{"id":"https://openalex.org/W2015806758","doi":"https://doi.org/10.1371/journal.pone.0024723","title":"Autism-Associated Gene Expression in Peripheral Leucocytes Commonly Observed between Subjects with Autism and Healthy Women Having Autistic Children","display_name":"Autism-Associated Gene Expression in Peripheral Leucocytes Commonly Observed between Subjects with Autism and Healthy Women Having Autistic Children","publication_year":2011,"publication_date":"2011-09-15","ids":{"openalex":"https://openalex.org/W2015806758","doi":"https://doi.org/10.1371/journal.pone.0024723","mag":"2015806758","pmid":"https://pubmed.ncbi.nlm.nih.gov/21935445","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3174190"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0024723","doi":"https://doi.org/10.1371/journal.pone.0024723","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0024723","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024723&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024723&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013949980","display_name":"Yuki Kuwano","orcid":"https://orcid.org/0009-0008-5473-5068","observed_orcids":["https://orcid.org/0009-0008-5473-5068"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yuki Kuwano","raw_affiliation_strings":["Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. kuwanoy@basic.med.tokushima-u.ac.jp","Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. kuwanoy@basic.med.tokushima-u.ac.jp","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004448747","display_name":"Yoko Kamio","orcid":"https://orcid.org/0000-0003-0240-3041","observed_orcids":["https://orcid.org/0000-0003-0240-3041"]},"institutions":[{"id":"https://openalex.org/I4210103779","display_name":"National Center of Neurology and Psychiatry","ror":"https://ror.org/0254bmq54","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210103779"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Kamio","raw_affiliation_strings":["Department of Child and Adolescent Mental Health, National Institute of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Child and Adolescent Mental Health, National Institute of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan","institution_ids":["https://openalex.org/I4210103779"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020202999","display_name":"Tomoko Kawai","orcid":"https://orcid.org/0000-0001-8137-0334","observed_orcids":["https://orcid.org/0000-0001-8137-0334"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Kawai","raw_affiliation_strings":["Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006611101","display_name":"Sakurako Katsuura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sakurako Katsuura","raw_affiliation_strings":["Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101763903","display_name":"Naoko Inada","orcid":"https://orcid.org/0009-0001-8203-783X","observed_orcids":["https://orcid.org/0009-0001-8203-783X","https://orcid.org/0000-0003-3920-5794"]},"institutions":[{"id":"https://openalex.org/I4210103779","display_name":"National Center of Neurology and Psychiatry","ror":"https://ror.org/0254bmq54","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210103779"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoko Inada","raw_affiliation_strings":["Department of Child and Adolescent Mental Health, National Institute of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Child and Adolescent Mental Health, National Institute of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan","institution_ids":["https://openalex.org/I4210103779"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Akiko Takaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165929","display_name":"National Rehabilitation Center for Persons with Disabilities","ror":"https://ror.org/058s63h23","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210165929"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Takaki","raw_affiliation_strings":["Chichibu-Gakuen Institution and Clinic for Intellectually Disabled Children, National Rehabilitation Center for Persons with Disabilities, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chichibu-Gakuen Institution and Clinic for Intellectually Disabled Children, National Rehabilitation Center for Persons with Disabilities, Saitama, Japan","institution_ids":["https://openalex.org/I4210165929"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067101451","display_name":"Kazuhito Rokutan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhito Rokutan","raw_affiliation_strings":["Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013949980"],"corresponding_institution_ids":["https://openalex.org/I922474255"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.1069,"has_fulltext":true,"cited_by_count":83,"citation_normalized_percentile":{"value":0.85438749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"9","first_page":"e24723","last_page":"e24723"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13393","display_name":"Child Nutrition and Feeding Issues","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":1.0},{"id":"https://openalex.org/keywords/peripheral-blood-leukocytes","display_name":"peripheral blood leukocytes","score":0.7480000257492065},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mothers-of-children-with-autism","display_name":"mothers of autistic children","score":0.8159999847412109},{"id":"https://openalex.org/keywords/fmr1","display_name":"FMR1 gene","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mecp2","display_name":"MeCP2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/autism-candidate-genes","display_name":"autism candidate genes","score":0.8140000104904175},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.7429999709129333},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.7300000190734863},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.8754391670227051},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.6920616030693054},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5857982635498047},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5837823152542114},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5577511787414551},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5070374011993408},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4844801127910614},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4416534900665283},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.4398554265499115},{"id":"https://openalex.org/C2778863441","wikidata":"https://www.wikidata.org/wiki/Q18028997","display_name":"MECP2","level":4,"score":0.4327356219291687},{"id":"https://openalex.org/C2776831707","wikidata":"https://www.wikidata.org/wiki/Q6691991","display_name":"Pervasive developmental disorder","level":4,"score":0.4227285087108612},{"id":"https://openalex.org/C2779388368","wikidata":"https://www.wikidata.org/wiki/Q3450985","display_name":"Neurodevelopmental disorder","level":3,"score":0.42202863097190857},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4021763503551483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3686516284942627},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3244636356830597},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3048505187034607},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.22127559781074524},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.16923031210899353}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009035","descriptor_name":"Mothers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0024723","doi":"https://doi.org/10.1371/journal.pone.0024723","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0024723","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024723&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2180655","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3174190","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3174190","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3174190","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:21935445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21935445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00906:0006772411","doi":null,"is_oa":true,"landing_page_url":"https://tokushima-u.repo.nii.ac.jp/records/2000209","pdf_url":"https://tokushima-u.repo.nii.ac.jp/record/2000209/files/pone_6_9_e24723.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"PLOS ONE","raw_type":"journal article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.289.6142","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.289.6142","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d0/6a/PLoS_One_2011_Sep_15_6(9)_e24723.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:02a0dfa2eb0b41d0be0d38c352ddef11","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/02a0dfa2eb0b41d0be0d38c352ddef11","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 9, p e24723 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/133347","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Autism_Associated_Gene_Expression_in_Peripheral_Leucocytes_Commonly_Observed_between_Subjects_with_Autism_and_Healthy_Women_Having_Autistic_Children/133347","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0024723","doi":"https://doi.org/10.1371/journal.pone.0024723","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0024723","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024723&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2697519753","display_name":"Boundary and heterogeneity of Pervasive Deve I opmenta I Di sorder Not Otherwise Specified\u7814\u7a76\u4ee3\u8868\u8005","funder_award_id":"22591311","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4124158964","display_name":"RNA Biology for Stress Assessment and Prediction of Major Depression","funder_award_id":"22390146","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5713074536","display_name":"A new method for stress assessment using stress-specific alternative splice variants","funder_award_id":"22659142","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6322846260","display_name":"The role of Tra2\u03b2mRNA variants in cellular proliferation and apoptosis","funder_award_id":"22790649","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015806758.pdf","grobid_xml":"https://content.openalex.org/works/W2015806758.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1494680225","https://openalex.org/W1504456054","https://openalex.org/W1964159332","https://openalex.org/W1968298980","https://openalex.org/W1971454096","https://openalex.org/W1972125984","https://openalex.org/W1980001686","https://openalex.org/W1980056577","https://openalex.org/W1983194657","https://openalex.org/W1986601943","https://openalex.org/W1988663056","https://openalex.org/W1995647101","https://openalex.org/W2006213039","https://openalex.org/W2008461666","https://openalex.org/W2013389390","https://openalex.org/W2024948778","https://openalex.org/W2027179362","https://openalex.org/W2030147716","https://openalex.org/W2035412136","https://openalex.org/W2038664279","https://openalex.org/W2039410816","https://openalex.org/W2044763721","https://openalex.org/W2063939202","https://openalex.org/W2065628230","https://openalex.org/W2071731410","https://openalex.org/W2078297574","https://openalex.org/W2078829538","https://openalex.org/W2096504331","https://openalex.org/W2097983973","https://openalex.org/W2100254283","https://openalex.org/W2101407138","https://openalex.org/W2113193134","https://openalex.org/W2115301408","https://openalex.org/W2117315813","https://openalex.org/W2123739801","https://openalex.org/W2131073955","https://openalex.org/W2139092938","https://openalex.org/W2140948518","https://openalex.org/W2142343384","https://openalex.org/W2146036559","https://openalex.org/W2150328639","https://openalex.org/W2151566815","https://openalex.org/W2159437054","https://openalex.org/W2172150641"],"related_works":["https://openalex.org/W7100091121","https://openalex.org/W2175467819","https://openalex.org/W2139102539","https://openalex.org/W2626106250","https://openalex.org/W7095733758","https://openalex.org/W7222568982","https://openalex.org/W2581124489","https://openalex.org/W2103112346","https://openalex.org/W1126741163","https://openalex.org/W2027179362"],"abstract_inverted_index":{"Autism":[0],"spectrum":[1],"disorder":[2,8],"(ASD)":[3],"is":[4,34],"a":[5,126,182],"severe":[6],"neuropsychiatric":[7],"which":[9],"has":[10],"complex":[11],"pathobiology":[12],"with":[13,60,73,92,156,172],"profound":[14],"influences":[15],"of":[16,32,54,135,139,196,233,250],"genetic":[17,183],"factors":[18,244],"in":[19,46,52,107,153,166,191,209,221],"its":[20],"development.":[21],"Although":[22],"the":[23,30,55,89,122,217,227,242,247,251],"numerous":[24],"autism":[25,33,198],"susceptible":[26],"genes":[27,95,103,200,219],"were":[28,96,104],"identified,":[29],"etiology":[31],"not":[35],"fully":[36],"explained.":[37],"Using":[38],"DNA":[39],"microarray,":[40],"we":[41],"examined":[42],"gene":[43,128,147,162],"expression":[44,129,148,163,195],"profiling":[45,164],"peripheral":[47,167,192],"blood":[48,82],"from":[49,169],"21":[50],"individuals":[51,155],"each":[53],"four":[56],"groups;":[57],"young":[58],"adults":[59],"ASD,":[61],"age-":[62],"and":[63,76,86,112,114,118,158,174,204,230,235],"gender-matched":[64],"healthy":[65,69],"subjects":[66,171],"(ASD":[67],"control),":[68],"mothers":[70,176],"having":[71,177],"children":[72,179],"ASD":[74,85,90,157,173,178,186,234],"(asdMO),":[75],"asdMO":[77,123],"control.":[78],"There":[79],"was":[80,150],"no":[81],"relationship":[83],"between":[84],"asdMO.":[87,159],"Comparing":[88],"group":[91,124],"control,":[93],"19":[94],"found":[97],"to":[98,185,225,240,246],"be":[99,188,207],"significantly":[100],"changed.":[101],"These":[102],"mainly":[105],"involved":[106],"cell":[108],"morphology,":[109],"cellular":[110],"assembly":[111],"organization,":[113],"nerve":[115],"system":[116],"development":[117],"function.":[119],"In":[120],"addition,":[121],"possessed":[125],"unique":[127,161],"signature":[130,149],"shown":[131],"as":[132,202],"significant":[133],"alterations":[134],"protein":[136],"synthesis":[137],"despite":[138],"their":[140],"nonautistic":[141],"diagnostic":[142],"status.":[143],"Moreover,":[144],"an":[145],"ASD-associated":[146,218],"commonly":[151],"observed":[152],"both":[154],"This":[160],"detected":[165,208],"leukocytes":[168,222],"affected":[170],"unaffected":[175],"suggest":[180,215],"that":[181,216],"predisposition":[184],"may":[187],"detectable":[189],"even":[190],"cells.":[193],"Altered":[194],"several":[197],"candidate":[199],"such":[201],"FMR-1":[203],"MECP2,":[205],"could":[206],"leukocytes.":[210],"Taken":[211],"together,":[212],"these":[213],"findings":[214],"identified":[220],"are":[223],"informative":[224],"explore":[226],"genetic,":[228],"epigenetic,":[229],"environmental":[231],"background":[232],"might":[236],"become":[237],"potential":[238],"tools":[239],"assess":[241],"crucial":[243],"related":[245],"clinical":[248],"onset":[249],"disorder.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
