{"id":"https://openalex.org/W2015622018","doi":"https://doi.org/10.1089/aid.2006.22.477","title":"An Immunoglobulin Fusion Protein Based on the gp120-CD4 Receptor Complex Potently Inhibits Human Immunodeficiency Virus Type 1 in Vitro","display_name":"An Immunoglobulin Fusion Protein Based on the gp120-CD4 Receptor Complex Potently Inhibits Human Immunodeficiency Virus Type 1 in Vitro","publication_year":2006,"publication_date":"2006-06-01","ids":{"openalex":"https://openalex.org/W2015622018","doi":"https://doi.org/10.1089/aid.2006.22.477","mag":"2015622018","pmid":"https://pubmed.ncbi.nlm.nih.gov/16796521"},"language":"en","primary_location":{"id":"doi:10.1089/aid.2006.22.477","doi":"https://doi.org/10.1089/aid.2006.22.477","is_oa":false,"landing_page_url":"https://doi.org/10.1089/aid.2006.22.477","pdf_url":null,"source":{"id":"https://openalex.org/S161282271","display_name":"AIDS Research and Human Retroviruses","issn_l":"0889-2229","issn":["0889-2229","1931-8405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Research and Human Retroviruses","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061216308","display_name":"John R. Vu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Vu","raw_affiliation_strings":["Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland 21201","Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland 21201","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031256695","display_name":"TIMOTHY R. FOUTS","orcid":"https://orcid.org/0000-0002-2429-2859","observed_orcids":["https://orcid.org/0000-0002-2429-2859"]},"institutions":[{"id":"https://openalex.org/I4210127751","display_name":"Profectus Biosciences (United States)","ror":"https://ror.org/02zy72z44","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127751"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Fouts","raw_affiliation_strings":["Profectus Biosciences, Inc., Baltimore, Maryland 21227"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Profectus Biosciences, Inc., Baltimore, Maryland 21227","institution_ids":["https://openalex.org/I4210127751"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033051900","display_name":"Katherine Bobb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127751","display_name":"Profectus Biosciences (United States)","ror":"https://ror.org/02zy72z44","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127751"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Bobb","raw_affiliation_strings":["Profectus Biosciences, Inc., Baltimore, Maryland 21227"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Profectus Biosciences, Inc., Baltimore, Maryland 21227","institution_ids":["https://openalex.org/I4210127751"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer Burns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160236","display_name":"TetraLogic Pharmaceuticals (United States)","ror":"https://ror.org/00a8x0890","country_code":"US","type":"company","lineage":["https://openalex.org/I4210160236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Burns","raw_affiliation_strings":["Gentara Corporation, Malvern, Pennsylvania 19355"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gentara Corporation, Malvern, Pennsylvania 19355","institution_ids":["https://openalex.org/I4210160236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048234512","display_name":"Brenda McDermott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brenda McDermott","raw_affiliation_strings":["Praecis Pharmaceuticals Inc., Waltham, Massachusetts 02451"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Praecis Pharmaceuticals Inc., Waltham, Massachusetts 02451","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043353900","display_name":"David I. Israel","orcid":"https://orcid.org/0000-0003-0427-0756","observed_orcids":["https://orcid.org/0000-0003-0427-0756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David I. Israel","raw_affiliation_strings":["Praecis Pharmaceuticals Inc., Waltham, Massachusetts 02451"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Praecis Pharmaceuticals Inc., Waltham, Massachusetts 02451","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037187532","display_name":"Karla Godfrey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karla Godfrey","raw_affiliation_strings":["Institute of Human Virology, Baltimore, Maryland 21201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Virology, Baltimore, Maryland 21201","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030545878","display_name":"Anthony L. DeVico","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony DeVico","raw_affiliation_strings":["Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland 21201","Institute of Human Virology, Baltimore, Maryland 21201","Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland 21201.; Institute of Human Virology, Baltimore, Maryland 21201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland 21201","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Institute of Human Virology, Baltimore, Maryland 21201","institution_ids":[]},{"raw_affiliation_string":"Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland 21201.; Institute of Human Virology, Baltimore, Maryland 21201","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4623,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.56257998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"22","issue":"6","first_page":"477","last_page":"490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.045099999755620956,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-neutralizing-antibodies","display_name":"HIV-1 neutralizing antibodies","score":0.7730000019073486},{"id":"https://openalex.org/keywords/ccr5-coreceptor","display_name":"CCR5 coreceptor","score":0.9089999794960022},{"id":"https://openalex.org/keywords/fc-fusion-protein","display_name":"Fc fusion protein","score":0.7279999852180481},{"id":"https://openalex.org/keywords/r5-tropic-hiv-1","display_name":"R5-tropic HIV-1","score":0.7929999828338623},{"id":"https://openalex.org/keywords/chemokine-binding","display_name":"chemokine binding","score":0.5849999785423279},{"id":"https://openalex.org/keywords/chemokine-receptor-antagonism","display_name":"chemokine receptor antagonism","score":0.546999990940094},{"id":"https://openalex.org/keywords/hiv-1-entry-inhibition","display_name":"HIV-1 entry inhibition","score":0.6299999952316284},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.6899999976158142},{"id":"https://openalex.org/keywords/hiv-1-therapy","display_name":"HIV-1 therapy","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.680665135383606},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6478191018104553},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6421160697937012},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.5228650569915771},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5126239657402039},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5111022591590881},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4701578617095947},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46736761927604675},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.4474150240421295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35159146785736084},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3325997591018677},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1461336612701416},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.13139063119888306},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11491629481315613}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/aid.2006.22.477","doi":"https://doi.org/10.1089/aid.2006.22.477","is_oa":false,"landing_page_url":"https://doi.org/10.1089/aid.2006.22.477","pdf_url":null,"source":{"id":"https://openalex.org/S161282271","display_name":"AIDS Research and Human Retroviruses","issn_l":"0889-2229","issn":["0889-2229","1931-8405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Research and Human Retroviruses","raw_type":"journal-article"},{"id":"pmid:16796521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16796521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS research and human retroviruses","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7599999904632568,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G233662523","display_name":"Immunity and Infection","funder_award_id":"T32AI007540","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3858197006","display_name":"HIV-1 PASSIVE IMMUNITY AGAINST CORECEPTOR INTERACTIONS","funder_award_id":"R01HL059796","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7291198773","display_name":"NOVEL HIV VACCINES","funder_award_id":"P01AI047490","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":100,"referenced_works":["https://openalex.org/W82820957","https://openalex.org/W1510768077","https://openalex.org/W1512026049","https://openalex.org/W1539312716","https://openalex.org/W1575399360","https://openalex.org/W1582593681","https://openalex.org/W1598711637","https://openalex.org/W1679721892","https://openalex.org/W1782049572","https://openalex.org/W1817018401","https://openalex.org/W1923928177","https://openalex.org/W1966515400","https://openalex.org/W1966815718","https://openalex.org/W1968594568","https://openalex.org/W1971777539","https://openalex.org/W1975932650","https://openalex.org/W1981164507","https://openalex.org/W1981440980","https://openalex.org/W1981644527","https://openalex.org/W1982944348","https://openalex.org/W1984811742","https://openalex.org/W1986574361","https://openalex.org/W1993634191","https://openalex.org/W1995303508","https://openalex.org/W1995420391","https://openalex.org/W1996183144","https://openalex.org/W2002164494","https://openalex.org/W2006734012","https://openalex.org/W2007021820","https://openalex.org/W2008130406","https://openalex.org/W2009324334","https://openalex.org/W2010638326","https://openalex.org/W2012730930","https://openalex.org/W2015404088","https://openalex.org/W2017551575","https://openalex.org/W2017977773","https://openalex.org/W2018600081","https://openalex.org/W2018964839","https://openalex.org/W2022522156","https://openalex.org/W2026444780","https://openalex.org/W2029288933","https://openalex.org/W2036741092","https://openalex.org/W2037580692","https://openalex.org/W2041557530","https://openalex.org/W2042578530","https://openalex.org/W2044046899","https://openalex.org/W2044052199","https://openalex.org/W2044809899","https://openalex.org/W2051377225","https://openalex.org/W2051785641","https://openalex.org/W2055208054","https://openalex.org/W2058252938","https://openalex.org/W2068659795","https://openalex.org/W2074969682","https://openalex.org/W2075926278","https://openalex.org/W2076760824","https://openalex.org/W2077153526","https://openalex.org/W2081769332","https://openalex.org/W2083612980","https://openalex.org/W2083803997","https://openalex.org/W2084197987","https://openalex.org/W2085577978","https://openalex.org/W2086783015","https://openalex.org/W2089174726","https://openalex.org/W2090763940","https://openalex.org/W2091330377","https://openalex.org/W2092664889","https://openalex.org/W2098781795","https://openalex.org/W2107656195","https://openalex.org/W2113282092","https://openalex.org/W2115906128","https://openalex.org/W2117719816","https://openalex.org/W2118820599","https://openalex.org/W2119745827","https://openalex.org/W2122985048","https://openalex.org/W2124467421","https://openalex.org/W2125231927","https://openalex.org/W2126597682","https://openalex.org/W2128461524","https://openalex.org/W2129875326","https://openalex.org/W2130635171","https://openalex.org/W2135739941","https://openalex.org/W2136056069","https://openalex.org/W2138758139","https://openalex.org/W2140478082","https://openalex.org/W2144644150","https://openalex.org/W2145718464","https://openalex.org/W2146519771","https://openalex.org/W2147169218","https://openalex.org/W2154319486","https://openalex.org/W2154728363","https://openalex.org/W2155951093","https://openalex.org/W2156178056","https://openalex.org/W2158294445","https://openalex.org/W2170412417","https://openalex.org/W2170449789","https://openalex.org/W2176220887","https://openalex.org/W4241646631","https://openalex.org/W4253858373","https://openalex.org/W4298141911"],"related_works":["https://openalex.org/W1709871131","https://openalex.org/W2008995850","https://openalex.org/W2319680604","https://openalex.org/W2259599096","https://openalex.org/W2151290321","https://openalex.org/W2036741092","https://openalex.org/W2126993406","https://openalex.org/W2932984801","https://openalex.org/W1578962611","https://openalex.org/W1975200253"],"abstract_inverted_index":{"Fusion":[0],"proteins":[1],"containing":[2,59],"immunoglobulin":[3,70],"Fc":[4],"domains":[5],"attached":[6],"to":[7,129,133,159,174,189],"bioactive":[8],"moieties":[9],"have":[10],"been":[11],"developed":[12],"as":[13,239],"therapeutic":[14,242],"agents":[15],"against":[16,244],"several":[17],"diseases.":[18],"Here,":[19],"we":[20],"describe":[21],"the":[22,36,65,89,117,137,175,185,225],"development":[23],"and":[24,111,132,171,217],"characteristics":[25],"of":[26,68,81,92,105,165,179,187,227],"a":[27,49,54,78,103,106,120,150,214,240],"novel":[28],"fusion":[29],"protein":[30],"(FLSC":[31],"R/T-IgG1)":[32],"that":[33,52,116,233],"targets":[34],"CCR5,":[35],"major":[37],"coreceptor":[38,176],"for":[39],"HIV-1":[40,211],"during":[41],"primary":[42,209],"infection.":[43],"FLSC":[44,75,100,156,182,192,205,234],"R/T-IgG1":[45,76,101,157,183,193,206,235],"was":[46,142,147,161],"expressed":[47],"from":[48,136],"synthetic":[50],"gene":[51],"linked":[53],"single":[55,152],"chain":[56,153],"gp120-CD4":[57,154],"complex":[58],"an":[60],"R5":[61,210],"gp120":[62],"sequence":[63],"with":[64,149,168],"hinge-CH2-CH3":[66],"portion":[67],"human":[69],"gamma":[71],"subtype":[72],"1.":[73],"Purified":[74],"exhibited":[77,102],"molecular":[79],"mass":[80,104],"189":[82],"kDa":[83],"under":[84,109],"reducing":[85,110],"conditions,":[86,113],"which":[87,114],"matched":[88],"expected":[90],"size":[91],"one":[93],"polypeptide":[94,108],"chain.":[95],"Chemically":[96],"crosslinked":[97],"or":[98],"untreated":[99],"360-kDa":[107],"nonreducing":[112],"indicated":[115],"molecule":[118,126],"adopts":[119],"disulfide-linked":[121],"bivalent":[122],"structure.":[123],"The":[124],"chimeric":[125],"bound":[127],"specifically":[128],"CCR5-expressing":[130],"cells":[131,167],"peptides":[134],"derived":[135],"CCR5":[138,160,169],"N-terminus.":[139],"Such":[140],"binding":[141,158,177,186],"more":[143],"efficient":[144],"than":[145],"what":[146],"obtained":[148],"monomeric":[151],"complex.":[155],"blocked":[162,184],"by":[163,172],"preincubation":[164],"coreceptor-expressing":[166],"ligands":[170],"antibody":[173],"domain":[178],"gp120.":[180],"Conversely,":[181],"chemokine":[188],"CCR5.":[190],"However,":[191],"did":[194,222],"not":[195,223],"trigger":[196],"intracellular":[197],"Ca2+":[198],"mobilization":[199],"in":[200,212],"peripheral":[201],"blood":[202],"mononuclear":[203],"cells.":[204],"potently":[207],"neutralized":[208],"both":[213],"PBMC-based":[215],"assay":[216],"cell":[218],"line-based":[219],"assays":[220],"but":[221],"affect":[224],"replication":[226],"X4":[228],"viruses.":[229],"These":[230],"findings":[231],"suggest":[232],"might":[236],"be":[237],"used":[238],"possible":[241],"agent":[243],"HIV.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
