{"id":"https://openalex.org/W2015790153","doi":"https://doi.org/10.1097/00005131-200204000-00006","title":"The Effect of Hemorrhagic Shock in a Caprine Tibial Fracture Model","display_name":"The Effect of Hemorrhagic Shock in a Caprine Tibial Fracture Model","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W2015790153","doi":"https://doi.org/10.1097/00005131-200204000-00006","mag":"2015790153","pmid":"https://pubmed.ncbi.nlm.nih.gov/11927806"},"language":"en","primary_location":{"id":"doi:10.1097/00005131-200204000-00006","doi":"https://doi.org/10.1097/00005131-200204000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005131-200204000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S65618785","display_name":"Journal of Orthopaedic Trauma","issn_l":"0890-5339","issn":["0890-5339","1531-2291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Trauma","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068218126","display_name":"Adam J. Starr","orcid":"https://orcid.org/0000-0003-3277-6703","observed_orcids":["https://orcid.org/0000-0003-3277-6703"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adam J. Starr","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072683993","display_name":"Robert D. Welch","orcid":"https://orcid.org/0000-0003-0358-2811","observed_orcids":["https://orcid.org/0000-0003-0358-2811"]},"institutions":[{"id":"https://openalex.org/I2802862759","display_name":"Texas Scottish Rite Hospital for Children","ror":"https://ror.org/03gd5jm66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802862759"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert D. Welch","raw_affiliation_strings":["Texas Scottish Rite Hospital for Children"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Scottish Rite Hospital for Children","institution_ids":["https://openalex.org/I2802862759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023131786","display_name":"Brian J. Eastridge","orcid":"https://orcid.org/0000-0001-8875-869X","observed_orcids":["https://orcid.org/0000-0001-8875-869X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian J. Eastridge","raw_affiliation_strings":["University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113463878","display_name":"William A. Pierce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802862759","display_name":"Texas Scottish Rite Hospital for Children","ror":"https://ror.org/03gd5jm66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802862759"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Pierce","raw_affiliation_strings":["Texas Scottish Rite Hospital for Children"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Scottish Rite Hospital for Children","institution_ids":["https://openalex.org/I2802862759"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107838887","display_name":"Hong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802862759","display_name":"Texas Scottish Rite Hospital for Children","ror":"https://ror.org/03gd5jm66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802862759"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Zhang","raw_affiliation_strings":["Texas Scottish Rite Hospital for Children"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Scottish Rite Hospital for Children","institution_ids":["https://openalex.org/I2802862759"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068218126"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":0.2512,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.62088628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"4","first_page":"250","last_page":"256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12249","display_name":"Veterinary Orthopedics and Neurology","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemorrhagic-shock","display_name":"hemorrhagic shock","score":0.996999979019165},{"id":"https://openalex.org/keywords/tibial-fractures","display_name":"tibial fractures","score":0.8859999775886536},{"id":"https://openalex.org/keywords/fracture-healing","display_name":"fracture healing","score":0.984000027179718},{"id":"https://openalex.org/keywords/goats","display_name":"goats","score":0.703000009059906},{"id":"https://openalex.org/keywords/external-fixation","display_name":"external fixation","score":0.6159999966621399},{"id":"https://openalex.org/keywords/fluid-resuscitation","display_name":"fluid resuscitation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.6669999957084656},{"id":"https://openalex.org/keywords/base-deficit","display_name":"base deficit","score":0.9629999995231628},{"id":"https://openalex.org/keywords/bone-histomorphometry","display_name":"bone histomorphometry","score":0.7889999747276306},{"id":"https://openalex.org/keywords/nonunion","display_name":"nonunion","score":0.7239999771118164},{"id":"https://openalex.org/keywords/callus-formation","display_name":"callus formation","score":0.6200000047683716},{"id":"https://openalex.org/keywords/torsional-strength","display_name":"torsional strength","score":0.531000018119812},{"id":"https://openalex.org/keywords/large-animal-model","display_name":"large animal model","score":0.578000009059906},{"id":"https://openalex.org/keywords/hypovolemic-shock","display_name":"hypovolemic shock","score":0.5090000033378601},{"id":"https://openalex.org/keywords/osteoblast-activity","display_name":"osteoblast activity","score":0.6370000243186951},{"id":"https://openalex.org/keywords/osteoid-surface","display_name":"osteoid surface","score":0.7760000228881836},{"id":"https://openalex.org/keywords/bone-volume-fraction","display_name":"bone volume fraction","score":0.5260000228881836},{"id":"https://openalex.org/keywords/osteoclast-activity","display_name":"osteoclast activity","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9287576675415039},{"id":"https://openalex.org/C2779330695","wikidata":"https://www.wikidata.org/wiki/Q7049641","display_name":"Nonunion","level":2,"score":0.7006626129150391},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.6346167325973511},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.5855807662010193},{"id":"https://openalex.org/C92162645","wikidata":"https://www.wikidata.org/wiki/Q655955","display_name":"Intramedullary rod","level":2,"score":0.5463902354240417},{"id":"https://openalex.org/C2777236700","wikidata":"https://www.wikidata.org/wiki/Q178366","display_name":"Tibia","level":2,"score":0.5427009463310242},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5259233713150024},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.48220622539520264},{"id":"https://openalex.org/C2780707029","wikidata":"https://www.wikidata.org/wiki/Q1512017","display_name":"Long bone","level":2,"score":0.4289226233959198},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.40295547246932983},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.166642427444458}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005596","descriptor_name":"Fractures, Closed","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005596","descriptor_name":"Fractures, Closed","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005596","descriptor_name":"Fractures, Closed","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006041","descriptor_name":"Goats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013978","descriptor_name":"Tibial Fractures","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D013978","descriptor_name":"Tibial Fractures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013978","descriptor_name":"Tibial Fractures","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D017102","descriptor_name":"Fracture Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005131-200204000-00006","doi":"https://doi.org/10.1097/00005131-200204000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005131-200204000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S65618785","display_name":"Journal of Orthopaedic Trauma","issn_l":"0890-5339","issn":["0890-5339","1531-2291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Trauma","raw_type":"journal-article"},{"id":"pmid:11927806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11927806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic trauma","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1982412615","https://openalex.org/W2001977326","https://openalex.org/W2023047307","https://openalex.org/W2034614189","https://openalex.org/W2040698802","https://openalex.org/W2041525374","https://openalex.org/W2048457639","https://openalex.org/W2052306725","https://openalex.org/W2061106208","https://openalex.org/W4295586792"],"related_works":["https://openalex.org/W2744980113","https://openalex.org/W2889184118","https://openalex.org/W2797183793","https://openalex.org/W3155808600","https://openalex.org/W2007600798","https://openalex.org/W2047193733","https://openalex.org/W2018311758","https://openalex.org/W2350179147","https://openalex.org/W2803198573","https://openalex.org/W7100455798"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,52,81,89,269,280,319,330],"purpose":[2],"of":[3,10,193,209,251,260,262,278,300,344,371,442,464],"this":[4,449],"study":[5,450],"was":[6,71,84,121,200,203,222,272,302,328,445,454],"to":[7,56,114,123,225,308,314,346,378,426,474],"assess":[8],"effects":[9],"hemorrhagic":[11,469],"shock":[12,59,70,79,82,182,227,234,246,293,325,391,458,470],"on":[13,298,342,348],"fracture":[14,21,479],"healing":[15,359,380,480],"in":[16,48,73,77,147,180,206,232,238,244,265,275,289,337,358,395,462,481],"a":[17,57,66,96,104,249,482],"large":[18],"animal":[19,199],"closed":[20,42,477],"model.":[22,484],"DESIGN:":[23],"Prospective":[24],"randomized":[25,55],"trial.":[26],"SETTING:":[27],"University":[28],"Medical":[29],"Center.":[30],"STUDY":[31],"SUBJECTS:":[32],"Eight":[33],"skeletally":[34],"mature":[35],"neutered":[36],"male":[37],"goats.":[38,51],"INTERVENTION:":[39],"Standardized":[40],"bilateral":[41],"midshaft":[43],"tibia":[44,254,283,478],"fractures":[45,100],"were":[46,54,93,101,112,134,142,155,175,376,417],"created":[47],"all":[49,374],"the":[50,74,78,129,140,153,181,207,219,226,233,239,245,266,276,292,324,369,372,390,457,465],"goats":[53,76,92,130,231],"hemorrhage,":[58],"and":[60,144,171,190,202,236,312,366,392,405,459],"resuscitation":[61],"group":[62,183,221,235,247,294,326,332],"(shock":[63],"group),":[64],"or":[65,431],"control":[67,97,220,240,331,393,460],"group.":[68,80,98,241],"Hemorrhagic":[69],"induced":[72],"four":[75,91,138,230],"state":[83],"maintained":[85],"for":[86,128,157,323],"thirty":[87],"minutes.":[88],"remaining":[90],"used":[94,113],"as":[95],"All":[99],"stabilized":[102],"with":[103,435],"standardized":[105],"external":[106,195],"fixator.":[107],"OUTCOME":[108],"MEASURES:":[109],"Swan-Ganz":[110],"catheters":[111],"record":[115],"cardiac":[116],"output":[117],"(CO).":[118],"Arterial":[119],"blood":[120],"sampled":[122],"determine":[124],"base":[125,321],"deficit":[126,322],"values":[127],"after":[131,150,310,316],"hemorrhage.":[132],"Radiographs":[133],"obtained":[135],"weekly.":[136],"After":[137],"weeks":[139],"tibias":[141,154],"harvested":[143],"nondestructively":[145],"tested":[146],"torsion.":[148],"Immediately":[149],"mechanical":[151],"testing,":[152],"processed":[156],"histologic":[158],"analysis.":[159],"Standard":[160],"histomorphologic":[161],"indices,":[162],"including":[163],"total":[164],"bone":[165,271,428],"volume":[166],"(TV/BV%),":[167],"osteoblast":[168],"surfaces":[169],"(Ob/BS%),":[170],"osteoid":[172],"surface":[173],"(OS/BS%),":[174],"measured.":[176,467],"RESULTS:":[177],"One":[178,211,242],"goat":[179,212,243,483],"became":[184],"agitated":[185],"upon":[186],"emergence":[187,349],"from":[188,340,350],"anesthesia":[189,301,345],"dislodged":[191],"two":[192],"his":[194,252],"fixator":[196],"pins.":[197],"This":[198,256],"killed":[201],"not":[204,273,424,472],"included":[205,274],"analysis":[208,277,353],"results.":[210,279],"that":[213],"would":[214],"have":[215],"been":[216],"entered":[217],"into":[218],"then":[223],"switched":[224],"group,":[228],"leaving":[229],"three":[237],"developed":[248],"nonunion":[250,257],"left":[253],"fracture.":[255],"occurred":[258],"because":[259],"loosening":[261],"pin":[263],"fixation":[264],"distal":[267],"tibia.":[268],"nonunited":[270],"animal's":[281],"right":[282],"healed":[284],"uneventfully.":[285],"Hemorrhage":[286],"uniformly":[287],"resulted":[288],"shock.":[290],"In":[291,448],"goats,":[295],"average":[296,320,338],"CO":[297,306],"induction":[299,343],"3.7":[303],"l/min.":[304],"Average":[305],"dropped":[307],"0.7":[309],"hemorrhage":[311],"rose":[313],"6.6":[315],"fluid":[317],"resuscitation.":[318],"animals":[327,333],"-9.9.":[329],"had":[334],"minor":[335],"drops":[336],"CO,":[339],"4.5":[341],"4.3":[347],"anesthesia.":[351],"Radiographic":[352],"showed":[354,385],"no":[355,386,418,451],"apparent":[356],"differences":[357,419],"between":[360,389,420,456],"groups":[361,394,461],"when":[362],"comparing":[363],"callus":[364,432],"area":[365],"density.":[367],"With":[368],"exception":[370],"nonunion,":[373],"tibiae":[375],"considered":[377],"be":[379],"normally":[381],"radiographically.":[382],"Biomechanical":[383],"testing":[384],"statistical":[387],"difference":[388,453],"maximum":[396],"torque":[397],"(p":[398,402,410,437],"=":[399,403,411,438],"0.95),":[400],"stiffness":[401],"0.64),":[404],"energy":[406],"absorbed":[407],"at":[408],"failure":[409],"0.91).":[412],"Histomorphologic":[413],"results":[414],"indicated":[415],"there":[416],"groups.":[421],"Shock":[422],"did":[423],"appear":[425,473],"influence":[427],"formation":[429],"rate":[430],"remodeling":[433],"compared":[434],"controls":[436],"0.6).":[439],"No":[440],"evidence":[441],"osteocyte":[443],"necrosis":[444],"observed.":[446],"CONCLUSIONS:":[447],"significant":[452],"found":[455],"any":[463],"parameters":[466],"Transient":[468],"does":[471],"adversely":[475],"affect":[476]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}