{"id":"https://openalex.org/W2015548677","doi":"https://doi.org/10.1111/j.1445-2197.1987.tb01315.x","title":"MORPHOLOGICAL CHANGES CAUSED BY EXPOSURE OF RABBIT OESOPHAGEAL MUCOSA TO HYDROCHLORIC ACID AND SODIUM TAUROCHOLATE","display_name":"MORPHOLOGICAL CHANGES CAUSED BY EXPOSURE OF RABBIT OESOPHAGEAL MUCOSA TO HYDROCHLORIC ACID AND SODIUM TAUROCHOLATE","publication_year":1987,"publication_date":"1987-02-01","ids":{"openalex":"https://openalex.org/W2015548677","doi":"https://doi.org/10.1111/j.1445-2197.1987.tb01315.x","mag":"2015548677","pmid":"https://pubmed.ncbi.nlm.nih.gov/3475052"},"language":"en","primary_location":{"id":"doi:10.1111/j.1445-2197.1987.tb01315.x","doi":"https://doi.org/10.1111/j.1445-2197.1987.tb01315.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1445-2197.1987.tb01315.x","pdf_url":null,"source":{"id":"https://openalex.org/S111387087","display_name":"Australian and New Zealand Journal of Surgery","issn_l":"0004-8682","issn":["0004-8682","1440-1622"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Australian and New Zealand Journal of Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082603294","display_name":"George Kiroff","orcid":"https://orcid.org/0000-0003-0523-5311","observed_orcids":["https://orcid.org/0000-0003-0523-5311"]},"institutions":[{"id":"https://openalex.org/I107656453","display_name":"South Australia Pathology","ror":"https://ror.org/01kvtm035","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I107656453"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"GeorgeK. Kiroff","raw_affiliation_strings":["Department of Surgery, University of Adelaide, Adelaide and the Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Adelaide, Adelaide and the Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia","institution_ids":["https://openalex.org/I107656453","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045754192","display_name":"TapenM. Mukerjhee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107656453","display_name":"South Australia Pathology","ror":"https://ror.org/01kvtm035","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I107656453"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"TapenM. Mukerjhee","raw_affiliation_strings":["Department of Surgery, University of Adelaide, Adelaide and the Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Adelaide, Adelaide and the Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia","institution_ids":["https://openalex.org/I107656453","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110323156","display_name":"BRUCE K. DIXON","orcid":"https://orcid.org/0000-0003-2173-3695","observed_orcids":["https://orcid.org/0000-0003-2173-3695"]},"institutions":[{"id":"https://openalex.org/I107656453","display_name":"South Australia Pathology","ror":"https://ror.org/01kvtm035","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I107656453"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Bruce Dixon","raw_affiliation_strings":["Department of Surgery, University of Adelaide, Adelaide and the Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Adelaide, Adelaide and the Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia","institution_ids":["https://openalex.org/I107656453","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110323574","display_name":"Peter G. Devitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107656453","display_name":"South Australia Pathology","ror":"https://ror.org/01kvtm035","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I107656453"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"PeterG. Devitt","raw_affiliation_strings":["Department of Surgery, University of Adelaide, Adelaide and the Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Adelaide, Adelaide and the Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia","institution_ids":["https://openalex.org/I107656453","https://openalex.org/I5681781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113573581","display_name":"G G Jamieson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107656453","display_name":"South Australia Pathology","ror":"https://ror.org/01kvtm035","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I107656453"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"GlynG. Jamieson","raw_affiliation_strings":["Department of Surgery, University of Adelaide, Adelaide and the Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Adelaide, Adelaide and the Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia","institution_ids":["https://openalex.org/I107656453","https://openalex.org/I5681781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113573581"],"corresponding_institution_ids":["https://openalex.org/I107656453","https://openalex.org/I5681781"],"apc_list":null,"apc_paid":null,"fwci":1.3647,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.79525862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"57","issue":"2","first_page":"119","last_page":"126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.7035999894142151,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.7035999894142151,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11658","display_name":"Esophageal and GI Pathology","score":0.18050000071525574,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-mucosa","display_name":"esophageal mucosa","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hydrochloric-acid","display_name":"hydrochloric acid","score":0.9150000214576721},{"id":"https://openalex.org/keywords/sodium-taurocholate","display_name":"sodium taurocholate","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bile-salts","display_name":"bile salts","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mucosal-injury","display_name":"mucosal injury","score":0.7990000247955322},{"id":"https://openalex.org/keywords/epithelial-desquamation","display_name":"epithelial desquamation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/stratum-spinosum","display_name":"stratum spinosum","score":0.7160000205039978},{"id":"https://openalex.org/keywords/basal-cells","display_name":"basal cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/stratum-granulosum","display_name":"stratum granulosum","score":0.8040000200271606},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C2776003677","wikidata":"https://www.wikidata.org/wiki/Q2738617","display_name":"Desquamation","level":2,"score":0.5869580507278442},{"id":"https://openalex.org/C2777436746","wikidata":"https://www.wikidata.org/wiki/Q2409","display_name":"Hydrochloric acid","level":2,"score":0.5776019096374512},{"id":"https://openalex.org/C2779922919","wikidata":"https://www.wikidata.org/wiki/Q2361534","display_name":"Stratum granulosum","level":3,"score":0.5155544281005859},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.4945385158061981},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.47457149624824524},{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.4743860065937042},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.46426156163215637},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44544118642807007},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.43486320972442627},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.43312662839889526},{"id":"https://openalex.org/C47089857","wikidata":"https://www.wikidata.org/wiki/Q2602702","display_name":"Stratum spinosum","level":3,"score":0.41348662972450256},{"id":"https://openalex.org/C2780369685","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell damage","level":2,"score":0.41016507148742676},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31766849756240845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26884734630584717},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23621982336044312},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006851","descriptor_name":"Hydrochloric Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013656","descriptor_name":"Taurocholic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1445-2197.1987.tb01315.x","doi":"https://doi.org/10.1111/j.1445-2197.1987.tb01315.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1445-2197.1987.tb01315.x","pdf_url":null,"source":{"id":"https://openalex.org/S111387087","display_name":"Australian and New Zealand Journal of Surgery","issn_l":"0004-8682","issn":["0004-8682","1440-1622"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Australian and New Zealand Journal of Surgery","raw_type":"journal-article"},{"id":"pmid:3475052","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3475052","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Australian and New Zealand journal of surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1574978899","https://openalex.org/W1985650274","https://openalex.org/W1997326143","https://openalex.org/W2024219177","https://openalex.org/W2034420190","https://openalex.org/W2037391219","https://openalex.org/W2074476123","https://openalex.org/W2090940415","https://openalex.org/W2101369093","https://openalex.org/W2122272040","https://openalex.org/W2141419320","https://openalex.org/W2158647313","https://openalex.org/W2169484065","https://openalex.org/W2173895357","https://openalex.org/W2212016272","https://openalex.org/W2212466117","https://openalex.org/W2264370189","https://openalex.org/W2334494206","https://openalex.org/W2334559133","https://openalex.org/W2396311851","https://openalex.org/W2411959109","https://openalex.org/W2412080131","https://openalex.org/W2426930087","https://openalex.org/W2429333738","https://openalex.org/W4300891087"],"related_works":["https://openalex.org/W7051435186","https://openalex.org/W2034420190","https://openalex.org/W1985650274","https://openalex.org/W1997326143","https://openalex.org/W2587846478","https://openalex.org/W1977852127","https://openalex.org/W2096162308","https://openalex.org/W2083381505","https://openalex.org/W2409068987","https://openalex.org/W2053560061"],"abstract_inverted_index":{"The":[0],"present":[1],"authors":[2],"have":[3],"studied":[4],"the":[5,33,58,64,71,98,110,124,133,143,154,186,191,195,200,205,214],"light":[6,74,210],"and":[7,24,68,75,101,130,157,198],"electron":[8,76],"microscopic":[9,211],"changes":[10,212],"in":[11,30,86,109,123,137,153,190,204,213],"rabbit":[12],"oesophageal":[13,144,183,196],"mucosa":[14,197],"which":[15],"has":[16],"been":[17],"exposed":[18],"to":[19,97,127,151,166,181],"solutions":[20],"of":[21,42,60,80,120,132,164,194,207],"hydrochloric":[22],"acid":[23,39,114],"sodium":[25],"taurocholate":[26,45,178],"(ST).":[27],"In":[28],"an":[29],"vivo":[31],"model":[32],"oesophagus":[34,65],"was":[35,66,94,106],"perfused":[36,89,115],"with":[37,172],"saline,":[38],"(0.1-40":[40],"mmol/l":[41,47,53],"H+)":[43],"or":[44,51,209],"(0.1-1.0":[46],"at":[48,54],"pH":[49],"2.0":[50],"1.0":[52],"neutral":[55,138],"pH).":[56],"At":[57],"end":[59],"each":[61],"perfusion":[62],"experiment":[63],"removed":[67],"assessed":[69],"by":[70],"naked":[72],"eye,":[73],"microscopy.":[77],"Some":[78],"desquamation":[79],"superficial":[81],"stratum":[82,99,158],"corneum":[83],"cells":[84,126,152],"occurred":[85,160],"all":[87],"specimens":[88],"for":[90],"5":[91],"h.":[92],"Injury":[93],"more":[95,107],"evident":[96],"spinosum":[100],"basal":[102,125,155],"cell":[103],"layers.":[104,135],"Damage":[105],"severe":[108],"bile":[111],"salt":[112],"plus":[113],"specimens,":[116],"varying":[117],"between":[118],"margination":[119],"nuclear":[121],"chromatin":[122],"complete":[128],"necrosis":[129],"separation":[131],"overlying":[134],"Taurocholate":[136],"solution":[139],"did":[140],"not":[141],"damage":[142,150,170,182,187,201],"epithelium.":[145],"Electron":[146],"microscopy":[147],"revealed":[148],"that":[149,177,185,199],"layers":[156,193],"granulosum":[159],"within":[161],"30":[162],"min":[163],"exposure":[165],"acidified":[167],"taurocholate,":[168],"this":[169],"increasing":[171],"time.":[173],"It":[174],"is":[175,179],"concluded":[176],"able":[180],"mucosa,":[184],"first":[188],"occurs":[189],"deeper":[192],"may":[202],"occur":[203],"absence":[206],"gross":[208],"mucosa.":[215]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
