{"id":"https://openalex.org/W2015756502","doi":"https://doi.org/10.1021/bi002825r","title":"Analysis of Chimeric Receptors Shows That Multiple Distinct Functional Activities of Scavenger Receptor, Class B, Type I (SR-BI), Are Localized to the Extracellular Receptor Domain","display_name":"Analysis of Chimeric Receptors Shows That Multiple Distinct Functional Activities of Scavenger Receptor, Class B, Type I (SR-BI), Are Localized to the Extracellular Receptor Domain","publication_year":2001,"publication_date":"2001-03-30","ids":{"openalex":"https://openalex.org/W2015756502","doi":"https://doi.org/10.1021/bi002825r","mag":"2015756502","pmid":"https://pubmed.ncbi.nlm.nih.gov/11318648"},"language":"en","primary_location":{"id":"doi:10.1021/bi002825r","doi":"https://doi.org/10.1021/bi002825r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi002825r","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005538765","display_name":"Margery A. Connelly","orcid":"https://orcid.org/0000-0002-3917-592X","observed_orcids":["https://orcid.org/0000-0002-3917-592X"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margery A. Connelly","raw_affiliation_strings":["Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I1335321130","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062835433","display_name":"Margarita de la Llera-Moya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margarita de la Llera-Moya","raw_affiliation_strings":["Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I1335321130","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081825967","display_name":"Pascale Monzo","orcid":"https://orcid.org/0000-0002-0081-3701","observed_orcids":["https://orcid.org/0000-0002-0081-3701"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pascale Monzo","raw_affiliation_strings":["Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I1335321130","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014813522","display_name":"Patricia G. Yancey","orcid":"https://orcid.org/0000-0002-1385-3366","observed_orcids":["https://orcid.org/0000-0002-1385-3366"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia G. Yancey","raw_affiliation_strings":["Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I1335321130","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038649069","display_name":"Denise Drazul\u2010Schrader","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise Drazul","raw_affiliation_strings":["Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I1335321130","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082856853","display_name":"Genevieve W. Stoudt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Genevieve Stoudt","raw_affiliation_strings":["Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I1335321130","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042619536","display_name":"Natalie Fournier","orcid":"https://orcid.org/0000-0002-8172-382X","observed_orcids":["https://orcid.org/0000-0002-8172-382X"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie Fournier","raw_affiliation_strings":["Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I1335321130","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110054509","display_name":"Seth M. Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth M. Klein","raw_affiliation_strings":["Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I1335321130","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110275577","display_name":"George H. Rothblat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George H. Rothblat","raw_affiliation_strings":["Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I1335321130","https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073817473","display_name":"David L. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Williams","raw_affiliation_strings":["Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, and Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I1335321130","https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.2269,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.93166287,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"40","issue":"17","first_page":"5249","last_page":"5259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scavenger-receptor-class-b-type-i","display_name":"scavenger receptor class B type I","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cd36","display_name":"CD36","score":0.8939999938011169},{"id":"https://openalex.org/keywords/chimeric-receptors","display_name":"chimeric receptors","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cholesterol-efflux","display_name":"cholesterol efflux","score":0.8999999761581421},{"id":"https://openalex.org/keywords/extracellular-domain","display_name":"extracellular domain","score":0.8330000042915344},{"id":"https://openalex.org/keywords/plasma-membrane-targeting","display_name":"plasma membrane targeting","score":0.5870000123977661},{"id":"https://openalex.org/keywords/cytoplasmic-tail","display_name":"cytoplasmic tail","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C41443022","wikidata":"https://www.wikidata.org/wiki/Q27796666","display_name":"Scavenger receptor","level":4,"score":0.9616899490356445},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6909627914428711},{"id":"https://openalex.org/C2779828298","wikidata":"https://www.wikidata.org/wiki/Q4035577","display_name":"CD36","level":3,"score":0.6906744241714478},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5977025628089905},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5683802366256714},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5490255951881409},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4629126191139221},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.46099379658699036},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44246286153793335},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4238133728504181},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.4145282506942749},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.3175157606601715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3147044777870178}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002788","descriptor_name":"Cholesterol Esters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018110","descriptor_name":"Receptors, Lipoprotein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018955","descriptor_name":"CD36 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018955","descriptor_name":"CD36 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018955","descriptor_name":"CD36 Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051116","descriptor_name":"Receptors, Scavenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051122","descriptor_name":"Scavenger Receptors, Class B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi002825r","doi":"https://doi.org/10.1021/bi002825r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi002825r","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:11318648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11318648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1928383308","display_name":"Scavenger Receptor BI in Cellular Cholesterol Metabolism","funder_award_id":"R01HL063768","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6455831643","display_name":"Cellular and Molecular Biology of Lipoprotein Metabolism","funder_award_id":"P01HL022633","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7463127805","display_name":"Selective Uptake and Hydrolysis of Cholesteryl Ester by SR-BI","funder_award_id":"R01HL058012","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1523684025","https://openalex.org/W1526016286","https://openalex.org/W1567994665","https://openalex.org/W1574380753","https://openalex.org/W1596816338","https://openalex.org/W1606057223","https://openalex.org/W1775749144","https://openalex.org/W1966609176","https://openalex.org/W1971700135","https://openalex.org/W1985170971","https://openalex.org/W1986963574","https://openalex.org/W1987401504","https://openalex.org/W1988997346","https://openalex.org/W1990720074","https://openalex.org/W1994967652","https://openalex.org/W1995515519","https://openalex.org/W2001995220","https://openalex.org/W2009636256","https://openalex.org/W2010496276","https://openalex.org/W2017905787","https://openalex.org/W2021133118","https://openalex.org/W2022690810","https://openalex.org/W2023426559","https://openalex.org/W2030479102","https://openalex.org/W2049409827","https://openalex.org/W2051134788","https://openalex.org/W2052095497","https://openalex.org/W2062030534","https://openalex.org/W2063358283","https://openalex.org/W2066455377","https://openalex.org/W2073308465","https://openalex.org/W2076490603","https://openalex.org/W2081695716","https://openalex.org/W2083446323","https://openalex.org/W2088800437","https://openalex.org/W2091958625","https://openalex.org/W2095153977","https://openalex.org/W2095365626","https://openalex.org/W2095715909","https://openalex.org/W2112465136","https://openalex.org/W2113504642","https://openalex.org/W2135503869","https://openalex.org/W2141367941","https://openalex.org/W2144760773","https://openalex.org/W2145532583","https://openalex.org/W2147415188","https://openalex.org/W2156818917","https://openalex.org/W2170417134","https://openalex.org/W2186760046","https://openalex.org/W2224266189","https://openalex.org/W2306336891","https://openalex.org/W2324147954","https://openalex.org/W2336481777","https://openalex.org/W2343798913","https://openalex.org/W2398973588","https://openalex.org/W2408988722"],"related_works":["https://openalex.org/W2317344102","https://openalex.org/W2170417134","https://openalex.org/W2100845424","https://openalex.org/W2088800437","https://openalex.org/W7100904602","https://openalex.org/W2128147958","https://openalex.org/W2008470057","https://openalex.org/W2095153977","https://openalex.org/W2062030534","https://openalex.org/W2073567961"],"abstract_inverted_index":{"Scavenger":[0],"receptor":[1,197],"BI":[2],"(SR-BI)":[3],"mediates":[4],"the":[5,24,29,36,63,89,121,137,155,173,196,199,216,227],"selective":[6,149],"uptake":[7],"of":[8,28,39,67,92,111,125,140,157,168,176,205],"high-density":[9],"lipoprotein":[10],"(HDL)":[11],"cholesteryl":[12],"ester":[13],"(CE),":[14],"a":[15,102],"process":[16],"by":[17,88],"which":[18],"HDL":[19,30,116,147],"CE":[20,148],"is":[21,207],"taken":[22],"into":[23],"cell":[25],"without":[26],"degradation":[27],"particle.":[31],"In":[32,99,120],"addition,":[33],"SR-BI":[34,72,131,141,206,228],"stimulates":[35],"bi-directional":[37,151],"flux":[38],"free":[40],"cholesterol":[41,55,76,80,94,97,159],"(FC)":[42],"between":[43],"cells":[44,59],"and":[45,78,129,154,161,182],"lipoproteins,":[46],"an":[47],"activity":[48,210],"that":[49,166],"may":[50],"be":[51],"responsible":[52],"for":[53,142,209,213],"net":[54],"efflux":[56],"from":[57,69],"peripheral":[58],"as":[60,62,86,211],"well":[61,212],"rapid":[64],"hepatic":[65],"clearance":[66],"FC":[68,152],"plasma":[70,83,200,217],"HDL.":[71],"also":[73],"increases":[74],"cellular":[75],"mass":[77,160],"alters":[79],"distribution":[81],"in":[82,190],"membrane":[84,93,158],"domains":[85,139,184],"judged":[87],"enhanced":[90],"sensitivity":[91],"to":[95,135,146,172,186,198,215,226],"extracellular":[96,174,229],"oxidase.":[98],"contrast,":[100],"CD36,":[101],"closely":[103],"related":[104,145],"class":[105],"B":[106],"scavenger":[107],"receptor,":[108],"has":[109],"none":[110],"these":[112,169,191],"activities":[113,144,170,192,223],"despite":[114],"binding":[115],"with":[117],"high":[118],"affinity.":[119],"present":[122],"study,":[123],"analyses":[124],"chimeric":[126],"SR-BI/CD36":[127],"receptors":[128],"domain-deleted":[130],"have":[132],"been":[133],"used":[134],"test":[136],"various":[138],"functional":[143,222],"uptake,":[150],"flux,":[153],"alteration":[156],"distribution.":[162],"The":[163,178,202],"results":[164],"show":[165],"each":[167],"localizes":[171],"domain":[175],"SR-BI.":[177],"N-terminal":[179],"cytoplasmic":[180],"tail":[181,204],"transmembrane":[183],"appear":[185],"play":[187],"no":[188],"role":[189],"other":[193],"than":[194],"targeting":[195,214],"membrane.":[201,218],"C-terminal":[203],"dispensable":[208],"Thus,":[219],"multiple":[220],"distinct":[221],"are":[224],"localized":[225],"domain.":[230]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}