{"id":"https://openalex.org/W2015776877","doi":"https://doi.org/10.1677/joe.0.0930201","title":"Adrenal circadian system in young and elderly human subjects: a comparative study","display_name":"Adrenal circadian system in young and elderly human subjects: a comparative study","publication_year":1982,"publication_date":"1982-05-01","ids":{"openalex":"https://openalex.org/W2015776877","doi":"https://doi.org/10.1677/joe.0.0930201","mag":"2015776877","pmid":"https://pubmed.ncbi.nlm.nih.gov/7086322"},"language":"en","primary_location":{"id":"doi:10.1677/joe.0.0930201","doi":"https://doi.org/10.1677/joe.0.0930201","is_oa":false,"landing_page_url":"https://doi.org/10.1677/joe.0.0930201","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030176148","display_name":"Yvan Touitou","orcid":"https://orcid.org/0000-0002-5990-0244","observed_orcids":["https://orcid.org/0000-0002-5990-0244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yvan Touitou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080720067","display_name":"Jos\u00e9 Sulon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jose\u0301 Sulon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108627846","display_name":"A Bogdan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andre\u0301 Bogdan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037083302","display_name":"C Touitou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine Touitou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113813656","display_name":"Alain Reinberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alain Reinberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007532908","display_name":"Herv\u00e9 Beck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herve\u0301 Beck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112434067","display_name":"Jean Claude Sodoyez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Claude Sodoyez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055270101","display_name":"Emilie Demey-Ponsart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emilie Demey-Ponsart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054287901","display_name":"Henri Van Cauwenberge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henri Van Cauwenberge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7745,"has_fulltext":false,"cited_by_count":131,"citation_normalized_percentile":{"value":0.8196877,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"93","issue":"2","first_page":"201","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.6317999958992004,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.6317999958992004,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.26899999380111694,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.06539999693632126,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.8500000238418579},{"id":"https://openalex.org/keywords/adrenal-cortex","display_name":"adrenal cortex","score":0.6159999966621399},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5989999771118164},{"id":"https://openalex.org/keywords/senile-dementia","display_name":"senile dementia","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.7889999747276306},{"id":"https://openalex.org/keywords/18-hydroxy-11-deoxycorticosterone","display_name":"18-hydroxy-11-deoxycorticosterone","score":0.9559999704360962},{"id":"https://openalex.org/keywords/urinary-17-ketosteroids","display_name":"urinary 17-ketosteroids","score":0.7910000085830688},{"id":"https://openalex.org/keywords/17-hydroxycorticosteroids","display_name":"17-hydroxycorticosteroids","score":0.9750000238418579},{"id":"https://openalex.org/keywords/acrophase","display_name":"acrophase","score":0.7720000147819519},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8090000152587891},{"id":"https://openalex.org/keywords/adrenocortical-function","display_name":"adrenocortical function","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.8875673413276672},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7859658002853394},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7245344519615173},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5970032215118408},{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.5379029512405396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5095105767250061}],"mesh":[{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003900","descriptor_name":"Desoxycorticosterone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015065","descriptor_name":"17-Hydroxycorticosteroids","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D015068","descriptor_name":"17-Ketosteroids","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D015070","descriptor_name":"18-Hydroxydesoxycorticosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015070","descriptor_name":"18-Hydroxydesoxycorticosterone","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1677/joe.0.0930201","doi":"https://doi.org/10.1677/joe.0.0930201","is_oa":false,"landing_page_url":"https://doi.org/10.1677/joe.0.0930201","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:7086322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7086322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of endocrinology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2020003574","https://openalex.org/W7098765640","https://openalex.org/W2405508980","https://openalex.org/W2017175171","https://openalex.org/W2139803108","https://openalex.org/W2021067171","https://openalex.org/W2333688428","https://openalex.org/W2471896705","https://openalex.org/W2033893537","https://openalex.org/W2128979836"],"abstract_inverted_index":{"Circadian":[0],"changes":[1,130],"in":[2,12,72,108,116,124,131,168,172,181,188,205,237,274,283,290,298,304],"plasma":[3,66,132,238,245,260],"18-hydroxy-11-deoxycorticosterone":[4],"(18-OH-DOC),":[5],"total":[6,68,104,149,261],"and":[7,25,48,69,90,142,150,203,216,226,239,241,248,263,270],"unbound":[8,70,112,151,217,246],"cortisol":[9,71,105,113,152,218,247,262],"were":[10,39,43,53,81,84,134,166,176,185,219,222,301],"studied":[11],"four":[13],"groups:":[14],"seven":[15],"healthy":[16,143],"young":[17,58,126,173,210],"men,":[18,21],"six":[19,22,26],"elderly":[20,23,27,121,137,144,169,182],"women":[24],"demented":[28,138,190],"patients":[29,122,139,170,183],"of":[30,36,78,87,103,111,120,148,164,208,214,224,235,244,259,268,294],"both":[31],"sexes.":[32],"The":[33,146,212,228],"daily":[34],"activities":[35],"the":[37,57,75,85,99,117,125,189,206,209,233,257,266,271,275,291],"subjects":[38,299],"synchronous;":[40],"blood":[41],"samples":[42,52],"taken":[44],"every":[45],"4":[46,49],"h":[47],"hourly":[50],"urine":[51,207,240],"collected":[54],"only":[55],"from":[56],"men.":[59,127,174,211],"A":[60,192],"circadian":[61,193],"rhythm":[62,194],"was":[63,106,114,195,230,253],"defined":[64,196],"for":[65,197],"18-OH-DOC,":[67,198],"all":[73],"groups;":[74],"secretory":[76],"patterns":[77],"these":[79],"steroids":[80,133],"parallel,":[82],"as":[83,221],"profiles":[86],"urinary":[88,249],"18-OH-DOC":[89,165,215,236],"unconjugated":[91,199,250],"cortisol.":[92],"When":[93],"compared":[94],"with":[95,157,179],"respect":[96],"to":[97],"sex,":[98],"24-h":[100],"mean":[101],"level":[102],"higher":[107,115],"women;":[109],"that":[110],"three":[118],"groups":[119],"than":[123,171],"No":[128],"major":[129,155,288],"observed":[135],"between":[136,232,242,256],"(mainly":[140],"women)":[141],"women.":[145],"phasing":[147],"showed":[153],"no":[154,287],"modifications":[156,289],"age,":[158],"sex":[159,180],"or":[160],"senile":[161],"dementia.":[162],"Acrophases":[163],"earlier":[167],"Amplitudes":[175],"not":[177],"modified":[178],"but":[184],"always":[186],"lower":[187],"patients.":[191],"cortisol,":[200],"17-hydroxycorticosteroids":[201],"(17-OH-CS)":[202],"17-ketosteroids":[204],"acrophases":[213,234,258],"close,":[220],"those":[223,243],"17-OH-CS":[225],"17-ketosteroids.":[227],"lag":[229],"short":[231],"cortisol;":[251],"it":[252],"much":[254],"larger":[255],"17-OH-CS.":[264],"Thus,":[265],"process":[267],"ageing,":[269,285],"possible":[272],"alterations":[273],"central":[276],"nervous":[277],"system":[278],"which":[279],"are":[280],"often":[281],"seen":[282],"normal":[284],"induced":[286],"temporal":[292],"organization":[293],"adrenocortical":[295],"function,":[296],"even":[297],"who":[300],"very":[302],"advanced":[303],"age.":[305]},"counts_by_year":[{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
