{"id":"https://openalex.org/W2015956932","doi":"https://doi.org/10.1002/ijc.20908","title":"Serial killing of tumor cells by cytotoxic T cells redirected with a CD19\u2010/CD3\u2010bispecific single\u2010chain antibody construct","display_name":"Serial killing of tumor cells by cytotoxic T cells redirected with a CD19\u2010/CD3\u2010bispecific single\u2010chain antibody construct","publication_year":2005,"publication_date":"2005-02-01","ids":{"openalex":"https://openalex.org/W2015956932","doi":"https://doi.org/10.1002/ijc.20908","mag":"2015956932","pmid":"https://pubmed.ncbi.nlm.nih.gov/15688411"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.20908","doi":"https://doi.org/10.1002/ijc.20908","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.20908","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.20908","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.20908","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Patrick Hoffmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Hoffmann","raw_affiliation_strings":["Micromet AG, Munich, Germany","The first two authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Micromet AG, Munich, Germany","institution_ids":[]},{"raw_affiliation_string":"The first two authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112172747","display_name":"Robert Hofmeister","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Hofmeister","raw_affiliation_strings":["Micromet AG, Munich, Germany","The first two authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Micromet AG, Munich, Germany","institution_ids":[]},{"raw_affiliation_string":"The first two authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067203103","display_name":"Klaus Brischwein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Klaus Brischwein","raw_affiliation_strings":["Micromet AG, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Micromet AG, Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064832635","display_name":"Christian Brandl","orcid":"https://orcid.org/0000-0001-7569-2003","observed_orcids":["https://orcid.org/0000-0001-7569-2003"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Brandl","raw_affiliation_strings":["Micromet AG, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Micromet AG, Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054887650","display_name":"Sandrine Crommer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandrine Crommer","raw_affiliation_strings":["Micromet AG, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Micromet AG, Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029898558","display_name":"Ralf Christian Bargou","orcid":"https://orcid.org/0000-0002-1221-7421","observed_orcids":["https://orcid.org/0000-0002-1221-7421"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210138940","display_name":"Helios Kliniken","ror":"https://ror.org/04fjkxc67","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138940"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Bargou","raw_affiliation_strings":["Robert-Ro\u0308ssle-Clinic, University Medical Center Charite\u0301, Humboldt University of Berlin, and Helios Kliniken, Berlin, Germany","Robert-R\u00f6ssle-Clinic, University Medical Center Charit\u00e9, Humboldt University of Berlin, and Helios Kliniken, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert-Ro\u0308ssle-Clinic, University Medical Center Charite\u0301, Humboldt University of Berlin, and Helios Kliniken, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I4210138940","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Robert-R\u00f6ssle-Clinic, University Medical Center Charit\u00e9, Humboldt University of Berlin, and Helios Kliniken, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I4210138940","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069106447","display_name":"Christian Itin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Itin","raw_affiliation_strings":["Micromet AG, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Micromet AG, Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001186865","display_name":"Nadja S. Prang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nadja Prang","raw_affiliation_strings":["Micromet AG, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Micromet AG, Munich, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058901224","display_name":"Patrick A. Baeuerle","orcid":"https://orcid.org/0009-0006-7117-2784","observed_orcids":["https://orcid.org/0009-0006-7117-2784"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Patrick A. Baeuerle","raw_affiliation_strings":["","Micromet AG, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Micromet AG, Munich, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5058901224"],"corresponding_institution_ids":[],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":2.2756,"has_fulltext":true,"cited_by_count":348,"citation_normalized_percentile":{"value":0.87973804,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"115","issue":"1","first_page":"98","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0949999988079071,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.08460000157356262,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-chain-antibody","display_name":"single-chain antibody","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.847000002861023},{"id":"https://openalex.org/keywords/t-cell-redirection","display_name":"T cell redirection","score":0.5899999737739563},{"id":"https://openalex.org/keywords/serial-murder","display_name":"serial murder","score":0.5860000252723694},{"id":"https://openalex.org/keywords/t-cell-motility","display_name":"T cell motility","score":0.7730000019073486},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.47600001096725464},{"id":"https://openalex.org/keywords/b-lymphoma","display_name":"B lymphoma","score":0.6370000243186951},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.574999988079071},{"id":"https://openalex.org/keywords/tumor-cell-lysis","display_name":"tumor cell lysis","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7375768423080444},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6002547144889832},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.5606417059898376},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5418272018432617},{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.53227698802948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5235369205474854},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5231313109397888},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.457692950963974},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.43575191497802734},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4286680221557617},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35742688179016113},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3495112657546997},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33159029483795166},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2772199511528015},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.18517369031906128},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16045400500297546},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09616264700889587}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007128","descriptor_name":"Immunoglobulin Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018715","descriptor_name":"Microscopy, Video","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018941","descriptor_name":"Antigens, CD19","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.20908","doi":"https://doi.org/10.1002/ijc.20908","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.20908","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.20908","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:15688411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15688411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/ijc.20908","doi":"https://doi.org/10.1002/ijc.20908","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.20908","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.20908","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015956932.pdf","grobid_xml":"https://content.openalex.org/works/W2015956932.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W62176468","https://openalex.org/W1520654963","https://openalex.org/W1529239585","https://openalex.org/W1840766718","https://openalex.org/W1964969705","https://openalex.org/W1967492452","https://openalex.org/W1984550821","https://openalex.org/W1987240796","https://openalex.org/W2003522381","https://openalex.org/W2023754920","https://openalex.org/W2034409643","https://openalex.org/W2052325839","https://openalex.org/W2062372065","https://openalex.org/W2062443745","https://openalex.org/W2066982596","https://openalex.org/W2076121010","https://openalex.org/W2076711139","https://openalex.org/W2079163177","https://openalex.org/W2079347212","https://openalex.org/W2083494119","https://openalex.org/W2110466399","https://openalex.org/W2116555417","https://openalex.org/W2160007096","https://openalex.org/W2304723751"],"related_works":["https://openalex.org/W2083494119","https://openalex.org/W1987678282","https://openalex.org/W1840766718","https://openalex.org/W2114310770","https://openalex.org/W2026023404","https://openalex.org/W2595360873","https://openalex.org/W2409295084","https://openalex.org/W2059222861","https://openalex.org/W2116555417","https://openalex.org/W2050090046"],"abstract_inverted_index":{"Certain":[0],"bispecific":[1,176,231],"antibodies":[2],"exhibit":[3],"an":[4],"extraordinary":[5],"potency":[6],"and":[7,46,72,102,150,154,164,169],"efficacy":[8],"for":[9,58],"target":[10,90,106,109,151,170,186,238],"cell":[11,44,110,119,128,152,187,239],"lysis":[12,188,240],"by":[13,147,174,189,241],"eliciting":[14],"a":[15,22,78,81,93,205,230],"polyclonal":[16],"T-cell":[17,148],"response.":[18],"One":[19],"example":[20],"is":[21,224],"CD19-/CD3-bispecific":[23],"single-chain":[24],"antibody":[25,232],"construct":[26],"(bscCD19xCD3),":[27],"which":[28,201],"at":[29,117],"femtomolar":[30],"concentrations":[31],"can":[32,233],"redirect":[33],"cytotoxic":[34],"T":[35,75,85,159,168,191,199,214,242],"cells":[36,76,86,91,160,171,180,192,215],"to":[37,68,80,213],"eliminate":[38,88],"human":[39],"B":[40,42,49,212],"lymphocytes,":[41],"lymphoma":[43],"lines":[45],"patient-derived":[47],"malignant":[48],"cells.":[50,107,243],"Here":[51],"we":[52],"have":[53],"further":[54],"explored":[55],"the":[56,70,139,175,194,225],"basis":[57],"this":[59,223],"high":[60],"potency.":[61],"Using":[62],"video-assisted":[63],"microscopy,":[64],"bscCD19xCD3":[65],"was":[66,112,144,202],"found":[67],"alter":[69],"motility":[71],"activity":[73],"of":[74,105,135,141,167,196,207,209,237],"from":[77,211],"scanning":[79,153],"killing":[82,129,143],"mode.":[83],"Individual":[84],"could":[87],"multiple":[89,235],"within":[92,114,131],"9":[94],"hr":[95,116],"time":[96],"period,":[97],"resulting":[98],"in":[99],"nuclear":[100],"fragmentation":[101],"membrane":[103],"blebbing":[104],"Complete":[108],"elimination":[111],"observed":[113],"24":[115],"effector-to-target":[118],"ratios":[120],"as":[121,123],"low":[122],"1:5.":[124],"Under":[125],"optimal":[126],"conditions,":[127],"started":[130],"minutes":[132],"after":[133],"addition":[134],"bscCD19xCD3,":[136],"suggesting":[137],"that":[138,229],"rate":[140],"serial":[142],"mostly":[145],"determined":[146],"movement":[149],"lysis.":[155],"At":[156],"all":[157],"times,":[158],"remained":[161],"highly":[162],"motile,":[163],"no":[165],"clusters":[166],"were":[172,181],"induced":[173],"antibody.":[177],"Bystanding":[178],"target-negative":[179],"not":[182],"detectably":[183],"affected.":[184],"Repeated":[185],"bscCD19xCD3-activated":[190],"increased":[193],"proportion":[195],"CD19/CD3":[197],"double-positive":[198],"cells,":[200],"most":[203],"likely":[204],"consequence":[206],"transfer":[208],"CD19":[210],"during":[216],"cytolytic":[217],"synapse":[218],"formation.":[219],"To":[220],"our":[221],"knowledge,":[222],"first":[226],"study":[227],"showing":[228],"sustain":[234],"rounds":[236]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":28},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":32},{"year":2016,"cited_by_count":31},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}