{"id":"https://openalex.org/W2015696792","doi":"https://doi.org/10.2146/ajhp130081","title":"Glucagon-like peptide-1 receptor agonists for weight loss in adult patients without diabetes","display_name":"Glucagon-like peptide-1 receptor agonists for weight loss in adult patients without diabetes","publication_year":2013,"publication_date":"2013-11-19","ids":{"openalex":"https://openalex.org/W2015696792","doi":"https://doi.org/10.2146/ajhp130081","mag":"2015696792","pmid":"https://pubmed.ncbi.nlm.nih.gov/24249759"},"language":"en","primary_location":{"id":"doi:10.2146/ajhp130081","doi":"https://doi.org/10.2146/ajhp130081","is_oa":false,"landing_page_url":"https://doi.org/10.2146/ajhp130081","pdf_url":null,"source":{"id":"https://openalex.org/S105051383","display_name":"American Journal of Health-System Pharmacy","issn_l":"1079-2082","issn":["1079-2082","1535-2900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Health-System Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073652733","display_name":"Anne R. Ottney","orcid":"https://orcid.org/0000-0002-0967-4453","observed_orcids":["https://orcid.org/0000-0002-0967-4453"]},"institutions":[{"id":"https://openalex.org/I191149221","display_name":"Ferris State University","ror":"https://ror.org/00cg1ev32","country_code":"US","type":"education","lineage":["https://openalex.org/I191149221"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anne Ottney","raw_affiliation_strings":["College of Pharmacy, Ferris State University, Lansing, MI, and Clinical Pharmacist, Family Medicine Residency Program, Sparrow/Michigan State University, Lansing","Anne Ottney, Pharm.D., BCPS, is Assistant Professor, College of Pharmacy, Ferris State University, Lansing, MI, and Clinical Pharmacist, Family Medicine Residency Program, Sparrow/Michigan State University, Lansing"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Ferris State University, Lansing, MI, and Clinical Pharmacist, Family Medicine Residency Program, Sparrow/Michigan State University, Lansing","institution_ids":["https://openalex.org/I191149221","https://openalex.org/I87216513"]},{"raw_affiliation_string":"Anne Ottney, Pharm.D., BCPS, is Assistant Professor, College of Pharmacy, Ferris State University, Lansing, MI, and Clinical Pharmacist, Family Medicine Residency Program, Sparrow/Michigan State University, Lansing","institution_ids":["https://openalex.org/I191149221","https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073652733"],"corresponding_institution_ids":["https://openalex.org/I191149221","https://openalex.org/I87216513"],"apc_list":{"value":4448,"currency":"USD","value_usd":4448},"apc_paid":null,"fwci":2.0791,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.83790449,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"70","issue":"23","first_page":"2097","last_page":"2103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9300000071525574},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.9879999756813049},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8299999833106995},{"id":"https://openalex.org/keywords/exenatide","display_name":"exenatide","score":0.8519999980926514},{"id":"https://openalex.org/keywords/liraglutide","display_name":"liraglutide","score":1.0},{"id":"https://openalex.org/keywords/orlistat","display_name":"orlistat","score":0.996999979019165},{"id":"https://openalex.org/keywords/satiety","display_name":"satiety","score":0.9679999947547913},{"id":"https://openalex.org/keywords/prediabetes","display_name":"prediabetes","score":0.9160000085830688},{"id":"https://openalex.org/keywords/nausea-and-vomiting","display_name":"nausea and vomiting","score":0.8309999704360962},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/insomnia","display_name":"insomnia","score":0.9800000190734863},{"id":"https://openalex.org/keywords/psychiatric-adverse-events","display_name":"psychiatric adverse events","score":0.5709999799728394},{"id":"https://openalex.org/keywords/non-diabetic-patients","display_name":"non-diabetic patients","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6347507238388062},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6242899298667908},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6101984977722168},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.6002135276794434},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5787862539291382},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.5288753509521484},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4942355453968048},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.48355886340141296},{"id":"https://openalex.org/C185280430","wikidata":"https://www.wikidata.org/wiki/Q14909910","display_name":"Glucagon-like peptide 1 receptor","level":4,"score":0.47497767210006714},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4623056948184967},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32973772287368774},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.28436464071273804},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.23070085048675537},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.22642898559570312}],"mesh":[{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069450","descriptor_name":"Liraglutide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077270","descriptor_name":"Exenatide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077403","descriptor_name":"Orlistat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008019","descriptor_name":"Life Style","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014688","descriptor_name":"Venoms","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014688","descriptor_name":"Venoms","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014688","descriptor_name":"Venoms","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2146/ajhp130081","doi":"https://doi.org/10.2146/ajhp130081","is_oa":false,"landing_page_url":"https://doi.org/10.2146/ajhp130081","pdf_url":null,"source":{"id":"https://openalex.org/S105051383","display_name":"American Journal of Health-System Pharmacy","issn_l":"1079-2082","issn":["1079-2082","1535-2900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Health-System Pharmacy","raw_type":"journal-article"},{"id":"pmid:24249759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24249759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1974942855","https://openalex.org/W1975756049","https://openalex.org/W1994320162","https://openalex.org/W2008526478","https://openalex.org/W2032376164","https://openalex.org/W2057176293","https://openalex.org/W2061777582","https://openalex.org/W2070260892","https://openalex.org/W2071522708","https://openalex.org/W2084142744","https://openalex.org/W2086177834","https://openalex.org/W2093372242","https://openalex.org/W2106699740","https://openalex.org/W2107037013","https://openalex.org/W2108556721","https://openalex.org/W2127178213","https://openalex.org/W2130210878","https://openalex.org/W2148287957","https://openalex.org/W2148449799","https://openalex.org/W2152423343","https://openalex.org/W2152835319","https://openalex.org/W2331430051","https://openalex.org/W3172478362","https://openalex.org/W3205005911"],"related_works":["https://openalex.org/W2511827836","https://openalex.org/W1774706564","https://openalex.org/W2086177834","https://openalex.org/W4377080456","https://openalex.org/W2320714872","https://openalex.org/W7204813478","https://openalex.org/W4213437296","https://openalex.org/W2807217225","https://openalex.org/W1643809894","https://openalex.org/W3157081314"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,53],"efficacy":[2],"and":[3,74,102,132,168,196],"safety":[4],"of":[5,39,91,112,136,156,165,207,219],"glucagon-like":[6],"peptide":[7],"(GLP)-1":[8],"receptor":[9,23,58,93,223],"agonists":[10,24,59,94,224],"for":[11,46,95,229],"weight":[12,30,47,61,96,145],"loss":[13,31,48,62,97,146],"in":[14,32,49,85,117,134,143,147,153,163,177,186,192],"adult":[15],"patients":[16,33,50,113,148,157,178,193,215,231],"without":[17,51,149,194],"diabetes":[18,195],"is":[19,63],"reviewed.":[20],"SUMMARY:":[21],"GLP-1":[22,57,92,222],"have":[25,98,114],"been":[26,115],"associated":[27],"with":[28,34,77,158,190,238],"significant":[29,144],"diabetes,":[35],"raising":[36],"the":[37,72,78,89,105,110,123,154,171],"question":[38],"whether":[40],"these":[41,180],"agents":[42],"could":[43],"be":[44,66],"used":[45],"diabetes.":[52,150],"mechanism":[54],"by":[55,201,214],"which":[56],"induce":[60],"believed":[64],"to":[65,68,82,108,138,234],"related":[67,81],"multiple":[69],"actions":[70],"involving":[71,119],"brain":[73],"gastrointestinal":[75],"tract,":[76],"primary":[79],"action":[80],"an":[83],"increase":[84],"satiety.":[86],"Trials":[87],"examining":[88],"effects":[90],"compared":[99],"exenatide,":[100],"liraglutide,":[101],"orlistat.":[103],"Of":[104],"studies":[106,164],"completed":[107],"date,":[109],"majority":[111],"enrolled":[116],"trials":[118],"liraglutide.":[120,166,220],"Based":[121],"on":[122],"reviewed":[124],"literature,":[125],"both":[126],"exenatide":[127],"10":[128],"\u03bcg":[129],"twice":[130],"daily":[131,141],"liraglutide":[133,191],"dosages":[135],"up":[137],"3":[139],"mg":[140],"resulted":[142],"A":[151,204],"decrease":[152],"proportion":[155],"prediabetes":[159],"was":[160,184,197,212],"also":[161],"found":[162],"Nausea":[167],"vomiting":[169],"were":[170],"most":[172],"frequently":[173],"reported":[174,185,213],"adverse":[175],"events":[176],"from":[179],"studies.":[181],"Symptomatic":[182],"hypoglycemia":[183],"only":[187],"one":[188],"study":[189],"not":[198,232],"objectively":[199],"confirmed":[200],"laboratory":[202],"data.":[203],"higher":[205],"frequency":[206],"psychiatric":[208],"disorders,":[209],"specifically":[210],"insomnia,":[211],"taking":[216],"high":[217],"doses":[218],"CONCLUSION:":[221],"offer":[225],"a":[226],"reasonable":[227],"alternative":[228],"nondiabetic":[230],"able":[233],"achieve":[235],"weight-loss":[236],"goals":[237],"lifestyle":[239],"modifications":[240],"alone.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}