{"id":"https://openalex.org/W2015659378","doi":"https://doi.org/10.1042/bj20120693","title":"Transcriptional networks driving enhancer function in the CFTR gene","display_name":"Transcriptional networks driving enhancer function in the CFTR gene","publication_year":2012,"publication_date":"2012-06-07","ids":{"openalex":"https://openalex.org/W2015659378","doi":"https://doi.org/10.1042/bj20120693","mag":"2015659378","pmid":"https://pubmed.ncbi.nlm.nih.gov/22671145","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3419791"},"language":"en","primary_location":{"id":"doi:10.1042/bj20120693","doi":"https://doi.org/10.1042/bj20120693","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20120693","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3419791","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029393280","display_name":"Jenny L. Kerschner","orcid":"https://orcid.org/0000-0002-1980-2543","observed_orcids":["https://orcid.org/0000-0002-1980-2543"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny\u00a0L. Kerschner","raw_affiliation_strings":["Human Molecular Genetics Program, Children's Memorial Research Center, Chicago, IL 60614, U.S.A., and Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Molecular Genetics Program, Children's Memorial Research Center, Chicago, IL 60614, U.S.A., and Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, U.S.A","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085606046","display_name":"Ann Harris","orcid":"https://orcid.org/0000-0002-6541-2546","observed_orcids":["https://orcid.org/0000-0002-6541-2546"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Harris","raw_affiliation_strings":["Human Molecular Genetics Program, Children's Memorial Research Center, Chicago, IL 60614, U.S.A., and Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Molecular Genetics Program, Children's Memorial Research Center, Chicago, IL 60614, U.S.A., and Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, U.S.A","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":2.0553,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.86577856,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"446","issue":"2","first_page":"203","last_page":"212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.6304000020027161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.6304000020027161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.33230000734329224,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cystic-fibrosis-transmembrane-conductance-regulator","display_name":"cystic fibrosis transmembrane conductance regulator","score":0.9660000205039978},{"id":"https://openalex.org/keywords/enhancer-function","display_name":"enhancer function","score":0.5899999737739563},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.753000020980835},{"id":"https://openalex.org/keywords/hnf1","display_name":"HNF1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cdx2","display_name":"CDX2","score":1.0},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.824999988079071},{"id":"https://openalex.org/keywords/transcriptional-regulatory-networks","display_name":"transcriptional regulatory networks","score":0.6759999990463257},{"id":"https://openalex.org/keywords/intestinal-gene-expression","display_name":"intestinal gene expression","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tissue-specific-transcription","display_name":"tissue-specific transcription","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.778130292892456},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6765545606613159},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6687036752700806},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.6441901326179504},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5637551546096802},{"id":"https://openalex.org/C2778428886","wikidata":"https://www.wikidata.org/wiki/Q420470","display_name":"Cystic fibrosis transmembrane conductance regulator","level":3,"score":0.5193001627922058},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4714820384979248},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.43966206908226013},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4228362441062927},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4057754576206207},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3948844075202942},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3786076307296753},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.3380592167377472},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26680219173431396}],"mesh":[{"descriptor_ui":"D000071616","descriptor_name":"CDX2 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020895","descriptor_name":"Enterocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051538","descriptor_name":"Hepatocyte Nuclear Factor 1-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051538","descriptor_name":"Hepatocyte Nuclear Factor 1-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051538","descriptor_name":"Hepatocyte Nuclear Factor 1-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051538","descriptor_name":"Hepatocyte Nuclear Factor 1-alpha","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bj20120693","doi":"https://doi.org/10.1042/bj20120693","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20120693","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:22671145","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22671145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2750004","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3419791","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3419791","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3419791","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochem J","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2750004","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3419791","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1858190111","display_name":"Tissue-specific regulation of a gene essential for airway epithelial function","funder_award_id":"R01HL094585","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7988443199","display_name":"Transcriptional networks coordinating luminal environment in the human epididymis: the role of the androgen receptor.","funder_award_id":"R01HD068901","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W31778427","https://openalex.org/W1574938804","https://openalex.org/W1595665778","https://openalex.org/W1964485689","https://openalex.org/W1969697265","https://openalex.org/W1971439111","https://openalex.org/W1978125302","https://openalex.org/W1978664503","https://openalex.org/W1979165357","https://openalex.org/W1985103909","https://openalex.org/W1989776482","https://openalex.org/W1990467798","https://openalex.org/W1990978338","https://openalex.org/W2003856528","https://openalex.org/W2006616124","https://openalex.org/W2010276256","https://openalex.org/W2026384939","https://openalex.org/W2028810156","https://openalex.org/W2031528002","https://openalex.org/W2037445818","https://openalex.org/W2037983934","https://openalex.org/W2043239577","https://openalex.org/W2045265674","https://openalex.org/W2047005748","https://openalex.org/W2047203795","https://openalex.org/W2054810829","https://openalex.org/W2055026964","https://openalex.org/W2065177159","https://openalex.org/W2067438558","https://openalex.org/W2069394195","https://openalex.org/W2073700708","https://openalex.org/W2077170717","https://openalex.org/W2078792089","https://openalex.org/W2080132636","https://openalex.org/W2080207188","https://openalex.org/W2080911334","https://openalex.org/W2082532751","https://openalex.org/W2084429962","https://openalex.org/W2089117232","https://openalex.org/W2090554418","https://openalex.org/W2099875487","https://openalex.org/W2102304447","https://openalex.org/W2111424853","https://openalex.org/W2112005772","https://openalex.org/W2112374340","https://openalex.org/W2121602794","https://openalex.org/W2122097157","https://openalex.org/W2123389364","https://openalex.org/W2123557204","https://openalex.org/W2123564569","https://openalex.org/W2127640118","https://openalex.org/W2128016314","https://openalex.org/W2128062921","https://openalex.org/W2129654351","https://openalex.org/W2134170971","https://openalex.org/W2138384280","https://openalex.org/W2141008053","https://openalex.org/W2145311204","https://openalex.org/W2152751895","https://openalex.org/W2168909179","https://openalex.org/W2171168707","https://openalex.org/W4236860921","https://openalex.org/W4297943700"],"related_works":["https://openalex.org/W3168853736","https://openalex.org/W1989776482","https://openalex.org/W2080207188","https://openalex.org/W2028130907","https://openalex.org/W4220978287","https://openalex.org/W2140932443","https://openalex.org/W2123557204","https://openalex.org/W2077170717","https://openalex.org/W2099875487","https://openalex.org/W2067471142"],"abstract_inverted_index":{"A":[0],"critical":[1,56,158],"cis-regulatory":[2,182],"element":[3,63],"for":[4,159],"the":[5,22,51,120,160,185,197],"CFTR":[6,70,148,166,186],"(cystic":[7],"fibrosis":[8],"transmembrane":[9],"conductance":[10],"regulator)":[11],"gene":[12,132],"is":[13,157],"located":[14],"in":[15,43,68,89,110,119,146,150,168,193],"intron":[16,121],"11,":[17],"100":[18],"kb":[19],"distal":[20],"to":[21,45,61],"promoter,":[23],"with":[24,36,180],"which":[25],"it":[26],"interacts.":[27],"This":[28],"sequence":[29],"contains":[30],"an":[31],"intestine-selective":[32],"enhancer":[33,37,126],"and":[34,64,77,104],"associates":[35],"signature":[38],"proteins,":[39],"such":[40],"as":[41,109],"p300,":[42],"addition":[44],"tissue-specific":[46],"TFs":[47,57,88,178],"(transcription":[48],"factors).":[49],"In":[50,72],"present":[52],"study":[53],"we":[54],"identify":[55],"that":[58,86,154,176],"are":[59],"recruited":[60],"this":[62,155],"demonstrate":[65,175],"their":[66,116],"importance":[67],"regulating":[69],"expression.":[71],"vitro":[73],"DNase":[74],"I":[75],"footprinting":[76],"EMSAs":[78],"(electrophoretic":[79],"mobility-shift":[80],"assays)":[81],"identified":[82,94],"four":[83],"cell-type-selective":[84],"regions":[85],"bound":[87],"vitro.":[90],"ChIP":[91,172],"(chromatin":[92],"immunoprecipitation)":[93],"FOXA1/A2":[95],"(forkhead":[96],"box":[97],"A1/A2),":[98],"HNF1":[99],"(hepatocyte":[100],"nuclear":[101],"factor":[102,156],"1)":[103],"CDX2":[105,141],"(caudal-type":[106],"homeobox":[107],"2)":[108],"vivo":[111],"trans-interacting":[112],"factors.":[113],"Mutation":[114],"of":[115,140,162,165,196],"binding":[117],"sites":[118],"11":[122],"core":[123],"compromised":[124],"its":[125],"activity":[127],"when":[128],"measured":[129],"by":[130],"reporter":[131],"assay.":[133],"Moreover,":[134],"siRNA":[135],"(small":[136],"interfering":[137],"RNA)-mediated":[138],"knockdown":[139],"caused":[142],"a":[143,189],"significant":[144],"reduction":[145],"endogenous":[147],"transcription":[149],"intestinal":[151,194],"cells,":[152],"suggesting":[153],"maintenance":[161],"high":[163],"levels":[164],"expression":[167,195],"these":[169,177],"cells.":[170],"The":[171],"data":[173],"also":[174],"interact":[179],"multiple":[181],"elements":[183],"across":[184],"locus,":[187],"implicating":[188],"more":[190],"global":[191],"role":[192],"gene.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}