{"id":"https://openalex.org/W2015795408","doi":"https://doi.org/10.1371/journal.pmed.1001213","title":"Six-Year Follow-Up of Impact of Co-proxamol Withdrawal in England and Wales on Prescribing and Deaths: Time-Series Study","display_name":"Six-Year Follow-Up of Impact of Co-proxamol Withdrawal in England and Wales on Prescribing and Deaths: Time-Series Study","publication_year":2012,"publication_date":"2012-05-08","ids":{"openalex":"https://openalex.org/W2015795408","doi":"https://doi.org/10.1371/journal.pmed.1001213","mag":"2015795408","pmid":"https://pubmed.ncbi.nlm.nih.gov/22589703","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3348153"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pmed.1001213","doi":"https://doi.org/10.1371/journal.pmed.1001213","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.1001213","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001213&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001213&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021170166","display_name":"Keith E Hawton","orcid":"https://orcid.org/0000-0003-4985-5715","observed_orcids":["https://orcid.org/0000-0003-4985-5715"]},"institutions":[{"id":"https://openalex.org/I2803066836","display_name":"Warneford Hospital","ror":"https://ror.org/03we1zb10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802171185","https://openalex.org/I2803066836"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Keith Hawton","raw_affiliation_strings":["Centre for Suicide Research, University of Oxford Department of Psychiatry, Warneford Hospital, Headington, Oxford, UK. keith.hawton@psych.ox.ac.uk","Centre for Suicide Research, University of Oxford Department of Psychiatry, Warneford Hospital, Headington, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Suicide Research, University of Oxford Department of Psychiatry, Warneford Hospital, Headington, Oxford, UK. keith.hawton@psych.ox.ac.uk","institution_ids":["https://openalex.org/I2803066836","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Centre for Suicide Research, University of Oxford Department of Psychiatry, Warneford Hospital, Headington, Oxford, UK","institution_ids":["https://openalex.org/I2803066836","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108670933","display_name":"Helen A. Bergen","orcid":"https://orcid.org/0009-0004-3570-5120","observed_orcids":["https://orcid.org/0009-0004-3570-5120"]},"institutions":[{"id":"https://openalex.org/I2803066836","display_name":"Warneford Hospital","ror":"https://ror.org/03we1zb10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802171185","https://openalex.org/I2803066836"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Helen Bergen","raw_affiliation_strings":["Centre for Suicide Research, University of Oxford, Department of Psychiatry, Warneford Hospital, Headington, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Suicide Research, University of Oxford, Department of Psychiatry, Warneford Hospital, Headington, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2803066836","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075164823","display_name":"Sue Simkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803066836","display_name":"Warneford Hospital","ror":"https://ror.org/03we1zb10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802171185","https://openalex.org/I2803066836"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sue Simkin","raw_affiliation_strings":["Centre for Suicide Research, University of Oxford, Department of Psychiatry, Warneford Hospital, Headington, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Suicide Research, University of Oxford, Department of Psychiatry, Warneford Hospital, Headington, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2803066836","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112336077","display_name":"Claudia Wells","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327095140","display_name":"Office for National Statistics","ror":"https://ror.org/021fhft25","country_code":"GB","type":"government","lineage":["https://openalex.org/I1327095140"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claudia Wells","raw_affiliation_strings":["Office for National Statistics, Government Buildings, Newport, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office for National Statistics, Government Buildings, Newport, United Kingdom","institution_ids":["https://openalex.org/I1327095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013137351","display_name":"Navneet Kapur","orcid":"https://orcid.org/0000-0002-3100-3234","observed_orcids":["https://orcid.org/0000-0002-3100-3234"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Navneet Kapur","raw_affiliation_strings":["Centre for Suicide Prevention, University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Suicide Prevention, University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027462458","display_name":"David Gunnell","orcid":"https://orcid.org/0000-0002-0829-6470","observed_orcids":["https://orcid.org/0000-0002-0829-6470"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Gunnell","raw_affiliation_strings":["School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom","Bristol Medical School (PHS)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"Bristol Medical School (PHS)","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5021170166"],"corresponding_institution_ids":["https://openalex.org/I2803066836","https://openalex.org/I40120149"],"apc_list":{"value":6460,"currency":"USD","value_usd":6460},"apc_paid":{"value":6460,"currency":"USD","value_usd":6460},"fwci":8.4226,"has_fulltext":true,"cited_by_count":82,"citation_normalized_percentile":{"value":0.98072231,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"9","issue":"5","first_page":"e1001213","last_page":"e1001213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dextropropoxyphene","display_name":"dextropropoxyphene","score":0.8669999837875366},{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":0.722000002861023},{"id":"https://openalex.org/keywords/drug-substitution","display_name":"drug substitution","score":0.5509999990463257},{"id":"https://openalex.org/keywords/analgesic-prescribing","display_name":"analgesic prescribing","score":0.9100000262260437},{"id":"https://openalex.org/keywords/drug-poisoning-deaths","display_name":"drug poisoning deaths","score":0.6399999856948853},{"id":"https://openalex.org/keywords/suicide","display_name":"suicide","score":0.7879999876022339},{"id":"https://openalex.org/keywords/unintentional-poisoning","display_name":"accidental poisoning","score":0.972000002861023},{"id":"https://openalex.org/keywords/oxycodone","display_name":"oxycodone","score":0.8109999895095825},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.5920000076293945},{"id":"https://openalex.org/keywords/codeine","display_name":"codeine","score":0.5979999899864197},{"id":"https://openalex.org/keywords/tramadol","display_name":"tramadol","score":0.6499999761581421},{"id":"https://openalex.org/keywords/drug-policy","display_name":"drug policy","score":0.492000013589859},{"id":"https://openalex.org/keywords/england-and-wales","display_name":"England and Wales","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8354857563972473},{"id":"https://openalex.org/C2909024267","wikidata":"https://www.wikidata.org/wiki/Q39046682","display_name":"Interrupted Time Series Analysis","level":2,"score":0.8220057487487793},{"id":"https://openalex.org/C2776029756","wikidata":"https://www.wikidata.org/wiki/Q407535","display_name":"Oxycodone","level":4,"score":0.585730254650116},{"id":"https://openalex.org/C508975757","wikidata":"https://www.wikidata.org/wiki/Q2268608","display_name":"Propoxyphene","level":3,"score":0.5517798662185669},{"id":"https://openalex.org/C2779777798","wikidata":"https://www.wikidata.org/wiki/Q407592","display_name":"Tramadol","level":3,"score":0.5395395755767822},{"id":"https://openalex.org/C126965237","wikidata":"https://www.wikidata.org/wiki/Q816335","display_name":"Accidental","level":2,"score":0.5331693291664124},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.5230953693389893},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.5193566083908081},{"id":"https://openalex.org/C2777866328","wikidata":"https://www.wikidata.org/wiki/Q174723","display_name":"Codeine","level":3,"score":0.496069997549057},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.4940784275531769},{"id":"https://openalex.org/C190385971","wikidata":"https://www.wikidata.org/wiki/Q373494","display_name":"Injury prevention","level":3,"score":0.47717180848121643},{"id":"https://openalex.org/C187155963","wikidata":"https://www.wikidata.org/wiki/Q629029","display_name":"Occupational safety and health","level":2,"score":0.4409763216972351},{"id":"https://openalex.org/C526869908","wikidata":"https://www.wikidata.org/wiki/Q3298118","display_name":"Suicide prevention","level":3,"score":0.425296813249588},{"id":"https://openalex.org/C2776315796","wikidata":"https://www.wikidata.org/wiki/Q3505252","display_name":"Drug overdose","level":3,"score":0.4168979525566101},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4028504192829132},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.3602839708328247},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.23176395893096924},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.21128711104393005},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.2034609317779541},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.17595139145851135},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1282019317150116},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000059","descriptor_name":"Accidents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":true},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":true},{"descriptor_ui":"D002423","descriptor_name":"Cause of Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004739","descriptor_name":"England","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":false},{"descriptor_ui":"D010098","descriptor_name":"Oxycodone","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":false},{"descriptor_ui":"D010818","descriptor_name":"Practice Patterns, Physicians'","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011431","descriptor_name":"Dextropropoxyphene","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":true},{"descriptor_ui":"D013405","descriptor_name":"Suicide","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D014852","descriptor_name":"Wales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055656","descriptor_name":"Prescriptions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062787","descriptor_name":"Drug Overdose","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pmed.1001213","doi":"https://doi.org/10.1371/journal.pmed.1001213","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.1001213","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001213&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2357705","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3348153","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3348153","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3348153","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Med","raw_type":"Text"},{"id":"pmid:22589703","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22589703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.803.6416","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.803.6416","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/35/b2/pmed.1001213.PMC3348153.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:77833b219ee74089a2b3311167cc468e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/77833b219ee74089a2b3311167cc468e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Medicine, Vol 9, Iss 5, p e1001213 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/125320","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Six_Year_Follow_Up_of_Impact_of_Co_proxamol_Withdrawal_in_England_and_Wales_on_Prescribing_and_Deaths_Time_Series_Study/125320","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:fec94f4e-746f-4b59-bbd4-01b5bd7245bc","doi":null,"is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:fec94f4e-746f-4b59-bbd4-01b5bd7245bc","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/ca5882b2-748d-47ed-a1a2-fea339d4efd0","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/ca5882b2-748d-47ed-a1a2-fea339d4efd0","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hawton, K, Bergen, H, Simkin, S, Wells, C, Kapur, N & Gunnell, D 2012, 'Six-year follow-up of impact of co-proxamol withdrawal in england and wales on prescribing and deaths: Time-series study', PL o S Medicine, vol. 9, no. 5, e1001213. https://doi.org/10.1371/journal.pmed.1001213","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/7827bcfb-a0fd-45ef-b18c-5bf2cc5dea81","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1983/7827bcfb-a0fd-45ef-b18c-5bf2cc5dea81","pdf_url":null,"source":{"id":"https://openalex.org/S7407055359","display_name":"Explore Bristol Research","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hawton, K, Bergen, H, Simkin, S, Wells, C, Kapur, N & Gunnell, D 2012, 'Six-year follow-up of impact of co-proxamol withdrawal in England and Wales on prescribing and deaths : time-series study', PLOS Medicine, vol. 9, no. 5, pp. e1001213. https://doi.org/10.1371/journal.pmed.1001213","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pmed.1001213","doi":"https://doi.org/10.1371/journal.pmed.1001213","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.1001213","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001213&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G5431728979","display_name":"A multi-centre programme of clinical and public health research in support of the National Suicide Prevention Strategy for England.","funder_award_id":"RP-PG-0606-1247","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G7758309549","display_name":null,"funder_award_id":"DH/DSH2008","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332007","display_name":"Oxford Health NHS Foundation Trust","ror":"https://ror.org/04c8bjx39"},{"id":"https://openalex.org/F4320335255","display_name":"Programme Grants for Applied Research","ror":"https://ror.org/0187kwz08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015795408.pdf","grobid_xml":"https://content.openalex.org/works/W2015795408.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W15728397","https://openalex.org/W95259077","https://openalex.org/W609446739","https://openalex.org/W1201749067","https://openalex.org/W1613539865","https://openalex.org/W1964342582","https://openalex.org/W1972578648","https://openalex.org/W1988702677","https://openalex.org/W1996925123","https://openalex.org/W2016516553","https://openalex.org/W2022579662","https://openalex.org/W2038868954","https://openalex.org/W2058592440","https://openalex.org/W2077221591","https://openalex.org/W2084363614","https://openalex.org/W2084979797","https://openalex.org/W2086543752","https://openalex.org/W2091301331","https://openalex.org/W2092519507","https://openalex.org/W2110132657","https://openalex.org/W2116463642","https://openalex.org/W2119566762","https://openalex.org/W2124145234","https://openalex.org/W2135889734","https://openalex.org/W2141871264","https://openalex.org/W2153433681","https://openalex.org/W2493993549","https://openalex.org/W4230029518","https://openalex.org/W4234980206","https://openalex.org/W6654475412"],"related_works":["https://openalex.org/W7100849736","https://openalex.org/W2116463642","https://openalex.org/W2015509672","https://openalex.org/W2902233311","https://openalex.org/W7098604829","https://openalex.org/W2086543752","https://openalex.org/W2077221591","https://openalex.org/W2512617863","https://openalex.org/W4232283774","https://openalex.org/W7096143703"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,132],"analgesic":[2],"co-proxamol":[3,55,137,179,286],"(paracetamol/dextropropoxyphene":[4],"combination)":[5],"has":[6],"been":[7],"widely":[8],"involved":[9],"in":[10,27,30,42,46,61,65,134,141,147,173,237,246,268,287,295,305],"fatal":[11],"poisoning.":[12],"Concerns":[13],"about":[14],"its":[15,25,139],"safety/effectiveness":[16],"profile":[17],"and":[18,37,39,57,59,63,90,96,104,122,159,184,210,266],"widespread":[19],"use":[20],"for":[21,110],"suicidal":[22],"poisoning":[23,177,228,296],"prompted":[24],"withdrawal":[26,34,41,56,140,284],"the":[28,52,87,108,206,256,279,283,288],"UK":[29],"2005,":[31],"with":[32,68,164,170,178],"partial":[33],"between":[35,54],"2005":[36,142],"2007,":[38],"full":[40],"2008.":[43],"Our":[44],"objective":[45],"this":[47,299],"study":[48,257],"was":[49,143,233,258,291],"to":[50,176,193,198,216,221],"assess":[51],"association":[53],"prescribing":[58,84,121,135,148],"deaths":[60,123,174,189,203,212,224,229,238,261,269,297,306],"England":[62],"Wales":[64],"2005-2010":[66,162],"compared":[67,163],"1998-2004,":[69],"including":[70],"estimation":[71],"of":[72,120,136,149,182,187,285],"possible":[73],"substitution":[74],"effects":[75],"by":[76,145],"other":[77,151,240,308],"analgesics.":[78,131,309],"METHODS":[79],"AND":[80],"FINDINGS:":[81],"We":[82,113],"obtained":[83],"data":[85,106],"from":[86,107,243],"NHS":[88],"Health":[89],"Social":[91],"Care":[92],"Information":[93],"Centre":[94],"(England)":[95],"Prescribing":[97],"Services":[98],"Partneriaeth":[99],"Cydwasanaethau":[100],"GIG":[101],"Cymru":[102],"(Wales),":[103],"mortality":[105],"Office":[109],"National":[111],"Statistics.":[112],"carried":[114],"out":[115],"an":[116,244],"interrupted":[117],"time-series":[118],"analysis":[119],"(suicide,":[124],"open":[125],"verdicts,":[126],"accidental":[127,227],"poisonings)":[128],"involving":[129,239,262,270,298,307],"single":[130,263],"reduction":[133,294],"following":[138,282],"accompanied":[144],"increases":[146],"several":[150],"analgesics":[152],"(co-codamol,":[153],"paracetamol,":[154],"codeine,":[155],"co-dydramol,":[156],"tramadol,":[157],"oxycodone,":[158],"morphine)":[160],"during":[161],"1998-2004.":[165],"These":[166],"changes":[167,267],"were":[168,230,251,254],"associated":[169],"major":[171,293],"reductions":[172],"due":[175],"receiving":[180],"verdicts":[181],"suicide":[183,202],"undetermined":[185],"cause":[186],"-21":[188],"(95%":[190,213],"CI":[191,214],"-34":[192],"-8)":[194],"per":[195,218],"quarter,":[196,219],"equating":[197,220],"approximately":[199],"500":[200],"fewer":[201,223],"(-61%)":[204],"over":[205],"6":[207,280],"years":[208,281],"2005-2010,":[209],"-25":[211],"-38":[215],"-12)":[217],"600":[222],"(-62%)":[225],"when":[226],"included.":[231],"There":[232],"little":[234],"observed":[235],"change":[236],"analgesics,":[241],"apart":[242],"increase":[245,304],"oxycodone":[247],"poisonings,":[248],"but":[249],"numbers":[250],"small.":[252],"Limitations":[253],"that":[255],"based":[259],"on":[260],"drugs":[264],"alone":[265],"prescribed":[271],"morphine":[272],"could":[273],"not":[274],"be":[275],"assessed.":[276],"CONCLUSIONS:":[277],"During":[278],"UK,":[289],"there":[290],"a":[292],"drug,":[300],"without":[301],"apparent":[302],"significant":[303]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}