{"id":"https://openalex.org/W2015984875","doi":"https://doi.org/10.1097/01.pcc.0000059422.26706.64","title":"Successful management of an extreme example of neonatal hyperprostaglandin-E syndrome (Bartter???s syndrome) with the new cyclooxygenase-2 inhibitor rofecoxib","display_name":"Successful management of an extreme example of neonatal hyperprostaglandin-E syndrome (Bartter???s syndrome) with the new cyclooxygenase-2 inhibitor rofecoxib","publication_year":2003,"publication_date":"2003-04-01","ids":{"openalex":"https://openalex.org/W2015984875","doi":"https://doi.org/10.1097/01.pcc.0000059422.26706.64","mag":"2015984875","pmid":"https://pubmed.ncbi.nlm.nih.gov/12749662"},"language":"en","primary_location":{"id":"doi:10.1097/01.pcc.0000059422.26706.64","doi":"https://doi.org/10.1097/01.pcc.0000059422.26706.64","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.pcc.0000059422.26706.64","pdf_url":null,"source":{"id":"https://openalex.org/S180821644","display_name":"Pediatric Critical Care Medicine","issn_l":"1529-7535","issn":["1529-7535","1947-3893"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043130465","display_name":"Nikolaus Alexander Haas","orcid":"https://orcid.org/0000-0002-2134-3091","observed_orcids":["https://orcid.org/0000-0002-2134-3091"]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nikolaus A. Haas","raw_affiliation_strings":["Department of Pediatric Cardiology and Pediatric Intensive Care, Olgahospital Stuttgart, Stuttgart, Germany","the Department of Pediatric Cardiology and Pediatric Intensive Care, Olgahospital Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Cardiology and Pediatric Intensive Care, Olgahospital Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I4210113917"]},{"raw_affiliation_string":"the Department of Pediatric Cardiology and Pediatric Intensive Care, Olgahospital Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I4210113917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038961426","display_name":"Robert Nossal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert Nossal","raw_affiliation_strings":["the Department of Pediatric Cardiology and Pediatric Intensive Care, Olgahospital Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Pediatric Cardiology and Pediatric Intensive Care, Olgahospital Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I4210113917"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christoph H. Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph H. Schneider","raw_affiliation_strings":["the Department of Pediatric Cardiology and Pediatric Intensive Care, Olgahospital Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Pediatric Cardiology and Pediatric Intensive Care, Olgahospital Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I4210113917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111403521","display_name":"Martin A. G. Lewin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin A. G. Lewin","raw_affiliation_strings":["the Department of Pediatric Cardiology and Pediatric Intensive Care, Olgahospital Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Pediatric Cardiology and Pediatric Intensive Care, Olgahospital Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I4210113917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061421523","display_name":"Volker Ocker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Volker Ocker","raw_affiliation_strings":["the Department of Pediatric Cardiology and Pediatric Intensive Care, Olgahospital Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Pediatric Cardiology and Pediatric Intensive Care, Olgahospital Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I4210113917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053089611","display_name":"Martin Holder","orcid":"https://orcid.org/0000-0002-6577-5400","observed_orcids":["https://orcid.org/0000-0002-6577-5400"]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Holder","raw_affiliation_strings":["the Department of Pediatric Cardiology and Pediatric Intensive Care, Olgahospital Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Pediatric Cardiology and Pediatric Intensive Care, Olgahospital Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I4210113917"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030528958","display_name":"Frank Uhlemann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Uhlemann","raw_affiliation_strings":["the Department of Pediatric Cardiology and Pediatric Intensive Care, Olgahospital Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Pediatric Cardiology and Pediatric Intensive Care, Olgahospital Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I4210113917"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210113917"],"apc_list":null,"apc_paid":null,"fwci":1.7363,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.82172803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"2","first_page":"249","last_page":"251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.26440000534057617,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.26440000534057617,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12272","display_name":"Cardiovascular Conditions and Treatments","score":0.24779999256134033,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.07280000299215317,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonatal-bartter-syndrome","display_name":"neonatal Bartter syndrome","score":0.890999972820282},{"id":"https://openalex.org/keywords/rofecoxib","display_name":"rofecoxib","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cox-2-inhibitors","display_name":"COX-2 inhibitors","score":0.9440000057220459},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.8069999814033508},{"id":"https://openalex.org/keywords/failure-to-thrive","display_name":"failure to thrive","score":0.6269999742507935},{"id":"https://openalex.org/keywords/growth-retardation","display_name":"growth retardation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/electrolyte-supplementation","display_name":"electrolyte supplementation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/neonatal-intensive-care","display_name":"neonatal intensive care","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9540567398071289},{"id":"https://openalex.org/C2778582115","wikidata":"https://www.wikidata.org/wiki/Q411412","display_name":"Rofecoxib","level":4,"score":0.7734019160270691},{"id":"https://openalex.org/C2777616141","wikidata":"https://www.wikidata.org/wiki/Q790971","display_name":"Bartter syndrome","level":3,"score":0.7269976139068604},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.6009803414344788},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4715709090232849},{"id":"https://openalex.org/C2776917539","wikidata":"https://www.wikidata.org/wiki/Q1497481","display_name":"Failure to thrive","level":2,"score":0.4673210680484772},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.46571946144104004},{"id":"https://openalex.org/C44315111","wikidata":"https://www.wikidata.org/wiki/Q1344580","display_name":"Enteral administration","level":3,"score":0.4382960796356201},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.43500828742980957},{"id":"https://openalex.org/C78722104","wikidata":"https://www.wikidata.org/wiki/Q21653202","display_name":"Parenteral nutrition","level":2,"score":0.3482781648635864},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3456647992134094},{"id":"https://openalex.org/C2778242168","wikidata":"https://www.wikidata.org/wiki/Q794086","display_name":"Hypokalemia","level":2,"score":0.23215165734291077},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001477","descriptor_name":"Bartter Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001477","descriptor_name":"Bartter Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.pcc.0000059422.26706.64","doi":"https://doi.org/10.1097/01.pcc.0000059422.26706.64","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.pcc.0000059422.26706.64","pdf_url":null,"source":{"id":"https://openalex.org/S180821644","display_name":"Pediatric Critical Care Medicine","issn_l":"1529-7535","issn":["1529-7535","1947-3893"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:12749662","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12749662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1608336039","https://openalex.org/W1921602963","https://openalex.org/W1972331427","https://openalex.org/W1978004808","https://openalex.org/W1989335464","https://openalex.org/W1995826486","https://openalex.org/W2006752467","https://openalex.org/W2022210596","https://openalex.org/W2030126289","https://openalex.org/W2034924716","https://openalex.org/W2036212752","https://openalex.org/W2036248761","https://openalex.org/W2037955097","https://openalex.org/W2038974751","https://openalex.org/W2046436667","https://openalex.org/W2050758656","https://openalex.org/W2058064884","https://openalex.org/W2091379747","https://openalex.org/W2093164617","https://openalex.org/W2094596045","https://openalex.org/W2098615604","https://openalex.org/W2131005839","https://openalex.org/W2403095026","https://openalex.org/W3188126663","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2027652732","https://openalex.org/W2014569965","https://openalex.org/W2045797247","https://openalex.org/W2508236632","https://openalex.org/W2412507262","https://openalex.org/W4317676357","https://openalex.org/W2068469252","https://openalex.org/W2013351014","https://openalex.org/W2006752467","https://openalex.org/W2091066751"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"describe":[2],"the":[3,70,75,143,150],"successful":[4],"treatment":[5,17,60],"of":[6,10,40,69,102,139,153],"an":[7],"unusual":[8],"case":[9],"severe":[11,107,137],"neonatal":[12,34,140],"Bartter's":[13,141],"syndrome":[14,36,155],"refractory":[15],"to":[16,51],"with":[18,33,61,135],"indomethacin.":[19,62],"DESIGN:":[20],"Case":[21],"report,":[22],"clinical.":[23],"SETTING:":[24],"Tertiary":[25],"care":[26,28],"intensive":[27],"unit.":[29],"PATIENTS:":[30],"A":[31,91],"patient":[32,76],"hyperprostaglandin-E":[35,154],"and":[37,47,54,84,96],"excessive":[38],"requirements":[39],"intravenous":[41],"(via":[42],"central":[43],"venous":[44],"catheter)":[45],"water":[46],"salt":[48],"supplementation,":[49],"failure":[50],"thrive,":[52],"vomiting,":[53],"massive":[55],"growth":[56],"retardation,":[57],"despite":[58,109],"adequate":[59],"MAIN":[63],"RESULT:":[64],"Four":[65],"weeks":[66],"after":[67,116,156],"induction":[68],"new":[71,144],"cyclooxygenase-2":[72,145],"inhibitor":[73,146],"rofecoxib,":[74],"was":[77,99],"well,":[78],"on":[79],"full":[80],"enteral":[81],"feeds,":[82],"thriving,":[83],"had":[85],"gained":[86],"600":[87],"g":[88],"in":[89,106,132],"weight.":[90],"lower":[92],"supplementary":[93],"potassium,":[94],"magnesium,":[95],"sodium":[97],"intake":[98],"required.":[100],"Reinstitution":[101],"indomethacin":[103,111,158],"therapy":[104],"resulted":[105],"deterioration,":[108],"high":[110],"doses;":[112],"symptoms":[113,152],"improved":[114],"again":[115],"rofecoxib":[117,147],"administration.":[118],"No":[119],"side":[120],"effects":[121],"have":[122],"been":[123],"seen":[124],"thus":[125],"far.":[126],"CONCLUSION:":[127],"This":[128],"report":[129],"shows":[130],"that":[131],"selected":[133],"patients":[134],"a":[136],"form":[138],"syndrome,":[142],"may":[148],"control":[149],"clinical":[151],"ineffective":[157],"therapy.":[159]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}