{"id":"https://openalex.org/W2015990146","doi":"https://doi.org/10.1016/s0002-9610(97)00279-1","title":"Treatment of large and locally advanced breast cancers using neoadjuvant chemotherapy","display_name":"Treatment of large and locally advanced breast cancers using neoadjuvant chemotherapy","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W2015990146","doi":"https://doi.org/10.1016/s0002-9610(97)00279-1","mag":"2015990146","pmid":"https://pubmed.ncbi.nlm.nih.gov/9515529"},"language":"en","primary_location":{"id":"doi:10.1016/s0002-9610(97)00279-1","doi":"https://doi.org/10.1016/s0002-9610(97)00279-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0002-9610(97)00279-1","pdf_url":null,"source":{"id":"https://openalex.org/S101510409","display_name":"The American Journal of Surgery","issn_l":"0002-9610","issn":["0002-9610","1879-1883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109966861","display_name":"Amin El-Tahir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amin Eltahir","raw_affiliation_strings":["Department of Surgery, University of Aberdeen, Scotland, United Kingdom","From the Surgical Nutrition and Metabolism Unit and the Departments of Surgery, Medical Oncology, and Clinical Oncology, University of Aberdeen, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Aberdeen, Scotland, United Kingdom","institution_ids":["https://openalex.org/I195460627"]},{"raw_affiliation_string":"From the Surgical Nutrition and Metabolism Unit and the Departments of Surgery, Medical Oncology, and Clinical Oncology, University of Aberdeen, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109248213","display_name":"Steven D. Heys","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steven D. Heys","raw_affiliation_strings":["From the Surgical Nutrition and Metabolism Unit and the Departments of Surgery, Medical Oncology, and Clinical Oncology, University of Aberdeen, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Surgical Nutrition and Metabolism Unit and the Departments of Surgery, Medical Oncology, and Clinical Oncology, University of Aberdeen, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111774230","display_name":"Andrew W. Hutcheon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew W. Hutcheon","raw_affiliation_strings":["From the Surgical Nutrition and Metabolism Unit and the Departments of Surgery, Medical Oncology, and Clinical Oncology, University of Aberdeen, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Surgical Nutrition and Metabolism Unit and the Departments of Surgery, Medical Oncology, and Clinical Oncology, University of Aberdeen, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tarun K. Sarkar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tarun K. Sarkar","raw_affiliation_strings":["From the Surgical Nutrition and Metabolism Unit and the Departments of Surgery, Medical Oncology, and Clinical Oncology, University of Aberdeen, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Surgical Nutrition and Metabolism Unit and the Departments of Surgery, Medical Oncology, and Clinical Oncology, University of Aberdeen, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113574041","display_name":"L. M. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"lan Smith","raw_affiliation_strings":["From the Surgical Nutrition and Metabolism Unit and the Departments of Surgery, Medical Oncology, and Clinical Oncology, University of Aberdeen, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Surgical Nutrition and Metabolism Unit and the Departments of Surgery, Medical Oncology, and Clinical Oncology, University of Aberdeen, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103423364","display_name":"Leslie G. Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Leslie G. Walker","raw_affiliation_strings":["From the Surgical Nutrition and Metabolism Unit and the Departments of Surgery, Medical Oncology, and Clinical Oncology, University of Aberdeen, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Surgical Nutrition and Metabolism Unit and the Departments of Surgery, Medical Oncology, and Clinical Oncology, University of Aberdeen, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110059807","display_name":"Antoine K. Ah-See","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Antoine K. Ah-See","raw_affiliation_strings":["From the Surgical Nutrition and Metabolism Unit and the Departments of Surgery, Medical Oncology, and Clinical Oncology, University of Aberdeen, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Surgical Nutrition and Metabolism Unit and the Departments of Surgery, Medical Oncology, and Clinical Oncology, University of Aberdeen, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026699102","display_name":"Oleg Eremin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Oleg Eremin","raw_affiliation_strings":["From the Surgical Nutrition and Metabolism Unit and the Departments of Surgery, Medical Oncology, and Clinical Oncology, University of Aberdeen, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Surgical Nutrition and Metabolism Unit and the Departments of Surgery, Medical Oncology, and Clinical Oncology, University of Aberdeen, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I195460627"],"apc_list":{"value":3830,"currency":"USD","value_usd":3830},"apc_paid":null,"fwci":1.6379,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.83474006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"175","issue":"2","first_page":"127","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/locally-advanced-breast-cancer","display_name":"locally advanced breast cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.8579999804496765},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9340000152587891},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.7710000276565552},{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":0.9670000076293945},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.7860000133514404},{"id":"https://openalex.org/keywords/surgical-treatment","display_name":"surgical treatment","score":0.4099999964237213},{"id":"https://openalex.org/keywords/tumor-response","display_name":"tumor response","score":0.593999981880188},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8309999704360962},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8949999809265137},{"id":"https://openalex.org/keywords/histopathological-response","display_name":"histopathological response","score":0.7829999923706055},{"id":"https://openalex.org/keywords/clinical-response","display_name":"clinical response","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.880342960357666},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7756658792495728},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.7536635398864746},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7103385329246521},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6476243138313293},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.642760157585144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6092789769172668},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.5552143454551697},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39219725131988525},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34965136647224426}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0002-9610(97)00279-1","doi":"https://doi.org/10.1016/s0002-9610(97)00279-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0002-9610(97)00279-1","pdf_url":null,"source":{"id":"https://openalex.org/S101510409","display_name":"The American Journal of Surgery","issn_l":"0002-9610","issn":["0002-9610","1879-1883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Surgery","raw_type":"journal-article"},{"id":"pmid:9515529","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9515529","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W218718492","https://openalex.org/W1543231979","https://openalex.org/W1892756525","https://openalex.org/W1913192549","https://openalex.org/W1962197769","https://openalex.org/W1964510050","https://openalex.org/W1970277618","https://openalex.org/W1977793701","https://openalex.org/W1988518707","https://openalex.org/W1994068579","https://openalex.org/W2008792450","https://openalex.org/W2018669222","https://openalex.org/W2018720652","https://openalex.org/W2031268280","https://openalex.org/W2032628874","https://openalex.org/W2047127173","https://openalex.org/W2052025976","https://openalex.org/W2086766680","https://openalex.org/W2091858047","https://openalex.org/W2111418719","https://openalex.org/W2112160480","https://openalex.org/W2121309812","https://openalex.org/W2139984188","https://openalex.org/W2167805334","https://openalex.org/W2403495700","https://openalex.org/W2409503344","https://openalex.org/W2418151756","https://openalex.org/W2478034463","https://openalex.org/W2995133996","https://openalex.org/W3147894994","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1986054377","https://openalex.org/W2247475310","https://openalex.org/W2098524926","https://openalex.org/W2187642494","https://openalex.org/W2941435422","https://openalex.org/W2375985972","https://openalex.org/W2287271371","https://openalex.org/W7100106846","https://openalex.org/W7017753912","https://openalex.org/W1543231979"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}