{"id":"https://openalex.org/W2015774847","doi":"https://doi.org/10.1007/s12032-012-0348-z","title":"Analysis of the clinico-hematological relevance of the breakpoint location within M-BCR in chronic myeloid leukemia","display_name":"Analysis of the clinico-hematological relevance of the breakpoint location within M-BCR in chronic myeloid leukemia","publication_year":2012,"publication_date":"2012-12-26","ids":{"openalex":"https://openalex.org/W2015774847","doi":"https://doi.org/10.1007/s12032-012-0348-z","mag":"2015774847","pmid":"https://pubmed.ncbi.nlm.nih.gov/23269583"},"language":"en","primary_location":{"id":"doi:10.1007/s12032-012-0348-z","doi":"https://doi.org/10.1007/s12032-012-0348-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12032-012-0348-z","pdf_url":null,"source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077880177","display_name":"Ayda Bennour","orcid":"https://orcid.org/0000-0003-2256-1493","observed_orcids":["https://orcid.org/0000-0003-2256-1493"]},"institutions":[{"id":"https://openalex.org/I4210087936","display_name":"H\u00f4pital Farhat Hached","ror":"https://ror.org/0059hys23","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210087936"]}],"countries":["TN"],"is_corresponding":true,"raw_author_name":"Ayda Bennour","raw_affiliation_strings":["Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia. aydabennour@yahoo.fr","Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia. aydabennour@yahoo.fr","institution_ids":["https://openalex.org/I4210087936"]},{"raw_affiliation_string":"Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia","institution_ids":["https://openalex.org/I4210087936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044700792","display_name":"Ines Ouahchi","orcid":"https://orcid.org/0000-0003-4116-1647","observed_orcids":["https://orcid.org/0000-0003-4116-1647","https://orcid.org/0000-0002-4324-0464"]},"institutions":[{"id":"https://openalex.org/I4210087936","display_name":"H\u00f4pital Farhat Hached","ror":"https://ror.org/0059hys23","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210087936"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Ines Ouahchi","raw_affiliation_strings":["Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia","Farhat Hached University Teaching Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia","institution_ids":["https://openalex.org/I4210087936"]},{"raw_affiliation_string":"Farhat Hached University Teaching Hospital","institution_ids":["https://openalex.org/I4210087936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112228935","display_name":"B\u00e9chir Achour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087936","display_name":"H\u00f4pital Farhat Hached","ror":"https://ror.org/0059hys23","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210087936"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Bechir Achour","raw_affiliation_strings":["Department of Clinical Hematology, Farhat Hached University Teaching Hospital, Sousse, Tunisia","Farhat Hached University Teaching Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Hematology, Farhat Hached University Teaching Hospital, Sousse, Tunisia","institution_ids":["https://openalex.org/I4210087936"]},{"raw_affiliation_string":"Farhat Hached University Teaching Hospital","institution_ids":["https://openalex.org/I4210087936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046279721","display_name":"Monia Zaier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087936","display_name":"H\u00f4pital Farhat Hached","ror":"https://ror.org/0059hys23","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210087936"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Monia Zaier","raw_affiliation_strings":["Department of Clinical Hematology, Farhat Hached University Teaching Hospital, Sousse, Tunisia","Farhat Hached University Teaching Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Hematology, Farhat Hached University Teaching Hospital, Sousse, Tunisia","institution_ids":["https://openalex.org/I4210087936"]},{"raw_affiliation_string":"Farhat Hached University Teaching Hospital","institution_ids":["https://openalex.org/I4210087936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108454894","display_name":"Yosra Ben Youssef","orcid":"https://orcid.org/0009-0008-5700-3436","observed_orcids":["https://orcid.org/0009-0008-5700-3436"]},"institutions":[{"id":"https://openalex.org/I4210087936","display_name":"H\u00f4pital Farhat Hached","ror":"https://ror.org/0059hys23","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210087936"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Yosra Ben Youssef","raw_affiliation_strings":["Department of Clinical Hematology, Farhat Hached University Teaching Hospital, Sousse, Tunisia","Farhat Hached University Teaching Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Hematology, Farhat Hached University Teaching Hospital, Sousse, Tunisia","institution_ids":["https://openalex.org/I4210087936"]},{"raw_affiliation_string":"Farhat Hached University Teaching Hospital","institution_ids":["https://openalex.org/I4210087936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035304141","display_name":"Abderrahim Kh\u00e9lif","orcid":"https://orcid.org/0000-0003-0220-3592","observed_orcids":["https://orcid.org/0000-0003-0220-3592"]},"institutions":[{"id":"https://openalex.org/I4210087936","display_name":"H\u00f4pital Farhat Hached","ror":"https://ror.org/0059hys23","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210087936"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Abderrahim Khelif","raw_affiliation_strings":["Department of Clinical Hematology, Farhat Hached University Teaching Hospital, Sousse, Tunisia","Farhat Hached University Teaching Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Hematology, Farhat Hached University Teaching Hospital, Sousse, Tunisia","institution_ids":["https://openalex.org/I4210087936"]},{"raw_affiliation_string":"Farhat Hached University Teaching Hospital","institution_ids":["https://openalex.org/I4210087936"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ali Saad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087936","display_name":"H\u00f4pital Farhat Hached","ror":"https://ror.org/0059hys23","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210087936"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Ali Saad","raw_affiliation_strings":["Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia","Farhat Hached University Teaching Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia","institution_ids":["https://openalex.org/I4210087936"]},{"raw_affiliation_string":"Farhat Hached University Teaching Hospital","institution_ids":["https://openalex.org/I4210087936"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052599171","display_name":"Halima Sennana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087936","display_name":"H\u00f4pital Farhat Hached","ror":"https://ror.org/0059hys23","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210087936"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Halima Sennana","raw_affiliation_strings":["Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia","Farhat Hached University Teaching Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia","institution_ids":["https://openalex.org/I4210087936"]},{"raw_affiliation_string":"Farhat Hached University Teaching Hospital","institution_ids":["https://openalex.org/I4210087936"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077880177"],"corresponding_institution_ids":["https://openalex.org/I4210087936"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":null,"fwci":1.6355,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.84516606,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"30","issue":"1","first_page":"348","last_page":"348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/bcr-abl-fusion-transcript","display_name":"BCR-ABL fusion transcripts","score":0.765999972820282},{"id":"https://openalex.org/keywords/philadelphia-chromosome","display_name":"Philadelphia chromosome","score":0.7580000162124634},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.8550000190734863},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.4909999966621399},{"id":"https://openalex.org/keywords/sex","display_name":"sex","score":0.628000020980835},{"id":"https://openalex.org/keywords/clinical-characteristics","display_name":"clinical features","score":0.3959999978542328},{"id":"https://openalex.org/keywords/hematological-characteristics","display_name":"hematological features","score":0.49900001287460327},{"id":"https://openalex.org/keywords/chronic-phase-cml","display_name":"chronic phase CML","score":0.6899999976158142},{"id":"https://openalex.org/keywords/bcr-gene-rearrangement","display_name":"BCR gene rearrangement","score":0.49000000953674316},{"id":"https://openalex.org/keywords/abl","display_name":"ABL","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.8131133317947388},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.7942768335342407},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7929077744483948},{"id":"https://openalex.org/C206936463","wikidata":"https://www.wikidata.org/wiki/Q634179","display_name":"Breakpoint","level":4,"score":0.7237701416015625},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.5692346692085266},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4802601635456085},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.4659624397754669},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4273323118686676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4198474884033203},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38907015323638916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38396745920181274},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3665509819984436},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3415563702583313},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3285723626613617},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24167916178703308},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.12602996826171875},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.12523451447486877},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016044","descriptor_name":"Fusion Proteins, bcr-abl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016313","descriptor_name":"Genes, abl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056905","descriptor_name":"Chromosome Breakpoints","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060885","descriptor_name":"Multiplex Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s12032-012-0348-z","doi":"https://doi.org/10.1007/s12032-012-0348-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12032-012-0348-z","pdf_url":null,"source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},{"id":"pmid:23269583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23269583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical oncology (Northwood, London, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W19100229","https://openalex.org/W19872180","https://openalex.org/W98326741","https://openalex.org/W180549284","https://openalex.org/W294399541","https://openalex.org/W1268306817","https://openalex.org/W1481929343","https://openalex.org/W1515452591","https://openalex.org/W1573399247","https://openalex.org/W1894088929","https://openalex.org/W1970446061","https://openalex.org/W1976185876","https://openalex.org/W1978403940","https://openalex.org/W1992844715","https://openalex.org/W1998593414","https://openalex.org/W1999912085","https://openalex.org/W2003807386","https://openalex.org/W2014088028","https://openalex.org/W2016656445","https://openalex.org/W2018427466","https://openalex.org/W2020092689","https://openalex.org/W2026708331","https://openalex.org/W2029459428","https://openalex.org/W2032164085","https://openalex.org/W2032281025","https://openalex.org/W2041053839","https://openalex.org/W2041172585","https://openalex.org/W2050998802","https://openalex.org/W2058100811","https://openalex.org/W2061431284","https://openalex.org/W2074198797","https://openalex.org/W2092372334","https://openalex.org/W2096298665","https://openalex.org/W2098454196","https://openalex.org/W2107030941","https://openalex.org/W2121706164","https://openalex.org/W2122487233","https://openalex.org/W2138253305","https://openalex.org/W2149298659","https://openalex.org/W2151615101","https://openalex.org/W2163839352","https://openalex.org/W2165321087","https://openalex.org/W2207680991","https://openalex.org/W2243673614","https://openalex.org/W2257794194","https://openalex.org/W2396009300","https://openalex.org/W2406908205","https://openalex.org/W2407603232","https://openalex.org/W2412127843","https://openalex.org/W2417665106","https://openalex.org/W6824293496"],"related_works":["https://openalex.org/W2111540556","https://openalex.org/W1983860551","https://openalex.org/W2990343211","https://openalex.org/W2415297533","https://openalex.org/W3025886498","https://openalex.org/W2199695377","https://openalex.org/W2044911709","https://openalex.org/W2418024814","https://openalex.org/W2243673614","https://openalex.org/W2163839352"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}