{"id":"https://openalex.org/W2015929976","doi":"https://doi.org/10.1002/eji.1830220814","title":"Adhesion molecule\u2010mediated signals regulate major histocompatibility complex\u2010unrestricted and CD3/T cell receptor\u2010triggered cytotoxicity","display_name":"Adhesion molecule\u2010mediated signals regulate major histocompatibility complex\u2010unrestricted and CD3/T cell receptor\u2010triggered cytotoxicity","publication_year":1992,"publication_date":"1992-08-01","ids":{"openalex":"https://openalex.org/W2015929976","doi":"https://doi.org/10.1002/eji.1830220814","mag":"2015929976","pmid":"https://pubmed.ncbi.nlm.nih.gov/1379184"},"language":"en","primary_location":{"id":"doi:10.1002/eji.1830220814","doi":"https://doi.org/10.1002/eji.1830220814","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830220814","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003992747","display_name":"Ricciarda Galandrini","orcid":"https://orcid.org/0000-0003-2660-1456","observed_orcids":["https://orcid.org/0000-0003-2660-1456"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ricciarda Galandrini","raw_affiliation_strings":["Istituto di Ematologia, Universit\u00e0 di Perugia, Italy","Istituto di Ematologia, Universita\u0300 di Perugia","Recipient of an AIRC Fellowship"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ematologia, Universit\u00e0 di Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"Istituto di Ematologia, Universita\u0300 di Perugia","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"Recipient of an AIRC Fellowship","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064275037","display_name":"Nicola Albi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Albi","raw_affiliation_strings":["Istituto di Ematologia, Universita\u0300 di Perugia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ematologia, Universita\u0300 di Perugia","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111888601","display_name":"Daniela Zarcone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Zarcone","raw_affiliation_strings":["Istituto di Anatomia Umana, Universita\u0300 di Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Anatomia Umana, Universita\u0300 di Genova","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111676384","display_name":"Carlo Enrico Grossi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo E. Grossi","raw_affiliation_strings":["Istituto Nazionale per la Ricerca sul Cancro, Genova","Istituto di Anatomia Umana, Universita\u0300 di Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale per la Ricerca sul Cancro, Genova","institution_ids":[]},{"raw_affiliation_string":"Istituto di Anatomia Umana, Universita\u0300 di Genova","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070029054","display_name":"Andrea Velardi","orcid":"https://orcid.org/0000-0003-3226-9891","observed_orcids":["https://orcid.org/0000-0003-3226-9891"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Andrea Velardi","raw_affiliation_strings":["Istituto di Ematologia, Universita\u0300 di Perugia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ematologia, Universita\u0300 di Perugia","institution_ids":["https://openalex.org/I27483092"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070029054"],"corresponding_institution_ids":["https://openalex.org/I27483092"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":0.9053,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.72160467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"22","issue":"8","first_page":"2047","last_page":"2053"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.4309000074863434,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.4309000074863434,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.27639999985694885,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.25119999051094055,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.9089999794960022},{"id":"https://openalex.org/keywords/lfa-3","display_name":"LFA-3","score":0.8849999904632568},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lfa-1","display_name":"LFA-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/cd58","display_name":"CD58","score":0.6549999713897705},{"id":"https://openalex.org/keywords/lymphocyte-function-associated-antigen-1","display_name":"CD11a/CD18","score":0.9150000214576721},{"id":"https://openalex.org/keywords/lymphokine-activated-killer-cells","display_name":"lymphokine-activated killer cells","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9300000071525574},{"id":"https://openalex.org/keywords/mhc-unrestricted-cytotoxicity","display_name":"MHC-unrestricted cytotoxicity","score":0.8820000290870667},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.7770000100135803},{"id":"https://openalex.org/keywords/anti-cd3-antibody","display_name":"anti-CD3 antibody","score":0.6359999775886536},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8830000162124634},{"id":"https://openalex.org/keywords/tumor-cell-lysis","display_name":"tumor cell lysis","score":0.7099999785423279},{"id":"https://openalex.org/keywords/cd2","display_name":"CD2","score":0.30799999833106995},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7061911821365356},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.6021618843078613},{"id":"https://openalex.org/C28651165","wikidata":"https://www.wikidata.org/wiki/Q4259786","display_name":"Lymphokine-activated killer cell","level":5,"score":0.5712371468544006},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5514930486679077},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5276433825492859},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5006110668182373},{"id":"https://openalex.org/C2778593620","wikidata":"https://www.wikidata.org/wiki/Q4042438","display_name":"Lymphocyte function-associated antigen 1","level":4,"score":0.49782323837280273},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48379987478256226},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4729337990283966},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.45495927333831787},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4538624584674835},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.43925705552101135},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.43213126063346863},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.38956424593925476},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3305765390396118},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2795174717903137},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27701741456985474},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.264423668384552},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.19239765405654907},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15947455167770386},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1454559564590454},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12568175792694092}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000945","descriptor_name":"Antigens, Differentiation, T-Lymphocyte","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008285","descriptor_name":"Major Histocompatibility Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015979","descriptor_name":"Killer Cells, Lymphokine-Activated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016169","descriptor_name":"Lymphocyte Function-Associated Antigen-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018801","descriptor_name":"CD2 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018968","descriptor_name":"CD58 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/eji.1830220814","doi":"https://doi.org/10.1002/eji.1830220814","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830220814","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:1379184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1379184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/41115","doi":null,"is_oa":false,"landing_page_url":"http://www.scopus.com/inward/record.url?eid=2-s2.0-0026637282&partnerID=65&md5=b297c013e859422a31d7580648ac9cb9","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1479909263","https://openalex.org/W1507459142","https://openalex.org/W1516808533","https://openalex.org/W1530114824","https://openalex.org/W1551917804","https://openalex.org/W1552761335","https://openalex.org/W1569428681","https://openalex.org/W1597701963","https://openalex.org/W1810482515","https://openalex.org/W1892813444","https://openalex.org/W1964264035","https://openalex.org/W1966286149","https://openalex.org/W1979560589","https://openalex.org/W1993876791","https://openalex.org/W2001875963","https://openalex.org/W2016620180","https://openalex.org/W2021685948","https://openalex.org/W2032549221","https://openalex.org/W2052083000","https://openalex.org/W2057073801","https://openalex.org/W2071435995","https://openalex.org/W2073892470","https://openalex.org/W2079041842","https://openalex.org/W2084356260","https://openalex.org/W2100045859","https://openalex.org/W2101283545","https://openalex.org/W2103493503","https://openalex.org/W2115131016","https://openalex.org/W2126181700","https://openalex.org/W2162535045","https://openalex.org/W2344520853","https://openalex.org/W2345968243"],"related_works":["https://openalex.org/W2057312481","https://openalex.org/W2063831546","https://openalex.org/W2025260365","https://openalex.org/W2117837558","https://openalex.org/W2119243490","https://openalex.org/W2040448563","https://openalex.org/W7217036563","https://openalex.org/W2418625441","https://openalex.org/W2058729893","https://openalex.org/W1513455672"],"abstract_inverted_index":{"Appropriate":[0],"experimental":[1],"conditions":[2],"were":[3,85],"devised":[4],"to":[5,87,155,183],"demonstrate":[6],"that":[7,22,201],"CD58":[8],"(LFA-3),":[9],"CD54":[10],"(ICAM-1)":[11],"and":[12,28,54,66,146,206,215,238,257],"CD11a/CD18":[13],"(LFA-1)":[14],"adhesion":[15],"molecules":[16,208],"are":[17,244],"the":[18,94,157,193,241,247,251,258,262],"source":[19],"of":[20,64,93,104,117,160,196,249,261],"signals":[21,211],"regulate":[23],"nonspecific":[24],"major":[25],"histocompatibility":[26],"complex-unrestricted":[27],"CD3/T":[29],"cell":[30,58,79,83,176],"receptor":[31],"(TcR)-triggered":[32],"cytotoxicity.":[33],"Using":[34],"anti-LFA-3":[35,105],"monoclonal":[36],"antibody":[37],"(mAb)-treated,":[38],"interleukin-2":[39],"(IL-2)-cultured":[40],"peripheral":[41],"blood":[42,175],"lymphocytes":[43],"(PBL)":[44],"or":[45],"cloned":[46],"CD3+/CD8+":[47],"cells":[48,90,145,182,214],"as":[49,60,231,233],"lymphocyte-activated":[50],"killer":[51],"(LAK)":[52],"effectors,":[53],"ligand":[55],"(CD2)-negative":[56],"tumor":[57,78,125,147,229],"lines":[59],"targets,":[61],"a":[62,163,171],"down-regulation":[63],"CD3-":[65,135],"CD3+":[67],"cell-mediated":[68],"LAK":[69,122,136,213],"activity":[70],"was":[71,107,131,167],"consistently":[72,120],"observed.":[73],"Anti-LFA-3":[74],"mAb":[75,106,115,139,178,190,202],"also":[76],"down-regulated":[77],"lysis":[80],"when":[81],"T":[82,181,217],"clones":[84],"triggered":[86],"kill":[88],"P815":[89],"through":[91],"stimulation":[92],"CD3/TcR":[95],"complex":[96],"by":[97,110,225],"an":[98],"anti-CD3":[99],"mAb.":[100,113],"The":[101],"inhibitory":[102],"effect":[103,130],"not":[108],"prevented":[109],"stimulatory":[111],"anti-CD2":[112],"Anti-ICAM-1":[114],"treatment":[116],"IL-2-cultured":[118,197],"PBL":[119],"up-regulated":[121,192],"cytotoxicity":[123,164],"against":[124,203,255],"target":[126,148],"cells.":[127],"However,":[128],"this":[129,152],"only":[132],"exerted":[133],"on":[134,228,234],"effectors.":[137],"Anti-LFA-1":[138],"blocked":[140],"conjugate":[141],"formation":[142],"between":[143],"effector":[144],"cells,":[149,240],"thus":[150],"rendering":[151],"model":[153,165],"unsuitable":[154],"evaluate":[156],"regulatory":[158,210],"role":[159],"LFA-1.":[161],"Therefore,":[162],"system":[166],"applied":[168],"in":[169,246],"which":[170],"hybrid":[172],"anti-CD3/anti-human":[173],"red":[174],"(HuRBC)":[177],"triggers":[179],"cytolytic":[180],"lyse":[184],"HuRBC.":[185],"In":[186],"these":[187,220],"experiments,":[188],"anti-LFA-1":[189],"markedly":[191],"lytic":[194],"ability":[195],"PBL.":[198],"We":[199],"conclude":[200],"LFA-3,":[204],"ICAM-1":[205],"LFA-1":[207],"deliver":[209],"for":[212],"cytotoxic":[216],"lymphocytes.":[218],"As":[219],"stimuli":[221],"may":[222],"be":[223],"delivered":[224],"ligands":[226],"expressed":[227],"targets":[230],"well":[232],"other":[235],"immune":[236,253,263],"competent":[237],"inflammatory":[239],"present":[242],"observations":[243],"relevant":[245],"context":[248],"both":[250],"host's":[252],"response":[254],"tumors":[256],"general":[259],"functioning":[260],"system.":[264]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}