{"id":"https://openalex.org/W2015754725","doi":"https://doi.org/10.1126/science.1228190","title":"Evolution of an MCM Complex in Flies That Promotes Meiotic Crossovers by Blocking BLM Helicase","display_name":"Evolution of an MCM Complex in Flies That Promotes Meiotic Crossovers by Blocking BLM Helicase","publication_year":2012,"publication_date":"2012-12-06","ids":{"openalex":"https://openalex.org/W2015754725","doi":"https://doi.org/10.1126/science.1228190","mag":"2015754725","pmid":"https://pubmed.ncbi.nlm.nih.gov/23224558","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3599781"},"language":"en","primary_location":{"id":"doi:10.1126/science.1228190","doi":"https://doi.org/10.1126/science.1228190","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1228190","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3599781","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023382934","display_name":"Kathryn P. Kohl","orcid":"https://orcid.org/0009-0004-5738-5105","observed_orcids":["https://orcid.org/0009-0004-5738-5105"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn P. Kohl","raw_affiliation_strings":["Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091112024","display_name":"Corbin D. Jones","orcid":"https://orcid.org/0000-0001-7281-7130","observed_orcids":["https://orcid.org/0000-0001-7281-7130"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corbin D. Jones","raw_affiliation_strings":["Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA","Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020880841","display_name":"Jeff J. Sekelsky","orcid":"https://orcid.org/0000-0002-4424-677X","observed_orcids":["https://orcid.org/0000-0002-4424-677X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeff Sekelsky","raw_affiliation_strings":["Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA","Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA","Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020880841"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":1.3916,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.7930436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"338","issue":"6112","first_page":"1363","last_page":"1365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meiotic-crossover","display_name":"meiotic crossover","score":0.8550000190734863},{"id":"https://openalex.org/keywords/mcm-proteins","display_name":"MCM proteins","score":0.7369999885559082},{"id":"https://openalex.org/keywords/blm-helicase","display_name":"BLM helicase","score":0.9110000133514404},{"id":"https://openalex.org/keywords/rec","display_name":"REC","score":0.5080000162124634},{"id":"https://openalex.org/keywords/mcm8","display_name":"MCM8","score":0.8069999814033508},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7519999742507935},{"id":"https://openalex.org/keywords/tsetse-flies","display_name":"tsetse flies","score":0.9929999709129333},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.5849999785423279},{"id":"https://openalex.org/keywords/evolution-of-meiosis","display_name":"evolution of meiosis","score":0.5720000267028809},{"id":"https://openalex.org/keywords/minichromosome-maintenance-complex","display_name":"minichromosome maintenance complex","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.6612000465393066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5600254535675049},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.5084506273269653},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48140859603881836},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.47320741415023804},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.44592323899269104},{"id":"https://openalex.org/C2779012473","wikidata":"https://www.wikidata.org/wiki/Q3235015","display_name":"RAD51","level":4,"score":0.42313557863235474},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32485276460647583},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003434","descriptor_name":"Crossing Over, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008540","descriptor_name":"Meiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014370","descriptor_name":"Tsetse Flies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1126/science.1228190","doi":"https://doi.org/10.1126/science.1228190","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1228190","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:23224558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23224558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2672253","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3599781","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3599781","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3599781","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"},{"id":"pmh:cdr.lib.unc.edu:p8418w618","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/vjsy-3309","pdf_url":"https://doi.org/10.17615/vjsy-3309","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Science, 338(6112)","raw_type":"Article"},{"id":"doi:10.17615/vjsy-3309","doi":"https://doi.org/10.17615/vjsy-3309","is_oa":true,"landing_page_url":"https://doi.org/10.17615/vjsy-3309","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2672253","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3599781","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3080255316","display_name":null,"funder_award_id":"5T32GM007092","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3757727673","display_name":"NRSA in Genetics","funder_award_id":"T32GM007092","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6384841310","display_name":"An Integrative Analysis of Gene Conversion","funder_award_id":"0618691","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7800027270","display_name":"Meiotic Recombination in Drosophila","funder_award_id":"R01GM061252","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015754725.pdf","grobid_xml":"https://content.openalex.org/works/W2015754725.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W791550880","https://openalex.org/W1755033191","https://openalex.org/W1903792504","https://openalex.org/W1920973730","https://openalex.org/W1927391337","https://openalex.org/W1968676497","https://openalex.org/W1969664012","https://openalex.org/W1985112184","https://openalex.org/W1994589056","https://openalex.org/W1995939500","https://openalex.org/W2002131406","https://openalex.org/W2002748750","https://openalex.org/W2020311094","https://openalex.org/W2035424802","https://openalex.org/W2037993016","https://openalex.org/W2040469309","https://openalex.org/W2060259273","https://openalex.org/W2062018285","https://openalex.org/W2064414941","https://openalex.org/W2069050874","https://openalex.org/W2070499603","https://openalex.org/W2070550063","https://openalex.org/W2077841551","https://openalex.org/W2092749739","https://openalex.org/W2099487576","https://openalex.org/W2110335151","https://openalex.org/W2114171007","https://openalex.org/W2122271166","https://openalex.org/W2132632499","https://openalex.org/W2132926880","https://openalex.org/W2135332716","https://openalex.org/W2136144795","https://openalex.org/W2140360876","https://openalex.org/W2141292631","https://openalex.org/W2141652419","https://openalex.org/W2143876129","https://openalex.org/W2144066733","https://openalex.org/W2155362972","https://openalex.org/W2158874089","https://openalex.org/W2166238348","https://openalex.org/W2992898155"],"related_works":["https://openalex.org/W2976711172","https://openalex.org/W4238947715","https://openalex.org/W2064414941","https://openalex.org/W2941416622","https://openalex.org/W2743448862","https://openalex.org/W2566672350","https://openalex.org/W2133728431","https://openalex.org/W2071464739","https://openalex.org/W2964507669","https://openalex.org/W2303717154"],"abstract_inverted_index":{"Generation":[0],"of":[1,10,38,53,90,113],"meiotic":[2,110],"crossovers":[3,78],"in":[4,61,81,115],"many":[5],"eukaryotes":[6],"requires":[7],"the":[8,15,28,91,109],"elimination":[9],"anti-crossover":[11],"activities":[12],"by":[13],"using":[14],"Msh4-Msh5":[16,114],"heterodimer":[17],"to":[18],"block":[19],"helicases.":[20],"Msh4":[21],"and":[22,31,66,85],"Msh5":[23],"have":[24],"been":[25],"lost":[26],"from":[27,70],"flies":[29],"Drosophila":[30,82],"Glossina,":[32],"but":[33],"we":[34],"identified":[35],"a":[36,71,104],"complex":[37,106],"minichromosome":[39],"maintenance":[40],"(MCM)":[41],"proteins":[42],"that":[43,49,55,107],"functionally":[44],"replace":[45],"Msh4-Msh5.":[46],"We":[47],"found":[48],"REC,":[50],"an":[51],"ortholog":[52,96],"MCM8":[54],"evolved":[56],"under":[57],"strong":[58],"positive":[59],"selection":[60],"flies,":[62],"interacts":[63],"with":[64],"MEI-217":[65],"MEI-218,":[67],"which":[68],"arose":[69],"previously":[72],"undescribed":[73],"metazoan-specific":[74],"MCM":[75],"protein.":[76],"Meiotic":[77],"were":[79,101],"reduced":[80],"rec,":[83],"mei-217,":[84],"mei-218":[86],"mutants;":[87],"however,":[88],"removal":[89],"Bloom":[92],"syndrome":[93],"helicase":[94],"(BLM)":[95],"restored":[97],"crossovers.":[98],"Thus,":[99],"MCMs":[100],"co-opted":[102],"into":[103],"novel":[105],"replaced":[108],"pro-crossover":[111],"function":[112],"flies.":[116]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
