{"id":"https://openalex.org/W2015724165","doi":"https://doi.org/10.1016/0006-8993(93)90661-6","title":"Dopaminergic neuron B20 generates rhythmic neuronal activity in the feeding motor circuitry ofAplysia","display_name":"Dopaminergic neuron B20 generates rhythmic neuronal activity in the feeding motor circuitry ofAplysia","publication_year":1993,"publication_date":"1993-12-01","ids":{"openalex":"https://openalex.org/W2015724165","doi":"https://doi.org/10.1016/0006-8993(93)90661-6","mag":"2015724165","pmid":"https://pubmed.ncbi.nlm.nih.gov/8118689"},"language":"en","primary_location":{"id":"doi:10.1016/0006-8993(93)90661-6","doi":"https://doi.org/10.1016/0006-8993(93)90661-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0006-8993(93)90661-6","pdf_url":"https://www.sciencedirect.com/science/article/pii/0006899393906616/pdf","source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/0006899393906616/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050713716","display_name":"Thomas Teyke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Teyke","raw_affiliation_strings":["Center for Neurobiology and Behavior, College of Physicians and Surgeons Columbia University, New York, NY","Center for Neurobiology and Behavior, College of Physicians and Surgeons Columbia University, 722 West 168th Street \u2014 Research Annex, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurobiology and Behavior, College of Physicians and Surgeons Columbia University, New York, NY","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Center for Neurobiology and Behavior, College of Physicians and Surgeons Columbia University, 722 West 168th Street \u2014 Research Annex, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109234180","display_name":"Steven C. Rosen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven C. Rosen","raw_affiliation_strings":["Center for Neurobiology and Behavior, College of Physicians and Surgeons Columbia University, 722 West 168th Street \u2014 Research Annex, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurobiology and Behavior, College of Physicians and Surgeons Columbia University, 722 West 168th Street \u2014 Research Annex, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074307739","display_name":"Klaudiusz R. Weiss","orcid":"https://orcid.org/0000-0001-6887-2719","observed_orcids":["https://orcid.org/0000-0001-6887-2719"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Klaudiusz R. Weiss","raw_affiliation_strings":["Center for Neurobiology and Behavior, College of Physicians and Surgeons Columbia University, 722 West 168th Street \u2014 Research Annex, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurobiology and Behavior, College of Physicians and Surgeons Columbia University, 722 West 168th Street \u2014 Research Annex, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021940878","display_name":"Irving Kupfermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Irving Kupfermann","raw_affiliation_strings":["Center for Neurobiology and Behavior, College of Physicians and Surgeons Columbia University, 722 West 168th Street \u2014 Research Annex, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurobiology and Behavior, College of Physicians and Surgeons Columbia University, 722 West 168th Street \u2014 Research Annex, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021940878"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":{"value":3360,"currency":"USD","value_usd":3360},"fwci":0.5437,"has_fulltext":true,"cited_by_count":112,"citation_normalized_percentile":{"value":0.58150345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"630","issue":"1-2","first_page":"226","last_page":"237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.24150000512599945,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.043699998408555984,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aplysia","display_name":"Aplysia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.6169999837875366},{"id":"https://openalex.org/keywords/central-pattern-generator","display_name":"central pattern generator","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ergonovine","display_name":"ergonovine","score":0.972000002861023},{"id":"https://openalex.org/keywords/dopamine-receptor-antagonists","display_name":"dopamine antagonists","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8092135190963745},{"id":"https://openalex.org/C2778178740","wikidata":"https://www.wikidata.org/wiki/Q136564","display_name":"Aplysia","level":2,"score":0.747300386428833},{"id":"https://openalex.org/C169453685","wikidata":"https://www.wikidata.org/wiki/Q1054066","display_name":"Central pattern generator","level":3,"score":0.6278680562973022},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6274538040161133},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5904628038406372},{"id":"https://openalex.org/C2776752467","wikidata":"https://www.wikidata.org/wiki/Q1133903","display_name":"Motor neuron","level":3,"score":0.5795235633850098},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.5784688591957092},{"id":"https://openalex.org/C195735259","wikidata":"https://www.wikidata.org/wiki/Q16963239","display_name":"Buccal administration","level":2,"score":0.5328992009162903},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.5008854866027832},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4642418622970581},{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.4136372208595276},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.4125382602214813},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3268490433692932},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24340718984603882},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.14707502722740173},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1273033618927002},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.12081471085548401},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001048","descriptor_name":"Aplysia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002610","descriptor_name":"Cheek","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004874","descriptor_name":"Ergonovine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010507","descriptor_name":"Periodicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017952","descriptor_name":"Ganglia, Invertebrate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017952","descriptor_name":"Ganglia, Invertebrate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-8993(93)90661-6","doi":"https://doi.org/10.1016/0006-8993(93)90661-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0006-8993(93)90661-6","pdf_url":"https://www.sciencedirect.com/science/article/pii/0006899393906616/pdf","source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},{"id":"pmid:8118689","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8118689","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/0006-8993(93)90661-6","doi":"https://doi.org/10.1016/0006-8993(93)90661-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0006-8993(93)90661-6","pdf_url":"https://www.sciencedirect.com/science/article/pii/0006899393906616/pdf","source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2005501046","display_name":null,"funder_award_id":"MH-35564","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2071209817","display_name":null,"funder_award_id":"MH 36730","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6460536115","display_name":"CELLULAR ANALYSIS OF BEHAVIOR","funder_award_id":"P01GM032099","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015724165.pdf","grobid_xml":"https://content.openalex.org/works/W2015724165.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W62923454","https://openalex.org/W1568775195","https://openalex.org/W1601617489","https://openalex.org/W1642710185","https://openalex.org/W1825471218","https://openalex.org/W1870493392","https://openalex.org/W1895782079","https://openalex.org/W1919231063","https://openalex.org/W1941778355","https://openalex.org/W1954137200","https://openalex.org/W1971642276","https://openalex.org/W1972784483","https://openalex.org/W1975278636","https://openalex.org/W2001490944","https://openalex.org/W2001766383","https://openalex.org/W2003126951","https://openalex.org/W2017708908","https://openalex.org/W2027735613","https://openalex.org/W2029330863","https://openalex.org/W2033405629","https://openalex.org/W2033867658","https://openalex.org/W2034422803","https://openalex.org/W2052889324","https://openalex.org/W2053049601","https://openalex.org/W2059673216","https://openalex.org/W2069126582","https://openalex.org/W2077777980","https://openalex.org/W2079781926","https://openalex.org/W2080917333","https://openalex.org/W2093808715","https://openalex.org/W2094527688","https://openalex.org/W2097708028","https://openalex.org/W2110084829","https://openalex.org/W2123893410","https://openalex.org/W2145996397","https://openalex.org/W2162930791","https://openalex.org/W2182136538","https://openalex.org/W2240227954","https://openalex.org/W2289817585","https://openalex.org/W2408547101","https://openalex.org/W2409143064","https://openalex.org/W2409711939","https://openalex.org/W2415614787","https://openalex.org/W2416683863","https://openalex.org/W2419502874","https://openalex.org/W2432603931"],"related_works":["https://openalex.org/W2127790631","https://openalex.org/W2079208703","https://openalex.org/W2337459685","https://openalex.org/W1642710185","https://openalex.org/W2110084829","https://openalex.org/W2217313672","https://openalex.org/W2160127961","https://openalex.org/W2086180674","https://openalex.org/W2145451215","https://openalex.org/W2113828815"],"abstract_inverted_index":{"We":[0],"have":[1],"identified":[2,47],"a":[3,15,94],"buccal":[4,34,41,98,105],"neuron":[5,75,174],"(B20)":[6],"that":[7,12,36,127,172],"exhibits":[8],"dopamine-like":[9],"histofluorescence":[10],"and":[11,92,106],"can":[13,65,118],"drive":[14,162],"rhythmic":[16,97],"motor":[17,22,53,99,185],"program":[18,68,102,117],"of":[19,24,32,46,83,112,136,141,152],"the":[20,67,71,123,134,137,150,153,163,170,180],"feeding":[21,52,73,113],"circuitry":[23],"Aplysia.":[25],"The":[26,101,115,165],"cell":[27],"fires":[28],"vigorously":[29],"during":[30,40],"episodes":[31],"patterned":[33],"activity":[35,145],"occur":[37],"spontaneously,":[38],"or":[39,59],"programs":[42,186],"elicited":[43],"by":[44,70,81,122],"stimulation":[45],"cerebral":[48,72,107,147,154],"command-like":[49,74,148],"neurons":[50,108],"for":[51,159,184],"programs.":[54],"Preventing":[55],"B20":[56,61,78,142,160,175],"from":[57],"firing,":[58],"firing":[60,140],"at":[62],"inappropriate":[63],"times,":[64],"modify":[66],"driven":[69],"CBI-2.":[76],"When":[77],"is":[79,156,176],"activated":[80],"means":[82],"constant":[84],"depolarizing":[85],"current":[86],"it":[87],"discharges":[88],"in":[89,133,146],"phasic":[90,144],"bursts,":[91],"evokes":[93,143],"sustained":[95],"coordinated":[96],"program.":[100,138,164],"incorporates":[103],"numerous":[104],"associated":[109,187],"with":[110,169,188],"aspects":[111],"responses.":[114],"B20-driven":[116],"be":[119,130],"reversibly":[120],"blocked":[121],"dopamine-antagonist":[124],"ergonovine,":[125],"suggesting":[126],"dopamine":[128],"may":[129],"causally":[131],"involved":[132],"generation":[135],"Although":[139],"neurons,":[149],"presence":[151],"ganglion":[155],"not":[157],"necessary":[158],"to":[161],"data":[166],"are":[167],"consistent":[168],"notion":[171],"dopaminergic":[173],"an":[177],"element":[178],"within":[179],"central":[181],"pattern":[182],"generator":[183],"feeding.":[189]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}