{"id":"https://openalex.org/W2015940468","doi":"https://doi.org/10.1136/gut.25.5.485","title":"Effects of oral cyclotropium bromide, hyoscine N-butylbromide and placebo on gastric emptying and antral motor activity in healthy man.","display_name":"Effects of oral cyclotropium bromide, hyoscine N-butylbromide and placebo on gastric emptying and antral motor activity in healthy man.","publication_year":1984,"publication_date":"1984-05-01","ids":{"openalex":"https://openalex.org/W2015940468","doi":"https://doi.org/10.1136/gut.25.5.485","mag":"2015940468","pmid":"https://pubmed.ncbi.nlm.nih.gov/6714792","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1432466"},"language":"en","primary_location":{"id":"doi:10.1136/gut.25.5.485","doi":"https://doi.org/10.1136/gut.25.5.485","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.25.5.485","pdf_url":"https://gut.bmj.com/content/gutjnl/25/5/485.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://gut.bmj.com/content/gutjnl/25/5/485.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110941817","display_name":"Georg Stacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"G Stacher","raw_affiliation_strings":["From the Psychophysiology Unit at the Psychiatric and First Surgical Clinic and the Department of Nuclear Medicine, Second Medical Clinic, University of Vienna, Vienna, Austria","Psychophysiologisches Labora-torium, Psychiatrische Universitatsklinik, Wahringer Gurtel 74-76, A-1090 Wien, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Psychophysiology Unit at the Psychiatric and First Surgical Clinic and the Department of Nuclear Medicine, Second Medical Clinic, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]},{"raw_affiliation_string":"Psychophysiologisches Labora-torium, Psychiatrische Universitatsklinik, Wahringer Gurtel 74-76, A-1090 Wien, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058111722","display_name":"Helmar Bergmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"H Bergmann","raw_affiliation_strings":["From the Psychophysiology Unit at the Psychiatric and First Surgical Clinic and the Department of Nuclear Medicine, Second Medical Clinic, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Psychophysiology Unit at the Psychiatric and First Surgical Clinic and the Department of Nuclear Medicine, Second Medical Clinic, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065662351","display_name":"Ernst Havlik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"E Havlik","raw_affiliation_strings":["From the Psychophysiology Unit at the Psychiatric and First Surgical Clinic and the Department of Nuclear Medicine, Second Medical Clinic, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Psychophysiology Unit at the Psychiatric and First Surgical Clinic and the Department of Nuclear Medicine, Second Medical Clinic, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024954234","display_name":"Giselheid Schmierer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"G Schmierer","raw_affiliation_strings":["From the Psychophysiology Unit at the Psychiatric and First Surgical Clinic and the Department of Nuclear Medicine, Second Medical Clinic, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Psychophysiology Unit at the Psychiatric and First Surgical Clinic and the Department of Nuclear Medicine, Second Medical Clinic, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108429909","display_name":"C. Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"C Schneider","raw_affiliation_strings":["From the Psychophysiology Unit at the Psychiatric and First Surgical Clinic and the Department of Nuclear Medicine, Second Medical Clinic, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Psychophysiology Unit at the Psychiatric and First Surgical Clinic and the Department of Nuclear Medicine, Second Medical Clinic, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8512,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.83338887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"25","issue":"5","first_page":"485","last_page":"490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12020","display_name":"Enhanced Recovery After Surgery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyoscine-n-butylbromide","display_name":"hyoscine-N-butylbromide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gastric-emptying","display_name":"gastric emptying","score":0.8240000009536743},{"id":"https://openalex.org/keywords/antimuscarinic-agents","display_name":"antimuscarinic agents","score":0.8569999933242798},{"id":"https://openalex.org/keywords/gastrointestinal-motility","display_name":"gastrointestinal motility","score":0.9139999747276306},{"id":"https://openalex.org/keywords/healthy-men","display_name":"healthy men","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C3020479747","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Gastric emptying","level":3,"score":0.8872132301330566},{"id":"https://openalex.org/C131253125","wikidata":"https://www.wikidata.org/wiki/Q609361","display_name":"Antrum","level":3,"score":0.8228983879089355},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6827623248100281},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5719741582870483},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5163077712059021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5078657269477844},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.442848265171051},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38485074043273926},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33880162239074707},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10668826103210449},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002086","descriptor_name":"Butylscopolammonium Bromide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005746","descriptor_name":"Gastric Emptying","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005769","descriptor_name":"Gastrointestinal Motility","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010276","descriptor_name":"Parasympatholytics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011706","descriptor_name":"Pyloric Antrum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011706","descriptor_name":"Pyloric Antrum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012602","descriptor_name":"Scopolamine Derivatives","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014326","descriptor_name":"Tropanes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/gut.25.5.485","doi":"https://doi.org/10.1136/gut.25.5.485","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.25.5.485","pdf_url":"https://gut.bmj.com/content/gutjnl/25/5/485.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1432466","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1432466","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Text"},{"id":"pmid:6714792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6714792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1136/gut.25.5.485","doi":"https://doi.org/10.1136/gut.25.5.485","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.25.5.485","pdf_url":"https://gut.bmj.com/content/gutjnl/25/5/485.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015940468.pdf","grobid_xml":"https://content.openalex.org/works/W2015940468.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W580043793","https://openalex.org/W1609704183","https://openalex.org/W1978258746","https://openalex.org/W1981196940","https://openalex.org/W2024967089","https://openalex.org/W2046961168","https://openalex.org/W2047119372","https://openalex.org/W2056660762","https://openalex.org/W2070532578","https://openalex.org/W2080416279","https://openalex.org/W2094477432","https://openalex.org/W2352505824","https://openalex.org/W2398261959","https://openalex.org/W2402094369","https://openalex.org/W2412475714","https://openalex.org/W2413419897","https://openalex.org/W2413620635","https://openalex.org/W2475143869"],"related_works":["https://openalex.org/W183688181","https://openalex.org/W2062805658","https://openalex.org/W2432109807","https://openalex.org/W2413620635","https://openalex.org/W2402094369","https://openalex.org/W2221010299","https://openalex.org/W2417967341","https://openalex.org/W2111082108","https://openalex.org/W1970375149","https://openalex.org/W1789868845"],"abstract_inverted_index":{"Cyclotropium":[0,126,153],"bromide,":[1,48,181],"a":[2,93,111,130,184],"new":[3],"antimuscarinic":[4],"agent,":[5],"inhibits":[6,208],"gastrointestinal":[7],"motility":[8],"in":[9,72,82],"animals":[10],"at":[11],"lower":[12],"doses":[13,43],"than":[14,159],"those":[15],"required":[16],"to":[17,110,129],"inhibit":[18],"gastric":[19,56,114,136,192,209],"acid":[20],"secretion":[21],"and":[22,30,53,58,120,138,147,191,211],"salivation.":[23],"In":[24,203],"man,":[25],"cyclotropium":[26,47,180,205],"bromide":[27,127,154,206],"suppresses":[28],"fasting":[29],"meal":[31,96],"stimulated":[32],"colonic":[33],"motility.":[34],"This":[35],"study":[36],"investigated":[37],"the":[38,90,162,177],"effects":[39,163,197],"of":[40,44,92,123,150,164],"single":[41],"oral":[42],"60":[45,49],"mg":[46,50],"hyoscine":[51,133,160,165],"N-butylbromide":[52,134,166],"placebo":[54],"on":[55,59],"emptying":[57,115,137,210],"antral":[60,124,151,188,213],"motor":[61],"activity.":[62],"Twenty":[63],"four":[64],"healthy":[65],"men":[66],"(mean":[67],"age":[68],"25":[69],"years)":[70],"participated":[71],"three":[73],"experiments":[74],"one":[75,201],"week":[76],"apart.":[77],"The":[78],"drugs":[79],"were":[80],"administered,":[81],"random":[83],"double":[84],"blind":[85],"fashion,":[86],"30":[87],"minutes":[88],"before":[89],"ingestion":[91],"semisolid":[94],"test":[95],"labelled":[97],"with":[98,117,199],"74":[99],"MBq":[100],"(2":[101],"mCi)":[102],"99mTc":[103],"sulphur":[104],"colloid.":[105],"A":[106],"gamma":[107],"camera":[108],"coupled":[109],"computer":[112],"monitored":[113],"together":[116],"amplitude,":[118,141],"frequency,":[119],"propagation":[121,148],"velocity":[122,149],"contractions.":[125,152],"and,":[128],"lesser":[131],"degree,":[132],"delayed":[135],"reduced":[139],"contraction":[140,189,214],"but":[142],"did":[143],"not":[144],"affect":[145],"frequency":[146],"was":[155,174,183],"significantly":[156,168],"more":[157],"active":[158],"N-butylbromide;":[161],"differed":[167],"from":[169],"placebo.":[170],"Antral":[171],"contractile":[172],"activity":[173],"present":[175],"all":[176],"time.":[178],"After":[179],"there":[182],"significant":[185],"correlation":[186],"between":[187],"amplitude":[190],"emptying.":[193],"No":[194],"adverse":[195],"side":[196],"occurred":[198],"any":[200],"treatment.":[202],"conclusion,":[204],"markedly":[207],"reduces":[212],"amplitude.":[215]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
