3837793171405792},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37145543098449707},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35765913128852844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3453441262245178},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2807648479938507},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2785106301307678},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.15637171268463135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12238761782646179},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043587","descriptor_name":"Receptor, Muscarinic M3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043587","descriptor_name":"Receptor, Muscarinic M3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0032571","doi":"https://doi.org/10.1371/journal.pone.0032571","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0032571","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032571&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2304933","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3292572","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22396777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22396777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3292572","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3292572/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.272.1161","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.272.1161","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/9d/54/PLoS_One_2012_Mar_2_7(3)_e32571.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:268228243f1c480d9bfdd4d69e24a4a3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/268228243f1c480d9bfdd4d69e24a4a3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 3, p e32571 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0032571","doi":"https://doi.org/10.1371/journal.pone.0032571","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0032571","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032571&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015995038.pdf","grobid_xml":"https://content.openalex.org/works/W2015995038.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1954362343","https://openalex.org/W1965957932","https://openalex.org/W1986382066","https://openalex.org/W1988131087","https://openalex.org/W1992389076","https://openalex.org/W1994788779","https://openalex.org/W1996227747","https://openalex.org/W2001156820","https://openalex.org/W2002064960","https://openalex.org/W2011235705","https://openalex.org/W2017804283","https://openalex.org/W2017885692","https://openalex.org/W2020932061","https://openalex.org/W2021440322","https://openalex.org/W2033064095","https://openalex.org/W2033373738","https://openalex.org/W2034002539","https://openalex.org/W2038569100","https://openalex.org/W2042869909","https://openalex.org/W2045255033","https://openalex.org/W2045984578","https://openalex.org/W2061340259","https://openalex.org/W2070323894","https://openalex.org/W2072079310","https://openalex.org/W2074016144","https://openalex.org/W2075860675","https://openalex.org/W2078341822","https://openalex.org/W2079642112","https://openalex.org/W2082830293","https://openalex.org/W2083812313","https://openalex.org/W2086309499","https://openalex.org/W2097277265","https://openalex.org/W2098404009","https://openalex.org/W2115812638","https://openalex.org/W2120219709","https://openalex.org/W2121236121","https://openalex.org/W2125625976","https://openalex.org/W2126073392","https://openalex.org/W2128960919","https://openalex.org/W2130065841","https://openalex.org/W2141927767","https://openalex.org/W2152947239","https://openalex.org/W2336144406","https://openalex.org/W2417655629","https://openalex.org/W2464514713"],"related_works":["https://openalex.org/W7100895174","https://openalex.org/W1965957932","https://openalex.org/W2134817600","https://openalex.org/W2029957979","https://openalex.org/W2088524598","https://openalex.org/W1565763167","https://openalex.org/W4400493288","https://openalex.org/W7118440256","https://openalex.org/W2625888671","https://openalex.org/W1978443526"],"abstract_inverted_index":{"The":[0,39],"M(3)":[1],"subtype":[2],"of":[3,31,53,67,82,172,218],"muscarinic":[4],"acetylcholine":[5],"receptors":[6],"(M(3)-mAChR)":[7],"plays":[8,190],"a":[9,169,186],"protective":[10],"role":[11,30,193],"in":[12,19,33,50,79,134,194],"myocardial":[13,56,68,121,199,237],"ischemia":[14,57,69,122,200,238],"and":[15,58,70,107,126,138,159,163,177,207],"microRNAs":[16],"(miRNAs)":[17],"participate":[18],"many":[20],"cardiac":[21,26],"pathophysiological":[22],"processes,":[23],"including":[24],"ischemia-induced":[25],"injury.":[27,123,239],"However,":[28],"the":[29,60,80,87,139,216,228],"miRNAs":[32,46,77],"M(3)-mAChR":[34,54,119,174,208,233],"mediated":[35,214],"cardioprotection":[36,81,210,235],"remains":[37],"unexplored.":[38],"present":[40],"study":[41],"was":[42,131],"designed":[43],"to":[44,75],"identify":[45,76],"that":[47,118,129,185],"are":[48],"involved":[49,78],"cardioprotective":[51],"effects":[52],"against":[55,236],"elucidate":[59],"underlying":[61],"mechanisms.":[62],"We":[63],"established":[64],"rat":[65],"model":[66],"performed":[71],"miRNA":[72],"microarray":[73],"analysis":[74,125],"M(3)-mAChR.":[83],"In":[84,146],"H9c2":[85,151],"cells,":[86],"viability,":[88,157],"intracellular":[89,94],"free":[90],"Ca(2+)":[91],"concentration":[92],"([Ca(2+)]i),":[93],"reactive":[95],"oxygen":[96],"species":[97],"(ROS),":[98],"miR-376b-5p":[99,130,148,180,219],"expression":[100,206],"level,":[101],"brain":[102],"derived":[103],"neurophic":[104],"factor":[105,109],"(BDNF)":[106],"nuclear":[108],"kappa-B":[110],"(NF-\u03baB)":[111],"levels":[112],"were":[113],"measured.":[114],"Our":[115,182],"results":[116],"demonstrated":[117],"protected":[120],"Microarray":[124],"qRT-PCR":[127],"revealed":[128],"significantly":[132],"up-regulated":[133],"ischemic":[135],"heart":[136],"tissue":[137],"M(3)-mAChRs":[140],"agonist":[141],"choline":[142],"reversed":[143],"its":[144],"up-regulation.":[145],"vitro,":[147],"promoted":[149],"H(2)O(2)-induced":[150],"cell":[152],"injuries":[153],"measured":[154],"by":[155,203,215,231],"cells":[156],"[Ca(2+)]i":[158],"ROS.":[160],"Western":[161],"blot":[162],"luciferase":[164],"assay":[165],"identified":[166],"BDNF":[167,205],"as":[168],"direct":[170],"target":[171],"miR-376b-5p.":[173],"activated":[175],"NF-\u03baB":[176],"thereby":[178],"inhibited":[179],"expression.":[181],"data":[183],"show":[184],"novel":[187],"M(3)-mAChR/NF-\u03baB/miR-376b-5p/BDNF":[188],"axis":[189],"an":[191],"important":[192],"modulating":[195],"cardioprotection.":[196],"MiR-376b-5p":[197],"promotes":[198],"injury":[201],"possibly":[202],"inhibiting":[204],"provides":[209,234],"at":[211],"least":[212],"partially":[213],"downregulation":[217],"through":[220],"NF-\u03baB.":[221],"These":[222],"findings":[223],"provide":[224],"new":[225],"insight":[226],"into":[227],"potential":[229],"mechanism":[230],"which":[232]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}