{"id":"https://openalex.org/W2015901442","doi":"https://doi.org/10.4161/cbt.5.12.3351","title":"Altered expression of FANCL confers mitomycin C sensitivity in Calu-6 lung cancer cells","display_name":"Altered expression of FANCL confers mitomycin C sensitivity in Calu-6 lung cancer cells","publication_year":2006,"publication_date":"2006-12-31","ids":{"openalex":"https://openalex.org/W2015901442","doi":"https://doi.org/10.4161/cbt.5.12.3351","mag":"2015901442","pmid":"https://pubmed.ncbi.nlm.nih.gov/17106252"},"language":"en","primary_location":{"id":"doi:10.4161/cbt.5.12.3351","doi":"https://doi.org/10.4161/cbt.5.12.3351","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.5.12.3351","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.5.12.3351?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.5.12.3351?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100433211","display_name":"Jun Zhang","orcid":"https://orcid.org/0000-0002-8760-6747","observed_orcids":["https://orcid.org/0000-0002-8760-6747"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Zhang","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084192942","display_name":"Xianshu Wang","orcid":"https://orcid.org/0000-0003-0581-6677","observed_orcids":["https://orcid.org/0000-0003-0581-6677"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianshu Wang","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology ; Mayo Clinic College of Medicine ; 200 First Street , SW , Rochester , MN 55905 ;","Mayo Clinic College of Medicine and Science;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology ; Mayo Clinic College of Medicine ; 200 First Street , SW , Rochester , MN 55905 ;","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic College of Medicine and Science;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110025486","display_name":"Chia-Ju Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chia-Ju Lin","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology ; Mayo Clinic College of Medicine ; 200 First Street , SW , Rochester , MN 55905 ;","Mayo Clinic College of Medicine and Science;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology ; Mayo Clinic College of Medicine ; 200 First Street , SW , Rochester , MN 55905 ;","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic College of Medicine and Science;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016908886","display_name":"Fergus J. Couch","orcid":"https://orcid.org/0000-0001-9417-9985","observed_orcids":["https://orcid.org/0000-0001-9417-9985"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fergus J Couch","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology ; Mayo Clinic College of Medicine ; 200 First Street , SW , Rochester , MN 55905 ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology ; Mayo Clinic College of Medicine ; 200 First Street , SW , Rochester , MN 55905 ;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044157771","display_name":"Peiwen Fei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peiwen Fei","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology ; Mayo Clinic College of Medicine ; 200 First Street , SW , Rochester , MN 55905 ;","Mayo Clinic College of Medicine and Science;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology ; Mayo Clinic College of Medicine ; 200 First Street , SW , Rochester , MN 55905 ;","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic College of Medicine and Science;","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":2710,"currency":"EUR","value_usd":2970},"apc_paid":null,"fwci":0.2717,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.53584342,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"12","first_page":"1632","last_page":"1636"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fancl","display_name":"FANCL","score":0.9850000143051147},{"id":"https://openalex.org/keywords/fanconi-anemia","display_name":"Fanconi anemia","score":0.8870000243186951},{"id":"https://openalex.org/keywords/fanconi-anemia-pathway","display_name":"Fanconi anemia pathway","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mitomycin-c-sensitivity","display_name":"mitomycin C sensitivity","score":0.9599999785423279},{"id":"https://openalex.org/keywords/calu-6-cells","display_name":"Calu-6 cells","score":0.7919999957084656},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/dna-cross-linking-agents","display_name":"DNA cross-linking agents","score":0.9319999814033508},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7049999833106995},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.8410000205039978},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.7850000262260437},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7107931971549988},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6297332048416138},{"id":"https://openalex.org/C2779338040","wikidata":"https://www.wikidata.org/wiki/Q19856779","display_name":"Mitomycin C","level":2,"score":0.47396060824394226},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41684508323669434},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3867759108543396},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37607696652412415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36967501044273376},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28087884187698364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21128660440444946},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09616687893867493}],"mesh":[{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005199","descriptor_name":"Fanconi Anemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016685","descriptor_name":"Mitomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019398","descriptor_name":"Genes, BRCA1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024522","descriptor_name":"Genes, BRCA2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052240","descriptor_name":"Fanconi Anemia Complementation Group L Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4161/cbt.5.12.3351","doi":"https://doi.org/10.4161/cbt.5.12.3351","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.5.12.3351","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.5.12.3351?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology & Therapy","raw_type":"journal-article"},{"id":"pmid:17106252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17106252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer biology & therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/cbt.5.12.3351","doi":"https://doi.org/10.4161/cbt.5.12.3351","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.5.12.3351","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.5.12.3351?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3394956840","display_name":"Roles of the Fanconi Anemia Pathway in Bladder Tumorigenesis","funder_award_id":"R01CA136532","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015901442.pdf","grobid_xml":"https://content.openalex.org/works/W2015901442.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1497406478","https://openalex.org/W1593424453","https://openalex.org/W1982046131","https://openalex.org/W1986096893","https://openalex.org/W2020382936","https://openalex.org/W2034269086","https://openalex.org/W2048446461","https://openalex.org/W2055611673","https://openalex.org/W2060165561","https://openalex.org/W2067471739","https://openalex.org/W2080772875","https://openalex.org/W2084310601","https://openalex.org/W2101161126","https://openalex.org/W2109630092","https://openalex.org/W2118726620","https://openalex.org/W2127808743","https://openalex.org/W2136074473","https://openalex.org/W2153172903","https://openalex.org/W2155700579"],"related_works":["https://openalex.org/W2095039429","https://openalex.org/W2101161126","https://openalex.org/W1979472043","https://openalex.org/W13548206","https://openalex.org/W2604441863","https://openalex.org/W3045474526","https://openalex.org/W2105830911","https://openalex.org/W2036933656","https://openalex.org/W2281834701","https://openalex.org/W2386989021"],"abstract_inverted_index":{"Fanconi":[0],"anemia":[1],"(FA)":[2],"results":[3],"from":[4],"mutations":[5],"in":[6,21,52,61,68,93,147,228],"a":[7,109,137,164,190,219],"group":[8],"of":[9,50,58,79,89,119,127,135,140,145,153,160,198,208],"genes":[10],"whose":[11],"products,":[12],"including":[13],"BRCA2":[14],"and":[15,42],"BACH1/BRIP1,":[16],"are":[17],"known":[18],"to":[19,28,83,172,189,201,224],"function":[20],"one":[22],"common":[23,220],"pathway":[24,60,82,92,167,212],"(the":[25],"FA-BRCA":[26,81,91,111,129,155,166,178,192,211],"pathway)":[27],"guard":[29],"genome":[30],"integrity,":[31],"especially":[32],"when":[33],"challenged":[34],"by":[35],"DNA":[36,225],"crosslinking":[37,226],"agents,":[38],"such":[39],"as":[40,170,218],"Cisplatin":[41],"mitomycin":[43],"C":[44],"(MMC).":[45],"The":[46],"extremely":[47],"high":[48],"incidence":[49],"cancer":[51,96,105,229],"FA":[53,121],"patients":[54],"reveals":[55],"the":[56,77,80,87,90,102,117,125,128,141,151,154,161,173,181,186,196,206],"essentialness":[57],"this":[59,65,114],"tumor":[62],"suppression.":[63],"However,":[64],"pathway's":[66],"involvement":[67],"nonFA":[69],"cancers":[70],"is":[71,185],"not":[72],"well":[73],"understood.":[74],"To":[75],"evaluate":[76],"contribution":[78],"cancer,":[84],"we":[85],"investigated":[86],"integrity":[88],"ten":[94],"human":[95],"cell":[97,106,115],"lines.":[98],"We":[99],"found":[100],"that":[101,205],"Calu-6":[103,199],"lung":[104],"line":[107],"carries":[108],"defective":[110,191],"pathway.":[112,179],"In":[113],"line,":[116],"examination":[118],"six":[120],"proteins,":[122],"essential":[123],"for":[124],"activation":[126,152],"pathway,":[130,156,193],"detected":[131],"substantially":[132],"reduced":[133],"expression":[134,184],"FANCL,":[136],"catalytic":[138],"subunit":[139],"ubiquitin":[142],"ligase/E3-complex.":[143],"Reconstitution":[144],"FANCL":[146,183],"these":[148],"cells":[149,162,174,200],"restored":[150],"but":[157],"MMC":[158,214],"sensitivity":[159,197],"with":[163,175,213],"complemented":[165],"was":[168],"decreased":[169],"compared":[171],"an":[176,209],"impaired":[177],"Collectively,":[180],"abnormal":[182],"cause":[187],"leading":[188],"which":[194],"confers":[195],"MMC.":[202],"This":[203],"suggests":[204],"correlation":[207],"intact":[210],"resistance":[215,223],"may":[216],"emerge":[217],"mechanism":[221],"underlying":[222],"agents":[227],"patients.":[230]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}