{"id":"https://openalex.org/W2015775280","doi":"https://doi.org/10.4103/2278-9596.136689","title":"Assessment of the efficacy and safety of methylene blue dye for sentinel lymph node mapping in early breast cancer with clinically negative axilla","display_name":"Assessment of the efficacy and safety of methylene blue dye for sentinel lymph node mapping in early breast cancer with clinically negative axilla","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2015775280","doi":"https://doi.org/10.4103/2278-9596.136689","mag":"2015775280"},"language":"en","primary_location":{"id":"doi:10.4103/2278-9596.136689","doi":"https://doi.org/10.4103/2278-9596.136689","is_oa":false,"landing_page_url":"https://doi.org/10.4103/2278-9596.136689","pdf_url":null,"source":{"id":"https://openalex.org/S2764553992","display_name":"Archives of International Surgery","issn_l":"2278-9596","issn":["2278-9596","2320-4761"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of International Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081707363","display_name":"Suman Kharkwal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091100","display_name":"Employees State Insurance Post Graduate Institute of Medical Sciences and Research","ror":"https://ror.org/00a9yh217","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210091100"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Suman Kharkwal","raw_affiliation_strings":["Department of Surgery, Employees' State Insurance Post Graduate Institute of Medical Sciences and Research, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Employees' State Insurance Post Graduate Institute of Medical Sciences and Research, New Delhi, India","institution_ids":["https://openalex.org/I4210091100"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110025206","display_name":"KS Charak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091100","display_name":"Employees State Insurance Post Graduate Institute of Medical Sciences and Research","ror":"https://ror.org/00a9yh217","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210091100"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"KS Charak","raw_affiliation_strings":["Department of Surgery, Employees' State Insurance Post Graduate Institute of Medical Sciences and Research, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Employees' State Insurance Post Graduate Institute of Medical Sciences and Research, New Delhi, India","institution_ids":["https://openalex.org/I4210091100"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101848216","display_name":"Arindam Mukherjee","orcid":"https://orcid.org/0000-0002-6048-4743","observed_orcids":["https://orcid.org/0000-0002-6048-4743"]},"institutions":[{"id":"https://openalex.org/I4210091100","display_name":"Employees State Insurance Post Graduate Institute of Medical Sciences and Research","ror":"https://ror.org/00a9yh217","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210091100"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arindam Mukherjee","raw_affiliation_strings":["Department of Surgery, Employees' State Insurance Post Graduate Institute of Medical Sciences and Research, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Employees' State Insurance Post Graduate Institute of Medical Sciences and Research, New Delhi, India","institution_ids":["https://openalex.org/I4210091100"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081707363"],"corresponding_institution_ids":["https://openalex.org/I4210091100"],"apc_list":null,"apc_paid":null,"fwci":0.1977,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.48471308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"4","issue":"1","first_page":"6","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.2720000147819519,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11258","display_name":"Breast Implant and Reconstruction","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylene-blue","display_name":"methylene blue","score":0.9290000200271606},{"id":"https://openalex.org/keywords/sentinel-lymph-node-biopsy","display_name":"sentinel lymph node biopsy","score":0.9610000252723694},{"id":"https://openalex.org/keywords/early-breast-cancer","display_name":"early breast cancer","score":0.8309999704360962},{"id":"https://openalex.org/keywords/clinically-negative-axilla","display_name":"clinically negative axilla","score":0.8410000205039978},{"id":"https://openalex.org/keywords/axillary-lymph-node-mapping","display_name":"axillary lymph node mapping","score":0.6140000224113464},{"id":"https://openalex.org/keywords/blue-dye","display_name":"blue dye","score":0.4189999997615814},{"id":"https://openalex.org/keywords/isosulfan-blue","display_name":"isosulfan blue","score":0.7200000286102295},{"id":"https://openalex.org/keywords/modified-radical-mastectomy","display_name":"modified radical mastectomy","score":0.8539999723434448},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.4819999933242798},{"id":"https://openalex.org/keywords/dye-safety","display_name":"dye safety","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8732897043228149},{"id":"https://openalex.org/C2780212769","wikidata":"https://www.wikidata.org/wiki/Q776290","display_name":"Sentinel lymph node","level":4,"score":0.8043778538703918},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7723791599273682},{"id":"https://openalex.org/C2776608951","wikidata":"https://www.wikidata.org/wiki/Q499","display_name":"Axilla","level":4,"score":0.7116681337356567},{"id":"https://openalex.org/C2779191827","wikidata":"https://www.wikidata.org/wiki/Q422134","display_name":"Methylene blue","level":4,"score":0.6800776124000549},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.6670161485671997},{"id":"https://openalex.org/C3018521938","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast carcinoma","level":4,"score":0.4663165211677551},{"id":"https://openalex.org/C179671157","wikidata":"https://www.wikidata.org/wiki/Q2422612","display_name":"Sentinel node","level":4,"score":0.45894092321395874},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.43886926770210266},{"id":"https://openalex.org/C2910733956","wikidata":"https://www.wikidata.org/wiki/Q848318","display_name":"Modified Radical Mastectomy","level":5,"score":0.42607927322387695},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.4245690107345581},{"id":"https://openalex.org/C2777649267","wikidata":"https://www.wikidata.org/wiki/Q340695","display_name":"Axillary lymph nodes","level":4,"score":0.42396917939186096},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3785131573677063},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3761517107486725},{"id":"https://openalex.org/C2777757722","wikidata":"https://www.wikidata.org/wiki/Q848318","display_name":"Mastectomy","level":4,"score":0.3590232729911804},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2266593873500824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.209985613822937},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C65165184","wikidata":"https://www.wikidata.org/wiki/Q218831","display_name":"Photocatalysis","level":3,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4103/2278-9596.136689","doi":"https://doi.org/10.4103/2278-9596.136689","is_oa":false,"landing_page_url":"https://doi.org/10.4103/2278-9596.136689","pdf_url":null,"source":{"id":"https://openalex.org/S2764553992","display_name":"Archives of International Surgery","issn_l":"2278-9596","issn":["2278-9596","2320-4761"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of International Surgery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1955110002","https://openalex.org/W1967841829","https://openalex.org/W1979586174","https://openalex.org/W1984532207","https://openalex.org/W1985464719","https://openalex.org/W1991515788","https://openalex.org/W1999525106","https://openalex.org/W2014136479","https://openalex.org/W2032955449","https://openalex.org/W2038938679","https://openalex.org/W2039110392","https://openalex.org/W2040770663","https://openalex.org/W2053603280","https://openalex.org/W2059481140","https://openalex.org/W2063496958","https://openalex.org/W2076726869","https://openalex.org/W2081974046","https://openalex.org/W2091051747","https://openalex.org/W2100680128","https://openalex.org/W2109476177","https://openalex.org/W2139855643","https://openalex.org/W2142517923","https://openalex.org/W2161911084","https://openalex.org/W2320208498","https://openalex.org/W2341373657","https://openalex.org/W4248422521"],"related_works":["https://openalex.org/W2790905168","https://openalex.org/W3108696189","https://openalex.org/W4413932857","https://openalex.org/W2122566236","https://openalex.org/W1982181623","https://openalex.org/W2059481140","https://openalex.org/W2383089298","https://openalex.org/W2039759486","https://openalex.org/W3029267297","https://openalex.org/W2348748492"],"abstract_inverted_index":{"Background":[0],":":[1],"The":[2,43,125,166,187,192],"benefits":[3],"of":[4,33,45,55,81,85,93,107,111,161,168,219],"sentinel":[5],"lymph":[6,101,126],"node":[7,69,231],"(SLN)":[8],"biopsy":[9,24,66,228],"in":[10,67,182,229],"breast":[11,71,94,146,169,233],"cancer":[12,170],"patients":[13,84],"with":[14,90,96,147,158],"clinically":[15,97],"negative":[16,70,98,200,232],"axillary":[17,68,100,149,230],"nodes":[18,102,127],"are":[19],"now":[20],"well":[21],"established.":[22],"SLN":[23,65,163,179,227],"has":[25],"been":[26],"performed":[27],"using":[28,185],"different":[29],"techniques":[30],"including":[31],"injection":[32],"isosulfan":[34],"blue":[35,57,114,130,221],"dye":[36,58,131],"(IBD),":[37],"radioactive":[38],"colloid,":[39],"and":[40,53,74,88,143,199,208,217],"methylene":[41,56,113,220],"blue.":[42],"aim":[44],"this":[46],"study":[47,213],"was":[48,115,141,151,171,180,190],"to":[49,156],"assess":[50],"the":[51,118,122,129,135,144,148,159,162,215],"safety":[52,216],"efficacy":[54,218],"(MBD)":[59],"as":[60,134,222],"a":[61,79,223],"mapping":[62,224],"agent":[63,225],"for":[64,153,226],"carcinoma.":[72],"Materials":[73],"Methods:":[75],"Between":[76],"February":[77],"2010-2012,":[78],"total":[80],"27":[82,177],"female":[83],"18":[86],"years":[87],"above,":[89],"established":[91],"diagnosis":[92],"carcinoma":[95],"ipsilateral":[99],"were":[103,132,204],"studied.":[104],"After":[105],"induction":[106],"anesthesia,":[108],"5":[109],"ml":[110],"1%":[112],"infiltrated":[116],"into":[117],"subareolar":[119],"tissue":[120,150],"on":[121],"affected":[123],"side.":[124],"receiving":[128],"excised":[133,145],"SLN.":[136],"Modified":[137],"radical":[138],"mastectomy":[139],"(MRM)":[140],"completed":[142],"sent":[152],"histopathological":[154],"examination":[155],"correlate":[157],"findings":[160],"biopsy.":[164],"Results:":[165],"incidence":[167],"highest":[172],"at":[173],"41-50":[174],"years.":[175],"Of":[176],"cases,":[178],"identified":[181],"24":[183],"cases":[184],"MBD.":[186],"identification":[188],"rate":[189],"88.9%.":[191],"sensitivity,":[193],"specificity,":[194],"positive":[195],"predictive":[196,201],"value":[197,202],"(PPV),":[198],"(NPV)":[203],"81.8,":[205],"100,":[206,207],"86.7%,":[209],"respectively.":[210],"Conclusion:":[211],"This":[212],"confirms":[214],"cancer.":[234]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
