{"id":"https://openalex.org/W2015738775","doi":"https://doi.org/10.1016/j.jconrel.2006.01.011","title":"Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB","display_name":"Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB","publication_year":2006,"publication_date":"2006-03-04","ids":{"openalex":"https://openalex.org/W2015738775","doi":"https://doi.org/10.1016/j.jconrel.2006.01.011","mag":"2015738775","pmid":"https://pubmed.ncbi.nlm.nih.gov/16516328","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2572756"},"language":"en","primary_location":{"id":"doi:10.1016/j.jconrel.2006.01.011","doi":"https://doi.org/10.1016/j.jconrel.2006.01.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2006.01.011","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2572756","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053771398","display_name":"Guobao Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guobao Wei","raw_affiliation_strings":["Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2209, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2209, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046679612","display_name":"Qiming Jin","orcid":"https://orcid.org/0000-0002-2277-2234","observed_orcids":["https://orcid.org/0000-0002-2277-2234","https://orcid.org/0000-0001-9945-8596"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiming Jin","raw_affiliation_strings":["Department of Periodontics/Prevention/Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics/Prevention/Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044774272","display_name":"William V. Giannobile","orcid":"https://orcid.org/0000-0002-7102-9746","observed_orcids":["https://orcid.org/0000-0002-7102-9746"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William V. Giannobile","raw_affiliation_strings":["Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2209, USA","Department of Periodontics/Prevention/Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2209, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Periodontics/Prevention/Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068805457","display_name":"Peter X. Ma","orcid":"https://orcid.org/0000-0002-0191-9487","observed_orcids":["https://orcid.org/0000-0002-0191-9487","https://orcid.org/0000-0002-7264-1443"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter X. Ma","raw_affiliation_strings":["Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109-1078, USA","Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2209, USA","Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109-1055, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109-1078, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2209, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109-1055, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068805457"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":4440,"currency":"USD","value_usd":4440},"apc_paid":null,"fwci":7.9699,"has_fulltext":false,"cited_by_count":211,"citation_normalized_percentile":{"value":0.98180905,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"112","issue":"1","first_page":"103","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pdgf-bb","display_name":"PDGF-BB","score":0.9620000123977661},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.6489999890327454},{"id":"https://openalex.org/keywords/growth-factor-delivery","display_name":"growth factor delivery","score":0.7730000019073486},{"id":"https://openalex.org/keywords/plga-microspheres","display_name":"PLGA microspheres","score":0.9570000171661377},{"id":"https://openalex.org/keywords/poly-l-lactic-acid","display_name":"poly(L-lactic acid)","score":0.6549999713897705},{"id":"https://openalex.org/keywords/biodegradable-scaffolds","display_name":"biodegradable scaffolds","score":0.8119999766349792},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7300000190734863},{"id":"https://openalex.org/keywords/burst-release","display_name":"burst release","score":0.9089999794960022},{"id":"https://openalex.org/keywords/gingival-fibroblasts","display_name":"gingival fibroblasts","score":0.8690000176429749},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.6610000133514404},{"id":"https://openalex.org/keywords/macroporous-structure","display_name":"macroporous structure","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.8435360789299011},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.6215797066688538},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5765789747238159},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.5752867460250854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4705486595630646},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4532738924026489},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.4520617723464966},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4431212246417999},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4066341519355774},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3899446129798889},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37825408577919006},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.2127569317817688},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15959078073501587},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05781453847885132},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077214","descriptor_name":"Becaplermin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020574","descriptor_name":"Proto-Oncogene Proteins c-sis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jconrel.2006.01.011","doi":"https://doi.org/10.1016/j.jconrel.2006.01.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2006.01.011","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},{"id":"pmid:16516328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16516328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of controlled release : official journal of the Controlled Release Society","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:2572756","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2572756","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Control Release","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2572756","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2572756","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Control Release","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3372933665","display_name":null,"funder_award_id":"DE 14755","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G4151940712","display_name":null,"funder_award_id":"DE13397","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G4425714299","display_name":null,"funder_award_id":"DE 15384","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G6028181279","display_name":"Biomimetic Nano Scaffolds","funder_award_id":"R21DE014755","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G6699045480","display_name":"Periodontal Engineering Using Biomimetic Nano Scaffolds","funder_award_id":"R01DE015384","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G8299534768","display_name":"Gene Therapy for Reconstructing Periodontal Tissues","funder_award_id":"R01DE013397","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W142867979","https://openalex.org/W1539664785","https://openalex.org/W1540362869","https://openalex.org/W1762724222","https://openalex.org/W1968528332","https://openalex.org/W1973699894","https://openalex.org/W1976061000","https://openalex.org/W1976937182","https://openalex.org/W1978585883","https://openalex.org/W1982775861","https://openalex.org/W1987659386","https://openalex.org/W1990551908","https://openalex.org/W1994806013","https://openalex.org/W1999619609","https://openalex.org/W2006047728","https://openalex.org/W2008465505","https://openalex.org/W2010777478","https://openalex.org/W2011528197","https://openalex.org/W2029137365","https://openalex.org/W2031725813","https://openalex.org/W2035817691","https://openalex.org/W2035896672","https://openalex.org/W2038843643","https://openalex.org/W2043657312","https://openalex.org/W2047833244","https://openalex.org/W2056004690","https://openalex.org/W2058795497","https://openalex.org/W2061479972","https://openalex.org/W2063671183","https://openalex.org/W2065100403","https://openalex.org/W2071807277","https://openalex.org/W2082087069","https://openalex.org/W2091232977","https://openalex.org/W2093547688","https://openalex.org/W2098799479","https://openalex.org/W2120856340","https://openalex.org/W2121592873","https://openalex.org/W2126607218","https://openalex.org/W2152840072","https://openalex.org/W2153389583","https://openalex.org/W2162294498","https://openalex.org/W2163245582","https://openalex.org/W2415099945"],"related_works":["https://openalex.org/W2090784789","https://openalex.org/W2073260359","https://openalex.org/W203191812","https://openalex.org/W825797924","https://openalex.org/W2374496753","https://openalex.org/W74736635","https://openalex.org/W3177089580","https://openalex.org/W4205460591","https://openalex.org/W2971955957","https://openalex.org/W2029279493"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}