{"id":"https://openalex.org/W2015756087","doi":"https://doi.org/10.1016/j.marenvres.2004.03.047","title":"A comparison of pollutant biomarker responses with transcriptional responses in European flounders (Platicthys flesus) subjected to estuarine pollution","display_name":"A comparison of pollutant biomarker responses with transcriptional responses in European flounders (Platicthys flesus) subjected to estuarine pollution","publication_year":2004,"publication_date":"2004-05-14","ids":{"openalex":"https://openalex.org/W2015756087","doi":"https://doi.org/10.1016/j.marenvres.2004.03.047","mag":"2015756087","pmid":"https://pubmed.ncbi.nlm.nih.gov/15178084"},"language":"en","primary_location":{"id":"doi:10.1016/j.marenvres.2004.03.047","doi":"https://doi.org/10.1016/j.marenvres.2004.03.047","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.marenvres.2004.03.047","pdf_url":null,"source":{"id":"https://openalex.org/S205788060","display_name":"Marine Environmental Research","issn_l":"0141-1136","issn":["0141-1136","1879-0291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Environmental Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Stephen George","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12093191","display_name":"University of Stirling","ror":"https://ror.org/045wgfr59","country_code":"GB","type":"education","lineage":["https://openalex.org/I12093191"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Stephen George","raw_affiliation_strings":["Institute of Aquaculture, University of Stirling, Stirling, Scotland FK9 4LA, UK. S.G.George@stir.ac.uk","Institute of Aquaculture; University of Stirling; Stirling Scotland FK9 4LA UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Aquaculture, University of Stirling, Stirling, Scotland FK9 4LA, UK. S.G.George@stir.ac.uk","institution_ids":["https://openalex.org/I12093191"]},{"raw_affiliation_string":"Institute of Aquaculture; University of Stirling; Stirling Scotland FK9 4LA UK","institution_ids":["https://openalex.org/I12093191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113435825","display_name":"M. Gubbins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152533","display_name":"Fisheries Research Services","ror":"https://ror.org/02g5zab91","country_code":"GB","type":"government","lineage":["https://openalex.org/I1289431368","https://openalex.org/I4387152533"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Gubbins","raw_affiliation_strings":["FRS Marine laboratory, Aberdeen, AB11 9DB, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FRS Marine laboratory, Aberdeen, AB11 9DB, Scotland, UK","institution_ids":["https://openalex.org/I4387152533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008153450","display_name":"Amy E. MacIntosh","orcid":"https://orcid.org/0000-0001-8438-7713","observed_orcids":["https://orcid.org/0000-0001-8438-7713"]},"institutions":[{"id":"https://openalex.org/I4387152533","display_name":"Fisheries Research Services","ror":"https://ror.org/02g5zab91","country_code":"GB","type":"government","lineage":["https://openalex.org/I1289431368","https://openalex.org/I4387152533"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. MacIntosh","raw_affiliation_strings":["FRS Marine laboratory, Aberdeen, AB11 9DB, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FRS Marine laboratory, Aberdeen, AB11 9DB, Scotland, UK","institution_ids":["https://openalex.org/I4387152533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028718591","display_name":"William J. Reynolds","orcid":"https://orcid.org/0000-0002-6472-5110","observed_orcids":["https://orcid.org/0000-0002-6472-5110"]},"institutions":[{"id":"https://openalex.org/I1332124652","display_name":"Centre for Environment, Fisheries and Aquaculture Science","ror":"https://ror.org/04r7rxc53","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1326803253","https://openalex.org/I1332124652","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W. Reynolds","raw_affiliation_strings":["CEFAS, Burnham-on-Crouch, CMO 8HA, England, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEFAS, Burnham-on-Crouch, CMO 8HA, England, UK","institution_ids":["https://openalex.org/I1332124652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109161081","display_name":"Victoria Saranne Sabine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12093191","display_name":"University of Stirling","ror":"https://ror.org/045wgfr59","country_code":"GB","type":"education","lineage":["https://openalex.org/I12093191"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"V. Sabine","raw_affiliation_strings":["Institute of Aquaculture, University of Stirling, Stirling, Scotland FK9 4LA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Aquaculture, University of Stirling, Stirling, Scotland FK9 4LA, UK","institution_ids":["https://openalex.org/I12093191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030100165","display_name":"Alexander P. Scott","orcid":"https://orcid.org/0000-0002-5540-1317","observed_orcids":["https://orcid.org/0000-0002-5540-1317"]},"institutions":[{"id":"https://openalex.org/I1332124652","display_name":"Centre for Environment, Fisheries and Aquaculture Science","ror":"https://ror.org/04r7rxc53","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1326803253","https://openalex.org/I1332124652","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Scott","raw_affiliation_strings":["CEFAS, Weymouth DT4 8UB, England, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEFAS, Weymouth DT4 8UB, England, UK","institution_ids":["https://openalex.org/I1332124652"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110238416","display_name":"J. Thain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1332124652","display_name":"Centre for Environment, Fisheries and Aquaculture Science","ror":"https://ror.org/04r7rxc53","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1326803253","https://openalex.org/I1332124652","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Thain","raw_affiliation_strings":["CEFAS, Burnham-on-Crouch, CMO 8HA, England, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEFAS, Burnham-on-Crouch, CMO 8HA, England, UK","institution_ids":["https://openalex.org/I1332124652"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12093191"],"apc_list":{"value":3440,"currency":"USD","value_usd":3440},"apc_paid":null,"fwci":4.099,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.93672129,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"58","issue":"2-5","first_page":"571","last_page":"575"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/european-flounder","display_name":"European flounder","score":0.7950000166893005},{"id":"https://openalex.org/keywords/estuarine-pollution","display_name":"estuarine pollution","score":0.9679999947547913},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.902999997138977},{"id":"https://openalex.org/keywords/heavy-metals","display_name":"heavy metals","score":0.9959999918937683},{"id":"https://openalex.org/keywords/estrogenic-compounds","display_name":"estrogenic compounds","score":0.9789999723434448},{"id":"https://openalex.org/keywords/vitellogenin","display_name":"vitellogenin","score":0.8190000057220459},{"id":"https://openalex.org/keywords/metallothionein","display_name":"metallothionein","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cyp1a","display_name":"CYP1A","score":0.7739999890327454},{"id":"https://openalex.org/keywords/ethoxyresorufin-o-deethylase","display_name":"ethoxyresorufin-O-deethylase","score":0.6320000290870667},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6869999766349792},{"id":"https://openalex.org/keywords/mrna-induction","display_name":"mRNA induction","score":0.5220000147819519},{"id":"https://openalex.org/keywords/tyne-estuary","display_name":"Tyne estuary","score":0.824999988079071},{"id":"https://openalex.org/keywords/fish-biomonitoring","display_name":"fish biomonitoring","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2779078696","wikidata":"https://www.wikidata.org/wiki/Q83134957","display_name":"Vitellogenin","level":3,"score":0.8154712915420532},{"id":"https://openalex.org/C82685317","wikidata":"https://www.wikidata.org/wiki/Q19829510","display_name":"Pollutant","level":2,"score":0.7809073328971863},{"id":"https://openalex.org/C109051061","wikidata":"https://www.wikidata.org/wiki/Q864610","display_name":"Biomonitoring","level":2,"score":0.7524539232254028},{"id":"https://openalex.org/C20719415","wikidata":"https://www.wikidata.org/wiki/Q416896","display_name":"Metallothionein","level":3,"score":0.604203462600708},{"id":"https://openalex.org/C88160329","wikidata":"https://www.wikidata.org/wiki/Q47053","display_name":"Estuary","level":2,"score":0.5860157608985901},{"id":"https://openalex.org/C521259446","wikidata":"https://www.wikidata.org/wiki/Q58734","display_name":"Pollution","level":2,"score":0.5429418683052063},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.5140989422798157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5125769972801208},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.34771424531936646},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.3326858878135681},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.3285413980484009},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.31786203384399414},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24479487538337708},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.21307256817817688},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20745310187339783},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10690364241600037}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004784","descriptor_name":"Environmental Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005432","descriptor_name":"Flounder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005432","descriptor_name":"Flounder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008668","descriptor_name":"Metallothionein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011084","descriptor_name":"Polycyclic Aromatic Hydrocarbons","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011084","descriptor_name":"Polycyclic Aromatic Hydrocarbons","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012623","descriptor_name":"Seawater","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014819","descriptor_name":"Vitellogenins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014819","descriptor_name":"Vitellogenins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019216","descriptor_name":"Metals, Heavy","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019216","descriptor_name":"Metals, Heavy","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D019363","descriptor_name":"Cytochrome P-450 CYP1A1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.marenvres.2004.03.047","doi":"https://doi.org/10.1016/j.marenvres.2004.03.047","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.marenvres.2004.03.047","pdf_url":null,"source":{"id":"https://openalex.org/S205788060","display_name":"Marine Environmental Research","issn_l":"0141-1136","issn":["0141-1136","1879-0291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Environmental Research","raw_type":"journal-article"},{"id":"pmid:15178084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15178084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine environmental research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","display_name":"Life below water","score":0.5769000053405762}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319995","display_name":"Department for Environment, Food and Rural Affairs, UK Government","ror":"https://ror.org/00tnppw48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W1965536658","https://openalex.org/W2037207398","https://openalex.org/W2110871998","https://openalex.org/W4301666475"],"related_works":["https://openalex.org/W2077897788","https://openalex.org/W2411233695","https://openalex.org/W2051912861","https://openalex.org/W263377308","https://openalex.org/W3045512468","https://openalex.org/W1991013755","https://openalex.org/W2024502335","https://openalex.org/W1974357589","https://openalex.org/W2065904691","https://openalex.org/W2007463085"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}