{"id":"https://openalex.org/W2015654377","doi":"https://doi.org/10.1038/sj.onc.1206579","title":"IL-10 signaling via IL-10E1 is dependent on tyrosine phosphorylation in the IL-10R \u03b1 chain in human primary prostate cancer cell lines","display_name":"IL-10 signaling via IL-10E1 is dependent on tyrosine phosphorylation in the IL-10R \u03b1 chain in human primary prostate cancer cell lines","publication_year":2003,"publication_date":"2003-06-11","ids":{"openalex":"https://openalex.org/W2015654377","doi":"https://doi.org/10.1038/sj.onc.1206579","mag":"2015654377","pmid":"https://pubmed.ncbi.nlm.nih.gov/12802285"},"language":"en","primary_location":{"id":"doi:10.1038/sj.onc.1206579","doi":"https://doi.org/10.1038/sj.onc.1206579","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1206579","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111797055","display_name":"Mark E. Stearns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark E Stearns","raw_affiliation_strings":["Department of Pathology and Laboratory, Drexel University College of Medicine, 15th and Vine Sts, Philadelphia, PA 19102-1192, USA. Stearnsm1@aol.com","Department of Pathology and Laboratory, Drexel University College of Medicine, 15th and Vine Sts, Philadelphia, PA 19102-1192, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory, Drexel University College of Medicine, 15th and Vine Sts, Philadelphia, PA 19102-1192, USA. Stearnsm1@aol.com","institution_ids":["https://openalex.org/I72816309"]},{"raw_affiliation_string":"Department of Pathology and Laboratory, Drexel University College of Medicine, 15th and Vine Sts, Philadelphia, PA 19102-1192, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110024947","display_name":"Youji Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youji Hu","raw_affiliation_strings":["Department of Pathology and Laboratory, Drexel University College of Medicine, Medicine, MS 435, 15th and Vine Sts, Philadelphia, 19102-1192, PA, USA","Department of Pathology and Laboratory, Drexel University College of Medicine, Medicine, MS 435, 15th and Vine Sts, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory, Drexel University College of Medicine, Medicine, MS 435, 15th and Vine Sts, Philadelphia, 19102-1192, PA, USA","institution_ids":["https://openalex.org/I72816309"]},{"raw_affiliation_string":"Department of Pathology and Laboratory, Drexel University College of Medicine, Medicine, MS 435, 15th and Vine Sts, Philadelphia, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"last","author":{"id":null,"display_name":"Min Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Wang","raw_affiliation_strings":["Department of Pathology and Laboratory, Drexel University College of Medicine, Medicine, MS 435, 15th and Vine Sts, Philadelphia, 19102-1192, PA, USA","Department of Pathology and Laboratory, Drexel University College of Medicine, Medicine, MS 435, 15th and Vine Sts, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory, Drexel University College of Medicine, Medicine, MS 435, 15th and Vine Sts, Philadelphia, 19102-1192, PA, USA","institution_ids":["https://openalex.org/I72816309"]},{"raw_affiliation_string":"Department of Pathology and Laboratory, Drexel University College of Medicine, Medicine, MS 435, 15th and Vine Sts, Philadelphia, USA","institution_ids":["https://openalex.org/I72816309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111797055"],"corresponding_institution_ids":["https://openalex.org/I72816309"],"apc_list":{"value":5990,"currency":"USD","value_usd":5990},"apc_paid":null,"fwci":0.5191,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.60180201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"22","issue":"24","first_page":"3781","last_page":"3791"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/jak1","display_name":"JAK1","score":0.6110000014305115},{"id":"https://openalex.org/keywords/tyk2","display_name":"TYK2","score":0.996999979019165},{"id":"https://openalex.org/keywords/prostate-cancer-cell-lines","display_name":"prostate cancer cell lines","score":0.6990000009536743},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/lim-domain","display_name":"LIM domain","score":0.6430000066757202},{"id":"https://openalex.org/keywords/receptor-signaling","display_name":"receptor signaling","score":0.453000009059906},{"id":"https://openalex.org/keywords/gfp-fusion-constructs","display_name":"GFP fusion constructs","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7572355270385742},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.6886013746261597},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.663846492767334},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5740578174591064},{"id":"https://openalex.org/C197153747","wikidata":"https://www.wikidata.org/wiki/Q24780316","display_name":"SH2 domain","level":4,"score":0.5595967769622803},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.5432374477386475},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.451095312833786},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4460311532020569},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.4191231429576874},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4163641333580017},{"id":"https://openalex.org/C104551158","wikidata":"https://www.wikidata.org/wiki/Q7187581","display_name":"Phosphorylation cascade","level":5,"score":0.41502225399017334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3919062912464142},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.3799581229686737},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3659305274486542},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.24456241726875305}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018123","descriptor_name":"Receptors, Interleukin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050800","descriptor_name":"STAT6 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053701","descriptor_name":"Receptors, Interleukin-10","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.onc.1206579","doi":"https://doi.org/10.1038/sj.onc.1206579","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1206579","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},{"id":"pmid:12802285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12802285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W569951484","https://openalex.org/W1538802759","https://openalex.org/W1703256892","https://openalex.org/W1829889392","https://openalex.org/W1856702249","https://openalex.org/W1972001843","https://openalex.org/W1981101169","https://openalex.org/W1981799488","https://openalex.org/W1986148855","https://openalex.org/W1998079753","https://openalex.org/W2003642195","https://openalex.org/W2003990693","https://openalex.org/W2003996476","https://openalex.org/W2008757961","https://openalex.org/W2011184409","https://openalex.org/W2027749164","https://openalex.org/W2029275361","https://openalex.org/W2030624761","https://openalex.org/W2034974668","https://openalex.org/W2038613403","https://openalex.org/W2046447629","https://openalex.org/W2052172628","https://openalex.org/W2052779439","https://openalex.org/W2055649671","https://openalex.org/W2060546545","https://openalex.org/W2067626539","https://openalex.org/W2069035291","https://openalex.org/W2078239174","https://openalex.org/W2084919802","https://openalex.org/W2090105988","https://openalex.org/W2094776015","https://openalex.org/W2101108802","https://openalex.org/W2128635872","https://openalex.org/W2135060422","https://openalex.org/W2139613570","https://openalex.org/W2414537042","https://openalex.org/W2419112487","https://openalex.org/W2439751934","https://openalex.org/W4231581694"],"related_works":["https://openalex.org/W7096665143","https://openalex.org/W2403418499","https://openalex.org/W2017107715","https://openalex.org/W1541252833","https://openalex.org/W2014860679","https://openalex.org/W1980424682","https://openalex.org/W2076803220","https://openalex.org/W1557001860","https://openalex.org/W1564256568","https://openalex.org/W1955441978"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}