{"id":"https://openalex.org/W2015602048","doi":"https://doi.org/10.1074/jbc.m909644199","title":"Structural Determinants in the C-terminal Domain of Apolipoprotein E Mediating Binding to the Protein Core of Human Aortic Biglycan","display_name":"Structural Determinants in the C-terminal Domain of Apolipoprotein E Mediating Binding to the Protein Core of Human Aortic Biglycan","publication_year":2000,"publication_date":"2000-06-01","ids":{"openalex":"https://openalex.org/W2015602048","doi":"https://doi.org/10.1074/jbc.m909644199","mag":"2015602048","pmid":"https://pubmed.ncbi.nlm.nih.gov/10751422"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m909644199","doi":"https://doi.org/10.1074/jbc.m909644199","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m909644199","pdf_url":"http://www.jbc.org/article/S0021925819801503/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819801503/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034759870","display_name":"Olga Klezovitch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Olga Klezovitch","raw_affiliation_strings":["Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA. oklezovi@medicine.bsd.uchicago.edu","Department of Medicine, University of Chicago, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA. oklezovi@medicine.bsd.uchicago.edu","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Medicine, University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040296683","display_name":"Marilena Formato","orcid":"https://orcid.org/0000-0001-9207-5787","observed_orcids":["https://orcid.org/0000-0001-9207-5787"]},"institutions":[{"id":"https://openalex.org/I159650629","display_name":"University of Sassari","ror":"https://ror.org/01bnjbv91","country_code":"IT","type":"education","lineage":["https://openalex.org/I159650629"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marilena Formato","raw_affiliation_strings":["Department of Physiological, Biochemical, and Cellular Sciences, University of Sassari, 07100 Sassari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological, Biochemical, and Cellular Sciences, University of Sassari, 07100 Sassari, Italy","institution_ids":["https://openalex.org/I159650629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109097974","display_name":"Gian Mario Cherchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159650629","display_name":"University of Sassari","ror":"https://ror.org/01bnjbv91","country_code":"IT","type":"education","lineage":["https://openalex.org/I159650629"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gian M. Cherchi","raw_affiliation_strings":["Department of Physiological, Biochemical, and Cellular Sciences, University of Sassari, 07100 Sassari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological, Biochemical, and Cellular Sciences, University of Sassari, 07100 Sassari, Italy","institution_ids":["https://openalex.org/I159650629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110083694","display_name":"Karl Heinrich Weisgraber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karl H. Weisgraber","raw_affiliation_strings":["Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, Department of Pathology, University of California, San Francisco, California 94141-9100"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, Department of Pathology, University of California, San Francisco, California 94141-9100","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103396070","display_name":"Angelo M. Scanu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelo M. Scanu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637","Department of Medicine, University of Chicago, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Medicine, University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034759870"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.9011,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.67214112,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"275","issue":"25","first_page":"18913","last_page":"18918"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.8130000233650208,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.8130000233650208,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.06539999693632126,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":1.0},{"id":"https://openalex.org/keywords/biglycan","display_name":"biglycan","score":0.9890000224113464},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.6990000009536743},{"id":"https://openalex.org/keywords/protein-protein-binding","display_name":"protein-protein binding","score":0.8899999856948853},{"id":"https://openalex.org/keywords/high-density-lipoprotein","display_name":"high-density lipoprotein","score":0.8650000095367432},{"id":"https://openalex.org/keywords/ionic-interactions","display_name":"ionic interactions","score":0.7680000066757202},{"id":"https://openalex.org/keywords/charged-amino-acid-residues","display_name":"charged amino acid residues","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.7029635310173035},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6659277677536011},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.5653606057167053},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5550690293312073},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.5256365537643433},{"id":"https://openalex.org/C2778916964","wikidata":"https://www.wikidata.org/wiki/Q14905499","display_name":"Biglycan","level":5,"score":0.5061470866203308},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4628324806690216},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4608478248119354},{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.4470415711402893},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.44677355885505676},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.42273199558258057},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3596944212913513},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3365441560745239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19125789403915405},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.12673252820968628},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.0959463119506836},{"id":"https://openalex.org/C2779794767","wikidata":"https://www.wikidata.org/wiki/Q18248676","display_name":"Decorin","level":4,"score":0.0826876163482666},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07442700862884521},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004134","descriptor_name":"Dimyristoylphosphatidylcholine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058578","descriptor_name":"Biglycan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m909644199","doi":"https://doi.org/10.1074/jbc.m909644199","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m909644199","pdf_url":"http://www.jbc.org/article/S0021925819801503/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:10751422","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10751422","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniss.it:11388/45123","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11388/45123","pdf_url":null,"source":{"id":"https://openalex.org/S4306401147","display_name":"UnissResearch (Universit\u00e0 degli Studi di Sassari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I159650629","host_organization_name":"University of Sassari","host_organization_lineage":["https://openalex.org/I159650629"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:zenodo.org:96029","doi":null,"is_oa":true,"landing_page_url":"https://www.openaccessrepository.it/record/96029","pdf_url":null,"source":{"id":"https://openalex.org/S4306402478","display_name":"INFM-OAR (INFN Catania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210116497","host_organization_name":"Istituto Nazionale di Fisica Nucleare, Sezione di Catania","host_organization_lineage":["https://openalex.org/I4210116497"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m909644199","doi":"https://doi.org/10.1074/jbc.m909644199","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m909644199","pdf_url":"http://www.jbc.org/article/S0021925819801503/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3786833126","display_name":"LIPOPROTEIN STRUCTURE/FUNCTION IN CHOLESTEROL METABOLISM","funder_award_id":"P01HL041633","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6075360317","display_name":null,"funder_award_id":"HL63115-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7285274494","display_name":"INTERACTIONS OF LP(A) WITH VASCULAR EXTRACELLULAR MATRIX","funder_award_id":"R01HL063115","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8858153447","display_name":"LIPOPROTEIN(A) HETEROGENEITY--STRUCTURE AND BIOLOGY","funder_award_id":"P01HL018577","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015602048.pdf","grobid_xml":"https://content.openalex.org/works/W2015602048.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W14380143","https://openalex.org/W134453782","https://openalex.org/W149726692","https://openalex.org/W274686055","https://openalex.org/W941423621","https://openalex.org/W1483795916","https://openalex.org/W1487164341","https://openalex.org/W1490077018","https://openalex.org/W1504348021","https://openalex.org/W1505230657","https://openalex.org/W1511588285","https://openalex.org/W1522309562","https://openalex.org/W1529259401","https://openalex.org/W1545622372","https://openalex.org/W1545878785","https://openalex.org/W1546262989","https://openalex.org/W1559121591","https://openalex.org/W1970259339","https://openalex.org/W1972960247","https://openalex.org/W1973681763","https://openalex.org/W1976387366","https://openalex.org/W1977507461","https://openalex.org/W1990717706","https://openalex.org/W1994731124","https://openalex.org/W2001861433","https://openalex.org/W2008071295","https://openalex.org/W2018563903","https://openalex.org/W2019405824","https://openalex.org/W2019414027","https://openalex.org/W2021292488","https://openalex.org/W2021304013","https://openalex.org/W2031899050","https://openalex.org/W2032561094","https://openalex.org/W2035252462","https://openalex.org/W2048890665","https://openalex.org/W2052240757","https://openalex.org/W2055138438","https://openalex.org/W2056908901","https://openalex.org/W2057795079","https://openalex.org/W2062578590","https://openalex.org/W2070837601","https://openalex.org/W2075073611","https://openalex.org/W2079517191","https://openalex.org/W2079564988","https://openalex.org/W2081065612","https://openalex.org/W2090708860","https://openalex.org/W2092846536","https://openalex.org/W2097242070","https://openalex.org/W2146844497","https://openalex.org/W2150436995","https://openalex.org/W2163919661","https://openalex.org/W2279858885","https://openalex.org/W2315335674","https://openalex.org/W2406479357","https://openalex.org/W2438320578"],"related_works":["https://openalex.org/W2022288613","https://openalex.org/W2001758099","https://openalex.org/W2099076719","https://openalex.org/W2006324786","https://openalex.org/W134453782","https://openalex.org/W2090708860","https://openalex.org/W1977728730","https://openalex.org/W2061095884","https://openalex.org/W2165320750","https://openalex.org/W2073051320"],"abstract_inverted_index":{"Apolipoprotein":[0],"(apo)":[1],"E-containing":[2],"high":[3],"density":[4],"lipoprotein":[5],"particles":[6],"were":[7,135],"reported":[8],"to":[9,45,61,187],"interact":[10],"in":[11,24,36,67,81,157,168,198],"vitro":[12,37],"with":[13,42,118,137],"the":[14,19,35,82,113,127,154,158,169,176,183,188],"proteoglycan":[15],"biglycan":[16],"(Bg),":[17],"but":[18],"direct":[20],"participation":[21],"of":[22,39,75,84,148,185,202],"apoE":[23,40,110,186],"this":[25,31,194],"binding":[26,38,78,184,195],"was":[27,79,89,131,166],"not":[28],"defined.":[29],"To":[30],"end,":[32],"we":[33],"examined":[34],"complexed":[41,117],"dimyristoylphosphatidylcholine":[43],"(DMPC)":[44],"human":[46],"aortic":[47],"Bg":[48,62,189],"before":[49],"and":[50,63,88,164,192,200],"after":[51],"glycosaminoglycan":[52],"(GAG)":[53],"depletion.":[54],"In":[55],"a":[56,68,72,138,146],"solid-phase":[57],"assay,":[58],"apoE.DMPC":[59],"bound":[60,120],"GAG-depleted":[64],"protein":[65,190],"core":[66,191],"similar":[69],"manner,":[70],"suggesting":[71],"protein-protein":[73],"mode":[74],"interaction.":[76],"The":[77],"decreased":[80],"presence":[83],"1":[85],"m":[86,96,103],"NaCl":[87],"partially":[90],"inhibited":[91],"by":[92],"either":[93],"positively":[94],"(0.2":[95,102],"lysine,":[97],"arginine)":[98],"or":[99],"negatively":[100],"charged":[101,155],"aspartic,":[104],"glutamic)":[105],"amino":[106],"acids.":[107],"A":[108],"recombinant":[109,149],"fragment":[111],"representing":[112],"C-terminal":[114,159,177],"10-kDa":[115],"domain,":[116],"DMPC,":[119],"as":[121,123],"efficiently":[122],"full-length":[124],"apoE,":[125],"whereas":[126],"N-terminal":[128],"22-kDa":[129],"domain":[130,160,178],"inactive.":[132],"Similar":[133],"results":[134,173],"obtained":[136],"gel":[139],"mobility":[140],"shift":[141],"assay.":[142],"Competition":[143],"studies":[144],"using":[145],"series":[147],"truncated":[150],"apoEs":[151],"showed":[152],"that":[153,175,193],"segment":[156],"between":[161],"residues":[162],"223":[163],"230":[165],"involved":[167],"binding.":[170],"Overall,":[171],"our":[172],"demonstrate":[174],"contains":[179],"elements":[180],"critical":[181],"for":[182],"is":[196],"ionic":[197],"nature":[199],"independent":[201],"GAGs.":[203]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
