{"id":"https://openalex.org/W2015641307","doi":"https://doi.org/10.1677/joe.0.1540231","title":"Increase by tri-iodothyronine of endothelin-1, fibronectin and von Willebrand factor in cultured endothelial cells","display_name":"Increase by tri-iodothyronine of endothelin-1, fibronectin and von Willebrand factor in cultured endothelial cells","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W2015641307","doi":"https://doi.org/10.1677/joe.0.1540231","mag":"2015641307","pmid":"https://pubmed.ncbi.nlm.nih.gov/9291833"},"language":"en","primary_location":{"id":"doi:10.1677/joe.0.1540231","doi":"https://doi.org/10.1677/joe.0.1540231","is_oa":false,"landing_page_url":"https://doi.org/10.1677/joe.0.1540231","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046330265","display_name":"Sabina M. Baumgartner-Parzer","orcid":"https://orcid.org/0000-0002-0928-6119","observed_orcids":["https://orcid.org/0000-0002-0928-6119"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"S M Baumgartner-Parzer","raw_affiliation_strings":["Department of Internal Medicine III, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L Wagner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Wagner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042840607","display_name":"Georg Reining","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Reining","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079620940","display_name":"Veronika Sexl","orcid":"https://orcid.org/0000-0001-9363-0412","observed_orcids":["https://orcid.org/0000-0001-9363-0412"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Sexl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048083486","display_name":"P. Nowotny","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Nowotny","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M M\u00fcller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Brunner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Brunner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110159347","display_name":"W. Waldh\u00e4usl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Waldh\u00e4usl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8517,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.71584617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"154","issue":"2","first_page":"231","last_page":"239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.12890000641345978,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.9430000185966492},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.9769999980926514},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":1.0},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/pkc-epsilon","display_name":"protein kinase C epsilon","score":0.734000027179718},{"id":"https://openalex.org/keywords/protein-kinase-c-delta","display_name":"protein kinase C delta","score":0.7250000238418579},{"id":"https://openalex.org/keywords/protein-kinase-c-zeta","display_name":"protein kinase C zeta","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6965547204017639},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6918432712554932},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.6478599905967712},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5687589645385742},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.5130709409713745},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.4799114167690277},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.45501625537872314},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4405823349952698},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.43452316522598267},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4249367117881775},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4207257926464081},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.420704185962677},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37464770674705505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3550252914428711},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2552829384803772},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.13056325912475586},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11286520957946777},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11156189441680908},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07110369205474854},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.051082223653793335},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016232","descriptor_name":"Endothelins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016232","descriptor_name":"Endothelins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1677/joe.0.1540231","doi":"https://doi.org/10.1677/joe.0.1540231","is_oa":false,"landing_page_url":"https://doi.org/10.1677/joe.0.1540231","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:9291833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9291833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.907.9149","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.907.9149","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://joe.endocrinology-journals.org/content/154/2/231.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1865972783","https://openalex.org/W2078181710","https://openalex.org/W7220762690","https://openalex.org/W2398682117","https://openalex.org/W2006684915","https://openalex.org/W2415820194","https://openalex.org/W2062355504","https://openalex.org/W2946248537","https://openalex.org/W2155379924","https://openalex.org/W2040391706"],"abstract_inverted_index":{"Hyperthyroidism":[0],"is":[1],"associated":[2],"with":[3,177,266],"elevated":[4],"plasma":[5,323],"levels":[6],"of":[7,74,144,154,263,298,304,325],"endothelium-derived":[8],"proteins":[9,327],"such":[10],"as":[11,100,102],"von":[12],"Willebrand":[13],"factor":[14],"(vWF),":[15],"fibronectin":[16],"(FN)":[17],"and":[18,39,42,68,149,161,207,241,259,278,301,307,314,328],"endothelin-1":[19],"(ET-1).":[20],"This":[21],"study":[22],"was":[23,136,253],"designed":[24],"to":[25,55,76,290],"characterize":[26],"the":[27,34,129,331],"mechanisms":[28],"involved":[29],"in":[30,47,255,260,286,320,330],"this":[31],"phenomenon":[32],"at":[33,318],"cellular":[35],"level.":[36],"vWF,":[37,305],"FN":[38,134,162,306],"ET-1":[40,181],"secretion":[41,81,135,182],"mRNA":[43,104,163,209,274,299],"expression":[44,105,164,210,300],"were":[45,244],"measured":[46,280],"human":[48],"umbilical":[49],"vein":[50],"endothelial":[51,326],"cells":[52,264],"(HUVECs)":[53],"exposed":[54],"tri-iodothyronine":[56],"(T3)":[57],"for":[58],"13":[59],"+/-":[60,86,95,109,117,125,142,152,170,186,194,202,214,222,230],"1":[61],"days,":[62],"using":[63],"ELISA,":[64],"Western":[65],"blot,":[66],"RIA":[67],"Northern":[69],"blot":[70],"analysis":[71],"respectively.":[72],"Exposure":[73],"HUVECs":[75,287],"T3":[77,178],"significantly":[78,137,246],"increased":[79,179,254,322],"vWF":[80,103],"(50":[82,106],"ng":[83,92,159,167,271],"T3/ml:":[84,93],"117":[85],"5%,":[87],"P":[88,97,111,119,146,156,172,188,196,204,216,224,232],"<":[89,98,112,120,147,157,173,189,197,205,217,225,233],"0.01;":[90],"100":[91,114,150,199,227,267],"127":[94],"26%,":[96],"0.01)":[99],"well":[101],"ng/ml:":[107,115,184,192,200,212,220,228],"116":[108,201],"13%,":[110],"0.001;":[113,190],"136":[116],"30%,":[118],"0.002)":[121],"(results":[122],"are":[123],"means":[124],"S.D.":[126],"analysed":[127],"by":[128,139,165,248,281,309],"Wilcoxon":[130],"signed":[131],"rank":[132],"test).":[133],"affected":[138,247],"50":[140,166,191,219,270],"(145":[141],"42%":[143],"control,":[145,155],"0.05)":[148,158,206],"(116.8":[151],"16%":[153],"T3/ml,":[160],"T3/ml":[168],"(123":[169],"20%,":[171,231],"0.05).":[174],"Long-term":[175],"incubation":[176],"both":[180],"(25":[183,211],"124":[185],"25%,":[187],"165":[193],"53%,":[195],"0.05;":[198,218],"17%,":[203],"prepro-ET-1":[208],"112":[213],"16%,":[215],"134":[221],"43%,":[223],"0.02;":[226],"120":[229],"0.02).":[234],"Protein":[235],"kinase":[236],"C":[237],"(PKC)":[238],"isoforms":[239],"epsilon":[240],"beta":[242,312],"II":[243],"not":[245,269],"T3,":[249],"whereas":[250],"PKC":[251,310],"alpha":[252],"whole":[256],"cell":[257,276],"lysates":[258],"membrane":[261],"fractions":[262],"incubated":[265],"but":[268],"T3/ml.":[272],"Prepro-ET-1":[273],"stability,":[275],"numbers":[277],"proliferation,":[279],"[3H]thymidine":[282],"assays,":[283],"remained":[284],"unaffected":[285],"after":[288],"exposure":[289],"T3.":[291],"These":[292],"data":[293],"indicate":[294],"thyroid":[295],"hormone-induced":[296],"upregulation":[297],"protein":[302],"synthesis":[303],"ET-1,":[308],"alpha-,":[311],"II-":[313],"epsilon-independent":[315],"pathways,":[316],"explaining,":[317],"least":[319],"part,":[321],"concentrations":[324],"peptides":[329],"hyperthyroid":[332],"state.":[333]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}