{"id":"https://openalex.org/W2015811490","doi":"https://doi.org/10.1371/journal.pone.0106371","title":"PiZ Mouse Liver Accumulates Polyubiquitin Conjugates That Associate with Catalytically Active 26S Proteasomes","display_name":"PiZ Mouse Liver Accumulates Polyubiquitin Conjugates That Associate with Catalytically Active 26S Proteasomes","publication_year":2014,"publication_date":"2014-09-11","ids":{"openalex":"https://openalex.org/W2015811490","doi":"https://doi.org/10.1371/journal.pone.0106371","mag":"2015811490","pmid":"https://pubmed.ncbi.nlm.nih.gov/25210780","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4161314"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0106371","doi":"https://doi.org/10.1371/journal.pone.0106371","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0106371","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0106371&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0106371&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087155160","display_name":"Christopher J. Haddock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Haddock","raw_affiliation_strings":["Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002817408","display_name":"Keith Blomenkamp","orcid":"https://orcid.org/0000-0002-0849-9497","observed_orcids":["https://orcid.org/0000-0002-0849-9497"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith Blomenkamp","raw_affiliation_strings":["Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048252196","display_name":"Madhav Chandra Gautam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madhav Gautam","raw_affiliation_strings":["Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080013728","display_name":"Jared James","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared James","raw_affiliation_strings":["Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008512249","display_name":"Joanna Mielcarska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanna Mielcarska","raw_affiliation_strings":["Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033768730","display_name":"Edward P. Gogol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Gogol","raw_affiliation_strings":["School of Biological Sciences, University of Missouri - Kansas City, Kansas City, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Missouri - Kansas City, Kansas City, Missouri, United States of America","institution_ids":["https://openalex.org/I75421653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024156994","display_name":"Jeffrey H. Teckman","orcid":"https://orcid.org/0000-0002-4870-2621","observed_orcids":["https://orcid.org/0000-0002-4870-2621"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Teckman","raw_affiliation_strings":["Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America; Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America","Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America","Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America; Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030004226","display_name":"Dorota Skowyra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dorota Skowyra","raw_affiliation_strings":["Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I47838141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030004226"],"corresponding_institution_ids":["https://openalex.org/I47838141"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.1366,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.49124246,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":"9","first_page":"e106371","last_page":"e106371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/26s-proteasome","display_name":"26S proteasome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/proteasome-assembly","display_name":"proteasome assembly","score":0.6679999828338623},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9750000238418579},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.6639999747276306},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.8320000171661377},{"id":"https://openalex.org/keywords/psmd4","display_name":"PSMD4","score":0.7260000109672546},{"id":"https://openalex.org/keywords/ubiquitin-binding-domain","display_name":"ubiquitin-binding domain","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.8962700366973877},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.7760171890258789},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7490766048431396},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5414164066314697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4729689657688141},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.4632941484451294},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4296422600746155},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33482983708381653},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.32711052894592285},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12305426597595215}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000515","descriptor_name":"alpha 1-Antitrypsin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000515","descriptor_name":"alpha 1-Antitrypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025821","descriptor_name":"Polyubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025821","descriptor_name":"Polyubiquitin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0106371","doi":"https://doi.org/10.1371/journal.pone.0106371","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0106371","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0106371&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3135130","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4161314","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4161314","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4161314","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:25210780","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25210780","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.787.2072","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.787.2072","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/29/20/pone.0106371.PMC4161314.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:c356ed57a93b4f9d97a73488f76df77a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c356ed57a93b4f9d97a73488f76df77a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 9, p e106371 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0106371","doi":"https://doi.org/10.1371/journal.pone.0106371","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0106371","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0106371&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5545096286","display_name":null,"funder_award_id":"F33 AI098415-01","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6800238362","display_name":"Poxvirus-mediated change to proteasomal peptide signatures in macrophages","funder_award_id":"1f33ai098415-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8295327878","display_name":null,"funder_award_id":"F33 AI098415","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015811490.pdf","grobid_xml":"https://content.openalex.org/works/W2015811490.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W1481321944","https://openalex.org/W1503393361","https://openalex.org/W1542217606","https://openalex.org/W1570610869","https://openalex.org/W1708445842","https://openalex.org/W1787874387","https://openalex.org/W1963755219","https://openalex.org/W1965773355","https://openalex.org/W1970512473","https://openalex.org/W1972380877","https://openalex.org/W1972939055","https://openalex.org/W1973668650","https://openalex.org/W1974935476","https://openalex.org/W1975044301","https://openalex.org/W1977498240","https://openalex.org/W1978698561","https://openalex.org/W1985190512","https://openalex.org/W1985494921","https://openalex.org/W1992174702","https://openalex.org/W1994039274","https://openalex.org/W1997369314","https://openalex.org/W1998289395","https://openalex.org/W1998498626","https://openalex.org/W2006158980","https://openalex.org/W2006406220","https://openalex.org/W2006975754","https://openalex.org/W2008155208","https://openalex.org/W2014500807","https://openalex.org/W2017033636","https://openalex.org/W2018340717","https://openalex.org/W2018349527","https://openalex.org/W2021242983","https://openalex.org/W2026312221","https://openalex.org/W2027140570","https://openalex.org/W2033300131","https://openalex.org/W2037825770","https://openalex.org/W2037922866","https://openalex.org/W2047650149","https://openalex.org/W2048982317","https://openalex.org/W2049743082","https://openalex.org/W2052106069","https://openalex.org/W2052842467","https://openalex.org/W2054341098","https://openalex.org/W2055653920","https://openalex.org/W2057233739","https://openalex.org/W2058226155","https://openalex.org/W2058757351","https://openalex.org/W2064028385","https://openalex.org/W2064810365","https://openalex.org/W2065323605","https://openalex.org/W2068033812","https://openalex.org/W2077538049","https://openalex.org/W2080363121","https://openalex.org/W2083120544","https://openalex.org/W2090829119","https://openalex.org/W2091293475","https://openalex.org/W2094181231","https://openalex.org/W2094898345","https://openalex.org/W2101335451","https://openalex.org/W2104485246","https://openalex.org/W2105400502","https://openalex.org/W2108102646","https://openalex.org/W2108136894","https://openalex.org/W2117894506","https://openalex.org/W2121506107","https://openalex.org/W2128921071","https://openalex.org/W2130915430","https://openalex.org/W2138083025","https://openalex.org/W2139947061","https://openalex.org/W2142273232","https://openalex.org/W2142395184","https://openalex.org/W2145007659","https://openalex.org/W2147465076","https://openalex.org/W2148966536","https://openalex.org/W2159567571","https://openalex.org/W2159831275","https://openalex.org/W2161910349","https://openalex.org/W2165209066","https://openalex.org/W2166987747","https://openalex.org/W2334275983","https://openalex.org/W2418313510","https://openalex.org/W6630226176","https://openalex.org/W6680257600"],"related_works":["https://openalex.org/W7201880689","https://openalex.org/W1998289395","https://openalex.org/W7096900905","https://openalex.org/W2080284300","https://openalex.org/W2563881582","https://openalex.org/W2055653920","https://openalex.org/W1787874387","https://openalex.org/W2142395184","https://openalex.org/W2114303321","https://openalex.org/W1987558289"],"abstract_inverted_index":{"Accumulation":[0],"of":[1,17,21,61,87,98,119,137,144,197,210,238,270,276],"aggregation-prone":[2],"human":[3,22],"alpha":[4,23],"1":[5,24],"antitrypsin":[6,25],"mutant":[7],"Z":[8],"(AT-Z)":[9],"protein":[10,265],"in":[11,84,116,168,192,255],"PiZ":[12,104,200],"mouse":[13],"liver":[14,18,64],"stimulates":[15],"features":[16],"injury":[19,65],"typical":[20],"type":[26],"ZZ":[27],"deficiency,":[28],"an":[29],"autosomal":[30],"recessive":[31],"genetic":[32],"disorder.":[33],"Ubiquitin-mediated":[34],"proteolysis":[35],"by":[36,204,281],"the":[37,52,59,67,85,117,120,176,193,256,274,277],"26S":[38,68,90,121,147,163,177,257,278],"proteasome":[39,178],"counteracts":[40],"AT-Z":[41,62,264],"accumulation":[42],"and":[43,92,122,125,139,170,219],"plays":[44],"other":[45,179],"roles":[46],"that,":[47],"when":[48],"inhibited,":[49],"could":[50],"exacerbate":[51],"injury.":[53],"However,":[54],"it":[55],"is":[56],"unknown":[57],"how":[58],"conditions":[60],"mediated":[63],"affect":[66],"proteasome.":[69],"To":[70],"address":[71],"this":[72,198],"question,":[73],"we":[74],"developed":[75],"a":[76,173,190],"rapid":[77],"extraction":[78],"strategy":[79],"that":[80,152,165,172,216,232,286],"preserves":[81],"polyubiquitin":[82,110,129,153,184,261],"conjugates":[83,111,130,154],"presence":[86],"catalytically":[88,145,161],"active":[89,146,162],"proteasomes":[91,164,258],"allows":[93],"their":[94],"separation":[95],"from":[96,235],"deposits":[97],"insoluble":[99],"AT-Z.":[100],"Compared":[101],"to":[102,134,160,183,222,290],"WT,":[103],"extracts":[105,201],"had":[106,131],"about":[107],"4-fold":[108],"more":[109],"with":[112,141,260],"no":[113],"apparent":[114],"change":[115],"levels":[118],"20S":[123],"proteasomes,":[124],"unassembled":[126,247],"subunits.":[127],"The":[128,241],"similar":[132,142,229],"affinities":[133],"ubiquitin-binding":[135],"domain":[136],"Psmd4":[138],"co-purified":[140,259],"amounts":[143],"complexes.":[148],"These":[149],"data":[150],"show":[151],"were":[155,166,202,243,252],"accumulating":[156],"despite":[157],"normal":[158],"recruitment":[159],"available":[167],"excess,":[169],"suggest":[171],"defect":[174],"at":[175,273],"than":[180],"compromised":[181],"binding":[182],"chain":[185],"or":[186],"peptidase":[187],"activity":[188],"played":[189],"role":[191],"accumulation.":[194],"In":[195],"support":[196],"idea,":[199],"characterized":[203],"high":[205],"molecular":[206],"weight,":[207],"reduction-sensitive":[208],"forms":[209],"selected":[211],"subunits,":[212,248],"including":[213],"ATPase":[214],"subunits":[215,251],"unfold":[217],"substrates":[218],"regulate":[220],"access":[221],"proteolytic":[223,291],"core.":[224,292],"Older":[225],"WT":[226],"mice":[227],"acquired":[228],"alterations,":[230],"implying":[231],"they":[233],"result":[234],"common":[236],"aspects":[237],"oxidative":[239,283],"stress.":[240],"changes":[242],"most":[244],"pronounced":[245],"on":[246],"but":[249],"some":[250],"altered":[253],"even":[254],"conjugates.":[262],"Thus,":[263],"aggregates":[266],"indirectly":[267],"impair":[268],"degradation":[269],"polyubiquitinated":[271],"proteins":[272],"level":[275],"proteasome,":[279],"possibly":[280],"inducing":[282],"stress-mediated":[284],"modifications":[285],"compromise":[287],"substrate":[288],"delivery":[289]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}