{"id":"https://openalex.org/W2015759207","doi":"https://doi.org/10.1194/jlr.m005041","title":"Glucose regulates fatty acid binding protein interaction with lipids and peroxisome proliferator-activated receptor \u03b1","display_name":"Glucose regulates fatty acid binding protein interaction with lipids and peroxisome proliferator-activated receptor \u03b1","publication_year":2010,"publication_date":"2010-07-14","ids":{"openalex":"https://openalex.org/W2015759207","doi":"https://doi.org/10.1194/jlr.m005041","mag":"2015759207","pmid":"https://pubmed.ncbi.nlm.nih.gov/20628144","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2952551"},"language":"en","primary_location":{"id":"doi:10.1194/jlr.m005041","doi":"https://doi.org/10.1194/jlr.m005041","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m005041","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1194/jlr.m005041","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012136829","display_name":"Heather Ann Hostetler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather A. Hostetler","raw_affiliation_strings":["Departments of Physiology and Pharmacology, Texas A&M University, TVMC, College Station, TX, USA","Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH","Departments of Physiology and Pharmacology, Texas A&M University, TVMC, College Station, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Physiology and Pharmacology, Texas A&M University, TVMC, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH","institution_ids":["https://openalex.org/I19648265"]},{"raw_affiliation_string":"Departments of Physiology and Pharmacology, Texas A&M University, TVMC, College Station, TX","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085920248","display_name":"Madhumitha Balanarasimha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madhumitha Balanarasimha","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH","institution_ids":["https://openalex.org/I19648265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100670326","display_name":"Huan Huang","orcid":"https://orcid.org/0000-0001-5392-2947","observed_orcids":["https://orcid.org/0000-0001-5392-2947"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huan Huang","raw_affiliation_strings":["Departments of Physiology and Pharmacology, Texas A&M University, TVMC, College Station, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Physiology and Pharmacology, Texas A&M University, TVMC, College Station, TX","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086686490","display_name":"Matthew S. Kelzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew S. Kelzer","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH","institution_ids":["https://openalex.org/I19648265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033202760","display_name":"Alagammai Kaliappan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alagammai Kaliappan","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH","institution_ids":["https://openalex.org/I19648265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056901612","display_name":"Ann B. Kier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann B. Kier","raw_affiliation_strings":["Pathobiology, Texas A&M University, TVMC, College Station, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathobiology, Texas A&M University, TVMC, College Station, TX","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046497078","display_name":"Friedhelm Schroeder","orcid":"https://orcid.org/0000-0002-3545-7962","observed_orcids":["https://orcid.org/0000-0002-3545-7962"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Friedhelm Schroeder","raw_affiliation_strings":["Departments of Physiology and Pharmacology, Texas A&M University, TVMC, College Station, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Physiology and Pharmacology, Texas A&M University, TVMC, College Station, TX","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046497078"],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.7698,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.83518355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"51","issue":"11","first_page":"3103","last_page":"3116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-fatty-acid-binding-protein","display_name":"liver fatty acid binding protein","score":0.9639999866485596},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.9089999794960022},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.7350000143051147},{"id":"https://openalex.org/keywords/glucose-1-phosphate","display_name":"glucose-1-phosphate","score":0.9639999866485596},{"id":"https://openalex.org/keywords/long-chain-fatty-acids","display_name":"long-chain fatty acids","score":0.9430000185966492},{"id":"https://openalex.org/keywords/lipid-binding","display_name":"lipid binding","score":0.421999990940094},{"id":"https://openalex.org/keywords/protein-conformation","display_name":"protein conformation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/nuclear-localization","display_name":"nuclear localization","score":0.5759999752044678},{"id":"https://openalex.org/keywords/fatty-acid-uptake","display_name":"fatty acid uptake","score":0.753000020980835},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.7123660445213318},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.6842050552368164},{"id":"https://openalex.org/C2776834966","wikidata":"https://www.wikidata.org/wiki/Q4082494","display_name":"Fatty acid-binding protein","level":3,"score":0.6400213241577148},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.5895296931266785},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.5518966317176819},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5439306497573853},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5325034856796265},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.528069019317627},{"id":"https://openalex.org/C188413054","wikidata":"https://www.wikidata.org/wiki/Q18030677","display_name":"Peroxisome proliferator-activated receptor alpha","level":5,"score":0.5059685111045837},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.5057103633880615},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.44555968046188354},{"id":"https://openalex.org/C21387880","wikidata":"https://www.wikidata.org/wiki/Q24781050","display_name":"Free fatty acid receptor","level":4,"score":0.44202110171318054},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.4274994134902954},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4246366024017334},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.41490834951400757},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3313907980918884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3152623176574707},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.21594664454460144},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.21096152067184448},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.17689961194992065},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.1314258873462677},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10406160354614258}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050556","descriptor_name":"Fatty Acid-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050556","descriptor_name":"Fatty Acid-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1194/jlr.m005041","doi":"https://doi.org/10.1194/jlr.m005041","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m005041","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmid:20628144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20628144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2952551","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2952551/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Lipid Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9442b775be9442e7a9793d9ce6394edb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9442b775be9442e7a9793d9ce6394edb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 51, Iss 11, Pp 3103-3116 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1194/jlr.m005041","doi":"https://doi.org/10.1194/jlr.m005041","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m005041","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3234955387","display_name":"FATTY ACID BINDING PROTEINS-LIGAND SPECIFICITY","funder_award_id":"R01DK041402","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4356733076","display_name":null,"funder_award_id":"DK-77573","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5553133660","display_name":"The role of long chain acyl-CoAs in nuclear receptor regulation","funder_award_id":"R00DK077573","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G657011587","display_name":"The role of long chain acyl-CoAs in nuclear receptor regulation","funder_award_id":"K99DK077573","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1488236903","https://openalex.org/W1505147288","https://openalex.org/W1594613389","https://openalex.org/W1965309337","https://openalex.org/W1967189772","https://openalex.org/W1969026949","https://openalex.org/W1972882325","https://openalex.org/W1978592925","https://openalex.org/W1979383399","https://openalex.org/W1989270637","https://openalex.org/W1995754186","https://openalex.org/W2004044023","https://openalex.org/W2007966392","https://openalex.org/W2009746612","https://openalex.org/W2010728780","https://openalex.org/W2011534687","https://openalex.org/W2033444035","https://openalex.org/W2033786341","https://openalex.org/W2034283257","https://openalex.org/W2037921429","https://openalex.org/W2040545856","https://openalex.org/W2041165301","https://openalex.org/W2041519751","https://openalex.org/W2044919305","https://openalex.org/W2045223517","https://openalex.org/W2057477742","https://openalex.org/W2066342925","https://openalex.org/W2070237777","https://openalex.org/W2071274012","https://openalex.org/W2077212752","https://openalex.org/W2082442877","https://openalex.org/W2098534934","https://openalex.org/W2102594014","https://openalex.org/W2106531102","https://openalex.org/W2112480013","https://openalex.org/W2120282127","https://openalex.org/W2129307092","https://openalex.org/W2136073260","https://openalex.org/W2145547330","https://openalex.org/W2145854759","https://openalex.org/W2150126813","https://openalex.org/W2267701340","https://openalex.org/W4256206092","https://openalex.org/W4301052166","https://openalex.org/W6693144015"],"related_works":["https://openalex.org/W2119196942","https://openalex.org/W3175412858","https://openalex.org/W1999359190","https://openalex.org/W1979383399","https://openalex.org/W1967189772","https://openalex.org/W2098534934","https://openalex.org/W4205755972","https://openalex.org/W2071274012","https://openalex.org/W1992110101","https://openalex.org/W2033786341"],"abstract_inverted_index":{"Although":[0],"the":[1,28,38,49,119,127,145],"pathophysiology":[2],"of":[3,10,51,108,121,133,141,149],"diabetes":[4],"is":[5],"characterized":[6],"by":[7],"elevated":[8],"levels":[9],"glucose":[11,20,52,66,101,134],"and":[12,21,67,75,93,105,139],"long-chain":[13],"fatty":[14,30,112],"acids":[15],"(LCFA),":[16],"nuclear":[17,106],"mechanisms":[18],"linking":[19],"LCFA":[22,36],"metabolism":[23],"are":[24],"poorly":[25],"understood.":[26],"As":[27],"liver":[29],"acid":[31,113],"binding":[32],"protein":[33],"(L-FABP)":[34],"shuttles":[35],"to":[37,144],"nucleus,":[39],"where":[40],"L-FABP":[41,63,86],"directly":[42],"interacts":[43],"with":[44,96],"peroxisome":[45],"proliferator-activated":[46],"receptor-\u03b1":[47],"(PPAR\u03b1),":[48],"effect":[50],"on":[53],"these":[54],"processes":[55],"was":[56],"examined.":[57],"In":[58,98],"vitro":[59],"studies":[60],"showed":[61],"that":[62],"strongly":[64],"bound":[65],"glucose-1-phosphate":[68],"(K(d)":[69],"=":[70,77],"103":[71],"\u00b1":[72,79],"19":[73],"nM":[74],"K(d)":[76],"20":[78],"3":[80],"nM,":[81],"respectively),":[82],"resulting":[83],"in":[84,118,135],"altered":[85],"conformation,":[87],"increased":[88],"affinity":[89],"for":[90,126,147],"lipid":[91],"ligands,":[92],"enhanced":[94],"interaction":[95],"PPAR\u03b1.":[97],"living":[99],"cells,":[100],"stimulated":[102],"cellular":[103],"uptake":[104,138],"localization":[107],"a":[109,130],"nonmetabolizable":[110],"fluorescent":[111],"analog":[114],"(BODIPY":[115],"C-16),":[116],"particularly":[117],"presence":[120],"L-FABP.":[122],"These":[123],"data":[124],"suggest":[125],"first":[128],"time":[129],"direct":[131],"role":[132],"facilitating":[136],"L-FABP-mediated":[137],"distribution":[140],"lipidic":[142],"ligands":[143],"nucleus":[146],"regulation":[148],"PPAR\u03b1":[150],"transcriptional":[151],"activity.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}