{"id":"https://openalex.org/W2015759399","doi":"https://doi.org/10.1016/0223-5234(91)90104-u","title":"Analogues of substance P containing an \u03b1-hydroxy, \u03b2-amino acid: synthesis and biological activity","display_name":"Analogues of substance P containing an \u03b1-hydroxy, \u03b2-amino acid: synthesis and biological activity","publication_year":1991,"publication_date":"1991-06-01","ids":{"openalex":"https://openalex.org/W2015759399","doi":"https://doi.org/10.1016/0223-5234(91)90104-u","mag":"2015759399"},"language":"en","primary_location":{"id":"doi:10.1016/0223-5234(91)90104-u","doi":"https://doi.org/10.1016/0223-5234(91)90104-u","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0223-5234(91)90104-u","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084500821","display_name":"Ariel Ewenson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"A Ewenson","raw_affiliation_strings":["Department of Organic The Hebrew University of Jerusalem, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic The Hebrew University of Jerusalem, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111520231","display_name":"R. Laufer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"R Laufer","raw_affiliation_strings":["Department of Biological The Hebrew University of Jerusalem, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological The Hebrew University of Jerusalem, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113642586","display_name":"M. Chorev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"M Chorev","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, The Hebrew University of Jerusalem, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, The Hebrew University of Jerusalem, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021610204","display_name":"Zvi Selinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Z Selinger","raw_affiliation_strings":["Department of Biological The Hebrew University of Jerusalem, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological The Hebrew University of Jerusalem, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019061095","display_name":"Chaim Gilon","orcid":"https://orcid.org/0000-0003-2724-2862","observed_orcids":["https://orcid.org/0000-0003-2724-2862"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"C Gilon","raw_affiliation_strings":["Department of Organic The Hebrew University of Jerusalem, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic The Hebrew University of Jerusalem, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I197251160"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":0.3552,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.47124849,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"4","first_page":"435","last_page":"442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.5562000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.5562000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.43309998512268066,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.9210000038146973},{"id":"https://openalex.org/keywords/4-phenylbutyrate","display_name":"4-phenylbutyric acid","score":0.9409999847412109},{"id":"https://openalex.org/keywords/neuropeptide-analogues","display_name":"neuropeptide analogs","score":0.7260000109672546},{"id":"https://openalex.org/keywords/peptide-synthesis","display_name":"peptide synthesis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/selective-precipitation","display_name":"selective precipitation","score":0.753000020980835},{"id":"https://openalex.org/keywords/diencephalon","display_name":"diencephalon","score":0.8629999756813049},{"id":"https://openalex.org/keywords/spasmogenic-activity","display_name":"spasmogenic activity","score":0.8709999918937683},{"id":"https://openalex.org/keywords/ileum","display_name":"ileum","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9411519765853882},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.6705136299133301},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.5490255951881409},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5260410308837891},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.49403268098831177},{"id":"https://openalex.org/C2779809887","wikidata":"https://www.wikidata.org/wiki/Q14864278","display_name":"Peptide synthesis","level":3,"score":0.43559858202934265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31886616349220276},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2707870602607727}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/0223-5234(91)90104-u","doi":"https://doi.org/10.1016/0223-5234(91)90104-u","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0223-5234(91)90104-u","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1480112484","https://openalex.org/W1982801021","https://openalex.org/W1995917515","https://openalex.org/W1999233231","https://openalex.org/W2002146198","https://openalex.org/W2005000306","https://openalex.org/W2012333045","https://openalex.org/W2035532439","https://openalex.org/W2041127309","https://openalex.org/W2045969451","https://openalex.org/W2058353527","https://openalex.org/W2059295982","https://openalex.org/W2060590560","https://openalex.org/W2070400735","https://openalex.org/W2070426238","https://openalex.org/W2071618583","https://openalex.org/W2075263641","https://openalex.org/W2091943860","https://openalex.org/W2167677186","https://openalex.org/W2173103740","https://openalex.org/W2409675826","https://openalex.org/W4252411364","https://openalex.org/W4300916967"],"related_works":["https://openalex.org/W1995917515","https://openalex.org/W1983662686","https://openalex.org/W2086082584","https://openalex.org/W1975461095","https://openalex.org/W2042611148","https://openalex.org/W2013678982","https://openalex.org/W2010326238","https://openalex.org/W2060590560","https://openalex.org/W2012285213","https://openalex.org/W2050522613"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}