{"id":"https://openalex.org/W2015696786","doi":"https://doi.org/10.1016/0014-5793(86)81534-4","title":"cDNA sequence of human \u03b2\u2010preprotachykinin, the common precursor to substance P and neurokinin A","display_name":"cDNA sequence of human \u03b2\u2010preprotachykinin, the common precursor to substance P and neurokinin A","publication_year":1986,"publication_date":"1986-11-10","ids":{"openalex":"https://openalex.org/W2015696786","doi":"https://doi.org/10.1016/0014-5793(86)81534-4","mag":"2015696786","pmid":"https://pubmed.ncbi.nlm.nih.gov/3770210"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(86)81534-4","doi":"https://doi.org/10.1016/0014-5793(86)81534-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(86)81534-4","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2886%2981534-4","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2886%2981534-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108167422","display_name":"Anthony J. Harmar","orcid":"https://orcid.org/0000-0002-3838-9264","observed_orcids":["https://orcid.org/0000-0002-3838-9264"]},"institutions":[{"id":"https://openalex.org/I2801618995","display_name":"Royal Edinburgh Hospital","ror":"https://ror.org/04jxcef68","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2801618995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A.J. Harmar","raw_affiliation_strings":["MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, Scotland","institution_ids":["https://openalex.org/I2801618995"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Armstrong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801618995","display_name":"Royal Edinburgh Hospital","ror":"https://ror.org/04jxcef68","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2801618995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Armstrong","raw_affiliation_strings":["MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, Scotland","institution_ids":["https://openalex.org/I2801618995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043041537","display_name":"John C. Pascall","orcid":"https://orcid.org/0000-0002-9506-1441","observed_orcids":["https://orcid.org/0000-0002-9506-1441"]},"institutions":[{"id":"https://openalex.org/I2801618995","display_name":"Royal Edinburgh Hospital","ror":"https://ror.org/04jxcef68","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2801618995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J.C. Pascall","raw_affiliation_strings":["MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, Scotland","institution_ids":["https://openalex.org/I2801618995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084052287","display_name":"Karen E. Chapman","orcid":"https://orcid.org/0000-0001-7777-6817","observed_orcids":["https://orcid.org/0000-0001-7777-6817"]},"institutions":[{"id":"https://openalex.org/I2801618995","display_name":"Royal Edinburgh Hospital","ror":"https://ror.org/04jxcef68","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2801618995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K. Chapman","raw_affiliation_strings":["MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, Scotland","institution_ids":["https://openalex.org/I2801618995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031642400","display_name":"Roberta Rosie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801618995","display_name":"Royal Edinburgh Hospital","ror":"https://ror.org/04jxcef68","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2801618995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. Rosie","raw_affiliation_strings":["MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, Scotland","institution_ids":["https://openalex.org/I2801618995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111432326","display_name":"Ann Curtis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801618995","display_name":"Royal Edinburgh Hospital","ror":"https://ror.org/04jxcef68","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2801618995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Curtis","raw_affiliation_strings":["MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, Scotland","institution_ids":["https://openalex.org/I2801618995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025463920","display_name":"James J. Going","orcid":"https://orcid.org/0000-0001-9120-919X","observed_orcids":["https://orcid.org/0000-0001-9120-919X"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Going","raw_affiliation_strings":["University Department of Pathology, Medical Buildings, Teviot Place, Edinburgh EH8 9AG, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Pathology, Medical Buildings, Teviot Place, Edinburgh EH8 9AG, Scotland","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113863127","display_name":"C.R.W. Edwards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C.R.W. Edwards","raw_affiliation_strings":["University Department of Medicine, Western General Hospital, Edinburgh EH4 2XU, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Medicine, Western General Hospital, Edinburgh EH4 2XU, Scotland","institution_ids":["https://openalex.org/I2800150677"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076966259","display_name":"George Fink","orcid":"https://orcid.org/0000-0002-0713-527X","observed_orcids":["https://orcid.org/0000-0002-0713-527X"]},"institutions":[{"id":"https://openalex.org/I2801618995","display_name":"Royal Edinburgh Hospital","ror":"https://ror.org/04jxcef68","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2801618995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. Fink","raw_affiliation_strings":["MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, Scotland","institution_ids":["https://openalex.org/I2801618995"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":3.2631,"has_fulltext":true,"cited_by_count":96,"citation_normalized_percentile":{"value":0.93086899,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"208","issue":"1","first_page":"67","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.8769999742507935},{"id":"https://openalex.org/keywords/neurokinin-a","display_name":"neurokinin A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuropeptide-k","display_name":"neuropeptide K","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cdna-sequence","display_name":"cDNA sequence","score":0.8230000138282776},{"id":"https://openalex.org/keywords/neuropeptide-processing","display_name":"neuropeptide processing","score":0.6970000267028809},{"id":"https://openalex.org/keywords/basic-amino-acid-residues","display_name":"basic amino acid residues","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2777056410","wikidata":"https://www.wikidata.org/wiki/Q408566","display_name":"Neurokinin A","level":5,"score":0.7869086265563965},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.7759091854095459},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.7142361402511597},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.6569613814353943},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.5883833765983582},{"id":"https://openalex.org/C84148353","wikidata":"https://www.wikidata.org/wiki/Q863908","display_name":"Nucleic acid sequence","level":3,"score":0.5312100648880005},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5211767554283142},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49964237213134766},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4945513904094696},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.47801530361175537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4771518111228943},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4731104373931885},{"id":"https://openalex.org/C189482833","wikidata":"https://www.wikidata.org/wiki/Q869146","display_name":"cDNA library","level":4,"score":0.44778570532798767},{"id":"https://openalex.org/C137130169","wikidata":"https://www.wikidata.org/wiki/Q15316325","display_name":"Tachykinin receptor 1","level":5,"score":0.43826061487197876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42637526988983154},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3840258717536926},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10336074233055115}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015320","descriptor_name":"Tachykinins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(86)81534-4","doi":"https://doi.org/10.1016/0014-5793(86)81534-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(86)81534-4","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2886%2981534-4","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:3770210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3770210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/0014-5793(86)81534-4","doi":"https://doi.org/10.1016/0014-5793(86)81534-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(86)81534-4","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2886%2981534-4","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015696786.pdf","grobid_xml":"https://content.openalex.org/works/W2015696786.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W89013752","https://openalex.org/W1558516755","https://openalex.org/W1978594266","https://openalex.org/W1983636660","https://openalex.org/W1984547809","https://openalex.org/W1991486518","https://openalex.org/W2029153838","https://openalex.org/W2042096080","https://openalex.org/W2047712117","https://openalex.org/W2060333964","https://openalex.org/W2074231493","https://openalex.org/W2091239909","https://openalex.org/W2091383653","https://openalex.org/W2094876611","https://openalex.org/W2422516311","https://openalex.org/W2901307123"],"related_works":["https://openalex.org/W2026183391","https://openalex.org/W2069144078","https://openalex.org/W2278172898","https://openalex.org/W1989348387","https://openalex.org/W1980435560","https://openalex.org/W2048529652","https://openalex.org/W2046958244","https://openalex.org/W1975331386","https://openalex.org/W2024923241","https://openalex.org/W1984547809"],"abstract_inverted_index":{"The":[0,16,35],"nucleotide":[1],"sequence":[2,69],"of":[3,18,31,62,70,77],"cDNA":[4],"encoding":[5,47],"the":[6,63,68],"human":[7,22,36,64],"substance":[8,33,48],"P":[9,49],"precursor,":[10],"beta-preprotachykinin":[11],"(beta-PPT),":[12],"has":[13],"been":[14],"determined.":[15],"source":[17],"mRNA":[19],"was":[20],"a":[21,28],"laryngeal":[23],"carcinoid":[24],"tumour":[25],"that":[26],"contained":[27],"high":[29],"concentration":[30],"immunoreactive":[32],"P.":[34],"beta-PPT":[37,65],"polypeptide":[38,66],"is":[39],"129":[40],"amino":[41,57],"acids":[42],"long":[43],"and":[44,50],"contains":[45],"regions":[46],"neurokinin":[51,78],"A,":[52],"each":[53],"flanked":[54],"by":[55],"basic":[56],"acid":[58],"residues.":[59],"Residues":[60],"72-107":[61],"encode":[67],"neuropeptide":[71],"K,":[72],"an":[73],"N-terminally":[74],"extended":[75],"form":[76],"A":[79],"recently":[80],"isolated":[81],"from":[82],"porcine":[83],"brain.":[84]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
