{"id":"https://openalex.org/W201587640","doi":null,"title":"Cone visual cell degeneration in ground squirrel retina: disruption of morphology and cyclic nucleotide metabolism by lodoacetic acid.","display_name":"Cone visual cell degeneration in ground squirrel retina: disruption of morphology and cyclic nucleotide metabolism by lodoacetic acid.","publication_year":1983,"publication_date":"1983-09-01","ids":{"openalex":"https://openalex.org/W201587640","mag":"201587640","pmid":"https://pubmed.ncbi.nlm.nih.gov/6885310"},"language":"en","primary_location":{"id":"pmid:6885310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6885310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005767794","display_name":"Debora B. Farber","orcid":"https://orcid.org/0000-0002-3207-697X","observed_orcids":["https://orcid.org/0000-0002-3207-697X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D B Farber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050446604","display_name":"Dennis W. Souza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D W Souza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"D G Chase","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D G Chase","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2491,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.77832988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"24","issue":"9","first_page":"1236","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cone-photoreceptor-degeneration","display_name":"cone photoreceptor degeneration","score":0.9649999737739563},{"id":"https://openalex.org/keywords/iodoacetic-acid","display_name":"iodoacetate","score":0.9049999713897705},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.953000009059906},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":1.0},{"id":"https://openalex.org/keywords/cyclic-nucleotide-metabolism","display_name":"cyclic nucleotide metabolism","score":0.9490000009536743},{"id":"https://openalex.org/keywords/photoreceptor-morphology","display_name":"photoreceptor morphology","score":0.859000027179718},{"id":"https://openalex.org/keywords/macrophage-phagocytosis","display_name":"macrophage phagocytosis","score":0.843999981880188},{"id":"https://openalex.org/keywords/dark-adaptation","display_name":"dark adaptation","score":0.5649999976158142},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C2780197888","wikidata":"https://www.wikidata.org/wiki/Q416375","display_name":"Iodoacetic acid","level":3,"score":0.8540908694267273},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.8111007213592529},{"id":"https://openalex.org/C2780588931","wikidata":"https://www.wikidata.org/wiki/Q389250","display_name":"Ground squirrel","level":3,"score":0.5954732298851013},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5262638330459595},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.469482958316803},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43857455253601074},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4299294948577881},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4088127613067627},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3616817593574524},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3431265652179718},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26904571056365967},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11478579044342041},{"id":"https://openalex.org/C2776030879","wikidata":"https://www.wikidata.org/wiki/Q309200","display_name":"Squirrel monkey","level":2,"score":0.09828701615333557},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09725332260131836},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.09036871790885925}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007461","descriptor_name":"Iodoacetates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009712","descriptor_name":"Nucleotides, Cyclic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012589","descriptor_name":"Sciuridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019807","descriptor_name":"Iodoacetic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6885310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6885310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:201587640","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6885310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W5684781","https://openalex.org/W9575570","https://openalex.org/W110054614","https://openalex.org/W178054813","https://openalex.org/W205682778","https://openalex.org/W1215731474","https://openalex.org/W1775749144","https://openalex.org/W1963591622","https://openalex.org/W1981481645","https://openalex.org/W1987834587","https://openalex.org/W1991151188","https://openalex.org/W1993860334","https://openalex.org/W2001488073","https://openalex.org/W2003990986","https://openalex.org/W2008424636","https://openalex.org/W2009317317","https://openalex.org/W2011820509","https://openalex.org/W2014140581","https://openalex.org/W2014162191","https://openalex.org/W2017083964","https://openalex.org/W2028803712","https://openalex.org/W2032045714","https://openalex.org/W2033269379","https://openalex.org/W2039316472","https://openalex.org/W2047404115","https://openalex.org/W2051747007","https://openalex.org/W2066542399","https://openalex.org/W2068689693","https://openalex.org/W2069941781","https://openalex.org/W2083790180","https://openalex.org/W2083824022","https://openalex.org/W2109401564","https://openalex.org/W2120247800","https://openalex.org/W2282054059","https://openalex.org/W2395200037","https://openalex.org/W2417623309","https://openalex.org/W2463901410"],"related_works":["https://openalex.org/W205682778","https://openalex.org/W182267893","https://openalex.org/W2076333474","https://openalex.org/W4396807133","https://openalex.org/W1591598614","https://openalex.org/W1997946452","https://openalex.org/W2061415148","https://openalex.org/W2056306332","https://openalex.org/W1981719793","https://openalex.org/W2010905463"],"abstract_inverted_index":{"Photoreceptor":[0],"degeneration":[1,211],"was":[2,19,65,113,136],"induced":[3],"in":[4,27,170,180],"the":[5,9,71,75,97,147,167,171,175,198,210,213],"cone-dominant":[6,172],"retina":[7,102,173],"of":[8,15,81,96,100,110,130,149,152,161,166,174,185,202,212],"ground":[10,176],"squirrel":[11,177],"by":[12,60,67],"intracardiac":[13],"injection":[14,89],"iodoacetic":[16,199],"acid.":[17],"Morphology":[18],"examined":[20],"and":[21,36,50,90,106,135,164,188],"cyclic":[22,111,162,168,186,189,203],"nucleotide":[23,204],"levels":[24,80,191],"were":[25,44,54,84,91,144],"determined":[26],"retinas":[28,83],"taken":[29],"at":[30,47,121,132,138,158],"various":[31],"times":[32,117],"between":[33,103],"35":[34],"min":[35],"11":[37],"days":[38,104],"after":[39,88],"injection.":[40],"Degenerating":[41],"cone":[42,52,153,181,214],"cells":[43,53],"first":[45],"detected":[46],"day":[48,61,133,139],"1":[49,105],"all":[51],"reduced":[55,92],"to":[56,93,115,123,128,193],"compact":[57],"dense":[58],"masses":[59],"4.":[62],"Cellular":[63],"debris":[64],"removed":[66],"macrophages":[68],"that":[69,157,197],"entered":[70],"photoreceptor":[72],"layer":[73],"from":[74],"inner":[76],"neuroretina.":[77],"Cyclic":[78],"AMP":[79,163,187],"dark-adapted":[82,98],"doubled":[85],"24":[86],"hrs":[87,125],"approximately":[94],"50%":[95,160],"level":[99],"control":[101],"3.":[107],"The":[108,183],"concentration":[109],"GMP":[112,169,190],"3":[114],"4":[116,122],"higher":[118],"than":[119],"normal":[120,131],"5":[124],"postinjection,":[126],"dropped":[127],"9%":[129],"4,":[134],"2%":[137],"11.":[140],"Since":[141],"these":[142],"changes":[143],"coincident":[145],"with":[146,209],"loss":[148],"morphologic":[150],"integrity":[151],"cells,":[154],"they":[155],"imply":[156],"least":[159],"most":[165],"is":[178],"present":[179],"cells.":[182],"elevation":[184],"prior":[192],"pathological":[194],"morphology":[195],"suggests":[196],"acid-induced":[200],"disruption":[201],"metabolism":[205],"may":[206],"be":[207],"associated":[208],"photoreceptors.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
