{"id":"https://openalex.org/W2015746396","doi":"https://doi.org/10.1074/jbc.m109812200","title":"Phosphorylation by Mitogen-activated Protein Kinase Mediates the Hypoxia-induced Turnover of the TAL1/SCL Transcription Factor in Endothelial Cells","display_name":"Phosphorylation by Mitogen-activated Protein Kinase Mediates the Hypoxia-induced Turnover of the TAL1/SCL Transcription Factor in Endothelial Cells","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W2015746396","doi":"https://doi.org/10.1074/jbc.m109812200","mag":"2015746396","pmid":"https://pubmed.ncbi.nlm.nih.gov/11904294"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m109812200","doi":"https://doi.org/10.1074/jbc.m109812200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109812200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m109812200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088016802","display_name":"Tong Tang","orcid":"https://orcid.org/0000-0003-1657-612X","observed_orcids":["https://orcid.org/0000-0003-1657-612X"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tong Tang","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA","Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004887935","display_name":"Jack L. Arbiser","orcid":"https://orcid.org/0000-0002-6798-6383","observed_orcids":["https://orcid.org/0000-0002-6798-6383"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack L. Arbiser","raw_affiliation_strings":["Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103504978","display_name":"Stephen J. Brandt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101790","display_name":"VA Tennessee Valley Healthcare System","ror":"https://ror.org/01c9rqr26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210112672"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen J. Brandt","raw_affiliation_strings":["Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232","Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232","Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232","Veterans Affairs Tennessee Valley Health Care System, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Veterans Affairs Tennessee Valley Health Care System, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I4210101790"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5103504978"],"corresponding_institution_ids":["https://openalex.org/I4210101790","https://openalex.org/I4390039299","https://openalex.org/I901861585"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.0427,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.73511322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"277","issue":"21","first_page":"18365","last_page":"18372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7720000147819519},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.9539999961853027},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/protein-turnover","display_name":"protein turnover","score":0.746999979019165},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/microvascular-endothelium","display_name":"microvascular endothelium","score":0.871999979019165},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/transcription-factor-regulation","display_name":"transcription factor regulation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/bhlh-transcription-factors","display_name":"bHLH transcription factors","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6060763597488403},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5454583168029785},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5402272939682007},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5083968043327332},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4934772253036499},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48950135707855225},{"id":"https://openalex.org/C20291555","wikidata":"https://www.wikidata.org/wiki/Q4677462","display_name":"Activating transcription factor 2","level":5,"score":0.4894062578678131},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.4873824715614319},{"id":"https://openalex.org/C57467964","wikidata":"https://www.wikidata.org/wiki/Q14888082","display_name":"Sp1 transcription factor","level":5,"score":0.46632319688796997},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4327143132686615},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3549794554710388},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2590002417564392},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18243548274040222},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.16260918974876404},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1110433042049408},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0875481367111206},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.053677886724472046},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073942","descriptor_name":"T-Cell Acute Lymphocytic Leukemia Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m109812200","doi":"https://doi.org/10.1074/jbc.m109812200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109812200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11904294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11904294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m109812200","doi":"https://doi.org/10.1074/jbc.m109812200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109812200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6000000238418579}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2316747042","display_name":"Regulation and Function of the TAL1/SCL Gene","funder_award_id":"R01HL049118","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W93459703","https://openalex.org/W103874031","https://openalex.org/W122007457","https://openalex.org/W1232714476","https://openalex.org/W1487917997","https://openalex.org/W1528493806","https://openalex.org/W1542461926","https://openalex.org/W1562891803","https://openalex.org/W1568017411","https://openalex.org/W1575638464","https://openalex.org/W1725765893","https://openalex.org/W1768681792","https://openalex.org/W1852214165","https://openalex.org/W1855397569","https://openalex.org/W1883936019","https://openalex.org/W1965372133","https://openalex.org/W1971915141","https://openalex.org/W1974870158","https://openalex.org/W1975003600","https://openalex.org/W1976195850","https://openalex.org/W1977290507","https://openalex.org/W1979964213","https://openalex.org/W1980692339","https://openalex.org/W1988351397","https://openalex.org/W1988838983","https://openalex.org/W1991738330","https://openalex.org/W1993243592","https://openalex.org/W1993593600","https://openalex.org/W1993983676","https://openalex.org/W1999047431","https://openalex.org/W2000624133","https://openalex.org/W2002223631","https://openalex.org/W2006136518","https://openalex.org/W2006447473","https://openalex.org/W2007694332","https://openalex.org/W2010348699","https://openalex.org/W2014575049","https://openalex.org/W2026778256","https://openalex.org/W2027955308","https://openalex.org/W2035936653","https://openalex.org/W2037856863","https://openalex.org/W2040762618","https://openalex.org/W2044864383","https://openalex.org/W2051740914","https://openalex.org/W2052071780","https://openalex.org/W2053544423","https://openalex.org/W2056521686","https://openalex.org/W2056877227","https://openalex.org/W2072692438","https://openalex.org/W2084011487","https://openalex.org/W2088380653","https://openalex.org/W2088692721","https://openalex.org/W2093846063","https://openalex.org/W2094509668","https://openalex.org/W2100837269","https://openalex.org/W2101466764","https://openalex.org/W2102526923","https://openalex.org/W2108916224","https://openalex.org/W2114483489","https://openalex.org/W2119121495","https://openalex.org/W2123885531","https://openalex.org/W2124732783","https://openalex.org/W2127754721","https://openalex.org/W2129007308","https://openalex.org/W2130239016","https://openalex.org/W2135836641","https://openalex.org/W2136855254","https://openalex.org/W2141020349","https://openalex.org/W2146651717","https://openalex.org/W2147921405","https://openalex.org/W2148686400","https://openalex.org/W2151537482","https://openalex.org/W2153071240","https://openalex.org/W2155884728","https://openalex.org/W2164461769","https://openalex.org/W2171046697","https://openalex.org/W2274586609","https://openalex.org/W2319136912","https://openalex.org/W2331070544","https://openalex.org/W2404288294","https://openalex.org/W2413098316","https://openalex.org/W2414377504","https://openalex.org/W2419175081","https://openalex.org/W2462390863","https://openalex.org/W2467916015"],"related_works":["https://openalex.org/W2068413770","https://openalex.org/W2135854114","https://openalex.org/W2108765715","https://openalex.org/W3200727805","https://openalex.org/W2084011487","https://openalex.org/W2065666078","https://openalex.org/W2414377504","https://openalex.org/W3202470225","https://openalex.org/W2060504290","https://openalex.org/W1968434665"],"abstract_inverted_index":{"The":[0],"basic":[1],"helix-loop-helix":[2],"transcription":[3,179],"factor":[4,180],"TAL1":[5,27,73,115,126,140,153],"(or":[6],"SCL),":[7],"originally":[8],"identified":[9],"from":[10,133],"its":[11,49],"involvement":[12],"by":[13],"a":[14,30,94,162,178],"chromosomal":[15],"rearrangement":[16],"in":[17,33,40,53,74,99,117,130,145,155,172],"T-cell":[18],"acute":[19],"lymphoblastic":[20],"leukemia,":[21],"is":[22,38,46,169],"required":[23],"for":[24,111,152,166,181],"hematopoietic":[25],"development.":[26],"also":[28,170],"has":[29],"critical":[31],"role":[32],"embryonic":[34],"vascular":[35],"remodeling":[36],"and":[37,69,80,102,136],"expressed":[39],"endothelial":[41,75,121,131,147,174],"cells":[42,132,175],"postnatally,":[43],"although":[44],"little":[45],"known":[47],"about":[48],"function":[50,154],"or":[51],"regulation":[52],"this":[54],"cell":[55,122],"type.":[56],"We":[57],"report":[58],"here":[59],"that":[60,85,106,161],"the":[61,88,100],"important":[62,165],"proangiogenic":[63],"stimulus":[64],"hypoxia":[65,86],"stimulates":[66],"phosphorylation,":[67],"ubiquitination,":[68],"proteasomal":[70],"breakdown":[71],"of":[72,93,114],"cells.":[76,148],"Tryptic":[77],"phosphopeptide":[78],"mapping":[79],"chemical":[81],"inhibitor":[82],"studies":[83],"showed":[84],"induced":[87],"mitogen-activated":[89],"protein":[90,163],"kinase-mediated":[91],"phosphorylation":[92,108],"single":[95],"serine":[96],"residue,":[97],"Ser(122),":[98],"protein,":[101],"site-directed":[103],"mutagenesis":[104],"demonstrated":[105],"Ser(122)":[107],"was":[109,128,142],"necessary":[110],"hypoxic":[112,173],"acceleration":[113],"turnover":[116,141],"an":[118],"immortalized":[119],"murine":[120],"line.":[123],"Finally,":[124],"whereas":[125],"expression":[127],"detected":[129],"both":[134],"large":[135],"small":[137],"vessels,":[138],"hypoxia-induced":[139],"observed":[143],"only":[144],"microvascular":[146],"Besides":[149],"their":[150],"implications":[151],"angiogenic":[156],"processes,":[157],"these":[158],"results":[159],"demonstrate":[160],"kinase(s)":[164],"mitogenic":[167],"signaling":[168],"utilized":[171],"to":[176],"target":[177],"destruction.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}