{"id":"https://openalex.org/W2015878053","doi":"https://doi.org/10.1038/sj.bjc.6603078","title":"HER2 expression as a potential marker for response to therapy targeted to the EGFR","display_name":"HER2 expression as a potential marker for response to therapy targeted to the EGFR","publication_year":2006,"publication_date":"2006-04-01","ids":{"openalex":"https://openalex.org/W2015878053","doi":"https://doi.org/10.1038/sj.bjc.6603078","mag":"2015878053","pmid":"https://pubmed.ncbi.nlm.nih.gov/16622439","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2361260"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjc.6603078","doi":"https://doi.org/10.1038/sj.bjc.6603078","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6603078","pdf_url":"https://www.nature.com/articles/6603078.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6603078.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045254331","display_name":"David R. Emlet","orcid":"https://orcid.org/0000-0003-2131-9902","observed_orcids":["https://orcid.org/0000-0003-2131-9902"]},"institutions":[{"id":"https://openalex.org/I2800275141","display_name":"Allegheny General Hospital","ror":"https://ror.org/02gy6qp39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1310421338","https://openalex.org/I2800275141"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D R Emlet","raw_affiliation_strings":["Laboratory of Cancer Cell Biology and Genetics, Department of Human Oncology, Drexel University College of Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Cell Biology and Genetics, Department of Human Oncology, Drexel University College of Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA","institution_ids":["https://openalex.org/I2800275141","https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051953313","display_name":"Russell S. Schwartz","orcid":"https://orcid.org/0000-0002-4970-2252","observed_orcids":["https://orcid.org/0000-0002-4970-2252"]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Schwartz","raw_affiliation_strings":["Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, 15213, PA, USA","Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, 15213, PA, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, USA;","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K A Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800275141","display_name":"Allegheny General Hospital","ror":"https://ror.org/02gy6qp39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1310421338","https://openalex.org/I2800275141"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K A Brown","raw_affiliation_strings":["Department of Human Oncology, Laboratory of Cancer Cell Biology and Genetics, Drexel University College of Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, 15212, PA, USA","Department of Human Oncology, Laboratory of Cancer Cell Biology and Genetics, Drexel University College of Medicine, Allegheny General Hospital, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology, Laboratory of Cancer Cell Biology and Genetics, Drexel University College of Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, 15212, PA, USA","institution_ids":["https://openalex.org/I2800275141","https://openalex.org/I72816309"]},{"raw_affiliation_string":"Department of Human Oncology, Laboratory of Cancer Cell Biology and Genetics, Drexel University College of Medicine, Allegheny General Hospital, Pittsburgh, USA","institution_ids":["https://openalex.org/I2800275141","https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A A Pollice","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800275141","display_name":"Allegheny General Hospital","ror":"https://ror.org/02gy6qp39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1310421338","https://openalex.org/I2800275141"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A A Pollice","raw_affiliation_strings":["Department of Human Oncology, Laboratory of Cancer Cell Biology and Genetics, Drexel University College of Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, 15212, PA, USA","Department of Human Oncology, Laboratory of Cancer Cell Biology and Genetics, Drexel University College of Medicine, Allegheny General Hospital, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology, Laboratory of Cancer Cell Biology and Genetics, Drexel University College of Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, 15212, PA, USA","institution_ids":["https://openalex.org/I2800275141","https://openalex.org/I72816309"]},{"raw_affiliation_string":"Department of Human Oncology, Laboratory of Cancer Cell Biology and Genetics, Drexel University College of Medicine, Allegheny General Hospital, Pittsburgh, USA","institution_ids":["https://openalex.org/I2800275141","https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C A Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800275141","display_name":"Allegheny General Hospital","ror":"https://ror.org/02gy6qp39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1310421338","https://openalex.org/I2800275141"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C A Smith","raw_affiliation_strings":["Department of Human Oncology, Laboratory of Cancer Cell Biology and Genetics, Drexel University College of Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, 15212, PA, USA","Department of Human Oncology, Laboratory of Cancer Cell Biology and Genetics, Drexel University College of Medicine, Allegheny General Hospital, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology, Laboratory of Cancer Cell Biology and Genetics, Drexel University College of Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, 15212, PA, USA","institution_ids":["https://openalex.org/I2800275141","https://openalex.org/I72816309"]},{"raw_affiliation_string":"Department of Human Oncology, Laboratory of Cancer Cell Biology and Genetics, Drexel University College of Medicine, Allegheny General Hospital, Pittsburgh, USA","institution_ids":["https://openalex.org/I2800275141","https://openalex.org/I72816309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027859218","display_name":"Stanley E. Shackney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800275141","display_name":"Allegheny General Hospital","ror":"https://ror.org/02gy6qp39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1310421338","https://openalex.org/I2800275141"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S E Shackney","raw_affiliation_strings":["Department of Human Oncology, Laboratory of Cancer Cell Biology and Genetics, Drexel University College of Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, 15212, PA, USA","Department of Human Oncology, Laboratory of Cancer Cell Biology and Genetics, Drexel University College of Medicine, Allegheny General Hospital, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology, Laboratory of Cancer Cell Biology and Genetics, Drexel University College of Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, 15212, PA, USA","institution_ids":["https://openalex.org/I2800275141","https://openalex.org/I72816309"]},{"raw_affiliation_string":"Department of Human Oncology, Laboratory of Cancer Cell Biology and Genetics, Drexel University College of Medicine, Allegheny General Hospital, Pittsburgh, USA","institution_ids":["https://openalex.org/I2800275141","https://openalex.org/I72816309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027859218"],"corresponding_institution_ids":["https://openalex.org/I2800275141","https://openalex.org/I72816309"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":2.7726,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.90035214,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"94","issue":"8","first_page":"1144","last_page":"1153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-overexpression","display_name":"HER2 overexpression","score":0.9700000286102295},{"id":"https://openalex.org/keywords/anti-egfr-therapy","display_name":"anti-EGFR therapy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8730000257492065},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6179999709129333},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/her3","display_name":"HER3","score":0.8040000200271606},{"id":"https://openalex.org/keywords/mapk-phosphorylation","display_name":"MAPK phosphorylation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ag1478","display_name":"AG1478","score":0.9240000247955322},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9139999747276306},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.7555748224258423},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6619616746902466},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.5695319175720215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5677264332771301},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5433943271636963},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4972870647907257},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.475860059261322},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.47499027848243713},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.45257821679115295},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.450194388628006},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4490509629249573},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.43437460064888},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.43358609080314636},{"id":"https://openalex.org/C2777506169","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"EGFR inhibitors","level":4,"score":0.4121502637863159},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3794468939304352},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34575241804122925},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3324577212333679},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2813302278518677},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2135600447654724},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.1523473858833313},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09306630492210388}],"mesh":[{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020032","descriptor_name":"Tyrphostins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020893","descriptor_name":"Receptor, ErbB-3","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020893","descriptor_name":"Receptor, ErbB-3","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020893","descriptor_name":"Receptor, ErbB-3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047569","descriptor_name":"Laser Scanning Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.bjc.6603078","doi":"https://doi.org/10.1038/sj.bjc.6603078","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6603078","pdf_url":"https://www.nature.com/articles/6603078.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2361260","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2361260","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:16622439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16622439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/sj.bjc.6603078","doi":"https://doi.org/10.1038/sj.bjc.6603078","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6603078","pdf_url":"https://www.nature.com/articles/6603078.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308109","display_name":"Pennsylvania Department of Health","ror":"https://ror.org/00ra1fg11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015878053.pdf","grobid_xml":"https://content.openalex.org/works/W2015878053.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1523413020","https://openalex.org/W1590794385","https://openalex.org/W1593316358","https://openalex.org/W1659692600","https://openalex.org/W1969275840","https://openalex.org/W1985211051","https://openalex.org/W1989402142","https://openalex.org/W2007435673","https://openalex.org/W2036284007","https://openalex.org/W2036752075","https://openalex.org/W2040142253","https://openalex.org/W2056743298","https://openalex.org/W2066893161","https://openalex.org/W2074937243","https://openalex.org/W2078737225","https://openalex.org/W2095156669","https://openalex.org/W2100506523","https://openalex.org/W2101849511","https://openalex.org/W2108182027","https://openalex.org/W2111580206","https://openalex.org/W2114457864","https://openalex.org/W2115759102","https://openalex.org/W2120718661","https://openalex.org/W2121155023","https://openalex.org/W2121403704","https://openalex.org/W2130840817","https://openalex.org/W2131362842","https://openalex.org/W2135836172","https://openalex.org/W2141393790","https://openalex.org/W2142007492","https://openalex.org/W2142525191","https://openalex.org/W2143522519","https://openalex.org/W2143651667","https://openalex.org/W2146404049","https://openalex.org/W2146943926","https://openalex.org/W2154438442","https://openalex.org/W2155977433","https://openalex.org/W2157984203","https://openalex.org/W2158077354","https://openalex.org/W2161821474","https://openalex.org/W2163402367","https://openalex.org/W2165119042","https://openalex.org/W2168249659","https://openalex.org/W2168377135","https://openalex.org/W2170329700","https://openalex.org/W2206786835","https://openalex.org/W2318605753","https://openalex.org/W2334157097"],"related_works":["https://openalex.org/W56117981","https://openalex.org/W2124748060","https://openalex.org/W2325775796","https://openalex.org/W2139154837","https://openalex.org/W2133671622","https://openalex.org/W1941185983","https://openalex.org/W2083527129","https://openalex.org/W2730858185","https://openalex.org/W2067300576","https://openalex.org/W2737680693"],"abstract_inverted_index":{"Since":[0],"human":[1],"epidermal":[2,14],"growth":[3,15,74,133],"factor":[4,16],"receptor":[5,17],"2":[6],"(HER2)":[7],"is":[8],"known":[9],"to":[10,30,45,109,112,117],"participate":[11],"with":[12,39,144],"the":[13,40,119,139,150,162],"(EGFR)":[18],"in":[19],"mitogenic":[20],"signalling,":[21],"we":[22],"hypothesised":[23],"that":[24],"HER2":[25,41,58,83,147,156,159],"overexpression":[26,160],"might":[27],"indicate":[28],"responsiveness":[29],"EGFR":[31,113],"targeted":[32,114],"therapies.":[33],"MCF7":[34,68],"breast":[35],"cancer":[36],"cells":[37,69],"transfected":[38],"gene":[42],"were":[43,70,107,142],"subcloned":[44,63],"establish":[46],"a":[47],"set":[48],"of":[49,57,81,91,126,132,135,138,146,169],"genetically":[50],"related":[51],"cell":[52,64,77,79,152],"lines":[53,65],"expressing":[54],"graded":[55],"levels":[56,90,125,131,145],"by":[59,72,78,99],"immunoblot":[60],"analysis.":[61],"The":[62,130],"and":[66,76,84,97,116,124,137,157],"parental":[67],"characterised":[71],"their":[73],"characteristics,":[75],"patterns":[80],"EGFR,":[82,155],"HER3":[85],"expression":[86,148],"as":[87,89],"well":[88],"phosphorylated":[92],"mitogen-activated":[93],"protein":[94],"kinase":[95,128],"(MAPK)":[96],"AKT":[98],"laser":[100],"scanning":[101],"cytometry":[102],"(LSC).":[103],"Growth":[104],"inhibition":[105,134],"assays":[106],"used":[108],"characterise":[110],"response":[111,123],"therapy,":[115],"determine":[118],"relationship":[120],"between":[121],"therapeutic":[122],"tyrosine":[127],"expression.":[129],"AG1478":[136],"AG1478-trastuzumab":[140],"combinations":[141,168],"correlated":[143],"among":[149],"different":[151],"lines.":[153],"Among":[154],"HER3,":[158],"was":[161],"best":[163],"single":[164],"predictive":[165,174],"marker,":[166],"but":[167],"two":[170],"markers":[171],"provided":[172],"additional":[173],"information.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
